Entry
Name
Spliceosome - Vulpes lagopus (Arctic fox)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Other DBs
Organism
Vulpes lagopus (Arctic fox) [GN:
vlg ]
Gene
121471369 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741 ]
121473712 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852 ]
121474641 TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897 ]
121478384 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086 ]
121478441 SNRPB2; U2 small nuclear ribonucleoprotein B'' isoform X1 [KO:K11094 ]
121479511 U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836 ]
121479871 PRPF40B; pre-mRNA-processing factor 40 homolog B isoform X1 [KO:K12821 ]
121480920 HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884 ]
121481840 PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821 ]
121482921 U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837 ]
121483165 GPKOW; G-patch domain and KOW motifs-containing protein [KO:K13101 ]
121484233 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
121484247 SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093 ]
121484257 U2AF1L4; splicing factor U2AF 26 kDa subunit isoform X1 [KO:K12836 ]
121485309 SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839 ]
121485680 SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X1 [KO:K11096 ]
121488470 HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888 ]
121490626 PHF5A; PHD finger-like domain-containing protein 5A isoform X1 [KO:K12834 ]
121491167 SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846 ]
121491558 SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896 ]
121491654 USP39; U4/U6.U5 tri-snRNP-associated protein 2 isoform X1 [KO:K12847 ]
121491907 PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843 ]
121492894 ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875 ]
121493062 SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893 ]
121494151 LSM7; U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626 ]
121494268 HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887 ]
121496102 LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623 ]
121496643 HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741 ]
121497228 SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900 ]
121497352 TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824 ]
121498179 SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857 ]
121498606 NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883 ]
121498696 PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
Reference
Authors
Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will CL, Urlaub H, Kastner B, Luhrmann R, Stark H
Title
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Journal
Reference
Authors
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Title
Structure of the human activated spliceosome in three conformational states.
Journal
Reference
Authors
Haselbach D, Komarov I, Agafonov DE, Hartmuth K, Graf B, Dybkov O, Urlaub H, Kastner B, Luhrmann R, Stark H
Title
Structure and Conformational Dynamics of the Human Spliceosomal B(act) Complex.
Journal
Reference
Authors
Zhan X, Lu Y, Shi Y
Title
Molecular basis for the activation of human spliceosome.
Journal
KO pathway