KEGG   PATHWAY: cbrc04820
Entry
cbrc04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Corvus brachyrhynchos (American crow)
Class
Cellular Processes; Cell motility
Pathway map
cbrc04820  Cytoskeleton in muscle cells
cbrc04820

Organism
Corvus brachyrhynchos (American crow) [GN:cbrc]
Gene
103611192  DES; desmin [KO:K07610]
103611245  TPM3; tropomyosin alpha-3 chain isoform X9 [KO:K09290]
103611277  THBS3; thrombospondin-3 [KO:K04659]
103611308  LMNA; lamin [KO:K12641]
103611408  MYOZ3; myozenin-3 [KO:K26050]
103611428  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
103611457  PDLIM7; LOW QUALITY PROTEIN: PDZ and LIM domain protein 7 [KO:K19867]
103611543  TPM2; tropomyosin beta chain isoform X4 [KO:K10374]
103611793  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
103611922  FMNL3; formin-like protein 3 [KO:K23957]
103612071  ITGA10; integrin alpha-10 [KO:K06586]
103612141  SYNE3; LOW QUALITY PROTEIN: nesprin-3 [KO:K21761]
103612267  VIM; vimentin [KO:K07606]
103612292  COL1A2; collagen alpha-2(I) chain [KO:K06236]
103612294  SGCE; epsilon-sarcoglycan isoform X2 [KO:K27061]
103612338  ITGA8; integrin alpha-8 [KO:K06584]
103612569  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
103612691  LBR; lamin-B receptor isoform X1 [KO:K19532] [EC:1.3.1.70]
103612761  COL11A1; LOW QUALITY PROTEIN: collagen alpha-1(XI) chain [KO:K19721]
103612792  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
103612800  COL3A1; collagen alpha-1(III) chain isoform X1 [KO:K19720]
103612811  ITGAV; integrin alpha-V [KO:K06487]
103613007  SDC2; syndecan-2 [KO:K16336]
103613105  FBLN1; fibulin-1 isoform X1 [KO:K17307]
103613228  SGCG; gamma-sarcoglycan [KO:K12564]
103613546  ITGB8; integrin beta-8 isoform X2 [KO:K06591]
103613742  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
103613857  MYH15; myosin-15 [KO:K24220]
103613884  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
103613958  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
103614037  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
103614081  [KO:K17751]
103614084  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
103614138  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
103614245  DAG1; dystroglycan [KO:K06265]
103614269  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
103614426  TMEM43; transmembrane protein 43 [KO:K27488]
103614458  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
103614554  [KO:K06255]
103614619  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
103614639  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
103614666  MYOT; myotilin [KO:K19875]
103614758  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
103614833  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
103615032  DMD; dystrophin isoform X1 [KO:K10366]
103615126  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
103615211  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
103615413  ACTB; actin, cytoplasmic 1 [KO:K05692]
103615439  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
103615473  MYH11; myosin-11 [KO:K10352]
103615644  SDC4; syndecan-4 [KO:K16338]
103615880  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
103615933  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103616191  CAPZB; LOW QUALITY PROTEIN: F-actin-capping protein subunit beta [KO:K10365]
103616230  SNTA1; LOW QUALITY PROTEIN: alpha-1-syntrophin [KO:K24063]
103616234  MYH7B; myosin-7B isoform X1 [KO:K24220]
103616277  NRAP; nebulin-related-anchoring protein [KO:K24421]
103616373  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
103616460  LMNB1; lamin-B1 [KO:K07611]
103616473  FBN2; fibrillin-2 [KO:K23342]
103616486  TNNT2; troponin T, cardiac muscle isoform X4 [KO:K12045]
103616487  TNNI1; troponin I, slow skeletal muscle isoform X1 [KO:K10371]
103616496  LMOD1; LOW QUALITY PROTEIN: leiomodin-1 [KO:K22030]
103616502  MYBPH; LOW QUALITY PROTEIN: myosin-binding protein H [KO:K24494]
103616509  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
103616625  ITGA4; integrin alpha-4 [KO:K06483]
103616627  TTN; titin [KO:K12567] [EC:2.7.11.1]
103616639  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103616783  FMNL2; formin-like protein 2 [KO:K23957]
103616786  NEB; LOW QUALITY PROTEIN: nebulin [KO:K18267]
103616825  MYOM3; myomesin-3 isoform X1 [KO:K24495]
103616877  FHL3; four and a half LIM domains protein 3 isoform X2 [KO:K24414]
103616908  TRIM63; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
103616953  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
103616999  ITGB3; integrin beta-3 [KO:K06493]
103617074  FMN2; formin-2 isoform X1 [KO:K02184]
103617164  ZYX; zyxin [KO:K06273]
103617370  TNNC2; troponin C, skeletal muscle [KO:K12042]
103617534  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
103617621  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
103617622  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
103617693  FBLN2; fibulin-2 [KO:K17307]
103617820  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
103617991  [KO:K24220]
103617996  MYH10; myosin-10 isoform X1 [KO:K10352]
103618001  [KO:K24220]
103618003  [KO:K24220]
103618005  [KO:K24220]
103618054  MYH9; myosin-9 [KO:K10352]
103618096  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
103618404  TPM1; tropomyosin alpha-1 chain isoform X3 [KO:K10373]
103618431  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
103618444  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
103618456  MYOM1; myomesin-1 isoform X1 [KO:K24495]
103618716  VCAN; LOW QUALITY PROTEIN: versican core protein [KO:K06793]
103618795  [KO:K17751]
103618809  SYNE2; LOW QUALITY PROTEIN: nesprin-2 [KO:K19346]
103618828  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X2 [KO:K04512]
103618901  NID2; nidogen-2 [KO:K06826]
103618935  ITGA11; integrin alpha-11 [KO:K06587]
103618942  ANK2; LOW QUALITY PROTEIN: ankyrin-2 [KO:K09255]
103619133  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
103619184  MYOM2; myomesin-2 isoform X1 [KO:K24495]
103619221  [KO:K27393]
103619421  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
103619449  SYNE1; nesprin-1 [KO:K19326]
103619491  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
103619562  PKP2; LOW QUALITY PROTEIN: plakophilin-2 [KO:K12642]
103619571  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
103619678  ITGB5; integrin beta-5 [KO:K06588]
103619785  [KO:K19721]
103619887  MYL4; myosin light chain 4 [KO:K12750]
103619926  COL1A1; collagen alpha-1(I) chain [KO:K06236]
103619928  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
103620065  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
103620067  [KO:K06115]
103620390  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
103620438  [KO:K10388]
103620610  NEBL; nebulette isoform X1 [KO:K25865]
103620654  LMNB2; lamin-B2 [KO:K07611]
103620671  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103620686  TMOD4; tropomodulin-4 [KO:K10370]
103620769  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
103620775  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
103620831  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
103620922  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
103620988  THBS1; thrombospondin-1 [KO:K16857]
103621084  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
103621175  FBN3; fibrillin-3 [KO:K23342]
103621183  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
103621242  [KO:K10370]
103621243  [KO:K10370]
103621258  [KO:K06825]
103621337  [KO:K07611]
103621640  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
103621652  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
103621682  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
103621727  ITGB4; integrin beta-4 [KO:K06525]
103621749  [KO:K24220]
103621804  [KO:K27382]
103621842  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
103621856  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
103622010  CSRP3; cysteine and glycine-rich protein 3 isoform X2 [KO:K09377]
103622050  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
103622070  SDC3; syndecan-3 [KO:K16337]
103622075  LMOD2; LOW QUALITY PROTEIN: leiomodin-2 [KO:K22030]
103622246  ENO1; alpha-enolase [KO:K01689] [EC:4.2.1.11]
103622295  AGRN; LOW QUALITY PROTEIN: agrin [KO:K06254]
103622471  SGCZ; zeta-sarcoglycan isoform X2 [KO:K27062]
103622488  PDLIM3; PDZ and LIM domain protein 3 isoform X2 [KO:K23353]
103622547  SGCB; beta-sarcoglycan [KO:K12566]
103622601  ACTG2; LOW QUALITY PROTEIN: actin, gamma-enteric smooth muscle [KO:K12315]
103622687  FMNL1; LOW QUALITY PROTEIN: formin-like protein 1 [KO:K23957]
103622798  FHL1; four and a half LIM domains protein 1 isoform X4 [KO:K14365]
103622866  SDC1; syndecan-1 [KO:K06257]
103622910  [KO:K19867]
103622911  [KO:K05692]
103623003  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
103623096  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
103623183  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X3 [KO:K06114]
103623197  COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721]
103623240  COL5A1; collagen alpha-1(V) chain [KO:K19721]
103623355  SSPN; sarcospan isoform X1 [KO:K22194]
103623517  SNTB1; beta-1-syntrophin [KO:K24064]
103623630  MYPN; myopalladin [KO:K22028]
103623646  ANK3; ankyrin-3 isoform X1 [KO:K09259]
103623658  LDB3; LIM domain-binding protein 3 isoform X10 [KO:K19867]
103623751  VCL; vinculin isoform X1 [KO:K05700]
103623914  MYL3; myosin light chain 3 [KO:K12749]
103623941  XIRP1; xin actin-binding repeat-containing protein 1 isoform X1 [KO:K27381]
103623968  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
103624028  ITGA1; integrin alpha-1 [KO:K06480]
103624030  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
103624077  ACTN2; alpha-actinin-2 isoform X9 [KO:K21073]
103624093  ACTA1; actin, alpha skeletal muscle [KO:K10354]
103624109  THBS2; thrombospondin-2 [KO:K04659]
103624153  NID1; LOW QUALITY PROTEIN: nidogen-1 [KO:K06826]
103624211  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
103624228  DSP; desmoplakin isoform X1 [KO:K10381]
103624256  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103624265  JUP; junction plakoglobin [KO:K10056]
103624322  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
103624330  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
103624340  FN1; fibronectin [KO:K05717]
103624385  LMOD3; leiomodin-3 isoform X1 [KO:K22030]
103624453  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
103624457  PDLIM1; PDZ and LIM domain protein 1 isoform X9 [KO:K23353]
103624506  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
103624645  ANKRD2; LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 2 [KO:K21434]
103624866  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
103624873  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
103624902  [KO:K17751]
103624933  TNNT3; LOW QUALITY PROTEIN: troponin T, fast skeletal muscle [KO:K12046]
103624935  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
103624983  DCN; decorin [KO:K04660]
103625278  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
103625371  ITGB6; LOW QUALITY PROTEIN: integrin beta-6 [KO:K06589]
103625453  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
103625480  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
103625517  DSC1; desmocollin-1 [KO:K07601]
103625518  DSG2; LOW QUALITY PROTEIN: desmoglein-2 [KO:K07597]
103625547  COMP; cartilage oligomeric matrix protein isoform X2 [KO:K04659]
108445371  [KO:K23958]
108447270  CAPZA3; LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-3 [KO:K10364]
108448451  SNTB2; beta-2-syntrophin [KO:K24064]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
cbrc04512  ECM-receptor interaction
cbrc04814  Motor proteins
KO pathway
ko04820   

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