KEGG   PATHWAY: vlg03040
Entry
vlg03040                    Pathway                                
Name
Spliceosome - Vulpes lagopus (Arctic fox)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
vlg03040  Spliceosome
vlg03040

Other DBs
GO: 0005681
Organism
Vulpes lagopus (Arctic fox) [GN:vlg]
Gene
121475054  U1 spliceosomal RNA [KO:K14276]
121474281  U1 spliceosomal RNA [KO:K14276]
121474406  U1 spliceosomal RNA [KO:K14276]
121492248  U1 spliceosomal RNA [KO:K14276]
121499192  U1 spliceosomal RNA [KO:K14276]
121494091  U1 spliceosomal RNA [KO:K14276]
121481739  U1 spliceosomal RNA [KO:K14276]
121483671  U1 spliceosomal RNA [KO:K14276]
121474293  U1 spliceosomal RNA [KO:K14276]
121492304  U2 spliceosomal RNA [KO:K14277]
121474305  U2 spliceosomal RNA [KO:K14277]
121481694  U2 spliceosomal RNA [KO:K14277]
121480455  U2 spliceosomal RNA [KO:K14277]
121496396  U2 spliceosomal RNA [KO:K14277]
121499203  U2 spliceosomal RNA [KO:K14277]
121474387  U4 spliceosomal RNA [KO:K14278]
121488585  U4 spliceosomal RNA [KO:K14278]
121475896  U4 spliceosomal RNA [KO:K14278]
121492314  U4 spliceosomal RNA [KO:K14278]
121486050  U4 spliceosomal RNA [KO:K14278]
121475897  U4 spliceosomal RNA [KO:K14278]
121494126  U4 spliceosomal RNA [KO:K14278]
121477196  U4 spliceosomal RNA [KO:K14278]
121490314  U4 spliceosomal RNA [KO:K14278]
121481719  U4 spliceosomal RNA [KO:K14278]
121501103  U4 spliceosomal RNA [KO:K14278]
121485879  U5 spliceosomal RNA [KO:K14279]
121498265  U5 spliceosomal RNA [KO:K14279]
121485877  U5 spliceosomal RNA [KO:K14279]
121481725  U5 spliceosomal RNA [KO:K14279]
121481724  U5 spliceosomal RNA [KO:K14279]
121477199  U6 spliceosomal RNA [KO:K14280]
121482178  U6 spliceosomal RNA [KO:K14280]
121499227  U6 spliceosomal RNA [KO:K14280]
121475871  U6 spliceosomal RNA [KO:K14280]
121483764  U6 spliceosomal RNA [KO:K14280]
121474718  U6 spliceosomal RNA [KO:K14280]
121490332  U6 spliceosomal RNA [KO:K14280]
121478464  U6 spliceosomal RNA [KO:K14280]
121476707  U6 spliceosomal RNA [KO:K14280]
121485923  U6 spliceosomal RNA [KO:K14280]
121492336  U6 spliceosomal RNA [KO:K14280]
121472447  U6 spliceosomal RNA [KO:K14280]
121479193  U6 spliceosomal RNA [KO:K14280]
121492234  U6 spliceosomal RNA [KO:K14280]
121488459  U6 spliceosomal RNA [KO:K14280]
121496428  U6 spliceosomal RNA [KO:K14280]
121474296  U6 spliceosomal RNA [KO:K14280]
121483639  U6 spliceosomal RNA [KO:K14280]
121477629  U6 spliceosomal RNA [KO:K14280]
121482188  U6 spliceosomal RNA [KO:K14280]
121485889  U6 spliceosomal RNA [KO:K14280]
121476712  U6 spliceosomal RNA [KO:K14280]
121485916  U6 spliceosomal RNA [KO:K14280]
121476709  U6 spliceosomal RNA [KO:K14280]
121474284  U6 spliceosomal RNA [KO:K14280]
121488500  U6 spliceosomal RNA [KO:K14280]
121496426  U6 spliceosomal RNA [KO:K14280]
121477200  U6 spliceosomal RNA [KO:K14280]
121490198  U6 spliceosomal RNA [KO:K14280]
121479171  U6 spliceosomal RNA [KO:K14280]
121474282  U6 spliceosomal RNA [KO:K14280]
121479596  U6 spliceosomal RNA [KO:K14280]
121475177  U6 spliceosomal RNA [KO:K14280]
121496361  U6 spliceosomal RNA [KO:K14280]
121494002  U6 spliceosomal RNA [KO:K14280]
121475170  U6 spliceosomal RNA [KO:K14280]
121496425  U6 spliceosomal RNA [KO:K14280]
121488429  U6 spliceosomal RNA [KO:K14280]
121474771  U6 spliceosomal RNA [KO:K14280]
121499237  U6 spliceosomal RNA [KO:K14280]
121488449  U6 spliceosomal RNA [KO:K14280]
121488426  U6 spliceosomal RNA [KO:K14280]
121476704  U6 spliceosomal RNA [KO:K14280]
121485942  U6 spliceosomal RNA [KO:K14280]
121493955  U6 spliceosomal RNA [KO:K14280]
121490202  U6 spliceosomal RNA [KO:K14280]
121474687  U6 spliceosomal RNA [KO:K14280]
121492340  U6 spliceosomal RNA [KO:K14280]
121492239  U6 spliceosomal RNA [KO:K14280]
121479612  U6 spliceosomal RNA [KO:K14280]
121493959  U6 spliceosomal RNA [KO:K14280]
121498305  U6 spliceosomal RNA [KO:K14280]
121501120  U6 spliceosomal RNA [KO:K14280]
121475174  U6 spliceosomal RNA [KO:K14280]
121474789  U6 spliceosomal RNA [KO:K14280]
121474748  U6 spliceosomal RNA [KO:K14280]
121485888  U6 spliceosomal RNA [KO:K14280]
121475868  U6 spliceosomal RNA [KO:K14280]
121485982  U6 spliceosomal RNA [KO:K14280]
121499233  U6 spliceosomal RNA [KO:K14280]
121493966  U6 spliceosomal RNA [KO:K14280]
121495534  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
121495108  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
121493870  DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
121500005  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
121497088  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
121497629  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
121473907  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
121488193  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
121489278  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
121478384  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
121490990  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
121485680  SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096]
121475425  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
121474063  small nuclear ribonucleoprotein E [KO:K11097]
121484631  small nuclear ribonucleoprotein E [KO:K11097]
121472347  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
121487731  small nuclear ribonucleoprotein E-like [KO:K11097]
121492853  small nuclear ribonucleoprotein E-like [KO:K11097]
121493817  small nuclear ribonucleoprotein E-like [KO:K11097]
121480892  small nuclear ribonucleoprotein E-like [KO:K11097]
121480889  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
121473905  small nuclear ribonucleoprotein F-like [KO:K11098]
121491797  small nuclear ribonucleoprotein F-like [KO:K11098]
121473049  small nuclear ribonucleoprotein G-like [KO:K11099]
121489870  small nuclear ribonucleoprotein G-like [KO:K11099]
121485341  small nuclear ribonucleoprotein G-like [KO:K11099]
121479895  small nuclear ribonucleoprotein G [KO:K11099]
121497219  small nuclear ribonucleoprotein G [KO:K11099]
121490818  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
121501406  small nuclear ribonucleoprotein G-like [KO:K11099]
121471480  small nuclear ribonucleoprotein G-like [KO:K11099]
121484247  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
121484326  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
121483252  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
121501115  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
121482867  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
121484331  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
121490054  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
121481840  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
121479871  PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821]
121493136  RBM25; RNA-binding protein 25 [KO:K12822]
121472709  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
121497352  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
121487657  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
121489323  LOW QUALITY PROTEIN: RNA-binding protein FUS-like [KO:K13098]
121489253  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
121478441  SNRPB2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094]
121475548  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
121495601  SF3A2; splicing factor 3A subunit 2 [KO:K12826]
121481643  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
121486209  splicing factor 3A subunit 3 [KO:K12827]
121480539  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
121472340  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
121500261  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
121490717  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
121485739  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
121491677  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
121490626  PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834]
121474162  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
121483808  splicing factor U2AF 35 kDa subunit-like protein [KO:K12836]
121484257  U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836]
121479511  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
121482921  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
121498696  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
121485309  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
121497850  RBM17; splicing factor 45 [KO:K12840]
121495736  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
121478726  U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
121474702  retinitis pigmentosa 9 protein-like [KO:K19604]
121474724  retinitis pigmentosa 9 protein [KO:K19604]
121475298  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
121481250  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121474506  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121482373  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121476563  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121490516  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121494916  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
121496102  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
121473810  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
121474458  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
121480878  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
121494151  LSM7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
121489229  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
121474763  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
121491907  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
121494887  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
121481468  PPIH; peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
121484310  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
121478636  NHP2-like protein 1 [KO:K12845]
121472571  NHP2-like protein 1 [KO:K12845]
121492030  NHP2-like protein 1 [KO:K12845]
121492121  SNU13; NHP2-like protein 1 isoform X1 [KO:K12845]
121491167  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
121491654  USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847]
121472131  SART1; U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
121497869  ZMAT2; zinc finger matrin-type protein 2 isoform X1 [KO:K12848]
121481601  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
121487632  PRPF38B; pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
121473712  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
121491281  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
121478080  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
121473397  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
121498179  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
121480011  DDX23; probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
121482088  TXNL4A; thioredoxin-like protein 4A isoform X1 [KO:K12859]
121498041  thioredoxin-like protein 4A [KO:K12859]
121471754  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
121499923  CDC5L; cell division cycle 5-like protein [KO:K12860]
121491035  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
121481611  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
121476465  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
121496287  spliceosome-associated protein CWC15 homolog [KO:K12863]
121478044  CTNNBL1; beta-catenin-like protein 1 [KO:K12864]
121489039  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
121489045  heat shock 70 kDa protein 1 [KO:K03283]
121473836  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
121482391  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
121474768  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
121492139  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
121499687  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
121495586  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
121482501  PQBP1; polyglutamine-binding protein 1 [KO:K12865]
121474790  LOW QUALITY PROTEIN: polyglutamine-binding protein 1-like [KO:K12865]
121480302  WBP11; WW domain-binding protein 11 [KO:K12866]
121493188  SNW1; SNW domain-containing protein 1 [KO:K06063]
121496263  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
121496590  pre-mRNA-splicing factor SYF2 isoform X1 [KO:K12868]
121497812  pre-mRNA-splicing factor SYF2-like [KO:K12868]
121477950  CRNKL1; crooked neck-like protein 1 isoform X1 [KO:K12869]
121496311  ISY1; pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
121473100  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
121481663  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
121494363  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
121488069  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
121487747  BUD31; protein BUD31 homolog [KO:K12873]
121484781  AQR; RNA helicase aquarius [KO:K12874]
121492894  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
121474161  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
121491112  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
121480265  MAGOHB; protein mago nashi homolog 2 [KO:K12877]
121481340  protein mago nashi homolog [KO:K12877]
121472097  protein mago nashi homolog [KO:K12877]
121499530  MAGOH; protein mago nashi homolog [KO:K12877]
121488928  THOC1; THO complex subunit 1 [KO:K12878]
121482808  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
121486134  THOC3; THO complex subunit 3 [KO:K12880]
121474034  ALYREF; THO complex subunit 4 [KO:K12881]
121495460  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
121482609  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
121498606  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
121480303  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
121480371  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121489222  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121490154  heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
121478108  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121471369  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
121496574  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121496643  HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741]
121497253  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121498097  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121499609  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121493588  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121493614  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121495721  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
121480920  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
121483145  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
121484233  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
121480898  heterogeneous nuclear ribonucleoprotein M-like isoform X1 [KO:K12887]
121494268  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
121488470  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
121492039  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
121474133  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
121472721  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
121495455  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
121478127  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
121496583  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
121493062  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
121491558  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
121475433  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
121474641  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
121477453  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
121497228  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

DBGET integrated database retrieval system