KEGG   PATHWAY: pleu04151
Entry
pleu04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Peromyscus leucopus (white-footed mouse)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pleu04151  PI3K-Akt signaling pathway
pleu04151

Other DBs
GO: 0043491
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680595  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680692  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
114680760  Tsc2; tuberin isoform X1 [KO:K07207]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114680817  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
114680857  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
114680916  Itga10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
114681254  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
114681341  Fgfr1; fibroblast growth factor receptor 1 isoform X4 [KO:K04362] [EC:2.7.10.1]
114681403  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
114681497  Flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681570  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X12 [KO:K05629]
114681584  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681739  Itga7; integrin alpha-7 isoform X9 [KO:K06583]
114681754  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
114681779  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114681924  Il4; interleukin-4 [KO:K05430]
114682088  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114682099  Rela; transcription factor p65 [KO:K04735]
114682147  [KO:K04659]
114682214  Pdgfa; platelet-derived growth factor subunit A [KO:K04359]
114682383  Mcl1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
114682499  Itga9; integrin alpha-9 [KO:K06585]
114682519  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682832  G6pc1; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
114682837  Brca1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
114682847  [KO:K04659]
114682879  [KO:K04291]
114683042  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114683184  Insr; insulin receptor isoform X3 [KO:K04527] [EC:2.7.10.1]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683214  Them4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
114683361  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
114683458  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
114683479  Fgf18; fibroblast growth factor 18 [KO:K04358]
114683507  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114683608  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
114683622  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
114683623  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
114683665  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
114683759  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
114683909  Vegfc; vascular endothelial growth factor C [KO:K05449]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684084  Stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
114684105  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
114684134  Efna2; ephrin-A2 [KO:K05462]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684630  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
114684652  Ntf4; neurotrophin-4 [KO:K12457]
114684727  Fgf21; fibroblast growth factor 21 [KO:K22429]
114685127  [KO:K02833]
114685139  Ifnb1; interferon beta [KO:K05415]
114685140  [KO:K05414]
114685141  [KO:K05414]
114685144  [KO:K05414]
114685147  [KO:K05414]
114685149  [KO:K05414]
114685150  [KO:K05414]
114685151  [KO:K05414]
114685152  [KO:K05414]
114685154  [KO:K05414]
114685155  [KO:K05414]
114685202  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
114685999  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114686218  [KO:K04079]
114686598  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
114686676  Cd19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
114686692  [KO:K04291]
114686767  Epo; erythropoietin [KO:K05437]
114686769  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
114686858  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
114687039  [KO:K07826]
114687177  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
114687192  Ppp2r5a; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114687327  Hgf; LOW QUALITY PROTEIN: hepatocyte growth factor [KO:K05460]
114687372  Eif4e; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
114687652  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
114687916  Pspn; LOW QUALITY PROTEIN: persephin [KO:K25416]
114687957  Jak3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
114687991  [KO:K04374]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688126  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
114688215  Pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
114688249  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114688303  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114688340  [KO:K04545]
114688364  [KO:K19719]
114688453  [KO:K05414]
114688454  [KO:K05414]
114688456  [KO:K05414]
114688459  [KO:K05414]
114688460  [KO:K05414]
114688461  [KO:K05414]
114688462  [KO:K05414]
114688463  [KO:K05414]
114688488  [KO:K02833]
114688557  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
114688889  [KO:K06236]
114688893  Nrtn; LOW QUALITY PROTEIN: neurturin [KO:K25414]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689064  [KO:K11583]
114689321  [KO:K05414]
114689322  [KO:K05414]
114689359  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114689480  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
114689517  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689662  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
114689726  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
114689756  Il6; interleukin-6 [KO:K05405]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690094  [KO:K13304] [EC:2.7.11.1]
114690258  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
114690390  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690474  [KO:K05438]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114691010  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
114691013  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
114691337  Thbs2; thrombospondin-2 [KO:K04659]
114691442  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691507  Vtn; vitronectin [KO:K06251]
114691660  Itga11; integrin alpha-11 [KO:K06587]
114691694  [KO:K04079]
114691790  Spp1; osteopontin isoform X1 [KO:K06250]
114691862  [KO:K06253]
114692223  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
114692317  Col9a1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
114692385  Fgfr2; fibroblast growth factor receptor 2 isoform X2 [KO:K05093] [EC:2.7.10.1]
114692435  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
114692588  Sgk2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
114692606  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
114692892  Chad; chondroadherin [KO:K06248]
114692897  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
114692904  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
114692912  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114692919  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
114692972  [KO:K02991]
114693042  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114693143  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
114693144  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X2 [KO:K21290]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114693314  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114693374  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
114693442  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
114693444  Col1a2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
114693493  [KO:K02833]
114693495  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
114693506  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
114693540  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693565  [KO:K06238]
114693566  Col6a6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693605  Fn1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
114693631  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
114693732  Jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114693771  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
114693842  Fgf9; fibroblast growth factor 9 [KO:K04358]
114693946  Itga8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
114694046  Ywhah; 14-3-3 protein eta [KO:K16198]
114694056  Fgfr3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
114694075  [KO:K13769]
114694090  Osm; oncostatin-M [KO:K05418]
114694276  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114694285  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114694353  Il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114694542  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114694576  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114694648  F2r; proteinase-activated receptor 1 [KO:K03914]
114694721  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
114695104  Col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
114695105  Col4a1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
114695166  Fgf20; fibroblast growth factor 20 [KO:K04358]
114695174  Ins; insulin [KO:K04526]
114695214  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
114695227  Fgf3; fibroblast growth factor 3 [KO:K04358]
114695229  Fgf4; fibroblast growth factor 4 [KO:K04358]
114695237  Fgf19; fibroblast growth factor 19 [KO:K22603]
114695247  Epor; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695341  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
114695462  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114695719  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
114695777  [KO:K09487]
114696332  Efna5; ephrin-A5 isoform X1 [KO:K05462]
114696334  [KO:K02991]
114696435  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
114696436  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
114696438  Irs1; insulin receptor substrate 1 [KO:K16172]
114696517  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114696519  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
114696553  [KO:K02833]
114696602  Itga5; integrin alpha-5 [KO:K06484]
114696632  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
114696640  Eif4b; eukaryotic translation initiation factor 4B [KO:K03258]
114696655  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
114696878  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
114697329  Ghr; growth hormone receptor isoform X2 [KO:K05080]
114697339  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
114697347  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
114697350  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
114697672  [KO:K02991]
114697883  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
114698087  Pgf; placenta growth factor isoform X1 [KO:K16859]
114698155  Lama3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
114698273  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
114698275  Lpar3; lysophosphatidic acid receptor 3 [KO:K04294]
114698332  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114698334  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
114698435  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
114698437  Ifnar2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
114698498  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114698577  Ngf; beta-nerve growth factor [KO:K02582]
114698582  Nras; GTPase NRas [KO:K07828]
114698613  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
114698782  Fgf17; fibroblast growth factor 17 [KO:K04358]
114698794  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
114698856  Ywhaq; 14-3-3 protein theta [KO:K16197]
114698889  Ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114698949  [KO:K03259]
114699133  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
114699134  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114699281  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114699474  [KO:K13304] [EC:2.7.11.1]
114699702  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
114699932  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
114700000  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114700070  Rheb; GTP-binding protein Rheb [KO:K07208]
114700088  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
114700288  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
114700321  [KO:K06465]
114700430  [KO:K04736]
114700491  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
114700616  Hsp90b1; endoplasmin [KO:K09487]
114700619  Igf1; insulin-like growth factor I isoform X2 [KO:K05459]
114700691  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
114700827  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700875  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
114700920  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114701036  Itgb8; integrin beta-8 [KO:K06591]
114701407  Fgf6; fibroblast growth factor 6 [KO:K04358]
114701440  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114701473  Fgf23; fibroblast growth factor 23 [KO:K22428]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701602  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
114701721  Prl; prolactin [KO:K05439]
114701725  Ereg; proepiregulin [KO:K09784]
114701727  Areg; amphiregulin [KO:K09782]
114701738  [KO:K05439]
114701749  [KO:K05439]
114701759  [KO:K05439]
114701771  [KO:K05439]
114701789  G6pc2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
114701802  [KO:K05439]
114701853  [KO:K05439]
114701863  [KO:K05439]
114701876  Angpt2; angiopoietin-2 [KO:K05466]
114701884  [KO:K05439]
114701911  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
114701991  Myc; myc proto-oncogene protein [KO:K04377]
114702071  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
114702098  Bdnf; brain-derived neurotrophic factor [KO:K04355]
114702114  [KO:K05439]
114702123  [KO:K05439]
114702144  [KO:K05439]
114702170  [KO:K05439]
114702177  [KO:K05439]
114702219  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
114702233  Itga2b; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
114702284  Itgb3; integrin beta-3 [KO:K06493]
114702393  Lamb3; laminin subunit beta-3 [KO:K06244]
114702744  Pkn3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
114702777  Tsc1; hamartin isoform X1 [KO:K07206]
114702794  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
114702810  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
114702811  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
114702904  [KO:K03914]
114703016  Itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703084  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
114703087  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114703207  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
114703598  Itgav; integrin alpha-V isoform X1 [KO:K06487]
114703643  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
114703730  Itga4; integrin alpha-4 [KO:K06483]
114703745  Itga1; integrin alpha-1 [KO:K06480]
114703788  Lamc3; laminin subunit gamma-3 [KO:K06247]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114704074  Lama1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
114704144  [KO:K02991]
114704195  Col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
114704204  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
114704240  Fgf10; fibroblast growth factor 10 [KO:K04358]
114704288  Csf3r; granulocyte colony-stimulating factor receptor isoform X2 [KO:K05061]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704479  Itga6; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704729  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
114704814  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114704849  Itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
114704891  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
114704897  Fgf16; fibroblast growth factor 16 [KO:K04358]
114704920  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
114705057  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114705208  Lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114705315  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
114705331  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114705549  Angpt4; angiopoietin-4 [KO:K05467]
114705602  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
114705711  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705780  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
114705782  Tlr4; toll-like receptor 4 isoform X2 [KO:K10160]
114705847  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
114705848  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
114705857  Tnxb; tenascin-X isoform X12 [KO:K06252]
114705915  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
114706157  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706184  Mtcp1; protein p13 MTCP-1 [KO:K16837]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706845  [KO:K13304] [EC:2.7.11.1]
114706869  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
114706899  Csf3; granulocyte colony-stimulating factor [KO:K05423]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114706940  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707063  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
114707170  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
114707177  Il2; interleukin-2 [KO:K05429]
114707287  Kitlg; kit ligand isoform X1 [KO:K05461]
114707321  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114707365  Pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114707382  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114707517  Foxo3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707629  Il7; interleukin-7 isoform X1 [KO:K05431]
114707842  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
114707893  Thbs3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
114707907  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
114707913  Efna4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
114707916  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
114707920  Il6r; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
114707937  Efna1; ephrin-A1 isoform X1 [KO:K05462]
114707941  Efna3; ephrin-A3 isoform X1 [KO:K05462]
114707992  Reln; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
114708007  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
114708093  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
114708136  Fgf8; fibroblast growth factor 8 isoform X2 [KO:K04358]
114708288  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
114708354  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
114708453  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
114708454  Lamb1; laminin subunit beta-1 [KO:K05636]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708534  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
114708654  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
114708715  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
114708775  Ntf3; neurotrophin-3 [KO:K04356]
114708777  Vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
114708790  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
114708819  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
114708827  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
114709027  Tnc; LOW QUALITY PROTEIN: tenascin [KO:K06252]
114709068  Fgf7; fibroblast growth factor 7 [KO:K04358]
114709086  [KO:K04542]
114709186  Thbs4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
114709386  Artn; artemin isoform X1 [KO:K25415]
114709516  Bcl2l11; LOW QUALITY PROTEIN: bcl-2-like protein 11 [KO:K16341]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114709782  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
114709825  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
114710188  Tlr2; toll-like receptor 2 [KO:K10159]
114710296  Ywhag; 14-3-3 protein gamma [KO:K16198]
114710338  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114710385  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114710523  [KO:K04371] [EC:2.7.11.24]
114710798  Prlr; prolactin receptor isoform X1 [KO:K05081]
114710803  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
119089216  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pleu00010  Glycolysis / Gluconeogenesis
pleu04010  MAPK signaling pathway
pleu04012  ErbB signaling pathway
pleu04062  Chemokine signaling pathway
pleu04064  NF-kappa B signaling pathway
pleu04068  FoxO signaling pathway
pleu04110  Cell cycle
pleu04115  p53 signaling pathway
pleu04150  mTOR signaling pathway
pleu04210  Apoptosis
pleu04370  VEGF signaling pathway
pleu04510  Focal adhesion
pleu04620  Toll-like receptor signaling pathway
pleu04630  JAK-STAT signaling pathway
pleu04662  B cell receptor signaling pathway
pleu04910  Insulin signaling pathway
KO pathway
ko04151   

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