KEGG   PATHWAY: xma03015
Entry
xma03015                    Pathway                                
Name
mRNA surveillance pathway - Xiphophorus maculatus (southern platyfish)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
xma03015  mRNA surveillance pathway
xma03015

Other DBs
GO: 0071028
Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102224591  ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
102228315  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
102229226  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
102218128  regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
102229932  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
102233713  protein mago nashi homolog [KO:K12877]
102217454  casc3; protein CASC3 [KO:K14323]
102230231  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
102226094  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
102221900  pnn; pinin [KO:K13114]
102237119  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
102217545  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
102229264  rnps1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
102220164  THO complex subunit 4 [KO:K12881]
102217946  THO complex subunit 4-like isoform X1 [KO:K12881]
102225349  ATP-dependent RNA helicase DDX19B-like [KO:K18655] [EC:5.6.2.7]
102229321  ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
102222697  gle1; nucleoporin GLE1 [KO:K18723]
102222705  nxf1; nuclear RNA export factor 1 [KO:K14284]
102237466  nxt2; NTF2-related export protein 2 [KO:K14285]
102229398  pym1; partner of Y14 and mago [KO:K14294]
102224403  srrm1; serine/arginine repetitive matrix protein 1 isoform X3 [KO:K13171]
102225982  rngtt; mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
102235108  rnmt; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
102220690  fus; RNA-binding protein FUS [KO:K13098]
102220505  TAR DNA-binding protein 43-like isoform X2 [KO:K23600]
102227033  tardbp; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
102229160  pabpn1; polyadenylate-binding protein 2 isoform X1 [KO:K14396]
102231342  pabpn1l; embryonic polyadenylate-binding protein 2 [KO:K14396]
102223658  nudt21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
102235230  cleavage and polyadenylation specificity factor subunit 7 [KO:K14398]
102223253  cpsf6; cleavage and polyadenylation specificity factor subunit 6 isoform X5 [KO:K14398]
102217227  papolg; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
102216608  clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
102228657  pcf11; pre-mRNA cleavage complex 2 protein Pcf11 [KO:K14400]
102228849  cpsf1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
102238047  cpsf2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
102220704  cleavage and polyadenylation specificity factor subunit 3-like [KO:K14403] [EC:3.1.27.-]
102227387  cpsf3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
102231355  cpsf4; cleavage and polyadenylation specificity factor subunit 4 [KO:K14404]
102237555  pre-mRNA 3'-end-processing factor FIP1-like isoform X1 [KO:K14405]
102230937  fip1l1; pre-mRNA 3'-end-processing factor FIP1 [KO:K14405]
102222481  wdr33; pre-mRNA 3' end processing protein WDR33 [KO:K15542]
102223275  wdr82; WD repeat-containing protein 82 [KO:K14962]
102223222  WD repeat-containing protein 82-like isoform X3 [KO:K14962]
102232527  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102219385  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102229527  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
102233529  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
102223696  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
102230984  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102220175  ssu72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
102232054  cstf1; cleavage stimulation factor subunit 1 [KO:K14406]
102227161  cstf2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
102225498  cstf3; cleavage stimulation factor subunit 3 [KO:K14408]
102222475  sympk; symplekin isoform X2 [KO:K06100]
102220933  RNA-binding protein Musashi homolog 1 [KO:K14411]
102216834  dazap1; DAZ-associated protein 1 isoform X2 [KO:K14411]
102232332  msi1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
102223905  msi2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
102234856  polyadenylate-binding protein 1 [KO:K13126]
102221478  pabpc1; polyadenylate-binding protein 1 [KO:K13126]
102230133  embryonic polyadenylate-binding protein B-like isoform X1 [KO:K13126]
102225611  pabpc4; polyadenylate-binding protein 4 [KO:K13126]
102219362  etf1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
102220839  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
102234904  gspt1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
102235710  regulator of nonsense transcripts 1-like isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102238036  regulator of nonsense transcripts 1 isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
102229634  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
102231795  smg1; serine/threonine-protein kinase SMG1 isoform X2 [KO:K08873] [EC:2.7.11.1]
102237763  smg7; protein SMG7 isoform X1 [KO:K14409]
102231063  smg5; protein SMG5 [KO:K11125]
102238347  smg6; telomerase-binding protein EST1A [KO:K11124] [EC:3.1.-.-]
102223777  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102221749  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102237558  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102218705  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
102223991  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
102237020  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
102220954  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
102225941  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
102232137  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X2 [KO:K04354]
102236397  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
102227765  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
102223746  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
102229339  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
102220157  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3 [KO:K11584]
102220866  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
102219851  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
102224452  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
102217180  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1 [KO:K11584]
102220780  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
102222605  hbs1l; HBS1-like protein isoform X2 [KO:K14416]
102229270  pelo; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
xma03013  Nucleocytoplasmic transport
xma03018  RNA degradation
xma03040  Spliceosome
KO pathway
ko03015   
LinkDB

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