KEGG   PATHWAY: setr04726
Entry
setr04726                   Pathway                                
Name
Serotonergic synapse - Suncus etruscus (white-toothed pygmy shrew)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
setr04726  Serotonergic synapse
setr04726

Other DBs
GO: 0007210
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
126021883  TPH2; tryptophan 5-hydroxylase 2 isoform X1 [KO:K00502] [EC:1.14.16.4]
126018561  TPH1; tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
126014154  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
125994914  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
126022196  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
126013230  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
125999147  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
126004344  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
126002075  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
126016231  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
125999516  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
126003511  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
126017277  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126024570  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
126017588  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126018105  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125998103  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
126022840  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
125996360  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
126017297  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126030861  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126027978  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126029893  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126033704  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126014260  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
126020067  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
126020108  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
126020233  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
126020234  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
125994861  cytochrome P450 2C25-like [KO:K07413] [EC:1.14.14.1]
125994862  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
125994864  cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
126033411  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
126033848  cytochrome P450 2C19-like [KO:K07413] [EC:1.14.14.1]
126006237  cytochrome P450 2D17-like [KO:K07414] [EC:1.14.14.1]
126006364  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
126006365  cytochrome P450 2D14-like [KO:K07414] [EC:1.14.14.1]
126006366  cytochrome P450 2D17-like [KO:K07414] [EC:1.14.14.1]
126010975  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126010977  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126010978  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126010985  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126010986  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126011645  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
126011096  cytochrome P450 4X1 [KO:K07428] [EC:1.14.14.1]
126033671  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
126027412  polyunsaturated fatty acid lipoxygenase ALOX12-like [KO:K00458] [EC:1.13.11.31]
126011028  polyunsaturated fatty acid lipoxygenase ALOX12-like [KO:K00458] [EC:1.13.11.31]
126027317  LOW QUALITY PROTEIN: polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
125997996  arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
126011015  polyunsaturated fatty acid lipoxygenase ALOX15-like isoform X1 [KO:K00460] [EC:1.13.11.33]
126008797  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
126013403  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
126011823  5-hydroxytryptamine receptor 3C-like [KO:K04819]
126011825  5-hydroxytryptamine receptor 3C-like [KO:K04819]
126012068  5-hydroxytryptamine receptor 3E-like isoform X1 [KO:K04819]
126012070  5-hydroxytryptamine receptor 3C-like [KO:K04819]
126015829  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
126015830  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
126024785  HTR4; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 4 [KO:K04160]
126006568  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
125994875  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
126013317  GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
126013337  neuroendocrine secretory protein 55-like [KO:K04632]
126026247  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126027843  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
126012378  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
126012223  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
126021830  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
126032460  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
126022758  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
126026048  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
126013722  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
126006736  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
126025707  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
126011175  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
126001507  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
126025486  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
126008870  5-hydroxytryptamine receptor 5B-like [KO:K04161]
126014071  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126022872  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125997317  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
126027101  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
126011605  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126031035  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126006589  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126012077  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126002081  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
125999572  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126017910  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
126030791  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126005956  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126026239  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126031195  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126028279  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126020263  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126003829  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126023960  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024701  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126033760  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
125999484  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126000312  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126010869  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126010895  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
126020118  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126024681  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126030830  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
126010822  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126001569  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126024671  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126020139  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126006887  caspase-3-like [KO:K02187] [EC:3.4.22.56]
126007206  caspase-3-like [KO:K02187] [EC:3.4.22.56]
126007207  caspase-3-like [KO:K02187] [EC:3.4.22.56]
126012235  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
126019084  HRAS; GTPase HRas [KO:K02833]
126022823  KRAS; GTPase KRas isoform X1 [KO:K07827]
125997372  NRAS; GTPase NRas [KO:K07828]
125999333  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
126010754  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125998044  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126021920  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
126030243  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
126020490  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
126008767  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
126025599  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
126013957  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
126015697  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
126026189  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
126007931  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
125999202  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125999206  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
setr00380  Tryptophan metabolism
setr00590  Arachidonic acid metabolism
setr04020  Calcium signaling pathway
setr04721  Synaptic vesicle cycle
setr04976  Bile secretion
KO pathway
ko04726   
LinkDB

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