KEGG   PATHWAY: tgt04820
Entry
tgt04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Tinamus guttatus (white-throated tinamou)
Class
Cellular Processes; Cell motility
Pathway map
tgt04820  Cytoskeleton in muscle cells
tgt04820

Organism
Tinamus guttatus (white-throated tinamou) [GN:tgt]
Gene
104564376  JUP; LOW QUALITY PROTEIN: junction plakoglobin [KO:K10056]
104564432  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
104564572  LMNB2; lamin-B2 [KO:K07611]
104564619  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104564641  [KO:K17751]
104564704  FBLN1; fibulin-1 [KO:K17307]
104564769  [KO:K06271]
104564770  [KO:K10374]
104564781  SGCB; beta-sarcoglycan [KO:K12566]
104564786  SNTB1; beta-1-syntrophin [KO:K24064]
104565199  SGCG; gamma-sarcoglycan [KO:K12564]
104565239  LAMA2; laminin subunit alpha-2 [KO:K05637]
104565272  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
104565278  NID1; nidogen-1 [KO:K06826]
104565393  ATP1B4; protein ATP1B4 [KO:K01540]
104565447  [KO:K19721]
104565602  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
104565605  COL1A2; collagen alpha-2(I) chain [KO:K06236]
104565632  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
104565652  ZYX; zyxin [KO:K06273]
104565661  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
104565749  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
104565799  [KO:K04659]
104565896  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
104565966  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
104566031  LMOD3; leiomodin-3 [KO:K22030]
104566091  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
104566213  MYH9; myosin-9 [KO:K10352]
104566362  [KO:K24220]
104566442  MYL3; myosin light chain 3 [KO:K12749]
104566651  DSP; desmoplakin [KO:K10381]
104566654  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
104566656  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
104566659  TNNT2; troponin T, cardiac muscle [KO:K12045]
104566673  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
104566682  ITGA11; integrin alpha-11 [KO:K06587]
104566698  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
104566707  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
104566723  [KO:K18267]
104566755  TNNC2; troponin C, skeletal muscle [KO:K12042]
104566842  [KO:K01490] [EC:3.5.4.6]
104566944  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
104567143  [KO:K07611]
104567262  DSG2; desmoglein-2 [KO:K07597]
104567550  LMOD2; leiomodin-2 [KO:K22030]
104567559  SDC4; syndecan-4 [KO:K16338]
104567663  XIRP1; LOW QUALITY PROTEIN: xin actin-binding repeat-containing protein 1 [KO:K27381]
104567667  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
104567703  [KO:K19867]
104567858  SUN1; SUN domain-containing protein 1 [KO:K19347]
104567875  COMP; cartilage oligomeric matrix protein [KO:K04659]
104567905  [KO:K17531] [EC:2.7.11.1]
104567934  [KO:K12314]
104568077  PDLIM5; PDZ and LIM domain protein 5 [KO:K19867]
104568159  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
104568294  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
104568391  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
104568453  DES; desmin [KO:K07610]
104568507  ITGB5; integrin beta-5 [KO:K06588]
104568801  ITGA4; integrin alpha-4 [KO:K06483]
104568814  SYNE1; nesprin-1 [KO:K19326]
104569101  [KO:K06793]
104569148  FMNL2; LOW QUALITY PROTEIN: formin-like protein 2 [KO:K23957]
104569278  AGRN; agrin [KO:K06254]
104569352  MYBPH; myosin-binding protein H [KO:K24494]
104569379  [KO:K24220]
104569449  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
104569452  [KO:K10365]
104569517  TRIM55; tripartite motif-containing protein 55 [KO:K10654]
104569529  FBN1; fibrillin-1 [KO:K06825]
104569635  [KO:K24495]
104569643  [KO:K12641]
104569822  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
104569960  FMN2; formin-2 [KO:K02184]
104570244  [KO:K01539] [EC:7.2.2.13]
104570258  NRAP; nebulin-related-anchoring protein [KO:K24421]
104570515  ITGA3; integrin alpha-3 [KO:K06482]
104570711  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
104570712  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
104570796  SSPN; sarcospan [KO:K22194]
104570904  PKP2; plakophilin-2 [KO:K12642]
104571107  TMOD2; tropomodulin-2 isoform X1 [KO:K10370]
104571109  TMOD3; tropomodulin-3 isoform X1 [KO:K10370]
104571129  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
104571235  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
104571240  ANK3; ankyrin-3 [KO:K09259]
104571519  COL1A1; collagen alpha-1(I) chain [KO:K06236]
104571577  [KO:K28413]
104571873  [KO:K10370]
104571963  MYOZ3; myozenin-3 [KO:K26050]
104572073  ITGAV; integrin alpha-V [KO:K06487]
104572188  ITGB4; integrin beta-4 [KO:K06525]
104572228  TTN; LOW QUALITY PROTEIN: titin [KO:K12567] [EC:2.7.11.1]
104572297  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
104572308  [KO:K05717]
104572392  [KO:K21073]
104572434  TLN2; talin-2 [KO:K06271]
104572461  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
104572615  CKM; creatine kinase M-type [KO:K27382]
104572749  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
104572809  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
104572810  PLEC; plectin [KO:K10388]
104572821  TPM4; tropomyosin alpha-4 chain [KO:K10375]
104572840  [KO:K06237]
104572938  SUN2; SUN domain-containing protein 2 [KO:K19347]
104573022  [KO:K05745]
104573046  ACTA1; actin, alpha skeletal muscle [KO:K10354]
104573173  THBS4; thrombospondin-4 [KO:K04659]
104573323  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
104573355  COL5A1; collagen alpha-1(V) chain [KO:K19721]
104573411  SYNE3; nesprin-3 [KO:K21761]
104573483  SDC1; syndecan-1 [KO:K06257]
104573696  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
104573928  ACTB; actin, cytoplasmic 1 [KO:K05692]
104573974  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
104574031  ITGB6; integrin beta-6 [KO:K06589]
104574314  THBS2; thrombospondin-2 [KO:K04659]
104574428  [KO:K24220]
104574511  MYL4; myosin light chain 4 [KO:K12750]
104574587  SGCD; delta-sarcoglycan [KO:K12563]
104574608  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
104574665  CSRP3; cysteine and glycine-rich protein 3 isoform X1 [KO:K09377]
104574900  NEBL; LOW QUALITY PROTEIN: nebulette [KO:K25865]
104574955  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
104575103  [KO:K04659]
104575210  SDC2; syndecan-2 [KO:K16336]
104575226  [KO:K06271]
104575227  [KO:K10374]
104575234  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
104575256  COL11A1; LOW QUALITY PROTEIN: collagen alpha-1(XI) chain [KO:K19721]
104575533  COL5A3; LOW QUALITY PROTEIN: collagen alpha-3(V) chain [KO:K19721]
104575584  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
104575589  LMNB1; lamin-B1 [KO:K07611]
104575813  SYNE2; nesprin-2 [KO:K19346]
104575850  SDC3; syndecan-3 [KO:K16337]
104575901  FBN3; fibrillin-3 [KO:K23342]
104575929  LAMA1; laminin subunit alpha-1 [KO:K05637]
104575997  DAG1; dystroglycan [KO:K06265]
104576055  MYH15; myosin-15 [KO:K24220]
104576409  ITGA9; integrin alpha-9 [KO:K06585]
104576450  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
104576516  TNNC1; LOW QUALITY PROTEIN: troponin C, slow skeletal and cardiac muscles [KO:K05865]
104576574  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
104576684  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
104576832  DCN; decorin [KO:K04660]
104576854  LMOD1; leiomodin-1 [KO:K22030]
104576890  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
104577149  ITGB1; integrin beta-1 [KO:K05719]
104577242  [KO:K09255]
104577301  [KO:K07601]
104577328  MYOM3; myomesin-3 [KO:K24495]
104577341  ITGA8; integrin alpha-8 [KO:K06584]
104577459  MYOZ1; myozenin-1 [KO:K26050]
104577465  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
104577538  MYOT; myotilin [KO:K19875]
104577607  [KO:K05692]
104577861  FBN2; fibrillin-2 isoform X1 [KO:K23342]
104577927  MYOM2; myomesin-2 [KO:K24495]
104577993  TMEM43; transmembrane protein 43 [KO:K27488]
104578054  [KO:K26998]
104578088  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
104578141  SNTA1; alpha-1-syntrophin [KO:K24063]
104578280  [KO:K26998]
104578358  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
104578387  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
104578388  SYNPO2; synaptopodin-2 [KO:K24066]
104578413  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
104578415  ITGA1; integrin alpha-1 [KO:K06480]
104578512  THBS1; thrombospondin-1 [KO:K16857]
104578629  TMOD1; tropomodulin-1 [KO:K10370]
104578865  VCL; vinculin [KO:K05700]
104578925  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
104578957  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
104578990  COL5A2; collagen alpha-2(V) chain [KO:K19721]
104578991  COL3A1; collagen alpha-1(III) chain [KO:K19720]
104579074  FHL1; four and a half LIM domains protein 1 [KO:K14365]
104579249  [KO:K10364]
104579429  FMNL1; formin-like protein 1 [KO:K23957]
104579794  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
104579880  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
104580110  FHL3; four and a half LIM domains protein 3 [KO:K24414]
104580154  MYPN; myopalladin [KO:K22028]
104580228  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
104580254  VIM; vimentin [KO:K07606]
104580470  MYH7B; myosin-7B [KO:K24220]
104580513  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104580575  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
104580728  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
104580935  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
104580936  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
104581215  ITGB8; integrin beta-8 [KO:K06591]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
tgt04512  ECM-receptor interaction
tgt04814  Motor proteins
KO pathway
ko04820   

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