KEGG   PATHWAY: nfu04144
Entry
nfu04144                    Pathway                                
Name
Endocytosis - Nothobranchius furzeri (turquoise killifish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
nfu04144  Endocytosis
nfu04144

Other DBs
GO: 0006897
Organism
Nothobranchius furzeri (turquoise killifish) [GN:nfu]
Gene
107392355  ADP-ribosylation factor 6 [KO:K07941]
107378086  arf6; ADP-ribosylation factor 6 [KO:K07941]
107375032  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107379733  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107394645  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
107393902  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
107393349  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
107384120  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
107395109  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
107383128  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
107392072  pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
107386502  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
107374425  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
107393448  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
107384380  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
107386210  dynamin-1-like isoform X1 [KO:K01528] [EC:3.6.5.5]
107390423  dynamin-2-like [KO:K23484] [EC:3.6.5.5]
107378301  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
107390942  clta; clathrin light chain A isoform X1 [KO:K04644]
107374276  cltb; clathrin light chain B isoform X1 [KO:K04645]
107380680  clathrin heavy chain 1-like isoform X1 [KO:K04646]
107386359  cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
107394263  clathrin heavy chain 1-like isoform X1 [KO:K04646]
107391808  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
107381936  AP-2 complex subunit alpha-2-like [KO:K11824]
107387063  ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
107384105  ap2m1; AP-2 complex subunit mu [KO:K11826]
107380299  ap2s1; AP-2 complex subunit sigma [KO:K11827]
107395454  AP-2 complex subunit sigma-like [KO:K11827]
107380508  EH domain-containing protein 2-like [KO:K12469]
107380158  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
107374334  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
107389601  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
107394548  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107372384  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
107393238  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
107383526  zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
107395797  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
107393511  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
107388715  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
107384334  transferrin receptor protein 1-like isoform X1 [KO:K06503]
107384335  transferrin receptor protein 1-like [KO:K06503]
107383062  transferrin receptor protein 1-like [KO:K06503]
107383161  melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
107383833  egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107393382  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
107375397  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107391665  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
107386693  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107388825  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107382005  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
107387219  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
107380353  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
107379537  E3 ubiquitin-protein ligase CBL-like [KO:K22518] [EC:2.3.2.27]
107383063  sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
107393257  endophilin-A2-like [KO:K11247]
107376849  endophilin-A1-like isoform X1 [KO:K11247]
107389171  sh3gl2; endophilin-A1 isoform X1 [KO:K11247]
107384132  endophilin-A2-like isoform X1 [KO:K11247]
107382675  endophilin-B1-like [KO:K11248]
107395107  endophilin-B2-like isoform X1 [KO:K21269]
107392059  endophilin-B1-like isoform X1 [KO:K21269]
107393465  endophilin-B2-like isoform X1 [KO:K21269]
107383691  amph; amphiphysin [KO:K12562]
107390159  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
107384639  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
107394843  epsin-3-like isoform X1 [KO:K12471]
107373120  epsin-3-like [KO:K12471]
107379685  epsin-1-like isoform X1 [KO:K12471]
107395398  epn3; epsin-3 [KO:K12471]
107376710  epn2; epsin-2 [KO:K12471]
107378285  epsin-3-like isoform X1 [KO:K12471]
107393150  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
107387338  eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
107384352  uncharacterized protein LOC107384352 isoform X1 [KO:K12472]
107383601  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
107380233  spartin-like isoform X1 [KO:K19366]
107386908  spg20; spartin isoform X1 [KO:K19366]
107381388  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
107374698  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
107387038  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
107383589  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107390387  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
107385376  itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
107391319  E3 ubiquitin-protein ligase Itchy-like isoform X1 [KO:K05632] [EC:2.3.2.26]
107376250  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
107376347  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
107391562  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
107382627  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
107376229  ldlr; low-density lipoprotein receptor [KO:K12473]
107382301  low-density lipoprotein receptor-like isoform X1 [KO:K12473]
107396970  low density lipoprotein receptor adapter protein 1-B-like [KO:K12474]
107377506  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
107392515  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
107377314  uncharacterized protein LOC107377314 [KO:K12474]
107374903  dab2; disabled homolog 2 isoform X1 [KO:K12475]
107389373  C-X-C chemokine receptor type 1-like [KO:K05050]
107389382  C-X-C chemokine receptor type 1-like [KO:K05050]
107380881  C-X-C chemokine receptor type 2-like [KO:K05050]
107384286  C-X-C chemokine receptor type 4-like [KO:K04189]
107390218  cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
107389806  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
107380487  G-protein-coupled receptor kinase 7A-like [KO:K00909] [EC:2.7.11.14]
107381624  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
107374459  grk7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
107386487  rhodopsin kinase-like isoform X1 [KO:K00909] [EC:2.7.11.14]
107396329  beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
107393217  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
107395648  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
107387089  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
107393676  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
107379904  arrb1; beta-arrestin-1 [KO:K04439]
107387174  arrestin red cell isoform 1 [KO:K04439]
107382422  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107384740  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107389504  neural Wiskott-Aldrich syndrome protein-like isoform X1 [KO:K23612]
107385718  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
107374499  formin-like protein 5 [KO:K23612]
107395617  formin-2-like [KO:K23612]
107377040  actin-related protein 2-like [KO:K17260]
107376067  actr2; actin-related protein 2 [KO:K17260]
107382736  actin-related protein 3-like [KO:K18584]
107373242  actin-related protein 3-like [KO:K18584]
107377239  actin-related protein 3 [KO:K18584]
107388883  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
107388895  actin-related protein 2/3 complex subunit 1A [KO:K05757]
107391795  actin-related protein 2/3 complex subunit 1A-like isoform X1 [KO:K05757]
107380879  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
107397155  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
107385715  actin-related protein 2/3 complex subunit 4 [KO:K05755]
107384938  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
107392887  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
107395200  WAS/WASL-interacting protein family member 2-like [KO:K19475]
107375905  wipf1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
107382427  wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
107395651  heat shock cognate 71 kDa protein-like [KO:K03283]
107372823  heat shock 70 kDa protein 1-like [KO:K03283]
107386347  heat shock cognate 70 kDa protein [KO:K03283]
107380091  heat shock cognate 70 kDa protein-like [KO:K03283]
107373895  heat shock 70 kDa protein 1 [KO:K03283]
107392909  dnajc6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
107389049  kiaa1033; WASH complex subunit 7 [KO:K18465]
107378776  kiaa0196; WASH complex subunit strumpellin isoform X1 [KO:K18464]
107375694  WASH complex subunit FAM21-like isoform X1 [KO:K18462]
107388840  WAS protein family homolog 1-like [KO:K18461]
107386120  ccdc53; WASH complex subunit CCDC53 [KO:K18463]
107395673  F-actin-capping protein subunit alpha-2 [KO:K10364]
107373675  F-actin-capping protein subunit alpha-1-like [KO:K10364]
107385773  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
107391626  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
107380096  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
107381867  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
107373720  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
107386733  sorting nexin-12 isoform X1 [KO:K17918]
107377531  snx3; sorting nexin-3 [KO:K17918]
107381712  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
107386091  stambp; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
107385713  ras-related protein Rab-7a [KO:K07897]
107385862  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
107385419  ras-related protein Rab-7a-like [KO:K07897]
107395391  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
107389653  stam2; signal transducing adapter molecule 2 [KO:K04705]
107383774  stam; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
107389004  tsg101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
107394834  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
107393642  mvb12b; multivesicular body subunit 12B isoform X1 [KO:K12186]
107390523  mvb12a; multivesicular body subunit 12A [KO:K12186]
107394757  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
107390849  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
107379998  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
107387120  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
107395823  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
107393482  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
107387459  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
107386973  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
107387666  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
107387268  chmp6; charged multivesicular body protein 6 [KO:K12195]
107390603  charged multivesicular body protein 4b [KO:K12194]
107384919  charged multivesicular body protein 4b-like [KO:K12194]
107382496  charged multivesicular body protein 4c-like [KO:K24782]
107392329  chmp3; charged multivesicular body protein 3 [KO:K12193]
107387462  chmp2a; charged multivesicular body protein 2a [KO:K12191]
107389400  chmp2b; charged multivesicular body protein 2b [KO:K12192]
107393609  chmp7; charged multivesicular body protein 7 [KO:K15053]
107383940  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
107393420  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
107389286  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
107377942  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
107386562  chmp1b; charged multivesicular body protein 1b [KO:K12197]
107389289  chmp1a; charged multivesicular body protein 1a [KO:K12197]
107383787  chmp5; charged multivesicular body protein 5 isoform X1 [KO:K12198]
107382522  charged multivesicular body protein 5 [KO:K12198]
107381610  ist1; IST1 homolog isoform X1 [KO:K19476]
107394795  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
107373557  spg21; maspardin isoform X1 [KO:K19367]
107377842  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
107381774  snx1; sorting nexin-1 [KO:K17917]
107380827  sorting nexin-1-like [KO:K17917]
107386119  snx2; sorting nexin-2 isoform X1 [KO:K17917]
107391919  snx6; sorting nexin-6 isoform X1 [KO:K17920]
107375573  snx5; sorting nexin-5 [KO:K17920]
107385632  sorting nexin-6-like isoform X1 [KO:K17920]
107390456  proto-oncogene tyrosine-protein kinase Src-like [KO:K05704] [EC:2.7.10.2]
107385404  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
107389003  hras; GTPase HRas [KO:K02833]
107375162  uncharacterized protein LOC107375162 isoform X1 [KO:K05069]
107376356  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
107375161  uncharacterized protein LOC107375161 [KO:K05069]
107386732  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
107390661  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107391369  rho-related GTP-binding protein RhoA-C [KO:K04513]
107385104  rho-related GTP-binding protein RhoA-B [KO:K04513]
107390932  rho-related GTP-binding protein RhoC [KO:K04513]
107394856  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107394428  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
107394429  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
107394430  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
107380468  folate receptor beta-like [KO:K13649]
107376224  rtbdn; retbindin [KO:K13649]
107388349  cav1; caveolin-1 [KO:K06278]
107388348  cav2; caveolin-2 [KO:K12958]
107385186  caveolin-2-like [KO:K12958]
107391351  caveolin-2-like [KO:K12958]
107385739  cav3; caveolin-3 [KO:K12959]
107378006  EH domain-containing protein 3 [KO:K12476]
107391916  EH domain-containing protein 4-like [KO:K12477]
107388955  eea1; early endosome antigen 1 [KO:K12478]
107394767  ras-related protein Rab-5A [KO:K07887]
107379171  ras-related protein Rab-5A-like [KO:K07887]
107389578  ras-related protein Rab-5B-like [KO:K07888]
107387854  rab5c; ras-related protein Rab-5C [KO:K07889]
107381932  ras-related protein Rab-5C [KO:K07889]
107387123  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
107391225  rbsn; rabenosyn-5 isoform X1 [KO:K12481]
107381195  rab4a; ras-related protein Rab-4A [KO:K07879]
107392400  RUN and FYVE domain-containing protein 1-like [KO:K12482]
107381873  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
107377368  EH domain-containing protein 1-like [KO:K12483]
107394469  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
107390162  sorting nexin-4-like [KO:K17919]
107381597  sorting nexin-4-like [KO:K17919]
107385401  ras-related protein Rab-22A [KO:K07891]
107383545  ras-related protein Rab-31-like [KO:K07891]
107377781  rab10; ras-related protein Rab-10 [KO:K07903]
107383584  ras-related protein Rab-8A-like [KO:K07901]
107393169  rab8a; ras-related protein Rab-8A [KO:K07901]
107396383  ras-related protein Rab-35-like [KO:K07876]
107393486  rab35; ras-related protein Rab-35 [KO:K07876]
107381538  rab11a; ras-related protein Rab-11A [KO:K07904]
107379123  rab25; ras-related protein Rab-25 [KO:K07904]
107393351  ras-related protein Rab-11B-like [KO:K07905]
107393354  ras-related protein Rab-11B-like [KO:K07905]
107384164  ras-related protein Rab-11B [KO:K07905]
107374723  rab11fip5; rab11 family-interacting protein 5 [KO:K12484]
107373208  rab11fip1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
107375552  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
107391828  uncharacterized protein LOC107391828 isoform X1 [KO:K12484]
107375344  zfyve27; protrudin isoform X1 [KO:K19368]
107385328  kinesin heavy chain isoform 5A-like isoform X1 [KO:K10396]
107396813  kinesin heavy chain isoform 5C-like [KO:K10396]
107383446  kif5b; kinesin-1 heavy chain [KO:K10396]
107390677  kinesin heavy chain isoform 5A-like [KO:K10396]
107384687  kif5c; kinesin heavy chain isoform 5C [KO:K10396]
107374530  kinesin-1 heavy chain-like [KO:K10396]
107391608  rab11 family-interacting protein 4A-like isoform X1 [KO:K12485]
107388058  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
107382218  rab11fip4; rab11 family-interacting protein 4 [KO:K12485]
107383437  partitioning defective 3 homolog isoform X1 [KO:K04237]
107382653  partitioning defective 3 homolog [KO:K04237]
107391437  pard6b; partitioning defective 6 homolog beta [KO:K06093]
107389514  partitioning defective 6 homolog alpha-like isoform X1 [KO:K06093]
107394702  partitioning defective 6 homolog gamma-like [KO:K06093]
107391401  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
107383607  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
107394771  cell division control protein 42 homolog [KO:K04393]
107379463  cell division control protein 42 homolog [KO:K04393]
107395067  cell division control protein 42 homolog [KO:K04393]
107390475  cell division control protein 42 homolog isoform X1 [KO:K04393]
107392537  smap1; stromal membrane-associated protein 1 [KO:K12486]
107383386  stromal membrane-associated protein 2-like isoform X1 [KO:K12486]
107373877  ARF GTPase-activating protein GIT1-like isoform X1 [KO:K05737]
107373695  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
107393967  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
107382543  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
107384974  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
107377923  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
107392212  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
107392272  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
107392735  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
107377352  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
107385549  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
107379876  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
107374920  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
107397025  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
107397333  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18439]
107381061  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
107384564  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12491]
107383869  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12491]
107391110  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K17848]
107385648  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
107395612  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
107386027  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
107381478  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
107372317  PH and SEC7 domain-containing protein 2-like [KO:K12494]
107387312  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
107374250  PH and SEC7 domain-containing protein 4-like [KO:K12494]
107376722  uncharacterized protein LOC107376722 isoform X1 [KO:K12494]
107388838  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
107391097  iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
107385495  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
107391501  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
107390503  iqsec2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
107391395  cytohesin-4-like isoform X1 [KO:K18441]
107376516  cytohesin-3 isoform X1 [KO:K18441]
107373824  cytohesin-3-like [KO:K18441]
107379708  cyth2; cytohesin-2 [KO:K18441]
107388166  cyth3; cytohesin-3 [KO:K18441]
107387731  cyth1; cytohesin-1 isoform X1 [KO:K18441]
107391405  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
107382897  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
107375488  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
107387296  ADP-ribosylation factor 1 [KO:K07937]
107378475  ADP-ribosylation factor 1-like [KO:K07937]
107383859  arf1; ADP-ribosylation factor 1 [KO:K07937]
107390893  arf3; ADP-ribosylation factor 3 [KO:K07938]
107385694  ADP-ribosylation factor 3-like [KO:K07938]
107385078  arf4; ADP-ribosylation factor 4 [KO:K07939]
107388892  ADP-ribosylation factor 5-like [KO:K07939]
107387912  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
nfu04060  Cytokine-cytokine receptor interaction
nfu04070  Phosphatidylinositol signaling system
nfu04130  SNARE interactions in vesicular transport
nfu04142  Lysosome
nfu04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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