KEGG   PATHWAY: sdul04144
Entry
sdul04144                   Pathway                                
Name
Endocytosis - Solanum dulcamara (climbing nightshade)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
sdul04144  Endocytosis
sdul04144

Other DBs
GO: 0006897
Organism
Solanum dulcamara (climbing nightshade) [GN:sdul]
Gene
129885843  phosphatidylinositol 4-phosphate 5-kinase 8-like [KO:K00889] [EC:2.7.1.68]
129886409  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
129902298  phosphatidylinositol 4-phosphate 5-kinase 1 [KO:K00889] [EC:2.7.1.68]
129877065  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
129877164  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
129870138  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
129877761  phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
129871196  phosphatidylinositol 4-phosphate 5-kinase 4-like isoform X1 [KO:K00889] [EC:2.7.1.68]
129882055  phosphatidylinositol 4-phosphate 5-kinase 9 [KO:K00889] [EC:2.7.1.68]
129898758  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
129886127  phospholipase D zeta 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
129886624  phospholipase D gamma 1-like [KO:K01115] [EC:3.1.4.4]
129887320  phospholipase D zeta 1 isoform X1 [KO:K01115] [EC:3.1.4.4]
129902317  phospholipase D delta-like isoform X1 [KO:K01115] [EC:3.1.4.4]
129889317  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
129889321  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
129876873  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
129889961  phospholipase D beta 1-like [KO:K01115] [EC:3.1.4.4]
129871681  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
129872806  phospholipase D delta [KO:K01115] [EC:3.1.4.4]
129895552  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
129895798  phospholipase D alpha 4 [KO:K01115] [EC:3.1.4.4]
129874311  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
129884605  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
129885939  dynamin-2A [KO:K01528] [EC:3.6.5.5]
129904068  dynamin-2A-like [KO:K01528] [EC:3.6.5.5]
129900787  clathrin heavy chain 1 isoform X1 [KO:K04646]
129880874  clathrin heavy chain 1-like [KO:K04646]
129895873  clathrin heavy chain 1-like [KO:K04646]
129898962  AP-2 complex subunit alpha-1-like [KO:K11824]
129904734  AP-2 complex subunit alpha-1-like isoform X1 [KO:K11824]
129899076  AP-2 complex subunit mu [KO:K11826]
129888764  AP-2 complex subunit mu-like [KO:K11826]
129902202  AP-2 complex subunit sigma [KO:K11827]
129885385  epsin-3-like [KO:K12471]
129889260  clathrin interactor EPSIN 1-like isoform X1 [KO:K12471]
129902966  clathrin interactor EPSIN 1-like isoform X1 [KO:K12471]
129904092  uncharacterized protein LOC129904092 [KO:K12471]
129883235  clathrin interactor EPSIN 2-like [KO:K12471]
129883400  clathrin interactor EPSIN 2 [KO:K12471]
129884464  uncharacterized protein LOC129884464 [KO:K12471]
129902049  uncharacterized protein LOC129902049 [KO:K12472]
129872255  uncharacterized protein LOC129872255 [KO:K12472]
129873538  uncharacterized protein LOC129873538 [KO:K12472]
129885326  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
129872003  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
129873395  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
129875009  actin-related protein 2 [KO:K17260]
129887489  actin-related protein 3-like [KO:K18584]
129880415  actin-related protein 3 [KO:K18584]
129880269  actin-related protein 2/3 complex subunit 1A-like isoform X1 [KO:K05757]
129903402  actin-related protein 2/3 complex subunit 2A [KO:K05758]
129883179  actin-related protein 2/3 complex subunit 2B isoform X1 [KO:K05758]
129891436  actin-related protein 2/3 complex subunit 3 [KO:K05756]
129883023  actin-related protein 2/3 complex subunit 4 [KO:K05755]
129886742  actin-related protein 2/3 complex subunit 5A [KO:K05754]
129885903  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
129887715  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
129902044  heat shock cognate 70 kDa protein 2-like [KO:K03283]
129902761  heat shock 70 kDa protein 7, chloroplastic-like [KO:K03283]
129903443  heat shock cognate 70 kDa protein [KO:K03283]
129870007  heat shock cognate 70 kDa protein 2-like [KO:K03283]
129893108  heat shock 70 kDa protein-like [KO:K03283]
129882231  heat shock cognate 70 kDa protein 2-like [KO:K03283]
129894335  heat shock 70 kDa protein-like [KO:K03283]
129894986  heat shock 70 kDa protein-like [KO:K03283]
129898600  heat shock cognate 70 kDa protein 1 [KO:K03283]
129875987  heat shock cognate 70 kDa protein 2 [KO:K03283]
129886147  F-actin-capping protein subunit alpha isoform X1 [KO:K10364]
129880038  probable F-actin-capping protein subunit beta [KO:K10365]
129894467  vacuolar protein sorting-associated protein 29 [KO:K18467]
129889231  vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
129871993  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
129881312  vacuolar protein sorting-associated protein 35B-like [KO:K18468]
129894404  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
129887339  AMSH-like ubiquitin thioesterase 3 [KO:K11866] [EC:3.4.19.12]
129871019  AMSH-like ubiquitin thioesterase 2 isoform X1 [KO:K11866] [EC:3.4.19.12]
129894122  AMSH-like ubiquitin thioesterase 1 isoform X1 [KO:K11866] [EC:3.4.19.12]
129885457  ras-related protein RABG3f [KO:K07897]
129887128  ras-related protein Rab7-like isoform X1 [KO:K07897]
129903247  ras-related protein Rab7 [KO:K07897]
129895913  ras-related protein Rab7 [KO:K07897]
129881731  protein ELC-like [KO:K12183]
129882110  protein ELC-like [KO:K12183]
129876126  protein ELC-like [KO:K12183]
129874212  vacuolar protein sorting-associated protein 28 homolog 2 [KO:K12184]
129896041  vacuolar protein sorting-associated protein 28 homolog 2-like [KO:K12184]
129877822  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
129875509  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
129877420  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
129886365  vacuolar protein sorting-associated protein 36 [KO:K12190]
129889627  vacuolar protein sorting-associated protein 25 isoform X1 [KO:K12189]
129888996  vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195]
129882648  vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195]
129902689  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
129889263  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
129880550  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
129899703  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
129903336  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
129871073  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
129872043  vacuolar protein sorting-associated protein 2 homolog 2 [KO:K12191]
129898742  vacuolar protein sorting-associated protein 2 homolog 3-like [KO:K12192]
129899248  vacuolar protein sorting-associated protein 2 homolog 3-like isoform X1 [KO:K12192]
129887066  uncharacterized protein LOC129887066 [KO:K15053]
129899877  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196]
129902321  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like isoform X1 [KO:K12196]
129902559  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 isoform X1 [KO:K12196]
129892309  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5 [KO:K12199]
129901290  ESCRT-related protein CHMP1B-like [KO:K12197]
129894056  ESCRT-related protein CHMP1A [KO:K12197]
129900342  vacuolar protein sorting-associated protein 60.1-like [KO:K12198]
129881072  vacuolar protein sorting-associated protein 60.2-like [KO:K12198]
129870100  vacuolar-sorting protein BRO1-like [KO:K12200]
129879891  vacuolar-sorting protein BRO1 isoform X1 [KO:K12200]
129889910  uncharacterized protein LOC129889910 [KO:K19367]
129882172  sorting nexin 1 [KO:K17917]
129899094  ras-related protein RABF1 [KO:K07889]
129873062  ras-related protein RHN1 isoform X1 [KO:K07889]
129885832  EH domain-containing protein 1-like [KO:K12483]
129877093  EH domain-containing protein 1-like [KO:K12483]
129893027  EH domain-containing protein 1-like isoform X1 [KO:K12483]
129871233  EH domain-containing protein 1-like [KO:K12483]
129902125  vacuolar protein sorting-associated protein 45 homolog isoform X1 [KO:K12479]
129900316  ras-related protein RABE1c-like [KO:K07901]
129903128  ras-related protein RABE1c [KO:K07901]
129877068  ras-related protein RABE1a-like [KO:K07901]
129870531  ras-related protein RABE1c-like [KO:K07901]
129882207  ras-related protein RABE1a [KO:K07901]
129885913  ras-related protein RABA2a [KO:K07904]
129886424  ras-related protein RABA3 [KO:K07904]
129886947  ras-related protein RGP1-like [KO:K07904]
129900776  ras-related protein Rab2BV [KO:K07904]
129901217  ras-related protein Rab11A [KO:K07904]
129877007  ras-related protein RABA4d-like [KO:K07904]
129891302  ras-related protein RABA1f [KO:K07904]
129904969  ras-related protein Rab11D [KO:K07904]
129877881  ras-related protein RABA2b-like [KO:K07904]
129891731  ras-related protein YPT3 [KO:K07904]
129870669  ras-related protein RABA1f-like [KO:K07904]
129880989  ras-related protein RABA5a-like [KO:K07904]
129873001  ras-related protein RABA1d [KO:K07904]
129895393  ras-related protein RABA1f-like [KO:K07904]
129895959  ras-related protein RABA5a-like [KO:K07904]
129883377  ras-related protein RABA5e-like [KO:K07904]
129896317  ras-related protein RABA2b-like [KO:K07904]
129898493  ras-related protein Rab11D-like [KO:K07904]
129889932  kinesin-like protein KIN-UB [KO:K10396]
129890842  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
129891190  ADP-ribosylation factor GTPase-activating protein AGD5 [KO:K12486]
129877771  ADP-ribosylation factor GTPase-activating protein AGD5-like isoform X1 [KO:K12486]
129873738  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
129896240  ADP-ribosylation factor GTPase-activating protein AGD5-like isoform X1 [KO:K12486]
129896955  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
129904915  ADP-ribosylation factor GTPase-activating protein AGD2-like [KO:K12489]
129880490  ADP-ribosylation factor GTPase-activating protein AGD3 isoform X1 [KO:K12489]
129893747  ADP-ribosylation factor GTPase-activating protein AGD1-like [KO:K12489]
129895113  ADP-ribosylation factor GTPase-activating protein AGD3-like isoform X1 [KO:K12489]
129876317  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
129882223  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
129888770  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
129889695  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
129885234  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
129886665  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
129870355  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
129880141  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
129872182  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
129894804  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
129874339  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
129898830  uncharacterized protein LOC129898830 [KO:K07937]
129886058  ADP-ribosylation factor 1-like [KO:K07937]
129887088  ADP-ribosylation factor 1 [KO:K07937]
129887387  ADP-ribosylation factor [KO:K07937]
129887936  ADP-ribosylation factor 2-like [KO:K07937]
129870380  ADP-ribosylation factor 2-like [KO:K07937]
129880350  ADP-ribosylation factor 2 [KO:K07937]
129872071  ADP-ribosylation factor 2-B-like [KO:K07937]
129895841  uncharacterized protein LOC129895841 [KO:K07937]
129883503  ADP-ribosylation factor 2-like [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
sdul04070  Phosphatidylinositol signaling system
sdul04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
LinkDB

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