KEGG   PATHWAY: tge04144
Entry
tge04144                    Pathway                                
Name
Endocytosis - Theropithecus gelada (gelada)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
tge04144  Endocytosis
tge04144

Other DBs
GO: 0006897
Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112604680  RAB11FIP5; rab11 family-interacting protein 5 isoform X1 [KO:K12484]
112604706  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
112605020  STAMBP; STAM-binding protein [KO:K11866] [EC:3.4.19.12]
112605123  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
112605177  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
112605185  EHD3; EH domain-containing protein 3 [KO:K12476]
112605244  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
112605731  SNX32; sorting nexin-32 [KO:K17920]
112605765  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
112605795  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
112605922  [KO:K13649]
112606042  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
112606048  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
112606118  TSG101; tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
112606398  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
112606411  GRK2; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
112606451  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
112606510  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
112606538  VPS37C; vacuolar protein sorting-associated protein 37C [KO:K12185]
112606583  FOLR2; folate receptor beta isoform X1 [KO:K13649]
112606584  FOLR1; folate receptor alpha [KO:K13649]
112606585  [KO:K13649]
112607278  EHD1; EH domain-containing protein 1 isoform X1 [KO:K12483]
112607359  HRAS; GTPase HRas isoform X1 [KO:K02833]
112607412  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112607575  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
112607637  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
112607811  CLTA; clathrin light chain A isoform X1 [KO:K04644]
112607846  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
112608081  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
112608120  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
112608124  [KO:K03283]
112608149  SH3GL2; endophilin-A1 [KO:K11247]
112608164  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
112608311  RHOC; rho-related GTP-binding protein RhoC isoform X1 [KO:K04513]
112608360  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
112608454  CHMP5; charged multivesicular body protein 5 isoform X1 [KO:K12198]
112608597  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
112608919  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
112609024  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
112609108  EPN2; epsin-2 isoform X1 [KO:K12471]
112609129  CYTH1; cytohesin-1 [KO:K18441]
112609323  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
112609402  EPN3; epsin-3 isoform X1 [KO:K12471]
112609472  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
112609475  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
112609501  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
112609543  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
112609726  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
112609794  RAB11FIP4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
112609910  CHMP6; charged multivesicular body protein 6 [KO:K12195]
112609975  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
112610028  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
112610053  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
112610136  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
112610330  WIPF2; WAS/WASL-interacting protein family member 2 [KO:K19475]
112610357  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
112610415  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
112610764  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
112610776  SPART; spartin [KO:K19366]
112611036  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
112611285  RAB31; ras-related protein Rab-31 [KO:K07891]
112611293  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
112611298  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
112611391  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112611408  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
112611541  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
112611902  [KO:K18441]
112612043  DNM2; dynamin-2 isoform X1 [KO:K23484]
112612079  RAB11B; ras-related protein Rab-11B [KO:K07905]
112612166  AP2S1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
112612219  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
112612272  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
112612363  EHD2; EH domain-containing protein 2 [KO:K12469]
112612632  EPN1; epsin-1 [KO:K12471]
112612660  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
112612810  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
112612889  CBLC; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
112613193  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
112613319  [KO:K18441]
112613346  MVB12A; multivesicular body subunit 12A isoform X1 [KO:K12186]
112613361  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
112613366  SH3GL1; endophilin-A2 isoform X1 [KO:K11247]
112613594  CHMP2A; charged multivesicular body protein 2a isoform X1 [KO:K12191]
112613943  IST1; IST1 homolog isoform X1 [KO:K19476]
112614090  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
112614102  RAB11FIP3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
112614435  VPS4A; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
112614590  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
112614815  VPS35; vacuolar protein sorting-associated protein 35 [KO:K18468]
112615453  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
112615501  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
112615571  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
112616591  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
112616913  [KO:K06751]
112616914  [KO:K06751]
112617270  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
112617420  [KO:K18952] [EC:2.7.11.13]
112617631  [KO:K06751]
112617682  [KO:K13649]
112617695  [KO:K06751]
112617697  [KO:K18462]
112617731  [KO:K06751]
112617747  [KO:K06751]
112617766  [KO:K06751]
112617801  [KO:K06751]
112617929  [KO:K06751]
112617939  [KO:K06751]
112618133  PDCD6IP; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
112618180  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
112618283  AP2M1; AP-2 complex subunit mu isoform X1 [KO:K11826]
112618402  SNX4; sorting nexin-4 isoform X1 [KO:K17919]
112618515  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
112618545  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
112618546  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
112618614  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
112618670  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
112618703  CCR5; C-C chemokine receptor type 5 [KO:K04180]
112618706  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
112618812  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
112618935  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
112619083  RAB5A; ras-related protein Rab-5A [KO:K07887]
112619375  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112619478  GRK7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
112619516  ARF4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
112619557  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
112619575  RBSN; rabenosyn-5 [KO:K12481]
112619594  CAV3; caveolin-3 [KO:K12959]
112620091  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112620160  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
112620245  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
112620296  ARF5; ADP-ribosylation factor 5 isoform X1 [KO:K07940]
112620698  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
112620836  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
112620860  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
112620957  WIPF3; WAS/WASL-interacting protein family member 3 [KO:K19475]
112620997  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
112621101  CAV2; caveolin-2 isoform X1 [KO:K12958]
112621178  AMPH; amphiphysin isoform X1 [KO:K12562]
112621180  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
112621198  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
112621200  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
112621447  CAV1; caveolin-1 isoform X1 [KO:K06278]
112622050  [KO:K04513]
112622167  [KO:K06751]
112622184  [KO:K06751]
112622185  [KO:K06751]
112622236  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
112622368  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
112622371  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
112622400  [KO:K06751]
112622401  [KO:K06751]
112622403  [KO:K06751]
112622405  [KO:K06751]
112622406  [KO:K06751]
112622407  [KO:K06751]
112622412  [KO:K06751]
112622432  [KO:K06751]
112622438  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
112622854  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
112622897  [KO:K12193]
112623761  HSPA1B; heat shock 70 kDa protein 1B isoform X1 [KO:K03283]
112623762  [KO:K03283]
112624536  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
112624597  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
112624951  VPS45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
112625154  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112625192  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
112625207  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
112625740  DAB2; disabled homolog 2 isoform X1 [KO:K12475]
112625764  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
112625901  SNX2; LOW QUALITY PROTEIN: sorting nexin-2 [KO:K17917]
112625972  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112626333  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
112626613  PSD2; PH and SEC7 domain-containing protein 2 [KO:K12494]
112626692  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
112626788  RUFY1; RUN and FYVE domain-containing protein 1 [KO:K12482]
112626850  CLTB; clathrin light chain B isoform X1 [KO:K04645]
112626943  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
112627360  RAB11A; ras-related protein Rab-11A isoform X1 [KO:K07904]
112627433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112627469  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
112627627  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
112627634  SPG21; maspardin isoform X1 [KO:K19367]
112627782  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
112627785  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
112627984  EHD4; EH domain-containing protein 4 [KO:K12477]
112628064  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
112628373  CHMP4A; LOW QUALITY PROTEIN: charged multivesicular body protein 4a [KO:K12194]
112628408  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
112628505  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112628643  SNX6; sorting nexin-6 [KO:K17920]
112628649  [KO:K07937]
112628676  ARF6; ADP-ribosylation factor 6 [KO:K07941]
112628684  SH3GL3; endophilin-A3 isoform X1 [KO:K11247]
112629354  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
112629761  VPS37A; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
112629865  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
112629884  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
112629900  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
112629913  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
112629987  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
112630010  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
112630116  CHMP7; charged multivesicular body protein 7 [KO:K15053]
112630575  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
112630727  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
112631182  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
112631208  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
112631213  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
112631241  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
112631244  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
112631319  [KO:K12491]
112631449  ZFYVE27; protrudin isoform X1 [KO:K19368]
112631500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112631620  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
112631680  GRK5; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
112631739  EPS15; epidermal growth factor receptor substrate 15 [KO:K12472]
112631816  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
112631937  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
112632040  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
112632113  VPS26A; vacuolar protein sorting-associated protein 26A [KO:K18466]
112632589  SNX5; sorting nexin-5 isoform X1 [KO:K17920]
112632650  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
112632686  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
112632844  CYTH4; cytohesin-4 isoform X1 [KO:K18441]
112632884  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
112632927  CLTCL1; clathrin heavy chain 2 [KO:K04646]
112633058  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
112633082  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
112633150  RAB22A; ras-related protein Rab-22A [KO:K07891]
112633179  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
112633351  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
112633452  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
112633515  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
112633533  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112634052  WASHC1; WASH complex subunit 1 isoform X1 [KO:K18461]
112634053  AGAP2; LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 [KO:K17848]
112634115  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
112634192  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
112634219  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
112634245  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
112634272  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
112634274  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112634552  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
112634596  RAB35; ras-related protein Rab-35 isoform X1 [KO:K07876]
112634685  [KO:K12495]
112634719  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
112634781  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
112634850  WASHC4; WASH complex subunit 4 isoform X1 [KO:K18465]
112634858  EEA1; early endosome antigen 1 [KO:K12478]
112635164  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
112635337  ARF3; ADP-ribosylation factor 3 [KO:K07938]
112635442  WASHC3; WASH complex subunit 3 isoform X1 [KO:K18463]
112635922  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
112636034  BIN1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
112636057  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
112636087  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
112636194  WIPF1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
112636294  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
112636377  CXCR4; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 4 [KO:K04189]
112636485  [KO:K03283]
112636596  STAM2; signal transducing adapter molecule 2 [KO:K04705]
112636637  CXCR1; C-X-C chemokine receptor type 1 isoform X1 [KO:K04175]
112636691  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
112636951  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
112636962  RAB10; ras-related protein Rab-10 [KO:K07903]
112636972  CHMP3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
tge04060  Cytokine-cytokine receptor interaction
tge04070  Phosphatidylinositol signaling system
tge04130  SNARE interactions in vesicular transport
tge04142  Lysosome
tge04350  TGF-beta signaling pathway
KO pathway
ko04144   

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