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ENTRY	nt06230
Name	Cell cycle (cancer)
Category	Disease view; Cancer signaling
Display	drug-target relation   disease type

N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00067    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00076    CDKN2A* ⌿ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00068        MDM2* ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00167        (vIRF1,vIRF3) ⊣ TP53 N00169        LANA ⊣ TP53 N00069                CDKN2A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00494            TAX ⊣ CDKN2A N00070                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00071                CDKN2A* ⌿ (CCND+CDK4/6) → RB1 ⌿ E2F N00168                vCyclin → CDK4/6 → RB1 ⌿ E2F N00072                    (CCND+CDK4*) → RB1 ⌿ E2F N00073                    (CCND+CDK4*) → RB1 ⌿ E2F N00275                    (CCND1*+CDK4) → RB1 ⌿ E2F N00170                    LANA → RB1 ⌿ E2F N00074                        RB1* ⌿ E2F N00075                        RB1* ⌿ E2F N00090        (MYC+MAX) ⊣ ZBTB17 ⇒ CDKN2B ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00088        (MYC*+MAX) ⊣ ZBTB17 ⇒ CDKN2B ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00495            TAX ⊣ CDKN2B N00089                (MYC*+MAX) ⇒ (CCND+CDK4/6) → RB1 ⌿ E2F N00091            (SCF+SKP2) ⊣ CDKN1B ⊣ ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F N00092    (MYC*+MAX) ⇒ CKS1B → (SCF+SKP2) ⊣ CDKN1B ⊣ (CCNE+CDK2) → RB1 ⌿ E2F N00093                CDKN1B* ⌿ (CCNE+CDK2) → RB1 ⌿ E2F N00254                CDKN1B* ⌿ (CCNE+CDK2) → RB1 ⌿ E2F N00255                    (CCNE*+CDK2) → RB1 ⌿ E2F N01336    ACh → CHRNA7 → ARRB1 → SRC → RAF1 → RB1 ⌿ E2F1 N01337    (NNK,NNN) → CHRNA7 → ARRB1 → SRC → RAF1 → RB1 ⌿ E2F1 ⇒ (BIRC5,XIAP,CDC6,C.. N00499    (ATM,ATR) → CHEK1 → TP53 ⇒ CDKN1A ⊣ (CDK1+CCNB) N00500    TAX ⊣ CHEK1 N00493        MAD1L1 → (MAD2L1/2+BUB1B+BU.. ⊣ (ANAPC+CDC20) ⊣ PTTG ⊣ ESPL1 N00222    TAX ⊣ MAD1L1 N00221            TAX → (ANAPC+CDC20) ⊣ PTTG ⊣ ESPL1