KEGG   PATHWAY: pyu00310
Entry
pyu00310                    Pathway                                
Name
Lysine degradation - Herpailurus yagouaroundi (jaguarundi)
Class
Metabolism; Amino acid metabolism
Pathway map
pyu00310  Lysine degradation
pyu00310

Module
pyu_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:pyu00310]
Other DBs
GO: 0006554
Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009989  PRDM7; probable histone-lysine N-methyltransferase PRDM7 [KO:K20796] [EC:2.1.1.354]
121010326  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
121010353  SETD1B; histone-lysine N-methyltransferase SETD1B [KO:K11422] [EC:2.1.1.354]
121010394  KMT5A; N-lysine methyltransferase KMT5A [KO:K11428] [EC:2.1.1.361]
121010539  PHYKPL; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
121010609  PRDM6; putative histone-lysine N-methyltransferase PRDM6 [KO:K20795] [EC:2.1.1.361]
121010631  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121011280  COLGALT1; procollagen galactosyltransferase 1 [KO:K11703] [EC:2.4.1.50]
121011346  KMT2B; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
121011581  NSD1; histone-lysine N-methyltransferase, H3 lysine-36 specific isoform X1 [KO:K15588] [EC:2.1.1.357]
121011783  SMYD2; N-lysine methyltransferase SMYD2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121011833  COLGALT2; procollagen galactosyltransferase 2 isoform X1 [KO:K11703] [EC:2.4.1.50]
121012940  SETDB2; histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
121013227  ACAT2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
121014044  GCDH; glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
121014778  SUV39H2; histone-lysine N-methyltransferase SUV39H2 isoform X1 [KO:K11419] [EC:2.1.1.355]
121014819  DHTKD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial isoform X1 [KO:K15791] [EC:1.2.4.-]
121015130  SMYD3; histone-lysine N-methyltransferase SMYD3 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121015632  ASH1L; histone-lysine N-methyltransferase ASH1L isoform X1 [KO:K06101] [EC:2.1.1.354]
121015834  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
121016355  CAMKMT; calmodulin-lysine N-methyltransferase isoform X1 [KO:K18826] [EC:2.1.1.60]
121017234  PIPOX; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
121017381  PRDM2; PR domain zinc finger protein 2 isoform X1 [KO:K11432] [EC:2.1.1.355]
121017669  PLOD3; LOW QUALITY PROTEIN: multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
121017975  NSD3; histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
121018772  ALDH16A1; aldehyde dehydrogenase family 16 member A1 isoform X1 [KO:K00128] [EC:1.2.1.3]
121019580  PRDM16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
121020251  EHMT1; histone-lysine N-methyltransferase EHMT1 isoform X1 [KO:K11420] [EC:2.1.1.355]
121020938  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase isoform X1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
121021278  PLOD1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 [KO:K00473] [EC:1.14.11.4]
121021471  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
121022169  SETD1A; histone-lysine N-methyltransferase SETD1A isoform X1 [KO:K11422] [EC:2.1.1.354]
121022333  EHMT2; histone-lysine N-methyltransferase EHMT2 isoform X1 [KO:K11420] [EC:2.1.1.355]
121022936  KMT2C; histone-lysine N-methyltransferase 2C [KO:K09188] [EC:2.1.1.354]
121023446  KMT5C; histone-lysine N-methyltransferase KMT5C isoform X1 [KO:K11429] [EC:2.1.1.362]
121023792  KMT5B; histone-lysine N-methyltransferase KMT5B isoform X1 [KO:K11429] [EC:2.1.1.362]
121024839  TMLHE; trimethyllysine dioxygenase, mitochondrial isoform X1 [KO:K00474] [EC:1.14.11.8]
121025917  SUV39H1; histone-lysine N-methyltransferase SUV39H1 isoform X1 [KO:K11419] [EC:2.1.1.355]
121026806  [KO:K11423] [EC:2.1.1.359]
121026808  [KO:K11423] [EC:2.1.1.359]
121027289  AADAT; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
121028154  EZH2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
121028418  AASS; alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
121028858  KMT2E; LOW QUALITY PROTEIN: inactive histone-lysine N-methyltransferase 2E [KO:K09189] [EC:2.1.1.354]
121028899  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
121029498  SETD7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
121031465  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
121032053  DLST; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
121033787  PLOD2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [KO:K13645] [EC:1.14.11.4]
121033966  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
121034100  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
121034697  ALDH1B1; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
121035347  ACAT1; acetyl-CoA acetyltransferase, mitochondrial [KO:K00626] [EC:2.3.1.9]
121035470  KMT2A; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
121037438  ECHS1; enoyl-CoA hydratase, mitochondrial isoform X1 [KO:K07511] [EC:4.2.1.17]
121038633  KMT2D; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
121039418  NSD2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
121041334  [KO:K11433] [EC:2.1.1.357]
121042245  HYKK; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
121043631  BBOX1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
121044215  HADHA; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
121044486  SMYD1; histone-lysine N-methyltransferase SMYD1 isoform X1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121045039  EZH1; histone-lysine N-methyltransferase EZH1 isoform X1 [KO:K17451] [EC:2.1.1.356]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
pyu00020  Citrate cycle (TCA cycle)
pyu00780  Biotin metabolism
KO pathway
ko00310   

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