KEGG PATHWAY: shr04061

KEGG

PATHWAY: shr04061

Entry

shr04061                    Pathway

Name

Viral protein interaction with cytokine and cytokine receptor - Sarcophilus harrisii (Tasmanian devil)

Description

Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.

Class

Environmental Information Processing; Signaling molecules and interaction

Pathway map

Viral protein interaction with cytokine and cytokine receptor

Organism

Sarcophilus harrisii (Tasmanian devil) [GN:shr]

Gene

C-C motif chemokine 3 [KO:K05408]

C-C motif chemokine 3-like 1 [KO:K05408]

C-C motif chemokine 3 [KO:K05408]

C-C motif chemokine 3-like [KO:K05408]

C-C motif chemokine 2 [KO:K14624]

uncharacterized protein LOC100921581 [KO:K16598]

uncharacterized protein LOC100934273 [KO:K21096]

CCL28; C-C motif chemokine 28 [KO:K05513]

CCL17; LOW QUALITY PROTEIN: C-C motif chemokine 17 [KO:K21083]

CCL22; C-C motif chemokine 22 [KO:K21095]

C-C motif chemokine 4-like [KO:K12964]

C-C motif chemokine 4 [KO:K12964]

C-C motif chemokine 3-like 1 [KO:K12964]

C-C motif chemokine 4-like [KO:K12964]

C-C motif chemokine 4-like [KO:K12964]

C-C motif chemokine 4-like [KO:K12964]

C-C motif chemokine 4-like [KO:K12964]

C-C motif chemokine 3 [KO:K12964]

C-C motif chemokine 4-like [KO:K12964]

CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]

C-C motif chemokine 13-like [KO:K05514]

CCL25; C-C motif chemokine 25 [KO:K13072]

CCL19; C-C motif chemokine 19 [KO:K05512]

CCL21; C-C motif chemokine 21 [KO:K16062]

growth-regulated alpha protein [KO:K05505]

CXCL8; interleukin-8 [KO:K10030]

CXCL9; C-X-C motif chemokine 9 [KO:K05416]

CXCL10; C-X-C motif chemokine 10 [KO:K12671]

C-X-C motif chemokine 10-like [KO:K12671]

CXCL13; C-X-C motif chemokine 13 [KO:K10032]

C-X-C motif chemokine 10-like [KO:K10032]

CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]

CXCL14; C-X-C motif chemokine 14 [KO:K10033]

cytokine SCM-1 beta [KO:K22675]

CX3CL1; fractalkine [KO:K05508]

IL10; LOW QUALITY PROTEIN: interleukin-10 [KO:K05443]

IL6; interleukin-6 [KO:K05405]

uncharacterized LOC100935068 precursor [KO:K05429]

interleukin-18-like [KO:K05482]

IL18; interleukin-18 [KO:K05482]

interleukin-18-like [KO:K05482]

IL19; interleukin-19 [KO:K05444]

IL20; interleukin-20 [KO:K22667]

IL24; interleukin-24 [KO:K22668]

TNF; tumor necrosis factor [KO:K03156]

LTA; lymphotoxin-alpha [KO:K05468]

TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]

TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]

IL34; interleukin-34 isoform X1 [KO:K22633]

CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]

C-C chemokine receptor type 1-like [KO:K04176]

C-C chemokine receptor type 3 [KO:K04178]

CCR4; C-C chemokine receptor type 4 isoform X1 [KO:K04179]

C-C chemokine receptor type 5 [KO:K04180]

C-C chemokine receptor type 5-like [KO:K04180]

CCR6; C-C chemokine receptor type 6 [KO:K04181]

CCR8; C-C chemokine receptor type 8 [KO:K04183]

ACKR4; atypical chemokine receptor 4 [KO:K04186]

CCR10; C-C chemokine receptor type 10 [KO:K04185]

CCR7; C-C chemokine receptor type 7 [KO:K04182]

C-X-C chemokine receptor type 1 [KO:K04175]

C-X-C chemokine receptor type 2 [KO:K05050]

CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]

CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]

CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]

ACKR3; atypical chemokine receptor 3 [KO:K04304]

XCR1; chemokine XC receptor 1 [KO:K04193]

CX3CR1; CX3C chemokine receptor 1 [KO:K04192]

IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]

IL10RB; interleukin-10 receptor subunit beta [KO:K05135]

IL6R; interleukin-6 receptor subunit alpha [KO:K05055]

IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]

IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]

IL2RB; interleukin-2 receptor subunit beta [KO:K05069]

IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]

IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]

IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]

IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]

IL20RB; interleukin-20 receptor subunit beta [KO:K05137]

IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]

TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]

TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]

LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]

tumor necrosis factor receptor superfamily member 14 [KO:K05152]

tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722]

CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]

Reference

Authors

Alcami A

Title

Viral mimicry of cytokines, chemokines and their receptors.

Journal

Nat Rev Immunol 3:36-50 (2003)
DOI:10.1038/nri980

Reference

Authors

Pontejo SM, Murphy PM

Title

Chemokines encoded by herpesviruses.

Journal

J Leukoc Biol 102:1199-1217 (2017)
DOI:10.1189/jlb.4RU0417-145RR

Reference

Authors

de Munnik SM, Smit MJ, Leurs R, Vischer HF

Title

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.

Journal

Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040

Reference

Authors

Vischer HF, Siderius M, Leurs R, Smit MJ

Title

Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

Journal

Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189

Reference

Authors

Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG

Title

Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.

Journal

Virology 236:316-27 (1997)
DOI:10.1006/viro.1997.8730

Reference

Authors

Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K

Title

Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.

Journal

J Virol 72:6104-12 (1998)
DOI:10.1128/JVI.72.7.6104-6112.1998

Reference

Authors

Damon I, Murphy PM, Moss B

Title

Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.

Journal

Proc Natl Acad Sci U S A 95:6403-7 (1998)
DOI:10.1073/pnas.95.11.6403

Reference

Authors

Dewin DR, Catusse J, Gompels UA

Title

Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.

Journal

J Immunol 176:544-56 (2006)
DOI:10.4049/jimmunol.176.1.544

Reference

Authors

Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ

Title

Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.

Journal

Mol Pharmacol 69:888-98 (2006)
DOI:10.1124/mol.105.015222

Reference

Authors

Wang D, Bresnahan W, Shenk T

Title

Human cytomegalovirus encodes a highly specific RANTES decoy receptor.

Journal

Proc Natl Acad Sci U S A 101:16642-7 (2004)
DOI:10.1073/pnas.0407233101

Reference

Authors

Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A

Title

Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.

Journal

PLoS Pathog 8:e1002497 (2012)
DOI:10.1371/journal.ppat.1002497

Reference

Authors

Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A

Title

A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.

Journal

Proc Natl Acad Sci U S A 103:5995-6000 (2006)
DOI:10.1073/pnas.0510462103

Reference

Authors

Tadagaki K, Nakano K, Yamanishi K

Title

Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.

Journal

J Virol 79:7068-76 (2005)
DOI:10.1128/JVI.79.11.7068-7076.2005

Reference

Authors

Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG

Title

Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.

Journal

J Leukoc Biol 74:676-82 (2003)
DOI:10.1189/jlb.0503206

Reference

Authors

Najarro P, Lee HJ, Fox J, Pease J, Smith GL

Title

Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.

Journal

J Gen Virol 84:3325-36 (2003)
DOI:10.1099/vir.0.19591-0

Reference

Authors

Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL

Title

Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.

Journal

J Gen Virol 87:809-16 (2006)
DOI:10.1099/vir.0.81427-0

Reference

Authors

Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA

Title

Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.

Journal

Eur J Immunol 38:763-77 (2008)
DOI:10.1002/eji.200737618

Reference

Authors

Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J

Title

The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.

Journal

J Immunol 158:604-13 (1997)

Reference

Authors

Yoon SI, Jones BC, Logsdon NJ, Walter MR

Title

Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.

Journal

Structure 13:551-64 (2005)
DOI:10.1016/j.str.2005.01.016

Reference

Authors

Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S

Title

Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).

Journal

Proc Natl Acad Sci U S A 97:1695-700 (2000)
DOI:10.1073/pnas.97.4.1695

Reference

Authors

Chang WL, Baumgarth N, Yu D, Barry PA

Title

Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.

Journal

J Virol 78:8720-31 (2004)
DOI:10.1128/JVI.78.16.8720-8731.2004

Reference

Authors

Li H, Wang H, Nicholas J

Title

Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.

Journal

J Virol 75:3325-34 (2001)
DOI:10.1128/JVI.75.7.3325-3334.2001

Reference

Authors

Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G

Title

HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.

Journal

Blood 98:823-9 (2001)
DOI:10.1182/blood.v98.3.823

Reference

Authors

Xiang Y, Moss B

Title

IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.

Journal

Proc Natl Acad Sci U S A 96:11537-42 (1999)
DOI:10.1073/pnas.96.20.11537

Reference

Authors

Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL

Title

A new member of the interleukin 10-related cytokine family encoded by a poxvirus.

Journal

J Gen Virol 85:1401-12 (2004)
DOI:10.1099/vir.0.79980-0

Reference

Authors

Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK

Title

The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.

Journal

J Virol 72:4015-21 (1998)
DOI:10.1128/JVI.72.5.4015-4021.1998

Reference

Authors

Snow AL, Martinez OM

Title

Epstein-Barr virus: evasive maneuvers in the development of PTLD.

Journal

Am J Transplant 7:271-7 (2007)
DOI:10.1111/j.1600-6143.2006.01650.x

Reference

Authors

Shim AH, Chang RA, Chen X, Longnecker R, He X

Title

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.

Journal

Proc Natl Acad Sci U S A 109:12962-7 (2012)
DOI:10.1073/pnas.1205309109

Reference

Authors

Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ

Title

The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.

Journal

J Biol Chem 277:21730-9 (2002)
DOI:10.1074/jbc.M200113200

Reference

Authors

Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G

Title

A secreted high-affinity inhibitor of human TNF from Tanapox virus.

Journal

Proc Natl Acad Sci U S A 100:4831-6 (2003)
DOI:10.1073/pnas.0737244100

Reference

Authors

Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A

Title

Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.

Journal

Biochem Pharmacol 76:1522-32 (2008)
DOI:10.1016/j.bcp.2008.07.030

Reference

Authors

Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA

Title

Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

Journal

Cell Host Microbe 13:324-35 (2013)
DOI:10.1016/j.chom.2013.02.003

KO pathway

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