KEGG   PATHWAY: pleu04150
Entry
pleu04150                   Pathway                                
Name
mTOR signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pleu04150  mTOR signaling pathway
pleu04150

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680595  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
114680760  Tsc2; tuberin isoform X1 [KO:K07207]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114680817  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
114681172  Rragc; ras-related GTP-binding protein C [KO:K16186]
114681196  Wdr24; GATOR complex protein WDR24 [KO:K20408]
114681257  Telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
114681319  Wnt7a; protein Wnt-7a [KO:K00572]
114681382  [KO:K03875]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681843  [KO:K02151]
114682581  Flcn; folliculin [KO:K09594]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682897  Ulk1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
114682960  Ulk2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
114682971  Wnt3a; protein Wnt-3a [KO:K00312]
114683006  Wnt9a; protein Wnt-9a [KO:K01064]
114683184  Insr; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
114683308  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
114683314  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
114683616  Slc3a2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
114683726  Lamtor2; LOW QUALITY PROTEIN: ragulator complex protein LAMTOR2 [KO:K20398]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684084  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684368  Akt1s1; proline-rich AKT1 substrate 1 isoform X4 [KO:K16184]
114685027  Lamtor4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
114685127  [KO:K02833]
114685687  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
114685753  Fzd7; frizzled-7 [KO:K02432]
114685999  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114686016  Fzd9; frizzled-9 [KO:K02842]
114686454  [KO:K14299]
114687372  Eif4e; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
114687523  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
114687963  Fzd1; frizzled-1 [KO:K02432]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688488  [KO:K02833]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689517  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
114689621  Sec13; protein SEC13 homolog [KO:K14004]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114690164  Seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
114690407  Strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690559  [KO:K16186]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114691083  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
114691347  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114692095  [KO:K20396]
114692203  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114692581  Lpin3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
114692972  [KO:K02991]
114693209  Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
114693466  Mios; GATOR complex protein MIOS [KO:K20407]
114693493  [KO:K02833]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693654  Castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
114693690  Fzd10; frizzled-10 [KO:K02842]
114693838  Cab39l; calcium-binding protein 39-like isoform X1 [KO:K08272]
114694010  Castor1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
114694044  Depdc5; GATOR complex protein DEPDC5 isoform X2 [KO:K20404]
114694590  Lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
114694717  Wnt2; protein Wnt-2 [KO:K00182]
114694836  Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
114694973  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
114695174  Ins; insulin [KO:K04526]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695428  Rragd; ras-related GTP-binding protein D [KO:K16186]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114695609  Wnt16; protein Wnt-16 [KO:K01558]
114695763  Fzd8; frizzled-8 [KO:K02375]
114695787  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
114696334  [KO:K02991]
114696417  Lpin2; phosphatidate phosphatase LPIN2 isoform X5 [KO:K15728] [EC:3.1.3.4]
114696438  Irs1; insulin receptor substrate 1 [KO:K16172]
114696553  [KO:K02833]
114696640  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
114697207  Wnt4; protein Wnt-4 [KO:K00408]
114697339  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
114697346  Rictor; rapamycin-insensitive companion of mTOR isoform X6 [KO:K08267]
114697360  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
114697672  [KO:K02991]
114697767  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
114697863  Cab39; calcium-binding protein 39 isoform X1 [KO:K08272]
114697883  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
114698582  Nras; GTPase NRas [KO:K07828]
114698691  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
114698833  Lpin1; LOW QUALITY PROTEIN: phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
114698843  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
114698949  [KO:K03259]
114699189  Prr5; proline-rich protein 5 isoform X1 [KO:K20411]
114699199  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
114699281  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114699472  [KO:K04370]
114699908  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
114699911  Fzd6; frizzled-6 [KO:K02376]
114699954  Lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
114700070  Rheb; GTP-binding protein Rheb [KO:K07208]
114700398  Fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
114700478  Fnip2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
114700619  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
114700740  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
114700757  Wnt5b; protein Wnt-5b [KO:K00444]
114700910  [KO:K04513]
114700959  Slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114702120  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
114702202  Wnt9b; protein Wnt-9b [KO:K01064]
114702239  Fzd2; frizzled-2 [KO:K02235]
114702271  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
114702510  Grb10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
114702777  Tsc1; hamartin isoform X1 [KO:K07206]
114702819  Rnf152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
114702851  Rragb; ras-related GTP-binding protein B isoform X2 [KO:K16185]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703115  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
114703597  Slc38a9; LOW QUALITY PROTEIN: sodium-coupled neutral amino acid transporter 9 [KO:K14995]
114703714  Rps6ka6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114704144  [KO:K02991]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704417  Stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
114704536  Clip1; CAP-Gly domain-containing linker protein 1 isoform X9 [KO:K10421]
114704689  Mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
114704729  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
114705069  Fzd5; frizzled-5 [KO:K02375]
114705144  Wnt8a; protein Wnt-8a [KO:K00714]
114705216  Rhoa; transforming protein RhoA [KO:K04513]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705810  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705848  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
114705951  Sesn2; sestrin-2 isoform X1 [KO:K20394]
114705974  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706595  Lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
114706754  Tti1; TELO2-interacting protein 1 homolog [KO:K20403]
114706830  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707200  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
114707263  Wnt2b; protein Wnt-2b [KO:K00182]
114707293  Fzd3; frizzled-3 isoform X1 [KO:K02329]
114708149  Wnt8b; protein Wnt-8b [KO:K00714]
114708251  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708546  Wnt10b; protein Wnt-10b [KO:K01357]
114708572  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114709033  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
114709100  Wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
114709307  Wnt10a; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
114709311  Wnt6; protein Wnt-6 [KO:K00445]
114709473  Nprl3; GATOR complex protein NPRL3 isoform X2 [KO:K20406]
114709621  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114709688  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
114710353  Lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
114710523  [KO:K04371] [EC:2.7.11.24]
114710708  Fzd4; frizzled-4 [KO:K02354]
114710748  Prr5l; proline-rich protein 5-like [KO:K20411]
114710987  Nprl2; GATOR complex protein NPRL2 [KO:K20405]
119089216  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pleu00561  Glycerolipid metabolism
pleu04010  MAPK signaling pathway
pleu04140  Autophagy - animal
pleu04151  PI3K-Akt signaling pathway
pleu04152  AMPK signaling pathway
pleu04810  Regulation of actin cytoskeleton
pleu04910  Insulin signaling pathway
KO pathway
ko04150   

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