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ENTRY	nt06519
Name	RLR signaling
Category	Pathway view; Immune system
Pathway	hsa04622 RIG-I-like receptor signaling pathway
Disease	H00290 Aicardi-Goutieres syndrome H01571 Singleton-Merten syndrome
Display	drug-target relation   disease type

N00469        RNA → RIGI → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1)     SGMRT2         RIGI*↗     IIAE5                 TRAF3* N00728    IAV     NS1 ⊣ RIGI N00565    HSV     US11 ⊣ (RIGI,MDA5) N00685    MV     V ⊣ MDA5 → MAVS N00271    HCV         (NS3,NS4A) ⊣ MAVS N00268    HBV         X ⊣ MAVS N00732    IAV         (PB1F2,PB2) ⊣ MAVS N00566    HSV             UL36USP ⊣ TRAF3 N00567    HSV                     ICP34.5 ⊣ (TBK1+IKBKE) N00734    IAV                     (PB1F2+CALCOCO2) ⊣ (TBK1+IKBKE) N01310    SARS-CoV-2                     nsp13 ⊣ TBK1 N01320    SARS-CoV-2                     nsp3 ⊣ ISG15 = IRF3 N00686    MV                         N → IRF3 ⇒ IFNB1 N00568    HSV                         US3 ⊣ IRF3 N00470    EBV                         BGLF4 ⊣ IRF3 N00687    MV                         (V,C) ⊣ IRF3 N01319    SARS-CoV-2                         (nsp6,ORF6) ⊣ IRF3   N01308        RNA → (MDA5,ZNFX1) → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1)     AGS7/SGMRT1         MDA5*↗     IMD95         MDA5*     IMD91         ZNFX1* N01309    SARS-CoV-2 nsp3 ⊣ ISG15 = MDA5   N00688        RNA → RIGI → MAVS → IKK → NFKBIA → NFKB ⇒ (IFNA,IFNB1) N00689    MV                     (V,P,C) ⊣ NFKB N00730    IAV                     NS1 ⊣ NFKB   N01564        RNF125 ⊣ (RIGI,MDA5)     Tenorio syndrome     RNF125*   N01565    ADAR ⊣ RNA     AGS6/DSH ADAR*

		Disease name	Disease category
SGMRT2	H01571	Singleton-Merten syndrome	Congenital malformation
IIAE5	H02536	Infection-induced acute encephalopathy	Nervous system disease
IAV	H00398	Influenza	Viral infectious disease
HSV	H00365	Herpes simplex virus infection	Viral infectious disease
MV	H00394	Measles	Viral infectious disease
HCV	H00048	Hepatocellular carcinoma	Cancer
HBV	H00048	Hepatocellular carcinoma	Cancer
SARS-CoV-2	H02398	COVID-19	Viral infectious disease
EBV	H00008	Burkitt lymphoma	Cancer
	H00007	Hodgkin lymphoma	Cancer
	H00054	Nasopharyngeal cancer	Cancer
AGS7/SGMRT1	H00290	Aicardi-Goutieres syndrome	Immune system disease
	H01571	Singleton-Merten syndrome	Congenital malformation
IMD95	H02525	Disorders of innate immunity	Immune system disease
IMD91	H02525	Disorders of innate immunity	Immune system disease
Tenorio syndrome	H01806	Tenorio syndrome	Congenital malformation
AGS6/DSH	H00290	Aicardi-Goutieres syndrome	Immune system disease
	H00880	Dyschromatosis symmetrica hereditaria	Skin disease