KEGG   PATHWAY: ptex00230
Entry
ptex00230                   Pathway                                
Name
Purine metabolism - Pseudonaja textilis (eastern brown snake)
Class
Metabolism; Nucleotide metabolism
Pathway map
ptex00230  Purine metabolism
ptex00230

Module
ptex_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ptex00230]
ptex_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ptex00230]
ptex_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ptex00230]
ptex_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ptex00230]
ptex_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ptex00230]
ptex_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ptex00230]
Other DBs
GO: 0006163 0042278
Organism
Pseudonaja textilis (eastern brown snake) [GN:ptex]
Gene
113434861  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
113437211  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
113436352  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
113447947  phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
113447996  phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
113435794  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
113445162  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
113446846  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
113435840  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
113436265  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
113436266  LOW QUALITY PROTEIN: trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
113449456  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
113433873  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
113440973  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
113448923  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
113438978  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
113439072  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
113440286  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
113445855  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
113437128  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
113437651  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
113432998  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
113455266  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
113449523  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
113439466  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
113446755  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
113447664  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
113451052  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
113454339  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
113454413  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
113454417  nucleoside diphosphate kinase, mitochondrial-like [KO:K00940] [EC:2.7.4.6]
113437089  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
113438712  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
113455256  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
113436707  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
113443964  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
113437046  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
113445602  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
113445656  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
113433401  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
113443386  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
113443346  NUDT16; U8 snoRNA-decapping enzyme isoform X1 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
113438138  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
113433211  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
113444938  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
113439821  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
113450666  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
113435611  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
113438441  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
113449267  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
113450433  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
113455242  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
113438235  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
113439567  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
113445805  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
113447175  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
113442063  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
113452489  exopolyphosphatase PRUNE1-like [KO:K01514] [EC:3.6.1.11]
113452494  exopolyphosphatase PRUNE1-like [KO:K01514] [EC:3.6.1.11]
113437370  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
113436537  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
113446325  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
113450840  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
113441153  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
113445503  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
113444984  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
113438325  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
113438988  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
113440492  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
113435864  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
113435867  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
113436937  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
113442669  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
113434367  GUCY2C; LOW QUALITY PROTEIN: heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
113451307  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
113450177  LOW QUALITY PROTEIN: retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
113444610  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
113449682  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
113444887  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
113434027  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
113440923  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
113437297  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
113437887  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
113440237  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
113434682  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
113444095  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
113442750  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
113449874  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
113437010  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
113437087  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
113444721  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
113439402  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
113434047  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
113439390  ADSS; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
113435048  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
113452442  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
113452447  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
113439591  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
113440580  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
113444297  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
113443014  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
113434396  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
113447125  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
113450648  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
113447024  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
113436059  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
113447937  adenylate kinase 4, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
113447990  adenylate kinase 4, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
113437646  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
113443303  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
113443882  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
113443927  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
113447999  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
113438404  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
113444031  ectonucleoside triphosphate diphosphohydrolase 2-like [KO:K01509] [EC:3.6.1.-]
113439360  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
113439593  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
113439594  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
113435215  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
113436020  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
113446981  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
113443237  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
113439614  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
113440003  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
113445346  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
113442363  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
113450522  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
113440986  bis(5'-adenosyl)-triphosphatase ENPP4-like isoform X1 [KO:K18424] [EC:3.6.1.29]
113434623  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
113449024  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
113435963  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ptex00030  Pentose phosphate pathway
ptex00220  Arginine biosynthesis
ptex00250  Alanine, aspartate and glutamate metabolism
ptex00260  Glycine, serine and threonine metabolism
ptex00340  Histidine metabolism
ptex00630  Glyoxylate and dicarboxylate metabolism
ptex00730  Thiamine metabolism
ptex00740  Riboflavin metabolism
ptex00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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