Entry Name Cortisol synthesis and secretion - Trichechus manatus latirostris (Florida manatee)
Description Cortisol is the main endogenous glucocorticoid, which affects a plethora of physiological functions, e.g., lipid and glucose metabolism, metabolic homeostasis and adaptation to stress. Cortisol production is primarily regulated by corticotropin (ACTH) in zona fasciculata. The stimulatory effect of ACTH on cortisol synthesis depends on cAMP dependent signaling, but also involves membrane depolarization and increased cytosolic Ca2+. Each of cAMP and Ca2+ induces the expression of StAR, stimulating intramitochondrial cholesterol transfer, as well as the steroidogenic enzymes in the pathway from cholesterol to cortisol (e.g., CHE, CYP17A1, CYP11B1).
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map tmu04927 Cortisol synthesis and secretion
Ortholog table Other DBs Organism Trichechus manatus latirostris (Florida manatee) [GN:
tmu ]
Gene 101361837 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632 ]
101358375 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437 ] [EC:3.1.4.53 ]
101359618 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437 ] [EC:3.1.4.53 ]
101346441 nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465 ]
101356255 pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355 ]
101356881 cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
101355964 cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
101349137 cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
101344337 cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
101344076 cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
101345798 cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
101340320 steroidogenic acute regulatory protein, mitochondrial [KO:K16931 ]
101347192 guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634 ]
101351856 voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854 ]
101344111 voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855 ]
101345870 voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856 ]
101360945 voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
101357085 voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
101340818 voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
101343945 voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857 ]
Compound C01176 17alpha-Hydroxyprogesterone
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05138 17alpha-Hydroxypregnenolone
Reference Authors Gallo-Payet N, Battista MC
Title Steroidogenesis-adrenal cell signal transduction.
Journal Reference Authors Enyeart JJ
Title Biochemical and Ionic signaling mechanisms for ACTH-stimulated cortisol production.
Journal Reference Authors Bandulik S, Tauber P, Lalli E, Barhanin J, Warth R
Title Two-pore domain potassium channels in the adrenal cortex.
Journal Reference Authors Liu H, Enyeart JA, Enyeart JJ
Title Angiotensin II inhibits native bTREK-1 K+ channels through a PLC-, kinase C-, and PIP2-independent pathway requiring ATP hydrolysis.
Journal Reference Authors Enyeart JJ, Danthi SJ, Liu H, Enyeart JA
Title Angiotensin II inhibits bTREK-1 K+ channels in adrenocortical cells by separate Ca2+- and ATP hydrolysis-dependent mechanisms.
Journal Reference Authors Shen WJ, Azhar S, Kraemer FB
Title ACTH Regulation of Adrenal SR-B1.
Journal Reference Authors Ruggiero C, Lalli E
Title Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes.
Journal Reference Authors Margioris AN, Tsatsanis C
Title ACTH Action on the Adrenals
Journal Endotext (2000)
Reference Authors Spiga F, Lightman SL
Title Dynamics of adrenal glucocorticoid steroidogenesis in health and disease.
Journal Reference Authors Tsai LC, Beavo JA
Title The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis.
Journal Reference Authors Odermatt A, Strajhar P, Engeli RT
Title Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools.
Journal Reference Authors Manna PR, Stetson CL, Slominski AT, Pruitt K
Title Role of the steroidogenic acute regulatory protein in health and disease.
Journal Reference Authors Jackson DS, Ramachandrappa S, Clark AJ, Chan LF
Title Melanocortin receptor accessory proteins in adrenal disease and obesity.
Journal Reference Authors Cerda-Reverter JM, Agulleiro MJ, Cortes R, Sanchez E, Guillot R, Leal E, Fernandez-Duran B, Puchol S, Eley M
Title Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors.
Journal Reference Authors Enyeart JJ, Enyeart JA
Title Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: properties and modulation by ACTH and AngII.
Journal Reference Authors Midzak A, Papadopoulos V
Title Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies.
Journal Reference Authors Calebiro D, Di Dalmazi G, Bathon K, Ronchi CL, Beuschlein F
Title cAMP signaling in cortisol-producing adrenal adenoma.
Journal Reference Authors Turcu AF, Auchus RJ
Title Adrenal steroidogenesis and congenital adrenal hyperplasia.
Journal Related tmu04960 Aldosterone-regulated sodium reabsorption
KO pathway LinkDB All DBs
