KEGG   PATHWAY: myd04625
Entry
myd04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Myotis davidii (David's myotis)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
myd04625  C-type lectin receptor signaling pathway
myd04625

Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102753923  CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
102753137  LSP1; lymphocyte-specific protein 1 [KO:K14957]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102757500  MRAS; muscle RAS oncogene homolog [KO:K07831]
102770869  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
102765159  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102770704  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102759568  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
102753538  IL12A; interleukin 12A [KO:K05406]
102756968  IL12B; interleukin 12B [KO:K05425]
102769803  IL1B; interleukin 1 beta [KO:K04519]
102772593  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
102755861  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102762988  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102760888  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102762701  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102773476  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102755292  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102764661  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102754756  CALM1; calmodulin 1 [KO:K02183]
102772033  CALM3; calmodulin 3 [KO:K02183]
102772812  CALML3; calmodulin like 3 [KO:K02183]
102773102  CALML5; calmodulin like 5 [KO:K02183]
102756281  CALM2; calmodulin 2 [KO:K02183]
102772521  CALML6; calmodulin like 6 [KO:K02183]
102764405  calmodulin-like [KO:K02183]
102755062  CALML4; calmodulin like 4 [KO:K02183]
102755500  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102753757  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102754623  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102774846  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102760712  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102763205  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102762996  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
102765232  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102774663  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
102773629  IL2; interleukin 2 [KO:K05429]
102774814  IL10; interleukin 10 [KO:K05443]
102763960  EGR2; early growth response 2 [KO:K12496]
102752540  EGR3; early growth response 3 [KO:K12497]
102774808  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102760591  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102755091  NLRP3; NLR family pyrin domain containing 3 [KO:K12800]
102770333  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102769699  caspase-1 [KO:K01370] [EC:3.4.22.36]
102754216  BCL10; B-cell CLL/lymphoma 10 [KO:K07368]
102752274  MALT1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
102761550  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102772051  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102773824  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102763089  NFKBIA; NFKB inhibitor alpha [KO:K04734]
102770715  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102758774  TNF; tumor necrosis factor [KO:K03156]
102760336  IL6; interleukin 6 [KO:K05405]
102765952  IL23A; interleukin 23 subunit alpha [KO:K05426]
102770309  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102770021  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102755728  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102756012  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102772062  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102764416  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102775351  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
107183844  JUNB; JunB proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102752693  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102759944  CBLB; Cbl proto-oncogene B [KO:K22517] [EC:2.3.2.27]
102760595  CLEC6A; C-type lectin domain family 6 member A [KO:K17514]
102759267  C-type lectin domain family 6 member A [KO:K17514]
102771438  FCER1G; Fc fragment of IgE receptor Ig [KO:K07983]
102758857  CD209; CD209 antigen-like protein 2 [KO:K06563]
102761091  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102751353  RHOA; ras homolog family member A [KO:K04513]
102755302  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102755844  KSR1; kinase suppressor of ras 1 [KO:K14958]
102752290  PLK3; polo like kinase 3 [KO:K08862] [EC:2.7.11.21]
102769511  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102760291  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102757059  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
102768335  IRF9; interferon regulatory factor 9 [KO:K04693]
102766233  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
107184378  IL17D; interleukin 17D [KO:K05492]
102765473  CYLD; CYLD lysine 63 deubiquitinase [KO:K08601] [EC:3.4.19.12]
102766849  CCL22; C-C motif chemokine ligand 22 [KO:K21095]
102775090  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102764343  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102766356  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102758951  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102763670  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102753036  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102760468  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102771162  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102766150  IRF1; interferon regulatory factor 1 [KO:K09444]
102760875  CLEC4D; C-type lectin domain family 4 member D [KO:K10058]
102753358  CLEC1B; C-type lectin domain family 1 member B [KO:K10070]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
Related
pathway
myd04658  Th1 and Th2 cell differentiation
myd04659  Th17 cell differentiation
KO pathway
ko04625   
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