Entry
Name
Cytokine-cytokine receptor interaction - Orcinus orca (killer whale)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
oor04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Orcinus orca (killer whale) [GN:
oor ]
Gene
101286998 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
101284848 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
101284384 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
101284641 IL36RN; interleukin-36 receptor antagonist protein isoform X1 [KO:K05483 ]
105748873 LOW QUALITY PROTEIN: uncharacterized protein LOC105748873 [KO:K05488 ]
105748024 LOW QUALITY PROTEIN: uncharacterized protein LOC105748024 [KO:K22632 ]
101278934 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
101280766 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
101272436 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
101285079 TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478 ]
101282902 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X2 [KO:K04721 ]
101284929 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
101288715 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X1 [KO:K05474 ]
101284821 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
101286299 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
101272939 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X2 [KO:K05469 ]
101272680 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479 ]
105747709 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X3 [KO:K05475 ]
101280750 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
101286197 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
101276254 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
101286817 CCR8; LOW QUALITY PROTEIN: C-C chemokine receptor type 8 [KO:K04183 ]
101275717 IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068 ]
101271954 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
101286718 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
101281237 IL4R; interleukin-4 receptor subunit alpha isoform X2 [KO:K05071 ]
101283027 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
105748918 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
101280976 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
101284340 IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076 ]
101275322 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
101274728 IL6R; interleukin-6 receptor subunit alpha isoform X5 [KO:K05055 ]
101287401 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
101272521 IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056 ]
101281920 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X3 [KO:K05063 ]
101273552 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
101277355 IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630 ]
101270054 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
101290362 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
101281088 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
101283710 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
101276303 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
101278501 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
101288886 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X2 [KO:K05138 ]
101285541 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
101277121 IL18RAP; interleukin-18 receptor accessory protein isoform X2 [KO:K05174 ]
101284987 IL17RB; LOW QUALITY PROTEIN: interleukin-17 receptor B [KO:K05165 ]
101282502 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
101289721 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X2 [KO:K05141 ]
101278832 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
101274879 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
101284022 FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390 ]
101281904 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
101271509 tumor necrosis factor receptor superfamily member 10A isoform X9 [KO:K04722 ]
101272846 TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X2 [KO:K05157 ]
101272121 EDAR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
101284101 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
101283550 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
101285576 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
101270027 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
101288565 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
101285445 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
101278975 CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160 ]
101275006 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
101276258 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X2 [KO:K05142 ]
101276012 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
101290457 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
101271339 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X2 [KO:K05150 ]
101276202 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X2 [KO:K05151 ]
101269175 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X3 [KO:K05155 ]
101273045 RELT; tumor necrosis factor receptor superfamily member 19L isoform X2 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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