KEGG    Network variation - RLR signaling
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ENTRYnt06519
NameRLR signaling
CategoryPathway view; Immune system
Pathwayhsa04622 RIG-I-like receptor signaling pathway
DiseaseH00290 Aicardi-Goutieres syndrome
H01571 Singleton-Merten syndrome
Display drug-target relation   disease type
N00469      RNARIGIMAVSTRAF3(TANK+NAP1+SINTBAD..(TBK1+IKBKE)(IRF7,IRF3)(IFNA,IFNB1)
    SGMRT2     RIGI*
N00728    IAV   NS1RIGI
N00565    HSV   US11(RIGI,MDA5)
N00685    MV   VMDA5MAVS
N00271    HCV     (NS3,NS4A)MAVS
N00268    HBV     XMAVS
N00732    IAV     (PB1F2,PB2)MAVS
N00566    HSV       UL36USPTRAF3
N00567    HSV           ICP34.5(TBK1+IKBKE)
N00734    IAV           (PB1F2+CALCOCO2)(TBK1+IKBKE)
N01310    SARS-CoV-2           nsp13TBK1
N01320    SARS-CoV-2           nsp3ISG15=IRF3
N00686    MV             NIRF3IFNB1
N00568    HSV             US3IRF3
N00470    EBV             BGLF4IRF3
N00687    MV             (V,C)IRF3
N01319    SARS-CoV-2             (nsp6,ORF6)IRF3
 
N01308      RNA(MDA5,ZNFX1)MAVSTRAF3(TANK+NAP1+SINTBAD..(TBK1+IKBKE)(IRF7,IRF3)(IFNA,IFNB1)
    AGS7/SGMRT1     MDA5*
    IMD95     MDA5*
    IMD91     ZNFX1*
N01309    SARS-CoV-2 nsp3ISG15=MDA5
 
N00688      RNARIGIMAVSIKKNFKBIANFKB(IFNA,IFNB1)
N00689    MV           (V,P,C)NFKB
N00730    IAV           NS1NFKB
 
N01564      RNF125(RIGI,MDA5)
    Tenorio syndrome   RNF125*
 
N01565    ADARRNA
    AGS6/DSH ADAR*

Disease nameDisease category
SGMRT2H01571Singleton-Merten syndromeCongenital malformation
IAVH00398InfluenzaViral infectious disease
HSVH00365Herpes simplex virus infectionViral infectious disease
MVH00394MeaslesViral infectious disease
HCVH00048Hepatocellular carcinomaCancer
HBVH00048Hepatocellular carcinomaCancer
SARS-CoV-2H02398COVID-19Viral infectious disease
EBVH00008Burkitt lymphomaCancer
H00007Hodgkin lymphomaCancer
H00054Nasopharyngeal cancerCancer
AGS7/SGMRT1H00290Aicardi-Goutieres syndromeImmune system disease
H01571Singleton-Merten syndromeCongenital malformation
IMD95H02525Disorders of innate immunityImmune system disease
IMD91H02525Disorders of innate immunityImmune system disease
Tenorio syndromeH01806Tenorio syndromeCongenital malformation
AGS6/DSHH00290Aicardi-Goutieres syndromeImmune system disease
H00880Dyschromatosis symmetrica hereditariaSkin disease