KEGG   PATHWAY: cabi00230
Entry
cabi00230                   Pathway                                
Name
Purine metabolism - Chelonoidis abingdonii (Abingdon island giant tortoise)
Class
Metabolism; Nucleotide metabolism
Pathway map
cabi00230  Purine metabolism
cabi00230

Module
cabi_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:cabi00230]
cabi_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:cabi00230]
cabi_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:cabi00230]
cabi_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:cabi00230]
cabi_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:cabi00230]
cabi_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:cabi00230]
cabi_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:cabi00230]
Other DBs
GO: 0006163 0042278
Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814731  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
116814801  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
116815112  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
116815325  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
116815676  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
116815880  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
116816451  PNP; purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
116816657  [KO:K12319] [EC:4.6.1.2]
116816745  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
116816929  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
116817086  [KO:K01466] [EC:3.5.2.5]
116817212  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
116817263  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
116817381  [KO:K01488] [EC:3.5.4.4]
116817646  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
116817690  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
116817716  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116817941  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
116818152  [KO:K11265] [EC:4.6.1.1]
116818537  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
116818576  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
116818944  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
116819001  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116819108  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
116819160  [KO:K01081] [EC:3.1.3.5]
116819520  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
116819535  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
116819572  [KO:K07127] [EC:3.5.2.17]
116819876  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
116819986  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
116820572  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
116821203  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
116823168  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116823359  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
116823406  [KO:K12319] [EC:4.6.1.2]
116823768  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
116824085  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
116824086  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
116824133  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
116824380  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
116824436  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
116824510  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
116824679  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
116824791  [KO:K13293] [EC:3.1.4.53]
116824822  [KO:K00939] [EC:2.7.4.3]
116825297  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
116825308  [KO:K00364] [EC:1.7.1.7]
116825488  NME3; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
116825535  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116825621  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
116825634  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
116825659  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
116825973  [KO:K00948] [EC:2.7.6.1]
116826015  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
116826225  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
116826786  [KO:K00088] [EC:1.1.1.205]
116826800  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
116826976  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116827004  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
116827259  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
116827304  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
116827539  [KO:K00940] [EC:2.7.4.6]
116827674  [KO:K01081] [EC:3.1.3.5]
116827794  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
116828095  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
116828284  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116828286  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116828360  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
116828369  [KO:K12324] [EC:4.6.1.2]
116828703  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
116828881  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
116829044  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
116829122  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
116829169  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
116829354  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
116830274  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
116830710  [KO:K01081] [EC:3.1.3.5]
116830876  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
116830928  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
116830980  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
116831018  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
116831134  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
116831153  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
116831237  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
116832051  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
116832171  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
116832177  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
116832284  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
116832408  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
116832574  HDDC2; HD domain-containing protein 2 isoform X1 [KO:K07023] [EC:3.1.3.89]
116832684  [KO:K22600] [EC:4.6.1.2]
116832717  NPR1; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
116833009  [KO:K00939] [EC:2.7.4.3]
116833029  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
116833336  [KO:K01081] [EC:3.1.3.5]
116833504  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
116833781  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
116834142  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
116834359  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
116834610  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
116834616  PPAT; amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
116834617  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
116834685  [KO:K13293] [EC:3.1.4.53]
116834742  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
116834849  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
116835120  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
116835360  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
116835408  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116835460  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
116835500  PGM2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
116835757  [KO:K00365] [EC:1.7.3.3]
116835765  [KO:K00365] [EC:1.7.3.3]
116835884  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
116835998  [KO:K01939] [EC:6.3.4.4]
116836040  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
116836184  AMPD2; LOW QUALITY PROTEIN: AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
116836566  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
116836827  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116836828  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116837016  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
116837504  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
116837667  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116837788  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
116838103  [KO:K01510] [EC:3.6.1.5]
116838107  [KO:K01510] [EC:3.6.1.5]
116838108  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
116838131  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
116838132  [KO:K12320] [EC:4.6.1.2]
116838329  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
116838330  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
116838534  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
116838556  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
116838704  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
116839023  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
116839051  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
116839373  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
116839407  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
116839656  GUCY2D; retinal guanylyl cyclase 1 isoform X1 [KO:K12321] [EC:4.6.1.2]
116839866  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
cabi00030  Pentose phosphate pathway
cabi00220  Arginine biosynthesis
cabi00250  Alanine, aspartate and glutamate metabolism
cabi00260  Glycine, serine and threonine metabolism
cabi00340  Histidine metabolism
cabi00630  Glyoxylate and dicarboxylate metabolism
cabi00730  Thiamine metabolism
cabi00740  Riboflavin metabolism
cabi00790  Folate biosynthesis
KO pathway
ko00230   

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