KEGG   PATHWAY: ray04020
Entry
ray04020                    Pathway                                
Name
Calcium signaling pathway - Rousettus aegyptiacus (Egyptian rousette)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ray04020  Calcium signaling pathway
ray04020

Other DBs
GO: 0019722
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107497081  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
107497088  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
107497158  GRPR; gastrin-releasing peptide receptor [KO:K04169]
107497163  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
107497167  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
107497293  VEGFD; vascular endothelial growth factor D [KO:K05449]
107497394  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
107497410  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
107497427  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
107497465  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
107497689  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
107497716  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
107497786  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
107497843  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
107498014  ADCY4; adenylate cyclase type 4 isoform X7 [KO:K08044] [EC:4.6.1.1]
107498017  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
107498045  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
107498193  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107498266  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
107498349  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
107498506  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
107498574  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
107498648  [KO:K05863]
107498846  SPHK2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
107498854  FGF21; fibroblast growth factor 21 [KO:K22429]
107498864  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
107498919  [KO:K05096] [EC:2.7.10.1]
107499062  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
107499583  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
107499586  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
107499598  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X3 [KO:K05857] [EC:3.1.4.11]
107499675  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
107499793  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107499822  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
107499858  NGF; beta-nerve growth factor [KO:K02582]
107500067  [KO:K04632]
107500068  [KO:K04632]
107500309  HRH1; histamine H1 receptor [KO:K04149]
107500540  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
107500692  ADORA2A; adenosine receptor A2a [KO:K04266]
107500818  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [KO:K04856]
107500851  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
107500865  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107500897  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X2 [KO:K05214]
107500922  FGF22; fibroblast growth factor 22 [KO:K04358]
107501245  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
107501285  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107501347  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
107501465  MRLN; myoregulin [KO:K22643]
107501531  F2R; proteinase-activated receptor 1 [KO:K03914]
107501614  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
107501627  [KO:K02183]
107501804  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
107501960  FGF7; fibroblast growth factor 7 [KO:K04358]
107501976  TFEB; transcription factor EB [KO:K15590]
107502007  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
107502078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
107502272  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
107502405  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
107502700  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
107502706  FGF20; fibroblast growth factor 20 [KO:K04358]
107502751  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
107502934  TACR1; substance-P receptor [KO:K04222]
107503061  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
107503090  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
107503262  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
107503410  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
107503555  PTAFR; platelet-activating factor receptor [KO:K04279]
107503628  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
107503801  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
107503844  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
107503931  FGF3; fibroblast growth factor 3 [KO:K04358]
107503972  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
107503977  FGF4; fibroblast growth factor 4 [KO:K04358]
107503988  ORAI3; protein orai-3 [KO:K16058]
107504061  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
107504090  TACR2; substance-K receptor [KO:K04223]
107504134  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
107504381  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
107504435  NTSR1; neurotensin receptor type 1 [KO:K04211]
107504850  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
107504874  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
107504952  OXTR; oxytocin receptor [KO:K04229]
107504978  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
107505355  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X4 [KO:K04849]
107505449  CCKAR; cholecystokinin receptor type A [KO:K04194]
107505691  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
107506097  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
107506114  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
107506438  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
107506458  DRD5; D(1B) dopamine receptor [KO:K05840]
107506524  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
107506545  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
107506741  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
107506795  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
107506933  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
107507115  FGF16; fibroblast growth factor 16 [KO:K04358]
107507351  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
107507449  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
107507553  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107507669  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
107507670  P2RX1; P2X purinoceptor 1 [KO:K05215]
107507677  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
107507967  CASQ1; calsequestrin-1 [KO:K23468]
107508151  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
107508158  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X2 [KO:K05857] [EC:3.1.4.11]
107508214  AVPR1A; vasopressin V1a receptor [KO:K04226]
107508606  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
107508797  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
107508819  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
107508927  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
107508975  AVPR1B; vasopressin V1b receptor [KO:K04227]
107509004  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
107509200  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
107509227  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107509443  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
107509488  [KO:K15040]
107509556  CALM2; calmodulin-2 [KO:K02183]
107509721  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
107510307  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
107510349  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
107510449  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
107510894  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
107511020  FGF18; fibroblast growth factor 18 [KO:K04358]
107511058  ADORA2B; adenosine receptor A2b [KO:K04267]
107511206  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107511552  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
107511575  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
107511576  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
107511590  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107511714  ADRB1; beta-1 adrenergic receptor [KO:K04141]
107511789  ORAI2; protein orai-2 [KO:K16057]
107511942  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
107511965  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
107512248  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
107512260  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
107512332  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
107512385  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
107512406  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
107512501  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
107512547  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
107512864  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
107512928  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
107512997  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107513070  EDNRB; endothelin receptor type B isoform X1 [KO:K04198]
107513162  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
107513229  P2RX4; P2X purinoceptor 4 [KO:K05218]
107513233  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
107513235  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
107513286  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
107513357  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
107513368  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
107513418  AGTR1; type-1 angiotensin II receptor [KO:K04166]
107513447  FGF6; fibroblast growth factor 6 [KO:K04358]
107513448  FGF23; fibroblast growth factor 23 [KO:K22428]
107513542  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
107513544  ADRB2; beta-2 adrenergic receptor [KO:K04142]
107513628  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107513888  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
107513994  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
107514053  [KO:K04161]
107514177  NTRK3; NT-3 growth factor receptor isoform X7 [KO:K05101] [EC:2.7.10.1]
107514322  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
107514447  FGF9; fibroblast growth factor 9 [KO:K04358]
107514464  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
107514499  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
107514546  TNNC2; troponin C, skeletal muscle [KO:K12042]
107514651  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
107514938  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
107514999  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
107515126  PLN; cardiac phospholamban [KO:K05852]
107515241  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
107515355  TRDN; triadin isoform X2 [KO:K23449]
107515454  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
107515457  CALM1; calmodulin-1 [KO:K02183]
107515459  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
107515755  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
107515804  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
107515937  HRH2; histamine H2 receptor isoform X3 [KO:K04150]
107515942  DRD1; D(1A) dopamine receptor [KO:K04144]
107515961  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107515971  ADRB3; beta-3 adrenergic receptor [KO:K04143]
107516018  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
107516034  CALM3; calmodulin-3 [KO:K02183]
107516091  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
107516440  FGF5; fibroblast growth factor 5 [KO:K04358]
107516535  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X12 [KO:K04851]
107516607  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
107516722  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
107516793  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
107516843  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107517086  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
107517122  TPCN1; two pore calcium channel protein 1 isoform X2 [KO:K16896]
107517193  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
107517194  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
107517358  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
107517559  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
107517573  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
107517623  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
107517631  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
107517636  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
107517774  EDNRA; endothelin-1 receptor [KO:K04197]
107517831  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
107517885  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
107517932  TACR3; neuromedin-K receptor [KO:K04224]
107518024  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
107518034  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
107518325  BDKRB2; B2 bradykinin receptor [KO:K03916]
107518413  P2RX3; P2X purinoceptor 3 isoform X2 [KO:K05217]
107518500  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
107518501  FGF2; fibroblast growth factor 2 [KO:K18497]
107518519  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
107518526  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
107518680  SLN; sarcolipin [KO:K22642]
107518787  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
107518789  RYR3; ryanodine receptor 3 [KO:K04963]
107518884  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
107518965  FGF10; fibroblast growth factor 10 [KO:K04358]
107519111  TGFA; protransforming growth factor alpha [KO:K08774]
107519399  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
107519426  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
107519437  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107519658  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X5 [KO:K00476] [EC:1.14.11.16]
107519913  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
107519930  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
107520024  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
107520107  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
107520124  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
107520129  TBXA2R; thromboxane A2 receptor [KO:K04264]
107520204  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107520319  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
107520393  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
107520480  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107520699  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
107520780  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
107520810  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
107520899  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
107520906  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
107520935  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X2 [KO:K04323]
107520956  RYR1; ryanodine receptor 1 isoform X2 [KO:K04961]
107521071  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
107521255  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
107521319  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859] [EC:3.1.4.11]
107521392  VEGFC; vascular endothelial growth factor C [KO:K05449]
107521477  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
107521680  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
107521786  ITPKC; inositol-trisphosphate 3-kinase C isoform X3 [KO:K00911] [EC:2.7.1.127]
107521889  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
118600310  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
118603014  FGF19; fibroblast growth factor 19 [KO:K22603]
118604038  CALML6; calmodulin-like protein 6 [KO:K02183]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ray04010  MAPK signaling pathway
ray04070  Phosphatidylinositol signaling system
ray04210  Apoptosis
ray04720  Long-term potentiation
ray04730  Long-term depression
KO pathway
ko04020   

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