KEGG ORTHOLOGY: K18497

ORTHOLOGY: K18497

Entry

K18497                      KO

Symbol

FGF2

Name

fibroblast growth factor 2

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04151

PI3K-Akt signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04810

Regulation of actin cytoskeleton

map05167

Kaposi sarcoma-associated herpesvirus infection

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05207

Chemical carcinogenesis - receptor activation

map05218

Melanoma

map05224

Breast cancer

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04014 Ras signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04015 Rap1 signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04020 Calcium signaling pathway
    K18497  FGF2; fibroblast growth factor 2
   04151 PI3K-Akt signaling pathway
    K18497  FGF2; fibroblast growth factor 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K18497  FGF2; fibroblast growth factor 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K18497  FGF2; fibroblast growth factor 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K18497  FGF2; fibroblast growth factor 2
   05205 Proteoglycans in cancer
    K18497  FGF2; fibroblast growth factor 2
   05207 Chemical carcinogenesis - receptor activation
    K18497  FGF2; fibroblast growth factor 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K18497  FGF2; fibroblast growth factor 2
   05218 Melanoma
    K18497  FGF2; fibroblast growth factor 2
   05224 Breast cancer
    K18497  FGF2; fibroblast growth factor 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K18497  FGF2; fibroblast growth factor 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K18497  FGF2; fibroblast growth factor 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K18497  FGF2; fibroblast growth factor 2
   00536 Glycosaminoglycan binding proteins
    K18497  FGF2; fibroblast growth factor 2
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K18497  FGF2; fibroblast growth factor 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K18497  FGF2; fibroblast growth factor 2

Other DBs

GO:

0005104

Genes

HSA:	2247(FGF2)

PTR:	641462(FGF2)

PPS:	100968351(FGF2)

GGO:	101137337(FGF2)

PON:	100459751(FGF2)

PPYG:

129035002(FGF2)

NLE:	100593123(FGF2)

HMH:	116463600(FGF2)

SSYN:

129480650(FGF2)

MCC:	574136(FGF2)

MCF:	102133679(FGF2)

MTHB:

126954986

MNI:	105486416(FGF2)

CSAB:

103236710(FGF2)

CATY:

105595795(FGF2)

PANU:

101003965(FGF2)

TGE:	112624619(FGF2)

MLEU:

105538400(FGF2)

RRO:	104661758(FGF2)

RBB:	108515579(FGF2)

TFN:	117085877(FGF2)

PTEH:

111546245(FGF2)

CANG:

105516422(FGF2)

CJC:	118152209(FGF2)

SBQ:	101030554(FGF2)

CIMI:

108304180(FGF2)

ANAN:

105731325(FGF2)

MMUR:

105882072(FGF2)

LCAT:

123638827(FGF2)

PCOQ:

105815256(FGF2)

OGA:	100942631(FGF2)

MMU:	14173(Fgf2)

MCAL:

110291557(Fgf2)

MPAH:

110320512(Fgf2)

RNO:	54250(Fgf2)

MCOC:

116095116(Fgf2)

ANU:	117706759(Fgf2)

ASYL:

127683399(Fgf2)

MUN:	110545886(Fgf2)

CGE:	100757429(Fgf2)

MAUA:

101834448(Fgf2)

PROB:

127223306(Fgf2)

PLEU:

114707170(Fgf2)

MORG:

121452838(Fgf2)

MFOT:

126499184

AAMP:

119826229(Fgf2)

NGI:	103746947(Fgf2)

HGL:	101720583(Fgf2)

CPOC:

100721182(Fgf2)

DORD:

105989908(Fgf2)

DSP:	122119078(Fgf2)

DMER:

138827034(Fgf2)

PLOP:

125341650(Fgf2)

OCU:

100009068

OPI:	101520285(FGF2)

OCZ:	121147506(FGF2)

TUP:	102498637(FGF2)

CFA:	403857(FGF2)

CLUD:

112642713(FGF2)

VVP:	112933647(FGF2)

VLG:	121493095(FGF2)

NPO:	129504328(FGF2)

AML:	100479986(FGF2)

UMR:	103661850(FGF2)

UAH:	113255677(FGF2)

UAR:	123793143(FGF2)

ELK:

111156005

LLV:

125093355

MPUF:

101671799(FGF2)

MNP:	132028444(FGF2)

MLK:	131828225(FGF2)

NVS:	122890262(FGF2)

ORO:	101369428(FGF2)

EJU:	114208195(FGF2)

ZCA:	113925505(FGF2)

MLX:	118022565(FGF2)

NSU:	110573062(FGF2)

LWW:

102741264

FCA:	100135772(FGF2)

PYU:	121030066(FGF2)

PBG:	122469044(FGF2)

PVIV:

125164816(FGF2)

LRUF:

124521134

LGF:	123592854(FGF2)

AJU:

106977090

PTG:	102969772(FGF2)

PPAD:

109246691(FGF2)

PUC:

125923095

PLEZ:

122218441(FGF2)

HHV:	120238033(FGF2)

BTA:	281161(FGF2)

BOM:	102284897(FGF2)

BIU:	109570879(FGF2)

BBUB:

102393273(FGF2)

BBIS:

105003247(FGF2)

CHX:	102186892(FGF2)

OAS:	443306(FGF2)

BTAX:

128062082(FGF2)

CSUM:

138093753(FGF2)

ODA:	120871375(FGF2)

CCAD:

122453183(FGF2)

MREE:

136146144(FGF2)

OVR:	110150828(FGF2)

MBEZ:

129542296(FGF2)

SSC:	397643(FGF2)

CFR:	116658259(FGF2)

CBAI:

105067112(FGF2)

CDK:	105093669(FGF2)

VPC:	102536146(FGF2)

BACU:

103015722(FGF2)

BMUS:

118895460(FGF2)

LVE:	103090898(FGF2)

OOR:	101280803(FGF2)

LALB:

132520018(FGF2)

DDP:	132426146(FGF2)

DLE:	111186075(FGF2)

PCAD:

102989017(FGF2)

PSIU:

116753904(FGF2) 116758288

PPHC:

136123082(FGF2)

NASI:

112399728(FGF2)

ECB:	100033955(FGF2)

MYB:	102246008(FGF2)

MYD:	102762815(FGF2)

MMYO:

118657980(FGF2)

MLF:	111825710(FGF2)

MDT:	132235554(FGF2)

MYUM:

139010558(FGF2)

PKL:	118711281(FGF2)

EFUS:

129149245(FGF2)

MNA:	107529795(FGF2)

DRO:	112312217(FGF2)

SHON:

118995576(FGF2)

AJM:	119037695(FGF2)

PDIC:

114502553(FGF2)

PHAS:

123813667(FGF2)

MMF:	118616042(FGF2)

PPAM:

129061435(FGF2)

HAI:	109374154(FGF2)

RFQ:	117037862(FGF2)

PALE:

107196088(FGF2)

PGIG:

120616271(FGF2)

RAY:	107518501(FGF2)

SARA:

101555369(FGF2)

SFUM:

130042343(FGF2)

SETR:

126003833(FGF2)

LAV:	100657533(FGF2)

TMU:

101342442

ETF:	101640090(FGF2)

DNM:	101423570(FGF2)

MDO:	619384(FGF2)

GAS:	123251436(FGF2)

SHR:	100934542(FGF2)

AFZ:

127541481

PCW:	110222958(FGF2)

TVP:	118854783(FGF2)

PBRV:

138174562(FGF2)

MLAO:

141517393(FGF2)

OAA:	114815531(FGF2)

GGA:	396413(FGF2)

PCOC:

116231214(FGF2)

MGP:	100550388(FGF2)

CJO:	107313543(FGF2)

TPAI:

128080445(FGF2)

LMUT:

125692512(FGF2)

NMEL:

110398111(FGF2)

APLA:

101798064(FGF2)

ACYG:

106042430(FGF2)

CATA:

118251228(FGF2)

AFUL:

116488431(FGF2)

TGU:	100227798(FGF2)

LSR:	110484373(FGF2)

SCAN:

103821418(FGF2)

PMOA:

120508667(FGF2)

OTC:	121339852(FGF2)

PRUF:

121361519(FGF2)

ATRC:

139602544(FGF2)

GFR:	102035880(FGF2)

FAB:	101807010(FGF2)

OMA:	130252458(FGF2)

PHI:	102104728(FGF2)

PMAJ:

107202986(FGF2)

CCW:	120409622(FGF2)

ACOE:

138109365(FGF2)

ETL:	114061094(FGF2)

ZAB:	102068443(FGF2)

ZLE:	135446975(FGF2)

SVG:	106859414(FGF2)

MMEA:

130579961(FGF2)

HRT:	120752523(FGF2)

SATI:

136360846(FGF2)

CCIC:

134044667(FGF2)

FPG:	101918253(FGF2)

FCH:	102054561(FGF2)

NNT:

104401254

SHAB:

115604795(FGF2)

ACUN:

113479640(FGF2)

TALA:

116962816(FGF2)

ACHC:

115343528(FGF2)

HALD:

104311887(FGF2)

AGEN:

126044714

HHAR:

128154360(FGF2)

GCL:

127015769

LDI:	104342836(FGF2)

DPUB:

104296220(FGF2)

PPUS:

135178751(FGF2)

PCAO:

104045159(FGF2)

PADL:

103926140(FGF2)

AFOR:

103907355(FGF2)

GSTE:

104261300(FGF2)

CLV:	110364865(FGF2)

MUI:	104544126(FGF2)

CMAC:

104480529(FGF2)

BREG:

104635922(FGF2)

ACAR:

114819061(FGF2)

CPEA:

104398817(FGF2)

CVF:	104289001(FGF2)

RTD:	128910384(FGF2)

CRID:

134515849(FGF2)

AAM:	106491847(FGF2)

AROW:

112973481(FGF2)

NPD:	112950246(FGF2)

DNE:	112996800(FGF2)

SCAM:

104149676(FGF2)

ASN:	102385563(FGF2)

AMJ:	102567370(FGF2)

CPOO:

109309334(FGF2)

GGN:	109301132(FGF2)

PSS:	102444616(FGF2)

CIZ:	142012683(FGF2)

CMY:	102931444(FGF2)

CCAY:

125635468(FGF2)

DCC:	119854425(FGF2)

CPIC:

122174672(FGF2)

CABI:

116834788(FGF2)

MRV:	120406846(FGF2)

ACS:	100559071(fgf2)

ASAO:

132776870(FGF2)

PVT:	110072861(FGF2)

SUND:

121931107(FGF2)

PBI:	103053614(FGF2)

PMUR:

107283368(FGF2)

CTIG:

120297492(FGF2)

TSR:	106542651(FGF2)

PGUT:

117654575(FGF2)

PCAE:

139320071(FGF2)

APRI:

131203162(FGF2)

PTEX:

113434610(FGF2)

NSS:	113411891(FGF2)

PMUA:

114604525(FGF2)

PRAF:

128421141(FGF2)

ZVI:	118083517(FGF2)

HCG:	128327609(FGF2)

GJA:	107109560(FGF2)

STOW:

125439948(FGF2)

EMC:	129336499(FGF2)

XLA:	100101279(fgf2) 108706695(fgf2.S)

XTR:	550087(fgf2)

NPR:	108790780(FGF2)

RTEM:

120918763(FGF2)

ACAT:

141111362(FGF2)

BBUF:

120989950(FGF2)

BGAR:

122944017(FGF2)

DTC:	141086205(FGF2)

PWL:	138301959(FGF2)

GSH:	117357714(FGF2)

DRE:	404231(fgf2)

SRX:	107714902 107717315

SANH:

107694403(fgf2) 107700884

SGH:	107559624(fgf1) 107568661

CCAR:

109065695 122147495(fgf2)

CAUA:

113058100 113114424 113114425

CGIB:

127971710 128027403

PTET:

122333592(fgf2)

LROH:

127176164(fgf2)

GRF:	141288217(fgf2)

OMC:	131553310(fgf2)

PPRM:

120465410(fgf2)

RKG:	130075364(fgf2)

MAMB:

125267517(fgf2)

CIDE:

127494051

CERY:

137027198(fgf2)

MASI:

127412776 127418115

TROS:

130545075(fgf2)

TDW:	130437687(fgf2)

MANU:

129421766(fgf2)

PDAB:

135761514(fgf2)

IPU:

108258196

IFU:	128623094(fgf2)

PHYP:

113528646

SMEO:

124396724(fgf2)

TFD:	113659263(fgf2)

TVC:	132861733(fgf2)

CGAR:

128544192(fgf2)

NGRA:

132868384(fgf2)

TRN:	134336086(fgf2)

AMEX:

103037892(fgf2)

CMAO:

118821109(fgf2)

EEE:	113589363(fgf2)

CHAR:

105901770(fgf2)

SPIL:

134068719(fgf2)

ASAD:

121694529(fgf2)

TRU:	101071373 115252306

TFS:	130530886(fgf2)

TNG:	GSTEN00024480G001

LCO:	104931006(fgf2)

NCC:	104957748(fgf2)

TBEN:

117485247(fgf2)

CGOB:

115014705(fgf2)

PGEO:

117453594(fgf2)

GACU:

117535102(fgf2)

EMAC:

134859725(fgf2)

ELY:	117260751(fgf2)

EFO:	125894199(fgf2)

PLEP:

121947824(fgf2)

SLUC:

116062503(fgf2)

ECRA:

117951309(fgf2)

ESP:	116696412(fgf2)

PFLV:

114563146(fgf2)

GAT:	120817426(fgf2)

PPUG:

119210066(fgf2)

AFB:	129090393(fgf2)

CLUM:

117737301(fgf2)

PSWI:

130209937(fgf2)

CANA:

137796381(fgf2)

CVE:	137868495(fgf2)

MSAM:

119889114(fgf2)

SCHU:

122879892(fgf2)

CUD:	121516087(fgf2)

SPUL:

138598690(fgf2)

LMIX:

132981682(fgf2)

HTC:	141793640(fgf2)

ALAT:

119007245(fgf2)

ASTR:

137602782(fgf2)

MZE:	101483487(fgf2)

ONL:	100696875(fgf2)

OAU:	116322839(fgf2)

OML:	112151220(fgf2)

CSAI:

133447443(fgf2)

XMA:	102225642(fgf2)

XCO:	114139089(fgf2)

XHE:	116714813(fgf2)

PRET:

103471877(fgf2)

PFOR:

103137295(fgf2)

PLAI:

106948218(fgf2)

PMEI:

106924838(fgf2)

GAF:	122836704(fgf2)

PPRL:

129360495 129360508

CVG:	107099215(fgf2)

CTUL:

119798711(fgf2)

GMU:	124859969(fgf2)

NFU:	107380334(fgf2)

KMR:	108236605(fgf2)

NWH:	119408776(fgf2)

AOCE:

111570066(fgf2)

EJA:	138210339(fgf2)

BFRE:

138631521(fgf2)

MCEP:

125008184(fgf2)

CSEM:

103390695(fgf2)

POV:	109641290(fgf2)

SSEN:

122778971(fgf2)

SSOE:

131472090(fgf2)

HHIP:

117769009(fgf2)

HSP:	118112066(fgf2)

PPLT:

128445840(fgf2)

SMAU:

118319853(fgf2)

LCF:

108901525

SDU:	111232376(fgf2)

SLAL:

111644654(fgf2)

XGL:	120785334(fgf2)

HCQ:	109529054(fgf2)

SSCV:

125986786(fgf2)

SBIA:

133508314(fgf2)

PEE:	133408191(fgf2)

PTAO:

133484625(fgf2)

BPEC:

110153728(fgf2)

ENY:	140348891(fgf2)

MALB:

109956730(fgf2)

BSPL:

114864904(fgf2)

SJO:	128362565(fgf2)

SSCO:

133986263(fgf2)

TTY:	137189867(fgf2)

GMH:	115551974(fgf2)

SASA:

106604591 106611625(fgf2)

STRU:

115171295 115205150(fgf2)

OTW:	112244661 112256299(fgf2)

OMY:	100136280 110505088(fgf2)

OGO:	123993474 124010408

ONE:	115129521 115130781

OKI:	109864944 109905247(fgf2)

OKE:	118363560(fgf2) 118378991

OMM:	135526464 135545947(fgf2)

OCLA:

139366333 139391178

SALP:

111965796 111967553(fgf2)

SNH:	120048001 120062265

SFON:

129827931 129858163

CCLU:

121534224(fgf2) 121541760

ELS:	105028130(fgf2)

OEP:	134032064(fgf2)

SFM:	108938772(fgf2)

PKI:	111832812 111835519(fgf2)

AANG:

118226718 118231483(fgf2)

AROT:

135254560 135259510(fgf2)

CCOG:

133131120 133135440(fgf2)

LOC:	102692334(fgf2)

PSPA:

121323680(fgf2) 121328899

ARUT:

117409611 117421144

PSEX:

120527622(fgf2)

LCM:	102351407(FGF2)

CMK:	103188323(fgf2)

RTP:	109916889(fgf2)

CPLA:

122539338(fgf2)

HOC:	132833422(fgf2)

SCAU:

119963362(fgf2)

LERI:

129704302(fgf2)

HAKA:

140726438(fgf2)

APLC:

OTU:

EPA:

ATEN:

ADF:

AMIL:

114947161 114957849 114964972 122959300 122959301 122959933

MCAZ:

138016772 138017058 138026863 138031234 138032974 138033789 138050764

MFOO:

137979911 137994443 138000436 138000478 138003103 138003897

PDAM:

SPIS:

HMG:

RES:

Reference

PMID:3780670

Authors

Abraham JA, Whang JL, Tumolo A, Mergia A, Friedman J, Gospodarowicz D, Fiddes JC

Title

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

Journal

EMBO J 5:2523-8 (1986)
DOI:10.1002/j.1460-2075.1986.tb04530.x

Sequence

[hsa:2247]

Reference

PMID:10716624

Authors

Okada-Ban M, Thiery JP, Jouanneau J

Title

Fibroblast growth factor-2.

Journal

Int J Biochem Cell Biol 32:263-7 (2000)
DOI:10.1016/S1357-2725(99)00133-8

Sequence

[hsa:2247]

LinkDB

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