KEGG   PATHWAY: phi00230
Entry
phi00230                    Pathway                                
Name
Purine metabolism - Pseudopodoces humilis (Tibetan ground-tit)
Class
Metabolism; Nucleotide metabolism
Pathway map
phi00230  Purine metabolism
phi00230

Module
phi_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:phi00230]
phi_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:phi00230]
phi_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:phi00230]
phi_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:phi00230]
phi_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:phi00230]
phi_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:phi00230]
phi_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:phi00230]
Other DBs
GO: 0006163 0042278
Organism
Pseudopodoces humilis (Tibetan ground-tit) [GN:phi]
Gene
102109066  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
102102216  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102100920  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102100121  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
102108856  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102103837  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
102109001  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
102111861  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
102109787  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102100614  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102100215  phosphoribosylformylglycinamidine synthase-like [KO:K01952] [EC:6.3.5.3]
102111686  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
106628861  uncharacterized protein LOC106628861 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102101611  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
102105144  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102100824  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
102100477  cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
102112924  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
102107601  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
102114623  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102099704  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
102104697  NT5C2; cytosolic purine 5'-nucleotidase isoform X3 [KO:K01081] [EC:3.1.3.5]
102109022  NT5DC4; 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
102110124  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
102103558  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
102101306  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
102110001  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102105932  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
102108426  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
102103545  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
102110866  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
102113373  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
102101831  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
102109073  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
102109256  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
102113928  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
102109563  NME6; nucleoside diphosphate kinase 6 isoform X2 [KO:K00940] [EC:2.7.4.6]
102112340  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102110072  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
102099317  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
102107727  ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102105445  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
102108288  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
102101855  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
102106545  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
102109632  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
102111896  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
102106931  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102108717  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
102110147  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
102102320  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
102102898  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
102113075  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
102102024  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
102105482  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
102105901  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
102099611  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
102105398  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
102108269  deoxycytidine kinase-like isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102106204  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102110015  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
102101371  PRUNE; protein prune homolog [KO:K01514] [EC:3.6.1.11]
102110269  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102113898  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102107286  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102101002  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
102106688  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102108193  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102103610  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102113474  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102106220  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
102106413  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
102105071  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102111535  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
102114027  LOW QUALITY PROTEIN: retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
102099657  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
106628815  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
102099290  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
102105257  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
102112344  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102105148  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
102111231  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102106375  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
102108761  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
102110415  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
102103831  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
102108906  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
102105421  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
102103199  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X2 [KO:K13758]
102112084  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
102106100  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
102108759  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3 [KO:K13761] [EC:3.1.4.35]
102102144  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102107472  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102105293  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
102111842  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
102110098  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
102099965  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
102114251  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
102103787  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
102107545  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
102106459  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
102100596  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
102101085  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
102101388  AK7; LOW QUALITY PROTEIN: adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102103075  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
102100197  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
102110983  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
102113515  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
102111260  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
102104773  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
102099376  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
102101638  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102099744  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102109936  cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
102107091  uncharacterized protein LOC102107091 [KO:K13293] [EC:3.1.4.53]
102101153  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
102113026  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
102099196  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
102106223  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
102108547  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
102107536  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
102101706  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
102114442  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
102108921  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102109266  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102109233  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
phi00030  Pentose phosphate pathway
phi00220  Arginine biosynthesis
phi00250  Alanine, aspartate and glutamate metabolism
phi00260  Glycine, serine and threonine metabolism
phi00340  Histidine metabolism
phi00630  Glyoxylate and dicarboxylate metabolism
phi00730  Thiamine metabolism
phi00740  Riboflavin metabolism
phi00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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