KEGG   PATHWAY: cgob04110
Entry
cgob04110                   Pathway                                
Name
Cell cycle - Cottoperca gobio
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
cgob04110  Cell cycle
cgob04110

Other DBs
GO: 0000278
Organism
Cottoperca gobio [GN:cgob]
Gene
115003471  [KO:K13377]
115003528  [KO:K11268] [EC:2.3.1.-]
115003864  bub1; LOW QUALITY PROTEIN: mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
115004019  [KO:K11268] [EC:2.3.1.-]
115004030  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
115004483  [KO:K06670]
115004558  ppp2r5d; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
115004643  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
115005048  [KO:K04377]
115005055  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
115005386  [KO:K09993]
115005681  [KO:K23605]
115005844  [KO:K02540] [EC:5.6.2.3]
115005955  [KO:K25163]
115006030  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
115006246  [KO:K02213]
115006247  [KO:K02213]
115006280  cul1; LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
115006426  [KO:K21770]
115006427  [KO:K21770]
115006436  [KO:K21770]
115006935  [KO:K04402]
115007221  cdkn2c; cyclin-dependent kinase 4 inhibitor C isoform X1 [KO:K06622]
115007276  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
115007488  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
115007515  [KO:K03364]
115007721  [KO:K06625]
115007867  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
115008042  [KO:K10152]
115008789  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
115008801  espl1; LOW QUALITY PROTEIN: separin [KO:K02365] [EC:3.4.22.49]
115008867  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
115009127  [KO:K04503]
115009194  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
115009437  [KO:K10151]
115009522  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
115009849  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
115009868  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
115009895  [KO:K06632] [EC:2.7.11.1]
115009907  [KO:K06636]
115010090  [KO:K09993]
115010140  ticrr; LOW QUALITY PROTEIN: treslin [KO:K26117]
115010161  e2f4; transcription factor E2F4 [KO:K04682]
115010242  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
115010264  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
115010295  [KO:K04685]
115010530  [KO:K16197]
115010614  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
115010898  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
115011309  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
115011323  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
115011372  e2f1; transcription factor E2F1 [KO:K17454]
115011756  [KO:K10151]
115011901  [KO:K04498] [EC:2.3.1.48]
115011923  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
115012294  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
115012395  [KO:K02091] [EC:2.7.11.22]
115012523  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
115012676  [KO:K10151]
115012711  ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
115013014  anapc5; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 5 [KO:K03352]
115013165  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
115013217  ccnh; cyclin-H isoform X1 [KO:K06634]
115013268  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
115013326  nipbl; LOW QUALITY PROTEIN: nipped-B-like protein [KO:K06672]
115013358  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
115013399  [KO:K04402]
115013417  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
115013478  cdc45; cell division control protein 45 homolog [KO:K06628]
115013578  [KO:K11547]
115013659  [KO:K11547]
115014048  anapc7; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 7 [KO:K03354]
115014050  [KO:K04500]
115014051  [KO:K04500]
115014144  pcna; proliferating cell nuclear antigen [KO:K04802]
115014241  pttg1; securin [KO:K06635]
115014330  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
115014433  [KO:K06671]
115014446  [KO:K06671]
115014641  [KO:K04382] [EC:3.1.3.16]
115014648  [KO:K13376]
115014700  ccna2; cyclin-A2 isoform X1 [KO:K06627]
115014826  [KO:K11479] [EC:2.7.11.1]
115015177  mcm7; LOW QUALITY PROTEIN: DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
115015234  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
115015422  [KO:K06620]
115015442  [KO:K04501]
115015509  [KO:K16197]
115015613  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
115015648  rad21; double-strand-break repair protein rad21 homolog [KO:K06670]
115015732  cdca5; sororin [KO:K17390]
115015796  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
115016013  [KO:K06626]
115016094  [KO:K06067] [EC:3.5.1.98]
115016219  sgo1; shugoshin 1 isoform X1 [KO:K11580]
115016510  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
115016527  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
115016679  [KO:K04402]
115016775  [KO:K04402]
115016829  [KO:K06672]
115017178  [KO:K05868]
115017230  [KO:K04501]
115017387  [KO:K03456]
115017431  [KO:K16198]
115017522  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
115017554  [KO:K06630]
115017895  [KO:K13375]
115017921  [KO:K21770]
115018004  atm; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
115018826  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
115018840  [KO:K06671]
115018952  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
115018956  rb1; retinoblastoma-associated protein [KO:K06618]
115019047  ccna1; cyclin-A1 isoform X1 [KO:K06627]
115019061  [KO:K16198]
115019091  pds5b; LOW QUALITY PROTEIN: sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
115019207  [KO:K06630]
115019282  cdc23; cell division cycle protein 23 homolog [KO:K03355]
115019388  skp1; S-phase kinase-associated protein 1 [KO:K03094]
115019394  [KO:K10779]
115019567  [KO:K02606]
115019593  [KO:K04498] [EC:2.3.1.48]
115019604  [KO:K02606]
115019687  cdt1; DNA replication factor Cdt1 [KO:K10727]
115019840  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
115019890  [KO:K25163]
115020097  mad2l1bp; MAD2L1-binding protein [KO:K26093]
115020172  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
115020420  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
115021164  dbf4; protein DBF4 homolog A isoform X1 [KO:K06629]
115021269  mtbp; LOW QUALITY PROTEIN: mdm2-binding protein [KO:K26116]
115021414  [KO:K06626]
115021567  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
115021577  e2f3; transcription factor E2F3 [KO:K06620]
115021730  [KO:K16197]
115021737  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
115021810  [KO:K06670]
115021869  ttk; dual specificity protein kinase TTK [KO:K08866] [EC:2.7.12.1]
115021983  [KO:K03363]
115022231  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
115022834  [KO:K04682]
115022853  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
115022954  [KO:K03364]
115023092  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
115023102  [KO:K03364]
115023121  mcm4; DNA replication licensing factor MCM4 isoform X1 [KO:K02212] [EC:5.6.2.3]
115023137  orc2; origin recognition complex subunit 2 isoform X1 [KO:K02604]
115023499  ppp2r5b; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
115023621  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
115023713  [KO:K04451]
115023879  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K04681]
115024290  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
115024467  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
115024508  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
115024893  [KO:K04498] [EC:2.3.1.48]
115024932  [KO:K04682]
115025013  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
115025495  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
115025812  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
115025962  [KO:K06671]
115026019  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115026630  mad1l1; LOW QUALITY PROTEIN: mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
115026698  tfdp1; transcription factor Dp-1 [KO:K04683]
115026784  cdc16; cell division cycle protein 16 homolog [KO:K03353]
115027159  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
115027174  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
115027215  tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
115027307  [KO:K04402]
115027344  bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
115027420  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
115027466  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
115027496  stag1; cohesin subunit SA-1 [KO:K06671]
115027587  ywhaq; 14-3-3 protein theta [KO:K16197]
115027770  [KO:K06067] [EC:3.5.1.98]
115027812  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
115028149  [KO:K06625]
115028243  orc5; origin recognition complex subunit 5 [KO:K02607]
115028457  [KO:K06624]
115028528  [KO:K10151]
115028937  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
115028976  [KO:K11584]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
cgob03030  DNA replication
cgob04010  MAPK signaling pathway
cgob04120  Ubiquitin mediated proteolysis
cgob04210  Apoptosis
KO pathway
ko04110   

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