KEGG   PATHWAY: oor04540
Entry
oor04540                    Pathway                                
Name
Gap junction - Orcinus orca (killer whale)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
oor04540  Gap junction
oor04540

Other DBs
GO: 0005921
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101277063  GJA1; gap junction alpha-1 protein [KO:K07372]
101288069  GJD2; gap junction delta-2 protein [KO:K07373]
101274338  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101276500  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
101277471  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
101271719  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
101287211  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101281603  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
101290342  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101278539  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101283152  EGF; pro-epidermal growth factor [KO:K04357]
101269459  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101272795  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101275398  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101271441  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101286587  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105748221  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
101284580  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
101271947  GTPase HRas-like isoform X4 [KO:K02833]
101286301  HRAS; GTPase HRas isoform X2 [KO:K02833]
101281897  KRAS; GTPase KRas isoform X2 [KO:K07827]
101276138  NRAS; GTPase NRas [KO:K07828]
101272984  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101286388  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101287162  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101273287  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101289394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101270305  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
101289255  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X9 [KO:K04463] [EC:2.7.12.2]
101284808  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
101289814  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
101289167  tubulin alpha-1C chain [KO:K07374]
101283945  tubulin alpha-1D chain-like [KO:K07374]
101284203  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101290059  tubulin alpha-3 chain [KO:K07374]
101269236  tubulin alpha-3 chain [KO:K07374]
101276235  TUBA8; tubulin alpha-8 chain [KO:K07374]
101281777  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101289567  tubulin alpha-1A chain [KO:K07374]
101271582  TUBB; tubulin beta chain [KO:K07375]
101269831  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
101277695  TUBB6; tubulin beta-6 chain [KO:K07375]
101280329  TUBB4A; tubulin beta-4A chain [KO:K07375]
101275905  TUBB4B; tubulin beta-4B chain [KO:K07375]
101274301  tubulin beta chain-like [KO:K07375]
101287587  TUBB1; tubulin beta-1 chain [KO:K07375]
101289275  tubulin beta-2B chain isoform X2 [KO:K07375]
101280075  CSNK1D; casein kinase I isoform X5 [KO:K08959] [EC:2.7.11.1]
101271295  CDK1; cyclin-dependent kinase 1 isoform X2 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101270894  TJP1; tight junction protein ZO-1 isoform X6 [KO:K05701]
101286166  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101281903  DRD1; D(1A) dopamine receptor [KO:K04144]
101286834  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
101282939  neuroendocrine secretory protein 55-like [KO:K04632]
101290465  DRD2; D(2) dopamine receptor [KO:K04145]
101278368  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101286207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101283651  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101289858  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101283178  ADCY5; adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
101273023  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101273592  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101273171  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101281654  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101272376  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101273911  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101271859  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101284631  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
101286066  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
101286756  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101280226  GRM5; metabotropic glutamate receptor 5 isoform X2 [KO:K04604]
101269696  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
101279781  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
101274558  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101270548  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101270961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
101281417  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X9 [KO:K05858] [EC:3.1.4.11]
101282737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
101281155  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101280894  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101276350  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
101277002  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101276418  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101275975  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
101279277  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
101284510  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
101279031  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
101279276  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
101280012  PRKG2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
oor04010  MAPK signaling pathway
oor04020  Calcium signaling pathway
oor04060  Cytokine-cytokine receptor interaction
oor04070  Phosphatidylinositol signaling system
oor04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   
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