KEGG   PATHWAY: tru04910
Entry
tru04910                    Pathway                                
Name
Insulin signaling pathway - Takifugu rubripes (torafugu)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
tru04910  Insulin signaling pathway
tru04910

Organism
Takifugu rubripes (torafugu) [GN:tru]
Gene
101065226  insulin-like isoform X2 [KO:K04526]
101074083  insulin receptor [KO:K04527] [EC:2.7.10.1]
101074430  insulin receptor-like isoform X2 [KO:K04527] [EC:2.7.10.1]
101069368  LOW QUALITY PROTEIN: insulin receptor substrate 1-B-like [KO:K16172]
101072794  insulin receptor substrate 1-B-like [KO:K16172]
101076043  insulin receptor substrate 2-like isoform X1 [KO:K07187]
101074788  insulin receptor substrate 2-B-like [KO:K07187]
101069496  insulin receptor substrate 2-like [KO:K07187]
101065244  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
101079698  phosphatidylinositol 3-kinase regulatory subunit beta-like isoform X1 [KO:K02649]
101061527  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101063692  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101077380  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101062512  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
101067191  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101068840  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101066166  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101072152  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
101076867  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101076701  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101073734  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101080181  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101065438  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101079608  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
101071975  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
101067898  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101077099  gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101079536  gys2; glycogen [starch] synthase, liver isoform X2 [KO:K00693] [EC:2.4.1.11]
101064018  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
101073968  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
101062384  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101069117  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
101074599  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101062903  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
105416299  protein phosphatase 1 regulatory subunit 3F isoform X1 [KO:K07189]
101061026  protein phosphatase 1 regulatory subunit 3D [KO:K07189]
101061580  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
105416933  uncharacterized protein LOC105416933 isoform X1 [KO:K07189]
105417774  uncharacterized protein LOC105417774 isoform X1 [KO:K07189]
101070088  protein phosphatase 1 regulatory subunit 3C-like isoform X1 [KO:K07189]
105418331  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
101069025  protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
101073702  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
101080204  phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
101077385  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
101068395  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
101078319  LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
101070284  phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
101074696  calm2; calmodulin-2 [KO:K02183]
101072558  calm3; calmodulin-3 [KO:K02183]
101068488  calmodulin [KO:K02183]
101064505  calmodulin-alpha-like [KO:K02183]
101076134  calml4; calmodulin-like protein 4 [KO:K02183]
115251026  calmodulin-like protein 4 [KO:K02183]
101073278  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
101075522  pygm; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
101074510  glycogen phosphorylase, muscle form-like [KO:K00688] [EC:2.4.1.1]
101065164  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
101071965  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101069822  cAMP-dependent protein kinase catalytic subunit alpha isoform X3 [KO:K04345] [EC:2.7.11.11]
101067856  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101066292  cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
101062935  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101062072  prkar1a; cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
101063193  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
101072991  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
101073002  cAMP-dependent protein kinase type II-beta regulatory subunit-like [KO:K04739]
101067955  cAMP-dependent protein kinase type II-alpha regulatory subunit-like isoform X1 [KO:K04739]
101070911  hormone-sensitive lipase-like [KO:K07188] [EC:3.1.1.79]
101067661  lipe; LOW QUALITY PROTEIN: hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
105419958  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101080003  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101066876  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
100049641  reggie protein 2a [KO:K07192]
100049642  reggie protein 1b [KO:K07192]
100049643  reggie protein 1a [KO:K07192]
100049640  flot1; flotillin-1 [KO:K07192]
101065075  sh2b2; SH2B adapter protein 2 isoform X1 [KO:K07193]
101078370  sorbs1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
101070370  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
101078613  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101063765  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
101079298  crk; adapter molecule crk [KO:K04438]
101065989  adapter molecule crk-like [KO:K04438]
101078357  crkl; crk-like protein [KO:K04438]
101073444  rapgef1; rap guanine nucleotide exchange factor 1 isoform X7 [KO:K06277]
101074921  rhoq; rho-related GTP-binding protein RhoQ [KO:K07194]
101076102  exoc7; exocyst complex component 7 isoform X4 [KO:K07195]
101062832  cdc42-interacting protein 4 homolog isoform X4 [KO:K07196]
101071608  cdc42-interacting protein 4 homolog isoform X2 [KO:K07196]
101070738  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
101061739  acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101077743  acacb; acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101069108  LOW QUALITY PROTEIN: fatty acid synthase [KO:K00665] [EC:2.3.1.85]
101074095  hexokinase-1-like isoform X2 [KO:K00844] [EC:2.7.1.1]
101067477  putative hexokinase HKDC1 isoform X1 [KO:K00844] [EC:2.7.1.1]
101067705  hk1; hexokinase-1 [KO:K00844] [EC:2.7.1.1]
101079462  glucokinase-like [KO:K00844] [EC:2.7.1.1]
101071533  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
101063910  gck; glucokinase isoform X1 [KO:K12407] [EC:2.7.1.2]
101076074  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X2 [KO:K07198] [EC:2.7.11.31]
101065197  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101077063  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
101075190  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
101077896  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105416222  prkag3; 5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101064981  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
101074638  prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
101070084  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
101071631  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
101072628  forkhead box protein O1-A [KO:K07201]
101073915  forkhead box protein O1-A-like [KO:K07201]
613234  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
101061994  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
101072977  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
101072756  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
101079099  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
101069203  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
101079325  fructose-1,6-bisphosphatase isozyme 2-like [KO:K03841] [EC:3.1.3.11]
101070903  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101071000  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101074470  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
115253237  rptor; regulatory-associated protein of mTOR [KO:K07204]
101074350  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
101069154  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
101062507  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
101070606  rps6; 40S ribosomal protein S6 [KO:K02991]
101071696  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101079890  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
115246466  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101076943  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
101079607  eukaryotic translation initiation factor 4E-1A isoform X1 [KO:K03259]
101062651  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101078733  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
101069572  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
115247916  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
101064275  tsc1; hamartin isoform X1 [KO:K07206]
101070860  hamartin-like isoform X2 [KO:K07206]
101078033  tsc2; tuberin isoform X1 [KO:K07207]
101063973  GTP-binding protein Rheb [KO:K07208]
101075993  rheb; GTP-binding protein Rheb [KO:K07208]
105418743  uncharacterized protein LOC105418743 [KO:K02158]
115250644  uncharacterized protein LOC115250644 [KO:K02158]
101071954  shc1; SHC-transforming protein 1 isoform X4 [KO:K06279]
101071160  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
101074404  SHC-transforming protein 3 [KO:K17448]
105417270  shc4; SHC-transforming protein 4 isoform X2 [KO:K17449]
101070656  grb2; growth factor receptor-bound protein 2 [KO:K04364]
101061204  growth factor receptor-bound protein 2-like isoform X2 [KO:K04364]
101070228  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101061547  sos2; son of sevenless homolog 2 [KO:K03099]
101079899  hras; GTPase HRas [KO:K02833]
101069736  GTPase HRas-like [KO:K07827]
101077708  kras; GTPase KRas isoform X1 [KO:K07827]
654307  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
653021  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
654310  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101063584  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101070236  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101078496  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101066563  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
101065999  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
101066845  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101072454  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
101065460  suppressor of cytokine signaling 1-like [KO:K04694]
100049621  socs1; suppressor of cytokine signaling 1 [KO:K04694]
100144308  socs2; suppressor of cytokine signaling 2 [KO:K04695]
115246597  LOW QUALITY PROTEIN: suppressor of cytokine signaling 2-like [KO:K04695]
778006  socs3; suppressor of cytokine signaling 3 [KO:K04696]
100144313  socs4; suppressor of cytokine signaling 4 [KO:K04697]
101062679  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
101075629  receptor-type tyrosine-protein phosphatase F isoform X8 [KO:K05695] [EC:3.1.3.48]
101063084  receptor-type tyrosine-protein phosphatase F-like isoform X1 [KO:K05695] [EC:3.1.3.48]
101073575  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101070190  mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
101067839  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101078548  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101062431  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101069844  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like isoform X1 [KO:K15909] [EC:3.1.3.86]
101065901  inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2 [KO:K15909] [EC:3.1.3.86]
101075361  inpp5a; type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X2 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
tru00010  Glycolysis / Gluconeogenesis
tru00061  Fatty acid biosynthesis
tru00500  Starch and sucrose metabolism
tru04010  MAPK signaling pathway
tru04070  Phosphatidylinositol signaling system
tru04210  Apoptosis
KO pathway
ko04910   
LinkDB

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