KEGG   PATHWAY: pcoq04010
Entry
pcoq04010                   Pathway                                
Name
MAPK signaling pathway - Propithecus coquereli (Coquerel's sifaka)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcoq04010  MAPK signaling pathway
pcoq04010

Other DBs
GO: 0000165
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105805030  [KO:K04358]
105805058  NTF3; neurotrophin-3 [KO:K04356]
105805081  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105805159  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105805175  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
105805188  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105805204  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105805211  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105805215  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105805290  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105805315  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105805373  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105805391  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105805561  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
105805652  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
105805749  FIGF; vascular endothelial growth factor D [KO:K05449]
105805879  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806045  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105806081  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105806205  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105806347  JUN; transcription factor AP-1 [KO:K04448]
105806470  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
105806600  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105806773  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
105806839  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105806970  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
105807026  HSPB1; heat shock protein beta-1 [KO:K04455]
105807488  SRF; serum response factor [KO:K04378]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105807545  KRAS; GTPase KRas [KO:K07827]
105807655  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105807665  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105807681  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
105807691  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105807785  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
105807933  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105807961  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105808133  FGF9; fibroblast growth factor 9 [KO:K04358]
105808263  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105808290  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105808330  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
105808407  RAP1B; ras-related protein Rap-1b [KO:K07836]
105808417  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
105808489  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105808669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
105808678  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105808785  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105808909  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
105809043  [KO:K04353]
105809290  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
105809321  FGF21; fibroblast growth factor 21 [KO:K22429]
105809394  NTF4; neurotrophin-4 [KO:K12457]
105809401  RRAS; ras-related protein R-Ras [KO:K07829]
105809498  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105809503  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
105809557  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
105809568  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105809799  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810553  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105810582  NGF; beta-nerve growth factor [KO:K02582]
105810591  NRAS; GTPase NRas [KO:K07828]
105810718  RASA1; ras GTPase-activating protein 1 [KO:K04352]
105810741  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810840  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105810904  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105811016  HGF; hepatocyte growth factor [KO:K05460]
105811092  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
105811166  ANGPT1; angiopoietin-1 [KO:K05465]
105811272  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
105811295  FGF22; fibroblast growth factor 22 [KO:K04358]
105811312  EFNA2; ephrin-A2 [KO:K05462]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105811507  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105811510  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105811549  FGF1; fibroblast growth factor 1 [KO:K18496]
105811628  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
105811685  STMN1; stathmin isoform X1 [KO:K04381]
105811700  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
105811717  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105811730  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105811840  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105811902  NRTN; neurturin [KO:K25414]
105811952  PSPN; persephin [KO:K25416]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105811966  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105812073  TGFA; protransforming growth factor alpha [KO:K08774]
105812103  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105812112  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105812407  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812813  EFNA5; ephrin-A5 [KO:K05462]
105812871  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105812907  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105812929  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105813088  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
105813188  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105813553  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
105813574  NF1; neurofibromin [KO:K08052]
105813939  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
105813943  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105814060  ARTN; artemin isoform X1 [KO:K25415]
105814128  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
105814232  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
105814234  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105814235  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105814236  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
105814272  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
105814474  FGF7; fibroblast growth factor 7 [KO:K04358]
105814556  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105814571  TRAF6; LOW QUALITY PROTEIN: TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105814653  FGF18; fibroblast growth factor 18 [KO:K04358]
105814660  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105814677  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105814712  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105814741  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105814785  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105814842  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105815064  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105815256  FGF2; fibroblast growth factor 2 [KO:K18497]
105815312  [KO:K04857]
105815570  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105815590  [KO:K04424] [EC:2.7.11.25]
105815695  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105815791  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105815854  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105815912  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
105815960  KITLG; kit ligand isoform X1 [KO:K05461]
105815999  [KO:K04440] [EC:2.7.11.24]
105816097  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105816099  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105816267  VEGFC; vascular endothelial growth factor C [KO:K05449]
105816304  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105816363  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105816487  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
105816530  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105816531  INS; insulin [KO:K04526]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816572  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105816783  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105816815  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105816821  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105816884  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
105817148  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105817331  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105817361  CRK; adapter molecule crk isoform X1 [KO:K04438]
105817525  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105817529  RELB; transcription factor RelB [KO:K09253]
105817570  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105817662  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
105817781  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105817877  [KO:K03283]
105817878  [KO:K03283]
105817879  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
105817898  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105817934  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105817992  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
105818000  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105818035  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105818077  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
105818162  JUND; transcription factor jun-D [KO:K04449]
105818292  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105818410  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105818690  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105818749  [KO:K04415] [EC:2.7.11.25]
105818750  [KO:K04415] [EC:2.7.11.25]
105818935  EGF; pro-epidermal growth factor [KO:K04357]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819080  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105819135  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105819344  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105819511  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105819621  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105819783  PGF; placenta growth factor isoform X1 [KO:K16859]
105819831  FOS; proto-oncogene c-Fos [KO:K04379]
105819899  MAX; protein max isoform X1 [KO:K04453]
105819909  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105819930  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
105819941  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
105820016  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105820319  IL1A; interleukin-1 alpha [KO:K04383]
105820326  IL1B; interleukin-1 beta [KO:K04519]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820424  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105820426  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105820427  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105820520  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
105820558  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
105820566  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820593  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105820763  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105820959  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105821114  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105821171  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105821206  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105821273  STK4; serine/threonine-protein kinase 4 [KO:K04411]
105821419  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
105821582  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105821583  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105821611  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105821682  DAXX; death domain-associated protein 6 [KO:K02308]
105821881  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105821936  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
105821937  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
105821975  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
105822091  RAP1A; ras-related protein Rap-1A [KO:K04353]
105822133  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105822163  [KO:K05450]
105822164  [KO:K05450]
105822257  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
105822317  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105822386  CRKL; crk-like protein [KO:K04438]
105822617  FGF23; fibroblast growth factor 23 [KO:K22428]
105822621  [KO:K04358]
105822691  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105822757  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
105822819  AREG; amphiregulin [KO:K09782]
105822822  EREG; proepiregulin [KO:K09784]
105822880  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105822925  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105823094  [KO:K17534] [EC:2.7.11.25]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823167  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105823351  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105823400  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105823513  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823644  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105823690  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105823878  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
105823921  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105824000  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
105824036  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105824147  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105824289  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105824302  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
105824348  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105824424  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105824525  FLNA; filamin-A isoform X1 [KO:K04437]
105824526  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105824543  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105824664  DUSP10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105824710  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105824991  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105825247  FGF20; fibroblast growth factor 20 [KO:K04358]
105825272  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105825283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
105825293  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105825498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105825541  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105825633  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105825988  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105826139  [KO:K04849]
105826180  FGF16; fibroblast growth factor 16 [KO:K04358]
105826215  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105826554  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105826598  MRAS; ras-related protein M-Ras [KO:K07831]
105826735  FGF10; fibroblast growth factor 10 [KO:K04358]
105826776  FGF3; fibroblast growth factor 3 [KO:K04358]
105826908  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105826943  [KO:K04857]
105827162  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105827289  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
105827300  VEGFB; vascular endothelial growth factor B [KO:K16858]
105827330  FGF19; fibroblast growth factor 19 [KO:K22603]
105827331  FGF4; fibroblast growth factor 4 [KO:K04358]
105827379  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105827407  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
105827467  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
105827576  ANGPT4; angiopoietin-4 [KO:K05467]
105827606  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [KO:K04859]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pcoq04070  Phosphatidylinositol signaling system
pcoq04110  Cell cycle
pcoq04115  p53 signaling pathway
pcoq04210  Apoptosis
pcoq04310  Wnt signaling pathway
pcoq04668  TNF signaling pathway
KO pathway
ko04010   

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