KEGG   PATHWAY: cgob04010
Entry
cgob04010                   Pathway                                
Name
MAPK signaling pathway - Cottoperca gobio
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cgob04010  MAPK signaling pathway
cgob04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Cottoperca gobio [GN:cgob]
Gene
115003471  [KO:K13377]
115003575  [KO:K16859]
115003585  dusp10; LOW QUALITY PROTEIN: dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
115003606  [KO:K04379]
115003607  [KO:K04379]
115003836  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
115004653  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
115004707  [KO:K04373] [EC:2.7.11.1]
115004842  [KO:K04373] [EC:2.7.11.1]
115004857  fgf4; fibroblast growth factor 4 [KO:K04358]
115004964  [KO:K04353]
115005048  [KO:K04377]
115005397  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115005436  [KO:K04853]
115005468  [KO:K04344]
115005482  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
115005557  [KO:K04454]
115005577  [KO:K04378]
115005674  map2k5; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
115005781  [KO:K04388] [EC:2.7.11.30]
115005792  [KO:K04375]
115005816  fgf3; fibroblast growth factor 3 [KO:K04358]
115005886  [KO:K04388] [EC:2.7.11.30]
115006097  [KO:K03283]
115006129  [KO:K07860]
115006162  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
115006184  [KO:K04359]
115006252  fgf19; fibroblast growth factor 19 [KO:K22603]
115006261  [KO:K04353]
115006528  [KO:K06268]
115006619  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115006668  [KO:K04372] [EC:2.7.11.1]
115006742  pdgfra; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
115006750  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
115006752  [KO:K16342] [EC:3.1.1.4]
115006808  [KO:K04527] [EC:2.7.10.1]
115006824  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
115006935  [KO:K04402]
115006950  kit; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
115007031  [KO:K04372] [EC:2.7.11.1]
115007076  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
115007113  kdr; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
115007203  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
115007241  map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
115007299  fgf22; fibroblast growth factor 22 [KO:K04358]
115007435  [KO:K04448]
115007473  [KO:K04347]
115007491  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
115007521  [KO:K04449]
115007592  faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
115007613  [KO:K05462]
115007738  cacna2d2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
115007757  [KO:K08774]
115007829  [KO:K04857]
115007899  [KO:K04353]
115007960  [KO:K04443] [EC:2.7.11.1]
115007966  [KO:K04441] [EC:2.7.11.24]
115008000  [KO:K05103] [EC:2.7.10.1]
115008038  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
115008089  [KO:K04859]
115008101  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
115008140  erbb3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
115008143  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
115008150  [KO:K04465]
115008314  [KO:K04860]
115008376  [KO:K04444] [EC:2.7.11.1]
115008416  [KO:K02582]
115008449  [KO:K04411]
115008458  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
115008542  [KO:K05465]
115008781  [KO:K04444] [EC:2.7.11.1]
115008836  [KO:K04393]
115008852  cacna1d; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
115009114  [KO:K04434]
115009147  [KO:K04861]
115009184  fgf6; fibroblast growth factor 6 [KO:K04358]
115009385  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
115009414  [KO:K04435]
115009461  kras; GTPase KRas [KO:K07827]
115009535  hras; GTPase HRas [KO:K02833]
115009546  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115009569  [KO:K17333]
115009626  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
115009719  [KO:K04349]
115009736  cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
115009747  hgf; hepatocyte growth factor [KO:K05460]
115009816  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
115009830  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
115009855  igf2; insulin-like growth factor II [KO:K13769]
115009993  kitlg; kit ligand isoform X1 [KO:K05461]
115010037  [KO:K04441] [EC:2.7.11.24]
115010056  [KO:K18018] [EC:3.1.3.48]
115010152  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
115010196  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
115010252  [KO:K22428]
115010449  [KO:K04393]
115010471  [KO:K04366] [EC:2.7.11.1]
115010496  [KO:K03283]
115010507  [KO:K04441] [EC:2.7.11.24]
115010596  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115010609  [KO:K04857]
115010612  [KO:K05084] [EC:2.7.10.1]
115010642  [KO:K04864]
115010677  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
115010687  epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
115010710  [KO:K04864]
115010778  [KO:K02582]
115010779  [KO:K02582]
115010783  [KO:K02677] [EC:2.7.11.13]
115010828  [KO:K18019] [EC:3.1.3.48]
115010976  casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
115011084  [KO:K04441] [EC:2.7.11.24]
115011263  [KO:K03158]
115011370  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115011375  [KO:K04443] [EC:2.7.11.1]
115011390  [KO:K04868]
115011424  [KO:K04423] [EC:2.7.11.25]
115011426  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
115011433  [KO:K04437]
115011622  [KO:K04392]
115011646  [KO:K02677] [EC:2.7.11.13]
115011693  [KO:K04345] [EC:2.7.11.11]
115011726  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
115011732  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
115011749  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
115011810  [KO:K04855]
115012036  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115012037  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
115012056  [KO:K04344]
115012147  [KO:K04358]
115012187  map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
115012209  [KO:K04364]
115012232  [KO:K04870]
115012254  [KO:K04371] [EC:2.7.11.24]
115012331  [KO:K07827]
115012343  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115012363  rras; ras-related protein R-Ras [KO:K07830]
115012366  dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
115012370  [KO:K02583]
115012463  pla2g4c; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
115012513  [KO:K04866]
115012614  [KO:K04347]
115012637  [KO:K04433] [EC:2.7.12.2]
115012736  atf4; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
115012768  [KO:K04359]
115012791  [KO:K04466] [EC:2.7.11.25]
115012819  [KO:K04869]
115012840  cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
115012934  [KO:K04849]
115013012  [KO:K04362] [EC:2.7.10.1]
115013216  rasa1; ras GTPase-activating protein 1 [KO:K04352]
115013223  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
115013251  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
115013355  il1b; interleukin-1 beta [KO:K04519]
115013356  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
115013399  [KO:K04402]
115013460  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
115013545  fgf10; fibroblast growth factor 10 [KO:K04358]
115013581  fgf17; fibroblast growth factor 17 [KO:K04358]
115013589  efna5; ephrin-A5 isoform X1 [KO:K05462]
115013664  [KO:K03173] [EC:2.3.2.27]
115013744  [KO:K05452]
115013794  [KO:K12326]
115013798  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
115013888  fgf5; fibroblast growth factor 5 [KO:K04358]
115014020  [KO:K04348] [EC:3.1.3.16]
115014112  ereg; proepiregulin [KO:K09784]
115014136  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115014137  taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
115014282  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
115014303  egf; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
115014313  [KO:K04348] [EC:3.1.3.16]
115014344  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
115014348  [KO:K04358]
115014370  [KO:K04358]
115014595  [KO:K05096] [EC:2.7.10.1]
115014635  [KO:K04358]
115014648  [KO:K13376]
115014680  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
115014681  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115014703  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
115014705  fgf2; fibroblast growth factor 2 [KO:K18497]
115014730  [KO:K18496]
115014733  pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
115014742  [KO:K04526]
115014745  [KO:K05091] [EC:2.7.10.1]
115014811  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
115014829  [KO:K04389]
115014913  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
115014922  [KO:K02187] [EC:3.4.22.56]
115015091  [KO:K04373] [EC:2.7.11.1]
115015104  [KO:K04440] [EC:2.7.11.24]
115015125  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
115015171  [KO:K04358]
115015179  vegfb; vascular endothelial growth factor B [KO:K05448]
115015182  [KO:K04358]
115015304  [KO:K05462]
115015367  [KO:K04393]
115015457  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
115015593  [KO:K04873]
115015600  daxx; death domain-associated protein 6 [KO:K02308]
115015630  [KO:K05466]
115015637  [KO:K04412]
115015660  [KO:K03156]
115015805  [KO:K04872]
115015930  [KO:K04381]
115015961  [KO:K05462]
115016058  angpt1; angiopoietin-1 [KO:K05465]
115016101  [KO:K04446]
115016186  [KO:K04871]
115016433  traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
115016440  [KO:K12326]
115016445  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115016617  [KO:K05452]
115016623  crkl; crk-like protein [KO:K04438]
115016627  [KO:K04440] [EC:2.7.11.24]
115016679  [KO:K04402]
115016775  [KO:K04402]
115016796  [KO:K04455]
115016821  [KO:K04448]
115016833  [KO:K04849]
115016852  [KO:K03173] [EC:2.3.2.27]
115016863  [KO:K05449]
115016885  [KO:K04360] [EC:2.7.10.1]
115016897  [KO:K05462]
115016903  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
115016975  [KO:K03156]
115017102  [KO:K04429] [EC:2.7.11.1]
115017290  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
115017293  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
115017317  [KO:K04420] [EC:2.7.11.25]
115017440  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
115017458  [KO:K09253]
115017484  [KO:K04429] [EC:2.7.11.1]
115017525  [KO:K04456] [EC:2.7.11.1]
115017545  rasa2; ras GTPase-activating protein 2 [KO:K08053]
115017571  [KO:K03283]
115017848  pak1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
115017856  [KO:K05093] [EC:2.7.10.1]
115017865  [KO:K19662] [EC:2.7.11.13]
115017895  [KO:K13375]
115017907  [KO:K04438]
115017913  nf1; neurofibromin isoform X1 [KO:K08052]
115017933  [KO:K05093] [EC:2.7.10.1]
115017944  [KO:K05085] [EC:2.7.10.1]
115017947  [KO:K04457] [EC:3.1.3.16]
115018000  map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
115018066  arrb1; beta-arrestin-1 [KO:K04439]
115018222  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
115018298  [KO:K04350]
115018474  [KO:K16510] [EC:2.7.11.1]
115018537  [KO:K04348] [EC:3.1.3.16]
115018552  [KO:K04439]
115018585  ins; insulin [KO:K04526]
115018604  [KO:K04456] [EC:2.7.11.1]
115018605  [KO:K04429] [EC:2.7.11.1]
115018698  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
115018832  [KO:K05090] [EC:2.7.10.1]
115019083  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
115019204  [KO:K04438]
115019250  [KO:K04865]
115019289  [KO:K04455]
115019308  [KO:K04457] [EC:3.1.3.16]
115019345  fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
115019444  [KO:K05089] [EC:2.7.10.1]
115019677  srf; serum response factor isoform X1 [KO:K04378]
115019686  [KO:K04390]
115019690  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
115019699  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
115019711  [KO:K06268]
115019820  [KO:K04456] [EC:2.7.11.1]
115019839  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
115019930  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
115019941  [KO:K04467] [EC:2.7.11.10]
115019949  angpt2; angiopoietin-2 [KO:K05466]
115020020  [KO:K17534] [EC:2.7.11.25]
115020027  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
115020041  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115020095  [KO:K04358]
115020429  [KO:K05459]
115020482  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
115020751  [KO:K04393]
115020771  [KO:K05462]
115020780  [KO:K02583]
115021104  [KO:K04393]
115021117  [KO:K03283]
115021190  [KO:K19663] [EC:2.7.11.13]
115021284  [KO:K04381]
115021489  [KO:K04426] [EC:2.7.11.25]
115021524  efna1; ephrin-A1 [KO:K05462]
115021567  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
115021582  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
115021671  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
115021761  [KO:K05448]
115021786  [KO:K04873]
115021793  [KO:K05462]
115021818  [KO:K04872]
115021892  [KO:K04446]
115022136  [KO:K04424] [EC:2.7.11.25]
115022186  [KO:K04345] [EC:2.7.11.11]
115022485  [KO:K04361] [EC:2.7.10.1]
115022522  [KO:K04369] [EC:2.7.12.2]
115022533  [KO:K04347]
115022612  [KO:K04852]
115022770  [KO:K25415]
115022820  [KO:K04527] [EC:2.7.10.1]
115022911  nrtn; neurturin [KO:K25414]
115022963  jun; transcription factor AP-1 [KO:K04448]
115023074  [KO:K04449]
115023092  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
115023413  ecsit; LOW QUALITY PROTEIN: evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
115023434  [KO:K04439]
115023463  [KO:K04735]
115023498  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
115023572  [KO:K04419] [EC:2.7.11.25]
115023659  pea15; astrocytic phosphoprotein PEA-15 [KO:K29115]
115023668  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
115023688  [KO:K04348] [EC:3.1.3.16]
115023713  [KO:K04451]
115024164  [KO:K04466] [EC:2.7.11.25]
115024221  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
115024223  [KO:K04461] [EC:3.1.3.16]
115024277  [KO:K05083] [EC:2.7.10.1]
115024278  [KO:K04429] [EC:2.7.11.1]
115024297  [KO:K02583]
115024389  [KO:K04430] [EC:2.7.12.2]
115024458  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115024543  [KO:K04440] [EC:2.7.11.24]
115024590  [KO:K04433] [EC:2.7.12.2]
115024627  [KO:K04464] [EC:2.7.11.24]
115024640  [KO:K04467] [EC:2.7.11.10]
115024904  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
115025050  [KO:K04380]
115025061  fgf21; fibroblast growth factor 21 isoform X1 [KO:K22429]
115025083  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
115025090  [KO:K04349]
115025303  cacnb2; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
115025332  [KO:K04421] [EC:2.7.11.25]
115025365  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
115025366  flt3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
115025450  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
115025518  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
115025720  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
115025807  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
115025812  myc; myc proto-oncogene protein isoform X1 [KO:K04377]
115025996  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
115026075  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
115026094  [KO:K05085] [EC:2.7.10.1]
115026107  mras; ras-related protein M-Ras [KO:K07831]
115026283  fgf7; fibroblast growth factor 7 [KO:K04358]
115026508  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
115026620  map3k13; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
115026677  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
115026717  [KO:K04358]
115026836  [KO:K04407] [EC:2.7.11.1]
115026861  [KO:K04386]
115026969  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
115026992  [KO:K16859]
115027042  [KO:K04373] [EC:2.7.11.1]
115027139  [KO:K05094] [EC:2.7.10.1]
115027161  [KO:K04445] [EC:2.7.11.1]
115027215  tgfb3; LOW QUALITY PROTEIN: transforming growth factor beta-3 proprotein [KO:K13377]
115027245  [KO:K03099]
115027307  [KO:K04402]
115027368  [KO:K05462]
115027399  [KO:K04379]
115027438  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
115027612  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
115027720  [KO:K04456] [EC:2.7.11.1]
115027785  map3k9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
115027812  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
115027838  [KO:K04453]
115028087  [KO:K04858]
115028088  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
115028206  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
115028254  igf1; insulin-like growth factor I [KO:K05459]
115028294  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
115028334  [KO:K04441] [EC:2.7.11.24]
115028355  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
115028365  [KO:K04441] [EC:2.7.11.24]
115028375  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
115028426  [KO:K05461]
115028547  ntf3; neurotrophin-3 [KO:K04356]
115028556  fgf23; fibroblast growth factor 23 [KO:K22428]
115028558  [KO:K04358]
115028611  [KO:K05460]
115028760  [KO:K04453]
115028848  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
115028876  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115028960  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cgob04020  Calcium signaling pathway
cgob04070  Phosphatidylinositol signaling system
cgob04110  Cell cycle
cgob04115  p53 signaling pathway
cgob04210  Apoptosis
cgob04310  Wnt signaling pathway
KO pathway
ko04010   

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