Entry Name Toll-like receptor signaling pathway - Paramormyrops kingsleyae
Description Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map pki04620 Toll-like receptor signaling pathway
Ortholog table Organism Paramormyrops kingsleyae [GN:
pki ]
Gene 111853849 ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392 ]
111836364 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
111860453 pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
111860909 pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
111853393 pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
111835615 pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
111834821 pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
111847640 phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649 ]
111860386 pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
111856594 phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649 ]
111837820 myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
111835987 tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
111843039 tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
111833172 nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
111860173 TIR domain-containing adapter molecule 1-like isoform X1 [KO:K05842 ]
111833952 tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160 ]
111855639 tumor necrosis factor receptor superfamily member 5-like [KO:K03160 ]
111842948 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220 ]
111845415 stat1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
111854344 signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221 ]
Reference Authors Kawai T, Akira S.
Title TLR signaling.
Journal Reference Authors O'Neill LA, Bowie AG.
Title The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
Journal Reference Authors Honda K, Taniguchi T.
Title IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and Type I interferons.
Journal Reference Authors Akira S, Uematsu S, Takeuchi O.
Title Pathogen recognition and innate immunity.
Journal Reference Authors Yamamoto M, Takeda K, Akira S.
Title TIR domain-containing adaptors define the specificity of TLR signaling.
Journal Reference Authors Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
Title The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
Journal Reference Authors Aderem A, Smith KD.
Title A systems approach to dissecting immunity and inflammation.
Journal Reference Authors Banerjee A, Gerondakis S.
Title Coordinating TLR-activated signaling pathways in cells of the immune system.
Journal Reference Authors Loniewski KJ, Patial S, Parameswaran N.
Title Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
Journal Reference Authors Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
Title Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and innate immunity.
Journal Related pki04060 Cytokine-cytokine receptor interaction
KO pathway LinkDB All DBs
