KEGG   PATHWAY: ray05020
Entry
ray05020                    Pathway                                
Name
Prion disease - Rousettus aegyptiacus (Egyptian rousette)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ray05020  Prion disease
ray05020

Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107505150  PRNP; major prion protein [KO:K05634]
107512956  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
107506514  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
107506838  neural cell adhesion molecule 2-like [KO:K06491]
107511293  LAMC1; laminin subunit gamma-1 [KO:K05635]
107519576  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
107497083  STIP1; stress-induced-phosphoprotein 1 [KO:K09553]
107519437  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107511590  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107498831  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
107506307  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
107503090  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
107514651  GRIN2A; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2A [KO:K05209]
107508606  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
107503801  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
107498864  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
107499583  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
107500897  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
107505355  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
107500540  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
107516535  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
107514999  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
107513628  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107506635  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
107512376  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
107503258  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
107500816  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
107501502  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
107520956  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
107520024  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
107518789  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
107504134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107497427  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
107511965  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
107504291  LOW QUALITY PROTEIN: caspase-12-like [KO:K04741] [EC:3.4.22.-]
107516843  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107517885  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107509227  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107506933  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
107499586  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
107497091  BAD; bcl2-associated agonist of cell death [KO:K02158]
107506795  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
107518519  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
107501347  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
107512501  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
107510449  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
107506524  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
107512547  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
107498648  ADP/ATP translocase 3-like [KO:K05863]
107520810  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
107517482  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
107518128  cytochrome c [KO:K08738]
107501830  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
107510456  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
107516793  calcium uniporter protein, mitochondrial [KO:K20858]
3666157  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3666158  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3666159  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3666160  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3666161  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3666162  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
3666163  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
107503551  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
107498174  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
107510187  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
107521562  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
107503054  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
107518757  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
107501488  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
107500215  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
107505569  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
107519918  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
107516331  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
107513442  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
107510586  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
107516106  NDUFAB1; LOW QUALITY PROTEIN: acyl carrier protein, mitochondrial [KO:K03955]
107510995  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
107519774  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
107503701  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
107511238  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
107504059  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
107503161  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
107517762  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
107501648  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
107502802  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
107519420  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
107499769  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
107521586  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
107506067  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
107501551  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
107505180  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
107504677  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
107511837  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
107509658  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
107517069  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
107499974  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
107500941  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
107503528  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
107515342  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
107519203  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
107499960  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
107501827  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
107504683  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
107512967  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
107515880  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
3666156  CYTB; cytochrome b [KO:K00412]
107503471  cytochrome c1, heme protein, mitochondrial [KO:K00413]
107513320  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
107516078  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
107517907  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
107500346  uncharacterized protein LOC107500346 isoform X1 [KO:K00417]
107497034  cytochrome b-c1 complex subunit 8 [KO:K00418]
107520492  cytochrome b-c1 complex subunit 9 [KO:K00419]
107500917  cytochrome b-c1 complex subunit 10 [KO:K00420]
3666155  COX3; cytochrome c oxidase subunit III [KO:K02262]
3666153  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3666154  COX2; cytochrome c oxidase subunit II [KO:K02261]
107502351  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
107512889  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
107510524  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
107509970  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
107505626  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
107501251  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
107513145  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
107515431  cytochrome c oxidase subunit 6B2 [KO:K02267]
107497665  cytochrome c oxidase subunit 6B1 [KO:K02267]
107511938  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-like [KO:K02268]
107507599  cytochrome c oxidase subunit 6C [KO:K02268]
107509286  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
107509593  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
107497645  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
107503849  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
107519004  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
107498048  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
107497080  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
107512344  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
107521221  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
107505971  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
107500926  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
107500091  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
3666151  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
107516139  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
107509866  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
107504969  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
107503791  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
107520368  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
107508540  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
3666152  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
107514414  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
107497282  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
107500521  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
107503668  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
107518428  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
107516149  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
107519400  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
107502125  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
107509459  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
107506651  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
107520678  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
107512091  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
107498041  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
107500159  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
107499048  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
107511508  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
107515474  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
107521811  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
107498130  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
107511840  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
107501981  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
107504916  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
107504976  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
107520710  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
107515236  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
107502179  PSMD12; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
107514642  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
107513474  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
107511919  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
107506504  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
107498998  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
107508548  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
107499882  26S proteasome non-ATPase regulatory subunit 14-like [KO:K03030]
107520970  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
107503669  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
107504477  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
107516309  C5; complement C5 [KO:K03994]
107512444  C6; complement component C6 [KO:K03995]
107512443  C7; complement component C7 [KO:K03996]
107518357  C8A; complement component C8 alpha chain [KO:K03997]
107518331  C8B; complement component C8 beta chain [KO:K03998]
107503117  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
107512432  C9; complement component C9 [KO:K04000]
107513061  C1QA; complement C1q subcomponent subunit A [KO:K03986]
107513063  C1QB; complement C1q subcomponent subunit B [KO:K03987]
107513062  C1QC; complement C1q subcomponent subunit C [KO:K03988]
107503644  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
107498470  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
107498471  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
107498469  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
107514882  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
107497470  CAV1; caveolin-1 isoform X1 [KO:K06278]
107497469  CAV2; caveolin-2 [KO:K12958]
107504953  CAV3; caveolin-3 [KO:K12959]
107520152  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107517828  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107513958  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107521668  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
107517899  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
107498704  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107516555  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
107503927  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
107502360  cytochrome b-245 light chain [KO:K08009]
107519268  NCF4; neutrophil cytosol factor 4 [KO:K08012]
107514979  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
107511296  NCF2; neutrophil cytosol factor 2 [KO:K08010]
107515925  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
107519267  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107497883  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107497895  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107500264  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
107500274  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
107512328  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107509910  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107515392  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
107515836  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
107497830  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107505169  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
107504977  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
107509179  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
107502779  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
107511864  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
107510647  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
107499057  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
107505683  CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
107498439  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
107518733  EGR1; early growth response protein 1 [KO:K09203]
107499426  CCL5; C-C motif chemokine 5 [KO:K12499]
107514909  IL1A; interleukin-1 alpha [KO:K04383]
107514900  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
107518120  IL6; interleukin-6 isoform X1 [KO:K05405]
107498497  TNF; tumor necrosis factor [KO:K03156]
107517741  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107502669  CSNK2A2; LOW QUALITY PROTEIN: casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
107512905  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
107498463  CSNK2B; casein kinase II subunit beta [KO:K03115]
107513931  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
107518439  KIF5B; kinesin-1 heavy chain [KO:K10396]
107501516  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
107513627  KLC3; kinesin light chain 3 [KO:K10407]
107497533  KLC2; kinesin light chain 2 [KO:K10407]
107498378  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
107501964  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
107516782  tubulin alpha-1B chain-like [KO:K07374]
107500328  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
107497847  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
107497857  tubulin alpha-3 chain-like [KO:K07374]
107514242  tubulin alpha-1A chain isoform X1 [KO:K07374]
107514243  tubulin alpha-1C chain [KO:K07374]
107516732  tubulin alpha-4A chain isoform X1 [KO:K07374]
107502098  tubulin beta-3 chain [KO:K07375]
107503105  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
107511148  TUBB4A; tubulin beta-4A chain [KO:K07375]
107521721  TUBB2A; tubulin beta-2A chain [KO:K07375]
107521722  tubulin beta-2B chain [KO:K07375]
107500090  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
107497724  TUBB6; tubulin beta-6 chain [KO:K07375]
107498082  TUBB; tubulin beta chain [KO:K07375]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
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Expert Rev Mol Med 18:e5 (2016)
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Reference
PMID:25584786
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Goold R, McKinnon C, Tabrizi SJ
  Title
Prion degradation pathways: Potential for therapeutic intervention.
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Mol Cell Neurosci 66:12-20 (2015)
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Reference
PMID:20889378
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Soto C, Satani N
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The intricate mechanisms of neurodegeneration in prion diseases.
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Trends Mol Med 17:14-24 (2011)
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Reference
PMID:27060771
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The stress of prion disease.
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Brain Res 1648:553-560 (2016)
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Reference
PMID:32565065
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Jones E, Mead S
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Genetic risk factors for Creutzfeldt-Jakob disease.
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Neurobiol Dis 142:104973 (2020)
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Reference
PMID:18245809
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Kovacs GG, Budka H
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Prion diseases: from protein to cell pathology.
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Am J Pathol 172:555-65 (2008)
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Reference
PMID:15695097
  Authors
Campana V, Sarnataro D, Zurzolo C
  Title
The highways and byways of prion protein trafficking.
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Trends Cell Biol 15:102-11 (2005)
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Reference
PMID:17051207
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Caughey B, Baron GS
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Prions and their partners in crime.
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Nature 443:803-10 (2006)
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Reference
PMID:11592845
  Authors
Chiesa R, Harris DA
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Prion diseases: what is the neurotoxic molecule?
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Neurobiol Dis 8:743-63 (2001)
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Reference
PMID:17085779
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Fasano C, Campana V, Zurzolo C
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Prions: protein only or something more? Overview of potential prion cofactors.
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J Mol Neurosci 29:195-214 (2006)
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Reference
PMID:14705136
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Neuroprotective functions of prion protein.
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J Neurosci Res 75:153-61 (2004)
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Reference
PMID:10398674
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Harris DA
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Cellular biology of prion diseases.
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Clin Microbiol Rev 12:429-44 (1999)
Reference
PMID:15890824
  Authors
Novakofski J, Brewer MS, Mateus-Pinilla N, Killefer J, McCusker RH
  Title
Prion biology relevant to bovine spongiform encephalopathy.
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J Anim Sci 83:1455-76 (2005)
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Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
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Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Biochem Biophys Res Commun 483:1148-1155 (2017)
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Reference
PMID:31618844
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Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
  Title
Prion Protein in Glioblastoma Multiforme.
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Int J Mol Sci 20:E5107 (2019)
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Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
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The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
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Int J Mol Sci 20:E6004 (2019)
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Reference
PMID:30710214
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Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
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Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
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Mol Neurobiol 56:6035-6045 (2019)
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Reference
PMID:23439666
  Authors
Song Z, Zhao D, Yang L
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
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Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
PMID:29194372
  Authors
Hughes D, Halliday M
  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
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Pathogens 6:E63 (2017)
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Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
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FEBS J 286:342-355 (2019)
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Reference
PMID:21722302
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Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
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Reference
PMID:18420416
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Ferreiro E, Oliveira CR, Pereira CM
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The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
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Neurobiol Dis 30:331-42 (2008)
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Reference
PMID:16844381
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Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
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An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
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Neurobiol Dis 23:669-78 (2006)
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Reference
PMID:21980554
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Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
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Commun Integr Biol 4:258-61 (2011)
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Reference
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Ciechanover A, Kwon YT
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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
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Exp Mol Med 47:e147 (2015)
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Reference
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Disease-associated prion protein oligomers inhibit the 26S proteasome.
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Mol Cell 26:175-88 (2007)
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Reference
PMID:10195903
  Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Science 284:339-43 (1999)
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Reference
PMID:14532116
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Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
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EMBO J 22:5435-45 (2003)
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Reference
PMID:31417367
  Authors
Zamponi E, Pigino GF
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Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
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Front Cell Neurosci 13:350 (2019)
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Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
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Reference
PMID:21196165
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Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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Reference
PMID:23479001
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Didonna A
  Title
Prion protein and its role in signal transduction.
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
  Authors
Shah SZA, Zhao D, Hussain T, Yang L
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The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
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J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
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Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
ray00190  Oxidative phosphorylation
ray03050  Proteasome
ray04020  Calcium signaling pathway
ray04140  Autophagy - animal
ray04141  Protein processing in endoplasmic reticulum
ray04142  Lysosome
ray04144  Endocytosis
ray04210  Apoptosis
ray04330  Notch signaling pathway
ray04610  Complement and coagulation cascades
ray04668  TNF signaling pathway
KO pathway
ko05020   
LinkDB

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