KEGG NETWORK: Network variation - Integrin signaling

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ENTRY	nt06548
Name	Integrin signaling
Category	Pathway view; Cellular process
Display	drug-target relation disease type

N01987		(COL,LAM)	→	ITGA1+ITGB1	→	(Adaptor,FAK,Src)
N01988		(COL,LAM)	→	ITGA2+ITGB1	→	(Adaptor,FAK,Src)
N01989		COL	→	ITGA10+ITGB1	→	(Adaptor,FAK,Src)
N01996		COL	→	ITGA11+ITGB1	→	(Adaptor,FAK,Src)
	OI1/2/3/4/OST/ICH/EDSARTH1/OIEDS1	COL1A1*
	OI2/3/4/OST/EDSCV/EDSARTH2/OIEDS2	COL1A2*
	Type II collagenopathies	COL2A1*
	HANAC/BSVD1	COL4A1*
	PADMAL/RATOR	COL4A1*↗
	BSVD2	COL4A2*
	ATS3A_3B/BFH2	COL4A3*
	ATS2/BFH1	COL4A4*
	ATS1	COL4A5*
	DFNX6	COL4A6*
	BTHLM1A/UCMD1A	COL6A1*
	Myosclerosis/BTHLM1B/UCMD1B	COL6A2*
	DYT27/BTHLM1C/UCMD1C	COL6A3*
	EDM6/STL4	COL9A1*
	EDM2/STL5	COL9A2*
	EDM3/STL6/IDD	COL9A3*
N01990		(LAM,RELN,THBS)	→	ITGA3+ITGB1	→	(Adaptor,FAK,Src)
N01991		LAM	→	ITGA6+ITGB1	→	(Adaptor,FAK,Src)
N01997		LAM	→	ITGA7+ITGB1	→	(Adaptor,FAK,Src)
N01992		LAM	→	ITGA6+ITGB4	→	(Adaptor,FAK,Src)
	PTBHS	LAMA1*
	LGMDR23/MDC1A	LAMA2*
	JEB2A/2B/2C	LAMA3*
	CMD1JJ	LAMA4*
	NPHS26/BBDS2	LAMA5*
	LIS5	LAMB1*
	PIERS/NPHS5	LAMB2*
	JEB1A/1B/AI1A	LAMB3*
	JEB3A/3B	LAMC2*
	OCCM	LAMC3*
	LIS2/ETL7	RELN*
	JEB7/ILNEB			ITGA3*
	JEB6			ITGA6*
	CMD			ITGA7*
	JEB5A/5B			ITGB4*
N01974		(VCAM1,OPN,TN,VEGF..	→	ITGA9+ITGB1	→	(Adaptor,FAK,Src)
N01921		(VCAM1,ICAM4,MADCA..	→	ITGA4+ITGB1	→	(Adaptor,FAK,Src)
N01973		(MADCAM1,VCAM1,FN1..	→	ITGA4+ITGB7	→	(Adaptor,FAK,Src)
N01978		CDH1	→	ITGAE+ITGB7	→	(Adaptor,FAK,Src)
N01975		ICAM	→	ITGAL+ITGB2	→	(Adaptor,FAK,Src)
N01976		(iC3b,FG,ICAM1/4)	→	ITGAM+ITGB2	→	(Adaptor,FAK,Src)
N01998		(iC3b,FG,ICAM1/4)	→	ITGAX+ITGB2	→	(Adaptor,FAK,Src)
N01977		(ICAM3,VCAM1,FG,FN..	→	ITGAD+ITGB2	→	(Adaptor,FAK,Src)
	LMPHM4	VEGFC*
	Malaria	ICAM1*
	BCDS1	CDH1*
	LAD1			ITGB2*
N01980		(FN1,FBN1,DPP,OPN,..	→	ITGA5+ITGB1	→	(Adaptor,FAK,Src)
N01981		((NPNT+FRAS1+FREM)..	→	ITGA8+ITGB1	→	(Adaptor,FAK,Src)
N01979		(FG,VWF,THBS,FN1,V..	→	ITGA2B+ITGB3	→	(Adaptor,FAK,Src)
N01982		(FN1,VTN,OPN)	→	ITGAV+ITGB1	→	(Adaptor,FAK,Src)
N01983		(VTN,OPN,VWF,FN1,D..	→	ITGAV+ITGB3	→	(Adaptor,FAK,Src)
N01984		(VTN,BSP,OPN,LAP)	→	ITGAV+ITGB5	→	(Adaptor,FAK,Src)
N01985		(FN1,TN,DSP,LAP)	→	ITGAV+ITGB6	→	(Adaptor,FAK,Src)
N01986		(FN1,LAP)	→	ITGAV+ITGB8	→	(Adaptor,FAK,Src)
	Afibrinogenemia/AMYLD2	FGA*
	Afibrinogenemia	FGB*
	Afibrinogenemia	FGG*
	VWD	VWF*
	EDSCL3/IDD	THBS2*
	EDM1/PSACH/CTS2	COMP*
	GFND/SMDCF	FN1*
	MFS/MASS/ECTOL1/WMS2/GPHYSD2/SSS/ACMICD	FBN1*
	DGI/DTDP2/DFNA39/DTDP2	DSPP*
	DFNA56	TNC*
	NEDSTO	TNR*
	EDSCLL1	TNXB*
	VUR8	TNXB*↗
	FRASRS1	FRAS1*
	BNAR/MOTA/TRIGNO2	FREM1*
	FRASRS2/CRYPTOP	FREM2*
	CF/CED/IBDIMDE	TGFB1*↗
	ARHR1	DMP1*
	GT1			ITGA2B*
	BDPLT16			ITGA2B*↗
	GT2			ITGB3*
	BDPLT24			ITGB3*↗
	AI1H			ITGB6*
	RHDA1			ITGA8*
	PVNH1/FGS2/CIIP/TOD/CVDPX					FLNA*
	FOS/FMD1					FLNA*↗
	SCT					FLNB*
	AO1/3/BD/LRS					FLNB*↗
	KNDLRS					FERMT1*
	LAD3					FERMT3*
	MDRCMTT					LIMS2*

		Disease name	Disease category
OI1/2/3/4/OST/ICH/EDSARTH1/OIEDS1	H00506	Osteogenesis imperfecta	Congenital malformation
	H01593	Osteoporosis	Musculoskeletal disease
	H02243	Ehlers-Danlos syndrome arthrochalasia type	Congenital malformation
	H02724	Combined osteogenesis imperfecta and Ehlers-Danlos syndrome	Congenital malformation
OI2/3/4/OST/EDSCV/EDSARTH2/OIEDS2	H00506	Osteogenesis imperfecta	Congenital malformation
	H01593	Osteoporosis	Musculoskeletal disease
	H02241	Ehlers-Danlos syndrome cardiac valvular type	Congenital malformation
	H02243	Ehlers-Danlos syndrome arthrochalasia type	Congenital malformation
	H02724	Combined osteogenesis imperfecta and Ehlers-Danlos syndrome	Congenital malformation
Type II collagenopathies	H00445	Osteoarthritis with mild chondrodysplasia	Congenital malformation
	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H00519	Spondyloepiphyseal dysplasia congenita	Congenital malformation
	H00520	Type II collagenopathies	Congenital malformation
	H01526	Legg-Calve-Perthes Disease	Musculoskeletal disease
	H01529	Avascular necrosis of femoral head	Musculoskeletal disease
	H02066	Achondrogenesis type II	Congenital malformation
	H02070	Kniest dysplasia	Congenital malformation
	H02071	Czech dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
	H02185	Spondylometaphyseal dysplasia	Congenital malformation
	H02187	Spondyloepimetaphyseal dysplasia	Congenital malformation
HANAC/BSVD1	H00579	Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)	Congenital malformation
	H00839	Porencephaly	Congenital malformation
	H00877	Brain small vessel disease	Cardiovascular disease
PADMAL/RATOR	H02718	Autosomal dominant pontine microangiopathy and leukoencephalopathy	Congenital malformation
	H02880	Retinal arterial tortuosity	Congenital malformation
BSVD2	H00839	Porencephaly	Congenital malformation
	H00877	Brain small vessel disease	Cardiovascular disease
ATS3A_3B/BFH2	H00581	Alport syndrome	Congenital malformation
	H00582	Benign familial hematuria	Urinary system disease
ATS2/BFH1	H00581	Alport syndrome	Congenital malformation
	H00582	Benign familial hematuria	Urinary system disease
ATS1	H00581	Alport syndrome	Congenital malformation
DFNX6	H01209	Deafness, X-linked	Nervous system disease
BTHLM1A/UCMD1A	H01340	Bethlem myopathy	Nervous system disease
	H01778	Ullrich disease	Nervous system disease
Myosclerosis/BTHLM1B/UCMD1B	H01338	Myosclerosis	Nervous system disease
	H01340	Bethlem myopathy	Nervous system disease
	H01778	Ullrich disease	Nervous system disease
DYT27/BTHLM1C/UCMD1C	H00831	Primary dystonia	Nervous system disease
	H01340	Bethlem myopathy	Nervous system disease
	H01778	Ullrich disease	Nervous system disease
EDM6/STL4	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
EDM2/STL5	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
EDM3/STL6/IDD	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H02072	Stickler syndrome	Congenital malformation
	H02539	Intervertebral disc disease	Musculoskeletal disease
PTBHS	H02464	Poretti-Boltshauser syndrome	Congenital malformation
LGMDR23/MDC1A	H00593	Limb-girdle muscular dystrophy	Nervous system disease
	H01958	Merosin-deficient congenital muscular dystrophy	Nervous system disease
JEB2A/2B/2C	H00586	Epidermolysis bullosa, junctional	Congenital malformation
	H00813	Laryngo onycho cutaneous syndrome	Congenital malformation
CMD1JJ	H00294	Dilated cardiomyopathy	Cardiovascular disease
NPHS26/BBDS2	H01657	Nephrotic syndrome	Urinary system disease
	H02629	Bent bone dysplasia syndrome	Congenital malformation
LIS5	H00268	Lissencephaly	Congenital malformation
PIERS/NPHS5	H00576	Pierson syndrome	Urinary system disease
	H01657	Nephrotic syndrome	Urinary system disease
JEB1A/1B/AI1A	H00586	Epidermolysis bullosa, junctional	Congenital malformation
	H00615	Amelogenesis imperfecta	Congenital malformation
JEB3A/3B	H00586	Epidermolysis bullosa, junctional	Congenital malformation
OCCM	H02501	Occipital cortical malformation	Congenital malformation
LIS2/ETL7	H00268	Lissencephaly	Congenital malformation
	H00809	Familial epilepsy temporal lobe (ETL)	Nervous system disease
JEB7/ILNEB	H00586	Epidermolysis bullosa, junctional	Congenital malformation
	H02500	Congenital interstitial lung disease with nephrotic syndrome and epidermolysis bullosa	Congenital malformation
JEB6	H00586	Epidermolysis bullosa, junctional	Congenital malformation
CMD	H00590	Congenital muscular dystrophies (CMD/MDC)	Nervous system disease
JEB5A/5B	H00586	Epidermolysis bullosa, junctional	Congenital malformation
LMPHM4	H00535	Lymphatic malformation	Congenital malformation
Malaria	H00361	Malaria	Parasitic infectious disease
BCDS1	H02474	Blepharocheilodontic syndrome	Congenital malformation
LAD1	H00099	Leukocyte adhesion deficiency	Primary immunodeficiency
Afibrinogenemia/AMYLD2	H00222	Congenital fibrinogen deficiency	Hematologic disease
	H00845	Familial amyloidosis	Nervous system disease
Afibrinogenemia	H00222	Congenital fibrinogen deficiency	Hematologic disease
VWD	H02092	von Willebrand disease	Hematologic disease
EDSCL3/IDD	H00802	Ehlers-Danlos syndrome	Congenital malformation
	H02539	Intervertebral disc disease	Musculoskeletal disease
EDM1/PSACH/CTS2	H00476	Multiple epiphyseal dysplasia	Congenital malformation
	H00477	Pseudoachondroplasia	Congenital malformation
	H00798	Familial carpal tunnel syndrome	Nervous system disease
GFND/SMDCF	H01260	Glomerulopathy with fibronectin deposits	Urinary system disease
	H02185	Spondylometaphyseal dysplasia	Congenital malformation
MFS/MASS/ECTOL1/WMS2/GPHYSD2/SSS/ACMICD	H00653	Marfan syndrome	Congenital malformation
	H00661	MASS phenotype	Congenital malformation
	H00662	Ectopia lentis	Congenital malformation
	H00673	Weill-Marchesani syndrome	Congenital malformation
	H00900	Geleophysic dysplasia	Congenital malformation
	H01173	Stiff skin syndrome	Skin disease
	H02228	Acromicric dysplasia	Congenital malformation
DGI/DTDP2/DFNA39/DTDP2	H00432	Hereditary dentine disorders	Congenital malformation
	H00604	Deafness, autosomal dominant	Nervous system disease
	H02348	Dentin dysplasia	Congenital malformation
DFNA56	H00604	Deafness, autosomal dominant	Nervous system disease
NEDSTO	H03007	Nonprogressive neurodevelopmental disorder with spasticity and transient opisthotonus	Congenital malformation
EDSCLL1	H00802	Ehlers-Danlos syndrome	Congenital malformation
VUR8	H01037	Vesicoureteral reflux	Urinary system disease
FRASRS1	H00687	Fraser syndrome	Congenital malformation
BNAR/MOTA/TRIGNO2	H00685	Bifid nose with or without anorectal and renal anomalies	Congenital malformation
	H00686	Manitoba oculotrichoanal syndrome	Congenital malformation
	H01207	Trigonocephaly	Congenital malformation
FRASRS2/CRYPTOP	H00687	Fraser syndrome	Congenital malformation
	H02852	Unilateral or bilateral isolated cryptophthalmos	Congenital malformation
CF/CED/IBDIMDE	H00218	Cystic fibrosis	Respiratory system disease
	H00434	Camurati-Engelmann disease	Congenital malformation
	H02669	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Immune system disease
ARHR1	H00214	Hypophosphatemic rickets	Inherited metabolic disorder
	H02139	Autosomal recessive hypophosphatemic rickets	Inherited metabolic disorder
GT1	H00226	Glanzmann thrombasthenia	Hematologic disease
BDPLT16	H01235	Bleeding disorder platelet-type	Hematologic disease
GT2	H00226	Glanzmann thrombasthenia	Hematologic disease
BDPLT24	H01235	Bleeding disorder platelet-type	Hematologic disease
AI1H	H00615	Amelogenesis imperfecta	Congenital malformation
RHDA1	H00822	Renal hypodysplasia and aplasia	Congenital malformation
PVNH1/FGS2/CIIP/TOD/CVDPX	H00270	Periventricular nodular heterotopia	Congenital malformation
	H00894	FG syndrome	Congenital malformation
	H01276	Chronic idiopathic intestinal pseudo-obstruction	Digestive system disease
	H02229	Terminal osseous dysplasia	Congenital malformation
	H02230	X-linked cardiac valvular dysplasia	Congenital malformation
FOS/FMD1	H00456	Fronto-otopalatodigital syndromes	Congenital malformation
	H02227	Frontometaphyseal dysplasia	Congenital malformation
SCT	H00499	Spondylocarpotarsal synostosis syndrome	Congenital malformation
AO1/3/BD/LRS	H02064	Atelosteogenesis type I and III	Congenital malformation
	H02067	Boomerang dysplasia	Congenital malformation
	H02048	Larsen syndrome	Congenital malformation
KNDLRS	H00588	Kindler syndrome	Skin disease
LAD3	H00099	Leukocyte adhesion deficiency	Primary immunodeficiency
MDRCMTT	H00593	Limb-girdle muscular dystrophy	Nervous system disease