KEGG   PATHWAY: tsr00230
Entry
tsr00230                    Pathway                                
Name
Purine metabolism - Thamnophis sirtalis (common garter snake)
Class
Metabolism; Nucleotide metabolism
Pathway map
tsr00230  Purine metabolism
tsr00230

Module
tsr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:tsr00230]
tsr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:tsr00230]
tsr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:tsr00230]
tsr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:tsr00230]
tsr_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:tsr00230]
tsr_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:tsr00230]
Other DBs
GO: 0006163 0042278
Organism
Thamnophis sirtalis (common garter snake) [GN:tsr]
Gene
106542940  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
106550928  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
106546379  PGM1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
106554452  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
106549445  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
106557431  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
106554315  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
106552129  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
106546638  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
106554316  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
106554752  uncharacterized protein LOC106554752 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
106544912  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
106542127  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
106553135  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
106548894  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
106549899  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
106552303  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
106552761  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
106544947  NT5C1A; cytosolic 5'-nucleotidase 1A isoform X1 [KO:K01081] [EC:3.1.3.5]
106540942  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
106556858  5'-nucleotidase domain-containing protein 4-like [KO:K01081] [EC:3.1.3.5]
106545989  snake venom 5'-nucleotidase-like [KO:K19970] [EC:3.1.3.5]
106549935  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
106549287  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
106556985  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
106546700  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
106546520  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
106547409  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
106546746  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
106555900  adenylate kinase 9-like [KO:K18533] [EC:2.7.4.3 2.7.4.6]
106541504  adenylate kinase 9-like [KO:K18533] [EC:2.7.4.3 2.7.4.6]
106545487  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
106550196  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
106537856  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
106543734  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
106551417  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
106539303  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
106552430  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
106538731  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
106555387  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
106538523  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
106541696  GMP reductase 2-like [KO:K00364] [EC:1.7.1.7]
106541847  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
106538483  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
106556770  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
106550808  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
106548038  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
106550152  deoxyguanosine kinase, mitochondrial-like [KO:K00904] [EC:2.7.1.113]
106550977  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
106555550  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
106546301  PRUNE; protein prune homolog [KO:K01514] [EC:3.6.1.11]
106543976  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
106545186  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
106555200  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
106549385  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
106553086  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
106539925  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
106554339  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
106542281  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
106551564  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
106555835  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
106553741  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
106549047  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
106556501  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
106539796  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
106539263  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
106539270  heat-stable enterotoxin receptor-like [KO:K12320] [EC:4.6.1.2]
106557179  retinal guanylyl cyclase 2-like [KO:K12321] [EC:4.6.1.2]
106544109  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
106546673  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
106538512  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
106550934  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
106541195  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
106551821  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
106545759  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
106539783  cGMP-inhibited 3',5'-cyclic phosphodiesterase A-like [KO:K19021] [EC:3.1.4.17]
106547323  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
106554715  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
106549902  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [KO:K13756] [EC:3.1.4.35]
106548495  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
106537932  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
106546949  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
106547353  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
106539728  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
106544217  adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
106554654  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
106541730  adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
106539290  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
106556952  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
106537531  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
106546041  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
106544871  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
106542424  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
106556842  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
106551567  adenylate kinase isoenzyme 5-like [KO:K00939] [EC:2.7.4.3]
106556974  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
106553051  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
106540467  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
106545786  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
106542100  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
106547295  adenylate kinase 8-like [KO:K00939] [EC:2.7.4.3]
106546514  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
106545693  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
106541825  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
106544191  ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
106538434  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
106554907  cAMP-specific 3',5'-cyclic phosphodiesterase 4C-like [KO:K13293] [EC:3.1.4.53]
106556924  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
106538328  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
106541552  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
106540918  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
106539005  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
106541938  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
106542806  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
106553902  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
106555283  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2-like [KO:K13811] [EC:2.7.7.4 2.7.1.25]
106537631  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
tsr00030  Pentose phosphate pathway
tsr00220  Arginine biosynthesis
tsr00250  Alanine, aspartate and glutamate metabolism
tsr00260  Glycine, serine and threonine metabolism
tsr00340  Histidine metabolism
tsr00630  Glyoxylate and dicarboxylate metabolism
tsr00730  Thiamine metabolism
tsr00740  Riboflavin metabolism
tsr00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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