KEGG   PATHWAY: pyu04914
Entry
pyu04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Puma yagouaroundi (jaguarundi)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
pyu04914  Progesterone-mediated oocyte maturation
pyu04914

Other DBs
GO: 0001556
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121010453  ANAPC5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
121010456  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010758  CDC23; cell division cycle protein 23 homolog [KO:K03355]
121010761  CDC25C; M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011032  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
121011146  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
121011208  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
121011233  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121012441  CDC25B; LOW QUALITY PROTEIN: M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
121012858  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
121013195  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014916  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121016977  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121017430  [KO:K08694]
121017491  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
121018073  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
121018174  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
121019375  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
121019600  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121019645  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1 [KO:K06633] [EC:2.7.11.1]
121019881  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
121020149  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
121020237  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121021139  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
121022189  KIF22; kinesin-like protein KIF22 [KO:K10403]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022444  [KO:K12456]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023736  SPDYC; speedy protein C [KO:K08694]
121023802  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121023965  INS; insulin [KO:K04526]
121024233  FZR1; fizzy-related protein homolog [KO:K03364]
121024845  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121025328  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
121025636  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121025949  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
121026094  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027636  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121028241  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121028803  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121029057  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
121029354  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029356  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029518  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
121030311  CCNA2; cyclin-A2 [KO:K06627]
121030414  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
121031569  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
121032306  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033704  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034857  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
121036524  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
121036668  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
121036766  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121036992  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform X1 [KO:K02602]
121037338  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
121037660  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
121038217  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
121038348  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
121038647  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121039226  ANAPC15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
121039469  PGR; progesterone receptor isoform X1 [KO:K08556]
121040120  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121040524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
121040954  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041777  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121042331  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
121042416  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121042990  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121044199  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121044293  SPDYA; speedy protein A isoform X1 [KO:K08694]
121044432  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
121044440  [KO:K08694]
121044441  ANAPC1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
121045271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
pyu04010  MAPK signaling pathway
pyu04110  Cell cycle
KO pathway
ko04914   

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