KEGG   PATHWAY: vpc04530
Entry
vpc04530                    Pathway                                
Name
Tight junction - Vicugna pacos (alpaca)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
vpc04530  Tight junction
vpc04530

Other DBs
GO: 0005923
Organism
Vicugna pacos (alpaca) [GN:vpc]
Gene
102530725  CRB3; protein crumbs homolog 3 isoform X1 [KO:K06090]
102529174  CLDN12; claudin-12 [KO:K06087]
102536631  claudin-18 [KO:K06087]
116276688  CLDN5; claudin-5 [KO:K06087]
102539094  CLDN14; claudin-14 [KO:K06087]
102541785  LOW QUALITY PROTEIN: claudin-6-like [KO:K06087]
102537462  CLDN7; claudin-7 [KO:K06087]
102529239  CLDN25; putative claudin-25 [KO:K06087]
102538345  LOW QUALITY PROTEIN: claudin-22-like [KO:K06087]
116280272  claudin-18-like [KO:K06087]
102525896  CLDN20; claudin-20 [KO:K06087]
102533848  CLDN8; claudin-8 [KO:K06087]
102534114  CLDN17; claudin-17 [KO:K06087]
102534529  CLDN10; claudin-10 isoform X2 [KO:K06087]
102542188  CLDN11; claudin-11 [KO:K06087]
102545685  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
102545932  CLDN1; claudin-1 [KO:K06087]
102540546  CLDN23; claudin-23 [KO:K06087]
102527028  CLDN15; claudin-15 [KO:K06087]
102541598  CLDN4; claudin-4 [KO:K06087]
102541857  CLDN3; claudin-3 [KO:K06087]
102539040  CLDN2; claudin-2 [KO:K06087]
102529940  CLDN9; claudin-9 [KO:K06087]
102530194  claudin-6 [KO:K06087]
102544099  CLDN19; claudin-19 isoform X2 [KO:K06087]
102535951  OCLN; occludin [KO:K06088]
102525157  F11R; junctional adhesion molecule A [KO:K06089]
102535793  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
102536916  JAM3; junctional adhesion molecule C [KO:K06785]
102536866  BVES; blood vessel epicardial substance isoform X2 [KO:K21108]
102530757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102542494  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
102534261  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
102532682  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
102543979  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
102543218  MPP4; MAGUK p55 subfamily member 4 [KO:K21109]
102537895  TJP3; tight junction protein ZO-3 [KO:K06097]
102539990  PATJ; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
102526123  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
102544003  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
102536562  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
102545866  AMOT; angiomotin isoform X2 [KO:K16819]
102534850  AMOTL1; angiomotin-like protein 1 isoform X3 [KO:K06104]
102543671  AMOTL2; angiomotin-like protein 2 [KO:K06104]
102527977  ARHGAP17; rho GTPase-activating protein 17 isoform X6 [KO:K20638]
102543993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102545412  NF2; merlin isoform X1 [KO:K16684]
102533787  LLGL2; LLGL scribble cell polarity complex component 2 isoform X6 [KO:K06094]
102539778  LLGL1; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 1 [KO:K06094]
102538971  DLG1; disks large homolog 1 isoform X3 [KO:K12076]
102527679  SCRIB; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
102536954  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102537087  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102545534  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
102543888  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X2 [KO:K03456]
102538057  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
102544198  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
102531046  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X2 [KO:K04354]
102526571  PARD3; partitioning defective 3 homolog [KO:K04237]
102527012  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
102531900  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
102542198  TJAP1; LOW QUALITY PROTEIN: tight junction-associated protein 1 [KO:K06105]
102538112  DLG2; disks large homolog 2 isoform X9 [KO:K12075]
102528489  DLG3; disks large homolog 3 isoform X2 [KO:K21098]
102539515  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
102525688  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X7 [KO:K13305] [EC:2.3.2.26]
102532417  CGN; cingulin [KO:K06102]
102541899  CGNL1; LOW QUALITY PROTEIN: cingulin-like protein 1 [KO:K21110]
102538795  ARHGEF2; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 2 [KO:K12791]
102534196  RHOA; transforming protein RhoA [KO:K04513]
102529017  GATA4; transcription factor GATA-4 [KO:K09183]
102528220  MARVELD3; MARVEL domain-containing protein 3 [KO:K21099]
102530799  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102528221  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102543430  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102539859  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102541687  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
116277639  T-cell surface glycoprotein CD1a-like [KO:K06448]
102535052  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
102535797  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
102535553  T-cell surface glycoprotein CD1a-like [KO:K06448]
102534798  T-cell surface glycoprotein CD1b-1-like isoform X1 [KO:K06448]
102536045  T-cell surface glycoprotein CD1c [KO:K06448]
102527896  CFTR; LOW QUALITY PROTEIN: cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102532580  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
102544835  YBX3; Y-box-binding protein 3 [KO:K06099]
102536005  SYMPK; LOW QUALITY PROTEIN: symplekin [KO:K06100]
102526038  PCNA; proliferating cell nuclear antigen [KO:K04802]
102529872  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102539783  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102539586  RUNX1; runt-related transcription factor 1 [KO:K08367]
102538531  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
102527430  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 isoform X3 [KO:K13365]
102545343  EZR; ezrin isoform X1 [KO:K08007]
102535240  RDX; radixin isoform X2 [KO:K05762]
102533991  MSN; moesin isoform X1 [KO:K05763]
102533967  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
102541205  actin, cytoplasmic 1-like [KO:K05692]
102527650  actin, cytoplasmic 1-like [KO:K05692]
102532595  actin, cytoplasmic 1-like [KO:K05692]
107032833  actin, cytoplasmic 1-like [KO:K05692]
102534524  ACTB; actin, cytoplasmic 1 [KO:K05692]
102535619  actin, cytoplasmic 1-like [KO:K05692]
102535408  actin, cytoplasmic 1-like [KO:K05692]
102526754  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102539274  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102544996  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102525041  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102526522  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102542946  HCLS1; hematopoietic lineage cell-specific protein isoform X2 [KO:K06106]
102542003  CTTN; src substrate cortactin isoform X1 [KO:K06106]
102537115  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
102536520  ACTR3; actin-related protein 3 [KO:K18584]
102533937  ACTR3B; actin-related protein 3B isoform X4 [KO:K18584]
102528792  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
102529051  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
102540824  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
102536822  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
102544243  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
102533014  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
102524705  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
102524897  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [KO:K20479]
102534036  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
102540333  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
102528179  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102534902  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102534704  RAB13; ras-related protein Rab-13 isoform X1 [KO:K06109]
102527844  ARHGEF18; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 18 [KO:K21066]
102539343  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102524824  ROCK2; rho-associated protein kinase 2 isoform X8 [KO:K17388] [EC:2.7.11.1]
102533574  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102532721  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
102544676  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102539712  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102535416  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
102544672  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X2 [KO:K07199]
102545566  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
102535505  PRKAG3; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
102525133  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
102535634  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
102538509  MYH9; myosin-9 [KO:K10352]
102544684  MYH14; myosin-14 isoform X2 [KO:K10352]
102530128  MYH11; myosin-11 isoform X2 [KO:K10352]
102545433  MYH10; myosin-10 isoform X4 [KO:K10352]
102542056  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
102542299  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
102530350  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102542460  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
102542872  myosin regulatory light chain 12B [KO:K12757]
102535158  IGSF5; immunoglobulin superfamily member 5 isoform X1 [KO:K06786]
102530819  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10 [KO:K05631]
102542458  SYNPO; synaptopodin [KO:K21112]
102540152  ACTN1; LOW QUALITY PROTEIN: alpha-actinin-1 [KO:K05699]
102533146  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102528895  MICALL2; LOW QUALITY PROTEIN: MICAL-like protein 2 [KO:K21068]
102525337  RAB8A; ras-related protein Rab-8A [KO:K07901]
102540903  RAB8B; ras-related protein Rab-8B [KO:K07902]
102545333  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
102544212  RAP1A; ras-related protein Rap-1A [KO:K04353]
102541402  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
102524829  AFDN; afadin [KO:K05702]
102536009  TJP2; tight junction protein ZO-2 isoform X2 [KO:K06098]
102546108  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
102546022  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
102535122  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
102541743  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102532432  tubulin alpha-1A chain-like [KO:K07374]
102527740  tubulin alpha-1 chain-like [KO:K07374]
102531296  tubulin alpha-1D chain [KO:K07374]
102532857  tubulin alpha-4A chain [KO:K07374]
102535993  tubulin alpha-3 chain-like [KO:K07374]
102528113  tubulin alpha-1A chain-like [KO:K07374]
102533275  tubulin alpha-1A chain-like [KO:K07374]
102537205  TUBA1C; tubulin alpha-1C chain [KO:K07374]
102531320  tubulin alpha-1 chain-like [KO:K07374]
102537241  TUBA8; tubulin alpha-8 chain [KO:K07374]
102527946  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
vpc04520  Adherens junction
vpc04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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