KEGG   PATHWAY: pcoq04150
Entry
pcoq04150                   Pathway                                
Name
mTOR signaling pathway - Propithecus coquereli (Coquerel's sifaka)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcoq04150  mTOR signaling pathway
pcoq04150

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804917  NPRL2; nitrogen permease regulator 2-like protein isoform X1 [KO:K20405]
105805081  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105805318  RRAGD; ras-related GTP-binding protein D [KO:K16186]
105805907  [KO:K02991]
105805950  LAMTOR4; ragulator complex protein LAMTOR4 [KO:K20399]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806302  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105806632  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
105806636  TSC1; hamartin [KO:K07206]
105807066  GATSL2; GATS-like protein 2 isoform X1 [KO:K23081]
105807089  FZD9; frizzled-9 [KO:K02842]
105807364  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105807545  KRAS; GTPase KRas [KO:K07827]
105807639  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105807655  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105807737  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105808009  WDR59; WD repeat-containing protein 59 isoform X1 [KO:K20409]
105808138  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
105808139  WNT3A; protein Wnt-3a [KO:K00312]
105808252  FZD4; frizzled-4 [KO:K02354]
105808762  WNT10A; protein Wnt-10a [KO:K01357]
105808766  WNT6; protein Wnt-6 [KO:K00445]
105808835  IRS1; insulin receptor substrate 1 [KO:K16172]
105808909  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
105809369  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105809778  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
105809796  FZD6; frizzled-6 isoform X1 [KO:K02376]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810548  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105810591  NRAS; GTPase NRas [KO:K07828]
105810592  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105811307  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
105811413  WNT11; protein Wnt-11 [KO:K01384]
105811494  LAMTOR1; ragulator complex protein LAMTOR1 isoform X1 [KO:K20397]
105811717  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105811735  SESN2; sestrin-2 [KO:K20394]
105811840  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105812010  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
105812065  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105812178  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
105812331  RRAGC; ras-related GTP-binding protein C [KO:K16186]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812691  SEC13; protein SEC13 homolog [KO:K14004]
105812910  WNT5B; protein Wnt-5b [KO:K00444]
105813061  TSC2; tuberin isoform X1 [KO:K07207]
105813066  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
105813132  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105813157  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
105813241  MIOS; WD repeat-containing protein mio [KO:K20407]
105813657  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
105814028  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
105814030  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814279  CAB39L; calcium-binding protein 39-like [KO:K08272]
105814514  RICTOR; rapamycin-insensitive companion of mTOR [KO:K08267]
105814569  PRR5L; proline-rich protein 5-like [KO:K20411]
105814677  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105814809  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
105814830  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
105814851  SEH1L; nucleoporin SEH1 [KO:K14299]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105815320  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105815471  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
105815675  WNT4; protein Wnt-4 [KO:K00408]
105815801  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105815840  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105815903  WNT10B; protein Wnt-10b [KO:K01357]
105816116  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105816125  FLCN; folliculin isoform X1 [KO:K09594]
105816304  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105816395  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
105816491  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
105816531  INS; insulin [KO:K04526]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816587  LPIN3; phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
105816611  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
105816636  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
105816721  CAB39; calcium-binding protein 39 [KO:K08272]
105816757  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105817130  WNT2; protein Wnt-2 [KO:K00182]
105817162  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
105817467  TBC1D7; TBC1 domain family member 7 [KO:K20396]
105817598  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105817908  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
105817973  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818818  FZD3; frizzled-3 [KO:K02329]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819075  WNT9B; protein Wnt-9b [KO:K01064]
105819079  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105819102  SLC38A9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
105819379  RHOA; transforming protein RhoA [KO:K04513]
105819434  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105819437  FZD7; frizzled-7 [KO:K02432]
105819510  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105819857  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820727  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105820951  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105821020  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
105821032  FZD10; frizzled-10 [KO:K02842]
105821051  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
105821309  GATSL3; GATS-like protein 3 [KO:K23080]
105821837  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
105822110  FZD2; frizzled-2 [KO:K02235]
105822317  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105822359  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105822497  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
105822594  NPRL3; nitrogen permease regulator 3-like protein isoform X1 [KO:K20406]
105822614  WDR24; WD repeat-containing protein 24 [KO:K20408]
105822702  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105822738  [KO:K00572]
105822747  PRR5; proline-rich protein 5 [KO:K20411]
105822932  [KO:K16344]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823275  DEPDC5; DEP domain-containing protein 5 [KO:K20404]
105823667  FZD8; frizzled-8 [KO:K02375]
105823861  [KO:K02152]
105823952  FZD5; frizzled-5 [KO:K02375]
105823986  STRADA; STE20-related kinase adapter protein alpha [KO:K08271]
105824057  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105824291  WNT8B; protein Wnt-8b [KO:K00714]
105824616  RHEB; GTP-binding protein Rheb [KO:K07208]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105824813  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825125  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
105825211  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105825364  [KO:K20411]
105825484  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105825529  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
105825645  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105826235  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105826277  FZD1; frizzled-1 [KO:K02432]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826694  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
105826755  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105826816  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105826841  WNT7A; protein Wnt-7a [KO:K00572]
105827009  [KO:K02991]
105827015  RRAGA; ras-related GTP-binding protein A [KO:K16185]
105827188  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
105827360  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pcoq00561  Glycerolipid metabolism
pcoq04010  MAPK signaling pathway
pcoq04140  Autophagy - animal
pcoq04151  PI3K-Akt signaling pathway
pcoq04152  AMPK signaling pathway
pcoq04810  Regulation of actin cytoskeleton
pcoq04910  Insulin signaling pathway
KO pathway
ko04150   

DBGET integrated database retrieval system