KEGG   PATHWAY: mze00310
Entry
mze00310                    Pathway                                
Name
Lysine degradation - Maylandia zebra (zebra mbuna)
Class
Metabolism; Amino acid metabolism
Pathway map
mze00310  Lysine degradation
mze00310

Module
mze_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:mze00310]
Other DBs
GO: 0006554
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101483693  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial [KO:K14157] [EC:1.5.1.8 1.5.1.9]
101482988  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101487147  aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
101480158  dhtkd1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
101475697  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
101463781  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
101467432  dld; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
101471797  glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
101479842  glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
101468911  trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
101473024  trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
101484421  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
101487381  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
101465947  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform X2 [KO:K00022] [EC:1.1.1.35]
101479361  acat1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
101479210  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
101485107  hykk; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
101479762  5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
101474751  pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101465341  camkmt; calmodulin-lysine N-methyltransferase isoform X1 [KO:K18826] [EC:2.1.1.60]
101478918  kmt2a; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
101486529  kmt2d; histone-lysine N-methyltransferase 2D isoform X1 [KO:K09187] [EC:2.1.1.354]
101465418  histone-lysine N-methyltransferase 2C isoform X1 [KO:K09188] [EC:2.1.1.354]
101481911  histone-lysine N-methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
101467874  histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
101481309  kmt2b; histone-lysine N-methyltransferase 2B isoform X1 [KO:K14959] [EC:2.1.1.354]
101483461  kmt2e; inactive histone-lysine N-methyltransferase 2E isoform X1 [KO:K09189] [EC:2.1.1.354]
101469655  setd1a; histone-lysine N-methyltransferase SETD1A [KO:K11422] [EC:2.1.1.354]
101470643  setd1b; histone-lysine N-methyltransferase SETD1B isoform X2 [KO:K11422] [EC:2.1.1.354]
101473334  setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
101474223  histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
101472002  histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
101465538  histone-lysine N-methyltransferase ASH1L [KO:K06101] [EC:2.1.1.354]
101478151  smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101476372  N-lysine methyltransferase SMYD2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101479308  histone-lysine N-methyltransferase SMYD1 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101473364  N-lysine methyltransferase SMYD2-A isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101481292  histone-lysine N-methyltransferase SMYD1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
101475727  suv39h1; histone-lysine N-methyltransferase SUV39H1 [KO:K11419] [EC:2.1.1.355]
101469152  histone-lysine N-methyltransferase EHMT1 [KO:K11420] [EC:2.1.1.355]
101481293  histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
101468177  ehmt2; histone-lysine N-methyltransferase EHMT2 isoform X2 [KO:K11420] [EC:2.1.1.355]
101465322  setdb1; histone-lysine N-methyltransferase SETDB1 isoform X1 [KO:K11421] [EC:2.1.1.366]
101467738  histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
101467872  PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
101475356  PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
101474304  ezh1; histone-lysine N-methyltransferase EZH1 [KO:K17451] [EC:2.1.1.356]
101464777  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
112429845  ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
101470671  histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
101468986  histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
112435269  histone-lysine N-methyltransferase SETMAR-like [KO:K11433] [EC:2.1.1.357]
101464914  histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1 [KO:K15588] [EC:2.1.1.357]
101485022  histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K15588] [EC:2.1.1.357]
101475058  nsd2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
101481339  nsd3; histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
101471514  setd2; histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
101473918  dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
101470368  kmt5a; N-lysine methyltransferase KMT5A [KO:K11428] [EC:2.1.1.361]
112434147  histone-lysine N-methyltransferase set-1-like [KO:K11428] [EC:2.1.1.361]
101485410  N-lysine methyltransferase KMT5A [KO:K11428] [EC:2.1.1.361]
112436186  histone-lysine N-methyltransferase set-1-like [KO:K11428] [EC:2.1.1.361]
112436306  uncharacterized protein LOC112436306 [KO:K11428] [EC:2.1.1.361]
101468308  prdm6; LOW QUALITY PROTEIN: putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
112433498  putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
101471827  kmt5b; histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
101477849  uncharacterized protein LOC101477849 [KO:K11429] [EC:2.1.1.362]
101468114  mecom; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
101472744  prdm16; PR domain zinc finger protein 16 isoform X1 [KO:K22410] [EC:2.1.1.367]
101473435  tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
101470125  aldh16a1; aldehyde dehydrogenase family 16 member A1 isoform X2 [KO:K00128] [EC:1.2.1.3]
101468171  aldh2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
101478333  aldehyde dehydrogenase, dimeric NADP-preferring isoform X1 [KO:K00128] [EC:1.2.1.3]
101478994  fatty aldehyde dehydrogenase isoform X1 [KO:K00128] [EC:1.2.1.3]
101479424  fatty aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
101480450  aldehyde dehydrogenase family 9 member A1-B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
101486789  aldehyde dehydrogenase family 9 member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
106676834  aldehyde dehydrogenase family 9 member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
101466552  bbox1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
101463708  plod1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
101482880  procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [KO:K13645] [EC:1.14.11.4]
101473400  procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
101465301  cercam; inactive glycosyltransferase 25 family member 3 [KO:K11703] [EC:2.4.1.50]
101463765  procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
101480600  procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
101469839  procollagen galactosyltransferase 2 [KO:K11703] [EC:2.4.1.50]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
mze00020  Citrate cycle (TCA cycle)
mze00780  Biotin metabolism
KO pathway
ko00310   
LinkDB

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