KEGG   PATHWAY: shab00230
Entry
shab00230                   Pathway                                
Name
Purine metabolism - Strigops habroptila (Kakapo)
Class
Metabolism; Nucleotide metabolism
Pathway map
shab00230  Purine metabolism
shab00230

Module
shab_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:shab00230]
shab_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:shab00230]
shab_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:shab00230]
shab_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:shab00230]
shab_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:shab00230]
shab_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:shab00230]
shab_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:shab00230]
Other DBs
GO: 0006163 0042278
Organism
Strigops habroptila (Kakapo) [GN:shab]
Gene
115610264  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
115616520  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
115605681  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
115611394  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
115610701  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
115612903  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
115612904  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
115603160  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
115610195  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
115601471  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
115601577  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
115603043  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
115610194  uncharacterized protein LOC115610194 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
115604857  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
115608502  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
115619580  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
115616473  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
115606623  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
115618511  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
115607561  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
115608712  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
115609757  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
115616127  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
115609316  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
115619268  LOW QUALITY PROTEIN: purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
115619789  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
115604361  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
115612618  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
115600855  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
115614905  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
115616527  nucleoside diphosphate kinase isoform X1 [KO:K00940] [EC:2.7.4.6]
115616528  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
115606356  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
115606359  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
115601758  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
115603877  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
115609669  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
115616892  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
115617175  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
115617176  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
115618458  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
115608700  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
115616560  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
115618471  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
115606056  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
115613603  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
115611640  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
115613736  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
115600881  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
115611360  GMPS; LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
115607179  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
115619375  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
115616878  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
115604317  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
115614394  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
115609859  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
115609570  HDDC2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
115618478  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
115610649  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
115605688  deoxycytidine kinase-like [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
115616164  deoxycytidine kinase-like isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
115612941  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
115602656  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
115612821  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
115614173  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
115610050  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
115608320  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
115618663  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
115601291  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
115616417  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
115607555  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
115619835  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
115610426  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
115604230  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
115610425  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
115611143  guanylate cyclase soluble subunit beta-2-like isoform X1 [KO:K12319] [EC:4.6.1.2]
115605273  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
115603022  retinal guanylyl cyclase 1-like isoform X1 [KO:K12321] [EC:4.6.1.2]
115604462  LOW QUALITY PROTEIN: retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
115602751  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
115601023  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
115610583  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
115608746  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
115603098  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
115603759  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
115605178  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X2 [KO:K19021] [EC:3.1.4.17]
115606830  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
115604800  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
115601362  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
115609138  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
115612130  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
115616745  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
115605295  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
115603729  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
115613796  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
115608305  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
115607077  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
115613573  ADSS2; LOW QUALITY PROTEIN: adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
115607131  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
115602189  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
115602281  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
115609136  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
115615301  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
115605738  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
115611262  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
115616938  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
115617217  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
115611705  AK4; LOW QUALITY PROTEIN: adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
115607329  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
115615678  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
115619384  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
115619782  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
115616975  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
115613673  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
115609388  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
115609389  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
115611614  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
115618215  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
115619459  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
115603390  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
115611984  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
115609703  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
115612469  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
115601383  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
115614542  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
115609514  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
115610418  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
115608481  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
115612222  uricase-like [KO:K00365] [EC:1.7.3.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
shab00030  Pentose phosphate pathway
shab00220  Arginine biosynthesis
shab00250  Alanine, aspartate and glutamate metabolism
shab00260  Glycine, serine and threonine metabolism
shab00340  Histidine metabolism
shab00630  Glyoxylate and dicarboxylate metabolism
shab00730  Thiamine metabolism
shab00740  Riboflavin metabolism
shab00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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