KEGG   PATHWAY: xtr00230
Entry
xtr00230                    Pathway                                
Name
Purine metabolism - Xenopus tropicalis (tropical clawed frog)
Class
Metabolism; Nucleotide metabolism
Pathway map
xtr00230  Purine metabolism
xtr00230

Module
xtr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:xtr00230]
xtr_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:xtr00230]
xtr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:xtr00230]
xtr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:xtr00230]
xtr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:xtr00230]
xtr_M00546  Purine degradation, xanthine => urea [PATH:xtr00230]
xtr_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:xtr00230]
xtr_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:xtr00230]
Other DBs
GO: 0006163 0042278
Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
101733174  nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
493375  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100498212  adprm.2; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
549367  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
407960  pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
549455  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
394745  prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
496485  prps2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
394937  ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
100485140  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
496927  gart; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
100216263  pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
100036662  paics.2; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
100488155  paics.1; multifunctional protein ADE2 isoform X5 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
448055  adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
448061  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
493317  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
448172  nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
394700  nt5c1a; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
548490  nt5c2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
100495335  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
100496104  nt5dc4; 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
100489347  nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
448370  pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
100494552  lacc1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
394936  hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
493428  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
550037  impdh1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
448725  nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
448695  nme3; nucleoside diphosphate kinase 3 precursor [KO:K00940] [EC:2.7.4.6]
100170458  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
394498  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
734101  nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
100144994  ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
448501  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
100125010  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
733458  entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
394537  cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
677731  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
677734  entpd5; ectonucleoside triphosphate diphosphohydrolase 5 precursor [KO:K01511] [EC:3.6.1.6]
677735  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
100327255  nudt16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
100380204  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
100497499  xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
448765  nudt2; bis(5'-nucleosyl)-tetraphosphatase [KO:K01518] [EC:3.6.1.17]
100494801  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
594932  gmpr2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
100135085  gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
100486841  gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
394964  guk1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
100145720  rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
394645  rrm2.1; ribonucleotide reductase M2, gene 1 [KO:K10808] [EC:1.17.4.1]
493274  rrm2.2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100144925  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100379693  hddc2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
100494916  dguok; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
594934  dck.1; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
549546  dck.2; deoxycytidine kinase, gene 2 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
733918  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
100379763  prune1; exopolyphosphatase PRUNE1 isoform X2 [KO:K01514] [EC:3.6.1.11]
116412036  protein prune homolog 2-like [KO:K01514] [EC:3.6.1.11]
100492373  adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100038110  dnajc27; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100497212  adcy4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100490464  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100493933  adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100127741  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
549366  uncharacterized protein LOC549366 [KO:K08048] [EC:4.6.1.1]
100126441  adcy9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100145454  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100496677  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
100379900  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X2 [KO:K12319] [EC:4.6.1.2]
100496697  gucy1b2; guanylate cyclase soluble subunit beta-2 [KO:K12319] [EC:4.6.1.2]
100486678  gucy2c; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
100496590  gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
100492820  gucy2f; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
100489435  retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
101732806  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
100492092  npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100488543  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
101732477  atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
100125056  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100036722  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
100495383  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
780063  pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
101730602  pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
100487373  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
780273  pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
100489913  pde6a; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
100487945  pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
100485634  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
108644463  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
100124827  pde6g; phosphodiesterase 6G [KO:K13759]
100498474  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
549499  pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
100493061  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
100488870  pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
100485841  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100379882  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
394644  adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
448339  adssl1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
595079  ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
100488507  ampd1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
100490248  ampd2; AMP deaminase 2 isoform X3 [KO:K01490] [EC:3.5.4.6]
549452  adk; adenosine kinase [KO:K00856] [EC:2.7.1.20]
100135194  ada.2; adenosine deaminase, gene 2 [KO:K01488] [EC:3.5.4.4]
496434  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
100487564  ada2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
448011  ak2; adenylate kinase 2, mitochondrial [KO:K00939] [EC:2.7.4.3]
448536  ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
100127649  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
496818  ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
100495400  ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
394708  ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
549921  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
100170447  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
407961  entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
100492066  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
100422807  enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100422808  enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100488846  pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
100380081  pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
780324  pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
100496479  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
100498541  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X4 [KO:K18436] [EC:3.1.4.53]
100037872  pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
100490787  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
100497070  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [KO:K18437] [EC:3.1.4.53]
448702  fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
550082  enpp4; bis(5'-adenosyl)-triphosphatase enpp4 precursor [KO:K18424] [EC:3.6.1.29]
448413  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100494746  papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
496896  uox; urate oxidase [KO:K00365] [EC:1.7.3.3]
100489904  urah; 5-hydroxyisourate hydrolase isoform X3 [KO:K07127] [EC:3.5.2.17]
100379820  urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
100498039  allantoinase, mitochondrial isoform X2 [KO:K01466] [EC:3.5.2.5]
394447  allc; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
xtr00030  Pentose phosphate pathway
xtr00220  Arginine biosynthesis
xtr00250  Alanine, aspartate and glutamate metabolism
xtr00260  Glycine, serine and threonine metabolism
xtr00340  Histidine metabolism
xtr00630  Glyoxylate and dicarboxylate metabolism
xtr00730  Thiamine metabolism
xtr00740  Riboflavin metabolism
xtr00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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