KEGG   PATHWAY: pbar03013
Entry
pbar03013                   Pathway                                
Name
Nucleocytoplasmic transport - Pogonomyrmex barbatus (red harvester ant)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pbar03013  Nucleocytoplasmic transport
pbar03013

Other DBs
GO: 0050658
Organism
Pogonomyrmex barbatus (red harvester ant) [GN:pbar]
Gene
105427890  aladin-like [KO:K14320]
105434045  nucleoporin GLE1 isoform X1 [KO:K18723]
105432083  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
105434381  mRNA export factor [KO:K14298]
105432069  LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96 [KO:K14297]
105433435  nuclear pore complex protein Nup214 [KO:K14317]
105422613  nuclear pore complex protein Nup88 [KO:K14318]
105429715  LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2-like [KO:K12172] [EC:2.3.2.-]
105422171  ran GTPase-activating protein 1 [KO:K14319]
105423897  SUMO-conjugating enzyme UBC9-B [KO:K10577]
105426746  small ubiquitin-related modifier 3-like [KO:K12160]
105427781  small ubiquitin-related modifier-like [KO:K12160]
105428381  nuclear pore complex protein Nup160 homolog [KO:K14303]
105431717  nuclear pore complex protein Nup85 [KO:K14304]
105428543  protein SEC13 homolog [KO:K14004]
105429532  nuclear pore complex protein Nup107 [KO:K14301]
105424105  nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
105423585  nucleoporin seh1-A [KO:K14299]
105422169  nucleoporin Nup43 [KO:K14305]
105427025  nucleoporin Nup37 [KO:K14302]
105424850  protein ELYS [KO:K25129]
105430248  nuclear pore glycoprotein p62 [KO:K14306]
105422083  nucleoporin p58/p45 isoform X1 [KO:K14307]
105425511  nuclear pore complex protein Nup54-like [KO:K14308]
105427856  LOW QUALITY PROTEIN: nuclear pore complex protein Nup205-like [KO:K14310]
105423845  nucleoporin NUP188 homolog [KO:K14311]
105424227  nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
105433499  nuclear pore complex protein Nup93-like [KO:K14309]
105428138  nucleoporin NUP53 [KO:K14313]
105432207  nucleoporin NDC1 [KO:K14315]
105429585  nuclear pore membrane glycoprotein 210 [KO:K14314]
105431007  putative GPI-anchored protein PB15E9.01c [KO:K14316]
105433327  Krueppel homolog 2 [KO:K20724]
105425445  nucleoprotein TPR-like [KO:K09291]
105433062  nuclear pore complex protein Nup50 [KO:K14295]
105423663  LOW QUALITY PROTEIN: nuclear pore complex protein Nup153 [KO:K14296]
105424912  importin subunit alpha-like [KO:K15043]
105427255  LOW QUALITY PROTEIN: importin subunit alpha-3-like [KO:K23583]
105427332  importin subunit alpha-7 [KO:K15042]
105422157  LOW QUALITY PROTEIN: importin subunit beta-1 [KO:K14293]
105433596  transportin-1 [KO:K18752]
105433641  transportin-3 [KO:K15436]
105432863  LOW QUALITY PROTEIN: importin-4-like [KO:K20221]
105431737  importin-5 [KO:K20222]
105426924  importin-7 [KO:K20223]
105424452  LOW QUALITY PROTEIN: importin-9 [KO:K20224]
105425817  importin-11 [KO:K25201]
105430806  importin-13 [KO:K25202]
105427835  snurportin-1 [KO:K13151]
105424257  exportin-1 [KO:K14290]
105422340  exportin-2 [KO:K18423]
105433459  exportin-4-like [KO:K25203]
105427024  exportin-5 [KO:K14289]
105422188  exportin-6-B isoform X1 [KO:K25204]
105432376  exportin-7 isoform X1 [KO:K18460]
105426228  GTP-binding nuclear protein Ran [KO:K07936]
105423274  elongation factor 1-alpha [KO:K03231]
105431732  elongation factor 1-alpha [KO:K03231]
105434310  LOW QUALITY PROTEIN: phosphorylated adapter RNA export protein [KO:K14291]
105424875  nuclear cap-binding protein subunit 1 [KO:K12882]
105424827  nuclear cap-binding protein subunit 2 [KO:K12883]
105433620  LOW QUALITY PROTEIN: 60S ribosomal export protein NMD3 [KO:K07562]
105430651  RNA-binding protein 8A [KO:K12876]
105425507  protein mago nashi homolog [KO:K12877]
105428782  protein CASC3 isoform X1 [KO:K14323]
105430185  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
105427891  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
105427979  histone deacetylase complex subunit SAP18 [KO:K14324]
105423900  RNA-binding protein with serine-rich domain 1-B-like [KO:K14325]
105426025  pinin [KO:K13114]
105428676  THO complex subunit 4 [KO:K12881]
105427848  regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
105431472  regulator of nonsense transcripts 2 [KO:K14327]
105422946  LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A [KO:K14328]
105424098  nuclear RNA export factor 1-like [KO:K14284]
105424100  nuclear RNA export factor 1-like [KO:K14284]
105425117  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
105427555  nuclear RNA export factor 1-like [KO:K14284]
105430759  nuclear RNA export factor 2 [KO:K14284]
105428653  NTF2-related export protein [KO:K14285]
105428547  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
105425343  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
105424007  LOW QUALITY PROTEIN: serine/arginine repetitive matrix protein 2-like [KO:K13171]
105431415  partner of Y14 and mago [KO:K14294]
105430904  LOW QUALITY PROTEIN: THO complex subunit 1 [KO:K12878]
105427123  THO complex subunit 2 isoform X1 [KO:K12879]
105432746  LOW QUALITY PROTEIN: THO complex subunit 5 homolog [KO:K13174]
105432695  THO complex subunit 6 homolog [KO:K13175]
105430874  THO complex subunit 7 homolog [KO:K13176]
105434085  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pbar03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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