Entry Name Legionellosis - Rattus norvegicus (rat)
Description Legionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated with Legionella species: Legionnaires' disease is the more severe form of the infection, which may involve pneumonia, and Pontiac fever is a milder respiratory illness.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map Disease Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 116643 Vcp; transitional endoplasmic reticulum ATPase [KO:K13525 ]
191568 Naip6; NLR family, apoptosis inhibitory protein 6 [KO:K12807 ]
24468 Hspa8; heat shock cognate 71 kDa protein [KO:K03283 ]
24963 Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283 ]
282817 Pycard; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
287269 Clk4; dual specificity protein kinase CLK4 isoform 3 [KO:K23561 ]
287276 Sar1b; GTP-binding protein SAR1b [KO:K07953 ] [EC:3.6.5.-]
294691 Naip5; baculoviral IAP repeat-containing protein 1f isoform X2 [KO:K12807 ]
298784 Nlrc4; NLR family CARD domain-containing protein 4 [KO:K12805 ]
301059 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
301434 Clk1; dual specificity protein kinase CLK1 [KO:K23561 ]
309452 Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469 ]
310710 Sec22b; vesicle-trafficking protein SEC22b [KO:K08517 ]
361842 Sar1a; GTP-binding protein SAR1a [KO:K07953 ] [EC:3.6.5.-]
54243 Cr1l; complement component receptor 1-like protein isoform 2 precursor [KO:K04011 ]
60350 Cd14; monocyte differentiation antigen CD14 precursor [KO:K04391 ]
64546 Il12b; interleukin-12 subunit beta precursor [KO:K05425 ]
680121 Haus8l2; heat shock cognate 71 kDa protein-like [KO:K03283 ]
78963 Apaf1; apoptotic protease-activating factor 1 [KO:K02084 ]
81503 Cxcl1; growth-regulated alpha protein precursor [KO:K05505 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
84405 Il12a; interleukin-12 subunit alpha precursor [KO:K05406 ]
84480 Bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464 ]
Compound C01277 1-Phosphatidyl-1D-myo-inositol 4-phosphate
Reference Authors Newton HJ, Ang DK, van Driel IR, Hartland EL
Title Molecular pathogenesis of infections caused by Legionella pneumophila.
Journal Reference Authors Shin S, Roy CR
Title Host cell processes that influence the intracellular survival of Legionella pneumophila.
Journal Reference Authors Ensminger AW, Isberg RR
Title Legionella pneumophila Dot/Icm translocated substrates: a sum of parts.
Journal Reference Authors Chang B, Kura F, Amemura-Maekawa J, Koizumi N, Watanabe H
Title Identification of a novel adhesion molecule involved in the virulence of Legionella pneumophila.
Journal Reference Authors Liu M, Conover GM, Isberg RR
Title Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages.
Journal Reference Authors Weber SS, Ragaz C, Hilbi H
Title The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE.
Journal Reference Authors Newton HJ, Sansom FM, Bennett-Wood V, Hartland EL
Title Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry.
Journal Reference Authors De Buck E, Anne J, Lammertyn E
Title The role of protein secretion systems in the virulence of the intracellular pathogen Legionella pneumophila.
Journal Reference Authors Chong A, Lima CA, Allan DS, Nasrallah GK, Garduno RA
Title The purified and recombinant Legionella pneumophila chaperonin alters mitochondrial trafficking and microfilament organization.
Journal Reference Authors Cooper NR
Title Complement evasion strategies of microorganisms.
Journal Reference Authors Machner MP, Isberg RR
Title Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.
Journal Reference Authors Neumeister B, Faigle M, Lauber K, Northoff H, Wesselborg S
Title Legionella pneumophila induces apoptosis via the mitochondrial death pathway.
Journal Reference Authors Laguna RK, Creasey EA, Li Z, Valtz N, Isberg RR
Title A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.
Journal Reference Authors Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F
Title A Legionella type IV effector activates the NF-kappaB pathway by phosphorylating the IkappaB family of inhibitors.
Journal Reference Authors Kubori T, Hyakutake A, Nagai H
Title Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.
Journal Reference Authors Shen X, Banga S, Liu Y, Xu L, Gao P, Shamovsky I, Nudler E, Luo ZQ
Title Targeting eEF1A by a Legionella pneumophila effector leads to inhibition of protein synthesis and induction of host stress response.
Journal Reference Authors Belyi Y, Stahl M, Sovkova I, Kaden P, Luy B, Aktories K
Title Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase.
Journal Reference Authors Belyi Y, Tabakova I, Stahl M, Aktories K
Title Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila.
Journal Reference Authors Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CB, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO
Title Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Journal Reference Authors Palusinska-Szysz M, Janczarek M
Title Innate immunity to Legionella and toll-like receptors - review.
Journal Related rno04610 Complement and coagulation cascades
rno04620 Toll-like receptor signaling pathway
KO pathway
