KEGG ORTHOLOGY: K04977

ORTHOLOGY: K04977

Entry

K04977                      KO

Symbol

TRPM2

Name

transient receptor potential cation channel subfamily M member 2 [EC:3.6.1.13]

Pathway

map04621

NOD-like receptor signaling pathway

map04921

Oxytocin signaling pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K04977  TRPM2; transient receptor potential cation channel subfamily M member 2
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K04977  TRPM2; transient receptor potential cation channel subfamily M member 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04977  TRPM2; transient receptor potential cation channel subfamily M member 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.13  ADP-ribose diphosphatase
     K04977  TRPM2; transient receptor potential cation channel subfamily M member 2
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Transient receptor potential channel (TRP)
   K04977  TRPM2; transient receptor potential cation channel subfamily M member 2

Other DBs

GO:	0047631 0005262

TC:

1.A.4.5.5

Genes

HSA:	7226(TRPM2)

PTR:	470101(TRPM2)

GGO:	101133784(TRPM2)

PON:	100440923(TRPM2)

PPYG:

129022612(TRPM2)

NLE:	100599657(TRPM2)

HMH:	116482271(TRPM2)

SSYN:

129483076(TRPM2)

MCC:	722161(TRPM2)

MCF:	102138225(TRPM2)

MTHB:

126950613

MNI:	105472513(TRPM2)

CSAB:

103219813(TRPM2)

CATY:

105575597(TRPM2)

PANU:

100999167(TRPM2)

TGE:	112620588(TRPM2)

MLEU:

105555535(TRPM2)

RRO:	104659939(TRPM2)

RBB:	108539793(TRPM2)

TFN:	117094499(TRPM2)

PTEH:

111526741(TRPM2)

CANG:

105520480(TRPM2)

CJC:	100393989(TRPM2)

SBQ:	101030727(TRPM2)

CIMI:

108311256(TRPM2)

ANAN:

105713269(TRPM2)

CSYR:

103258749(TRPM2)

MMUR:

105879092(TRPM2)

LCAT:

123630805(TRPM2)

PCOQ:

105824169(TRPM2)

OGA:	100952764(TRPM2)

MMU:	28240(Trpm2)

MCAL:

110303418(Trpm2)

MPAH:

110326610(Trpm2)

RNO:	294329(Trpm2)

MCOC:

116074975(Trpm2)

ANU:	117724520(Trpm2)

ASYL:

127669961(Trpm2)

MUN:	110556088(Trpm2)

MAUA:

101831746(Trpm2)

PROB:

127224154(Trpm2)

PLEU:

114685799(Trpm2)

MORG:

121435453(Trpm2)

MFOT:

126502781

AAMP:

119822795(Trpm2)

NGI:	103729355(Trpm2)

HGL:	101723317(Trpm2)

CPOC:

100720314(Trpm2)

CCAN:

109689139(Trpm2)

DORD:

105993972(Trpm2)

DSP:	122101316(Trpm2)

PLOP:

125351582(Trpm2)

NCAR:

124992449

MMMA:

107136538(Trpm2)

ITI:	101961813(Trpm2)

OCU:

103347481

OPI:	101534084(TRPM2)

TUP:	102485911(TRPM2)

GVR:	103586417(TRPM2)

CFA:	100856408(TRPM2)

CLUD:

112669211(TRPM2)

VVP:	112909537(TRPM2)

VLG:	121479542(TRPM2)

NPO:	129502255(TRPM2)

AML:	100479364(TRPM2)

UMR:	103680748(TRPM2)

UAH:	113251377(TRPM2)

UAR:	123778781(TRPM2)

ELK:

111155711

LLV:

125093441

MPUF:

101687733(TRPM2)

MNP:	132012458(TRPM2)

MLK:	131825448(TRPM2)

NVS:	122908224(TRPM2)

ORO:	101364340(TRPM2)

EJU:	114226450(TRPM2)

ZCA:	113917503(TRPM2)

MLX:	118026954(TRPM2)

NSU:	110571076(TRPM2)

FCA:	101090284(TRPM2)

PYU:	121035871(TRPM2)

PCOO:

112849423(TRPM2)

PBG:	122491103(TRPM2)

PVIV:

125159069(TRPM2)

LRUF:

124526232

LGF:	123610487(TRPM2)

AJU:

106985662

PTG:	102970544(TRPM2)

PPAD:

109256926(TRPM2)

PUC:

125920662

PLEZ:

122198566(TRPM2)

HHV:	120240680(TRPM2)

BTA:	508029(TRPM2)

BOM:	102268934(TRPM2)

BIU:	109561012(TRPM2)

BBUB:

102393505(TRPM2)

BBIS:

104985012(TRPM2)

CHX:	102171382(TRPM2)

OAS:	101103450(TRPM2)

BTAX:

128046161(TRPM2)

CSUM:

138086766(TRPM2)

ODA:	120856383(TRPM2)

CCAD:

122445409(TRPM2)

MREE:

136173347(TRPM2)

OVR:	110131145(TRPM2)

MBEZ:

129548396(TRPM2)

SSC:	100622032(TRPM2)

CFR:	102515296(TRPM2)

CBAI:

105078012(TRPM2)

CDK:	105103997(TRPM2)

VPC:	102532107(TRPM2)

BACU:

103013787(TRPM2)

BMUS:

118894976(TRPM2)

LVE:	103080844(TRPM2)

OOR:	101284630(TRPM2)

LALB:

132521379(TRPM2)

DLE:	111186366(TRPM2)

PCAD:

102976422 114486690(TRPM2)

PSIU:

116752800(TRPM2)

NASI:

112408642(TRPM2)

ECB:	100056810(TRPM2)

EPZ:	103565779(TRPM2)

EAI:	106824449(TRPM2)

MYB:	102263680(TRPM2)

MYD:	102758903(TRPM2)

MMYO:

118677091(TRPM2)

MLF:	102423513(TRPM2)

MDT:	132229939(TRPM2)

MYUM:

139004230(TRPM2)

PKL:	118723218(TRPM2)

EFUS:

103289778(TRPM2)

MNA:	107537463(TRPM2)

DRO:	112308924(TRPM2)

SHON:

119000267(TRPM2)

AJM:	119058737(TRPM2)

PDIC:

114491083(TRPM2)

PHAS:

123828014(TRPM2)

MMF:	118617132(TRPM2)

PPAM:

129072831(TRPM2)

HAI:	109372111(TRPM2)

RFQ:	117036195(TRPM2)

PALE:

102879615(TRPM2)

PVP:	105303033(TRPM2)

RAY:	107510207(TRPM2)

MJV:	108391422(TRPM2)

TOD:	119257152(TRPM2)

SARA:

101537616(TRPM2)

SFUM:

130028582(TRPM2)

SETR:

126025625(TRPM2)

LAV:	100661004(TRPM2)

TMU:

101344808

ETF:	101644187(TRPM2)

DNM:	101423980(TRPM2)

MDO:	100618566(TRPM2)

GAS:	123246941(TRPM2)

SHR:	100930450(TRPM2)

AFZ:

127562457

PCW:	110203516(TRPM2)

TVP:	118858722(TRPM2)

PBRV:

138170796(TRPM2)

OAA:	100083361(TRPM2)

TACU:

119930561(TRPM2)

GGA:	424835(TRPM2)

PCOC:

116230970(TRPM2)

MGP:	100544662(TRPM2)

CJO:	107317980(TRPM2)

TPAI:

128082730(TRPM2)

LMUT:

125697703(TRPM2)

NMEL:

110397643(TRPM2)

APLA:

101804620(TRPM2)

ACYG:

106039286(TRPM2)

CATA:

118247222(TRPM2)

AFUL:

116492348(TRPM2)

TGU:	100219588(TRPM2)

LSR:	110478650(TRPM2)

SCAN:

103815520(TRPM2)

PMOA:

120511263(TRPM2)

OTC:	121342120(TRPM2)

PRUF:

121364041(TRPM2)

ATRC:

139594794(TRPM2)

GFR:	102044472(TRPM2)

FAB:	101813560(TRPM2)

OMA:	130256578(TRPM2)

PHI:	102103212(TRPM2)

PMAJ:

107209054(TRPM2)

CCAE:

111933736(TRPM2)

CCW:	104696749(TRPM2)

CBRC:

103612006(TRPM2)

ACOE:

138114546(TRPM2)

ETL:	114064527(TRPM2)

ZAB:	102067025(TRPM2)

ZLE:	135451866(TRPM2)

ACHL:

103804708(TRPM2)

SVG:	106849650(TRPM2)

MMEA:

130582330(TRPM2)

HRT:	120757356(TRPM2)

SATI:

136365552(TRPM2)

CCIC:

134047568(TRPM2)

FPG:	101922187(TRPM2)

FCH:	102046268(TRPM2)

CCRI:

104159391(TRPM2)

NNT:	104403338(TRPM2)

SHAB:

115611999(TRPM2)

ACUN:

113483677(TRPM2)

TALA:

104368799(TRPM2)

ACHC:

115347589(TRPM2)

HALD:

104315935(TRPM2)

HLE:	104827897(TRPM2)

AGEN:

126039724

HHAR:

128149372(TRPM2)

GCL:

127019945

CSTI:

104553584(TRPM2)

LDI:	104343727(TRPM2)

DPUB:

104299318(TRPM2)

PPUS:

135186877(TRPM2)

AVIT:

104281248(TRPM2)

BRHI:

104494341(TRPM2)

EGZ:	104131287(TRPM2)

NNI:	104010647(TRPM2)

PCRI:

104028158(TRPM2)

PCAO:

104051664(TRPM2)

PADL:

103913688(TRPM2)

AFOR:

103903103(TRPM2)

FGA:	104077585(TRPM2)

GSTE:

104257999(TRPM2)

CLV:	102086708(TRPM2)

MUI:	104545198(TRPM2)

PGUU:

104466806(TRPM2)

PLET:

104625259(TRPM2)

EHS:	104506653(TRPM2)

CMAC:

104481891(TRPM2)

CUCA:

104065252(TRPM2)

TEO:	104378687(TRPM2)

BREG:

104638717(TRPM2)

OHA:	104327576(TRPM2)

ACAR:

104520695

CPEA:

104387920(TRPM2)

CVF:	104293566(TRPM2)

RTD:	128911433(TRPM2)

CRID:

134517349(TRPM2)

AAM:	106485607(TRPM2)

AROW:

112971718(TRPM2)

NPD:	112944863(TRPM2)

TGT:	104573186(TRPM2)

DNE:	112988710(TRPM2)

SCAM:

104137790(TRPM2)

ASN:	102380928(TRPM2)

AMJ:	102572960(TRPM2)

CPOO:

109308670(TRPM2)

GGN:	109294394(TRPM2)

PSS:

102451222

CMY:	102940574(TRPM2)

CCAY:

125642840(TRPM2)

CPIC:

101932366(TRPM2)

TST:	117883197(TRPM2)

CABI:

116820171(TRPM2)

MRV:	120372528(TRPM2)

ACS:	100556895(trpm2)

ASAO:

132770756(TRPM2)

PVT:	110075868(TRPM2)

SUND:

121926477(TRPM2)

PBI:	103066387(TRPM2)

PMUR:

107285902(TRPM2)

CTIG:

120317548(TRPM2)

TSR:	106537600(TRPM2)

PGUT:

117678783(TRPM2)

APRI:

131200773(TRPM2)

PTEX:

113436619(TRPM2)

NSS:	113412254(TRPM2)

VKO:	123033341(TRPM2)

PMUA:

114597702(TRPM2)

PRAF:

128414464(TRPM2)

ZVI:	118093380(TRPM2)

HCG:	128350696(TRPM2)

GJA:	107106671(TRPM2)

STOW:

125438156(TRPM2)

EMC:	129332021(TRPM2)

XLA:	108701480(trpm2.L) 108707608(trim26.L) 108710098

XTR:	100124999(trpm2) 100491139(trpm2l)

NPR:	108797589(TRPM2) 108799884

RTEM:

120928184 120928841 120943713(TRPM2)

BBUF:

120996658 121008782(TRPM2)

BGAR:

122931297 122945155(TRPM2)

PWL:	138249315 138249316 138249318 138249319 138249674

DRE:	799412(trpm2)

SRX:	107742818(trpm2)

SANH:

107675123(trpm2)

SGH:	107558377(trpm2) 107567425

CCAR:

109081928 109100303

CAUA:

113053712 113108227(trpm2)

CGIB:

127964309 128020185

PTET:

122333087(trpm2)

LROH:

127171478(trpm2)

OMC:	131547440(trpm2)

PPRM:

120487288(trpm2)

RKG:	130105388(trpm2)

MAMB:

125270790(trpm2)

CIDE:

127519287

CERY:

137035623(trpm2)

MASI:

127448218

TROS:

130555420(trpm2)

TDW:	130427438(trpm2)

MANU:

129451610 129452101

PDAB:

135733610(trpm2)

IPU:

108266159

IFU:	128608391(trpm2)

PHYP:

113546560(trpm2)

SMEO:

124379273(trpm2)

TFD:	113645375(trpm2)

TVC:	132850559(trpm2)

CGAR:

128524194(trpm2)

NGRA:

132892195(trpm2) 132892198

TRN:	134324694(trpm2)

AMEX:

103047362(trpm2)

CMAO:

118807595(trpm2)

EEE:

113577928

CHAR:

105905896(trpm2)

SPIL:

134077886 134077998 134077999 134078000 134078343 134078344

TRU:	101063636(trpm2)

TFS:	130522864(trpm2)

TNG:	GSTEN00030514G001

LCO:	104928826(trpm2)

NCC:

104961135

TBEN:

117485747(trpm2)

CGOB:

115026186(trpm2)

PGEO:

117466214(trpm2)

GACU:

117538362(trpm2)

EMAC:

134866992(trpm2)

ELY:	117250159(trpm2)

EFO:	125900145(trpm2)

PLEP:

121949246(trpm2)

SLUC:

116049737 116049746 116049755

ECRA:

117953235(trpm2)

ESP:	116674376 116697672(trpm2)

PFLV:

114563967(trpm2)

GAT:	120834411(trpm2)

PPUG:

119229279(trpm2)

AFB:	129104214(trpm2)

CLUM:

117750375(trpm2)

PSWI:

130203359(trpm2)

CANA:

137782867(trpm2)

CVE:	137866957(trpm2)

MSAM:

119903492 119904518(trpm2)

SCHU:

122885920(trpm2)

CUD:	121522260 121522462

SPUL:

138592139(trpm2)

LMIX:

132987301 132987302

ALAT:

119026477(trpm2)

ASTR:

137604926(trpm2)

MZE:	101475454(trpm2)

ONL:	100711841(trpm2)

OAU:	116335366(trpm2)

OLA:	101170060(trpm2)

OML:	112154921(trpm2)

CSAI:

133446011(trpm2)

XMA:	102227598(trpm2) 102227852

XCO:	114148705(trpm2)

XHE:	116723357 116723358 116723359

PRET:

103461103 103461649 103461650(trpm2)

PFOR:

103132409 103155498 103155764 103155774 103155777

PLAI:

106940833 106948017 106948032

PMEI:

106910456 106922748 106934187 106934188

GAF:	122839943 122839944

PPRL:

129360978 129361483

CVG:	107091885(trpm2)

CTUL:

119788720(trpm2)

GMU:	124871867(trpm2)

NFU:	107390129(trpm2)

KMR:

108240712

ALIM:

106523339(trpm2)

NWH:	119419090(trpm2)

AOCE:

111575581(trpm2)

EJA:	138201281(trpm2)

BFRE:

138620931(trpm2)

MCEP:

125017248(trpm2)

CSEM:

103392068(trpm2)

POV:	109631092(trpm2)

SSEN:

122783653(trpm2)

SSOE:

131455592(trpm2)

HHIP:

117754772(trpm2)

HSP:	118119639(trpm2)

PPLT:

128456310(trpm2)

SMAU:

118283199(trpm2)

LCF:

108880479

SDU:	111218874(trpm2)

SLAL:

111671500(trpm2)

XGL:	120801517(trpm2)

HCQ:	109523278(trpm2)

SSCV:

125973283(trpm2)

SBIA:

133512555(trpm2)

PEE:	133410632(trpm2)

PTAO:

133486638(trpm2)

BPEC:

110173054

ENY:	140359462(trpm2)

MALB:

109957089(trpm2)

BSPL:

114847666(trpm2)

SJO:	128367555(trpm2)

SSCO:

133993103(trpm2)

GMH:	115532845(trpm2)

SASA:

106582587

STRU:

115155382(trpm2)

OTW:	112238072(trpm2)

OMY:	110502207(trpm2)

OGO:	124037386(trpm2)

ONE:	115122285(trpm2)

OKI:	109879401(trpm2)

OKE:	118379042(trpm2)

OMM:	135547706(trpm2)

OCLA:

139380404

CCLU:

121555141(trpm2)

ELS:	105007749(trpm2)

OEP:	134017558(trpm2)

SFM:	108918243(trpm2)

PKI:	111858311(trpm2)

AANG:

118213674(trpm2)

AROT:

135240954(trpm2)

CCOG:

133116215 133116216 133116239 133116241 133116242 133116805

LOC:	102699238(trpm2)

PSPA:

121322247 121322668(trpm2)

ARUT:

117402953(trpm2) 117426474

PSEX:

120520543(trpm2) 120530683

LCM:	102359504(TRPM2)

CMK:	103176832(trpm2)

CPLA:

122551474(trpm2)

HOC:	132817675(trpm2)

LERI:

129698849(trpm2)

PMRN:

116938844(TRPM2)

LRJ:	133345820(TRPM2)

BFO:	118421987 118421996 118432365 118432810

BBEL:

109482219 109484626

SCLV:

120327911 120328147 120328463 120328467

SPU:	105443422 754831

AJJ:	139966116 139966118

APLC:

110976006 110990131 110990132

ARUN:

117287812 117288355

AAMU:

139937665 139937666

AFIL:

140141152 140141766 140142259 140143943 140146434 140158410 140170417

SKO:	100367635 102809947

PFLL:

139116705 139117515 139117861 139120547 139127226 139129455 139130301 139150784 139151019

PJA:

PCHN:

MNZ:

MRJ:

PORN:

EAF:

DSV:	119450844 119458868

RSAN:

119374469 119382222

RMP:	119168401 119170801

TUT:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

LPOL:

106464459 106467158 106470084

PMEO:

129584506 129584520 129592905

PVUL:

126818115 126824565

PCAN:

112556434 112559586 112560740 112561084

LSAX:

138947541 138969120 138978700

BGT:	106050894 106052735 106074598

GAE:	121384016 121385624

HRF:	124110477 124122562 124132740 124150830 124150848

HRJ:	124264062 124284684

HASI:

137272719 137283997 137284753 137285115 137294333 137298942

HCRA:

139450076 139465437 139468895 139468896 139469894

CRG:	105317633 105318910 105325948 105331961 105332384 105332694 105339803 105341917 117680632 117686916 117687700 136274621

CANU:

128162625 128162872 128171911 128172140 128185836

CVN:	111099029 111112589 111124528 111133145 111135947 111138159

OED:	125646155 125661866 125678974 125683018 125683715 130049728

MYI:	110443289 110454821 110456226 110464655

PMAX:

117314822 117329828 117333318 117334068

AIRR:

138321271 138328264 138331923

MMER:

123557382 123560878

RPHI:

132734910 132737397

DPOL:

127841285 127851126 127853965 127860136 127870075 127879099

MAEA:

128210323 128212276 128213066 128227814 128233439 128234026 128234145 128234741 128234763 128235634

OBI:

106871768

OSN:	115213802 115220802 115220909 115221041 115221043 115221077

LJP:	135461486 135472111 135472705 135473605

LAK:

106165225

SMM:	Smp_000050 Smp_130890

OVI:	T265_03361 T265_14336

EGL:	EGR_01769 EGR_01771 EGR_02679 EGR_05252

LLON:

135482573 135484248 135497591

NVE:

5500864

EPA:	110233261 110249041

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130622039 130625718 130644865

RES:

135682832

MBR:	MONBRDRAFT_27446 MONBRDRAFT_29245

EHX:	EMIHUDRAFT_468587

» show all

Reference

PMID:11804595

Authors

Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y

Title

LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.

Journal

Mol Cell 9:163-73 (2002)
DOI:10.1016/S1097-2765(01)00438-5

Reference

PMID:9806837

Authors

Nagamine K, Kudoh J, Minoshima S, Kawasaki K, Asakawa S, Ito F, Shimizu N

Title

Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain.

Journal

Genomics 54:124-31 (1998)
DOI:10.1006/geno.1998.5551

Sequence

[hsa:7226]

LinkDB

DBGET integrated database retrieval system