KEGG   PATHWAY: cimi04140
Entry
cimi04140                   Pathway                                
Name
Autophagy - animal - Cebus imitator (Panamanian white-faced capuchin)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
cimi04140  Autophagy - animal
cimi04140

Other DBs
GO: 0006914
Organism
Cebus imitator (Panamanian white-faced capuchin) [GN:cimi]
Gene
108281663  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
108281936  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
108282363  [KO:K02927]
108282623  [KO:K02927]
108282680  [KO:K04368] [EC:2.7.12.2]
108283281  [KO:K02977]
108283333  MTMR3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108283399  [KO:K10802]
108283458  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108283503  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
108283580  ATG4D; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
108284017  RRAGA; ras-related GTP-binding protein A [KO:K16185]
108284112  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
108284210  [KO:K08341]
108284294  [KO:K04345] [EC:2.7.11.11]
108284461  RAB8A; ras-related protein Rab-8A [KO:K07901]
108284469  IGBP1; immunoglobulin-binding protein 1 [KO:K17606]
108284538  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108284560  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
108284634  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108284646  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
108284687  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
108284872  IRS2; insulin receptor substrate 2 [KO:K07187]
108285034  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
108285114  [KO:K02977]
108285562  [KO:K21246]
108285587  RAB33B; ras-related protein Rab-33B [KO:K07920]
108285700  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
108285792  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108286022  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108286678  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108286750  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
108287186  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108287732  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108288014  RRAGD; ras-related GTP-binding protein D [KO:K16186]
108288399  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108288453  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108288457  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
108288726  INS; insulin [KO:K04526]
108288775  ATG10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
108288791  HRAS; GTPase HRas isoform X1 [KO:K02833]
108288917  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
108289093  GORASP1; Golgi reassembly-stacking protein 1 isoform X3 [KO:K26797]
108289201  [KO:K07828]
108289450  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
108289783  NBR1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
108289803  BECN1; beclin-1 isoform X1 [KO:K08334]
108290361  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
108290397  [KO:K02977]
108290774  ATG4B; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
108290923  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
108290925  TSC2; tuberin isoform X1 [KO:K07207]
108291018  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
108291524  RAB7A; ras-related protein Rab-7a [KO:K07897]
108292019  AKT1S1; proline-rich AKT1 substrate 1 isoform X3 [KO:K16184]
108292033  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108292298  [KO:K02927]
108292349  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
108292571  BNIP3; LOW QUALITY PROTEIN: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
108292658  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
108292739  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
108292805  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
108293173  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
108293471  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108293472  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
108293490  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
108293812  YKT6; synaptobrevin homolog YKT6 [KO:K08516]
108294063  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
108294370  RAB39B; ras-related protein Rab-39B [KO:K07925]
108294420  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
108294450  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
108294521  [KO:K08770]
108294571  SUPT20HL1; LOW QUALITY PROTEIN: transcription factor SPT20 homolog-like 1 [KO:K21245]
108294874  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
108294997  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108295214  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
108295228  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
108295422  TSC1; hamartin [KO:K07206]
108295514  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108295573  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108295697  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
108296197  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108296211  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
108296293  RRAGC; ras-related GTP-binding protein C [KO:K16186]
108296669  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108296861  [KO:K20184]
108297103  [KO:K06528]
108297214  PRAP1; proline-rich acidic protein 1 [KO:K21250]
108297459  RHEB; GTP-binding protein Rheb [KO:K07208]
108297748  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
108297776  ATG9B; autophagy-related protein 9B [KO:K17907]
108297796  [KO:K08516]
108298372  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
108298389  RRAS; ras-related protein R-Ras [KO:K07829]
108299046  [KO:K02977]
108299074  [KO:K19730]
108299701  RAB1A; ras-related protein Rab-1A [KO:K07874]
108299971  [KO:K07830]
108300272  KRAS; GTPase KRas isoform X2 [KO:K07827]
108300628  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
108300786  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108301025  [KO:K21246]
108301162  NRAS; GTPase NRas isoform X2 [KO:K07828]
108301563  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
108301609  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
108302068  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
108302246  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
108303090  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
108303747  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
108303868  STX17; syntaxin-17 isoform X1 [KO:K08491]
108304112  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
108304185  MRAS; ras-related protein M-Ras [KO:K07831]
108304501  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
108304551  [KO:K08336]
108304605  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
108304629  [KO:K02927]
108304802  IRS1; insulin receptor substrate 1 [KO:K16172]
108304864  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
108304868  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
108304926  [KO:K16185]
108304989  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
108305153  EPG5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
108305170  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
108305266  OPTN; optineurin isoform X1 [KO:K19946]
108305407  [KO:K02977]
108305537  [KO:K02977]
108305575  WDFY3; WD repeat and FYVE domain-containing protein 3 [KO:K22262]
108305750  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108305814  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108305935  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
108306132  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
108306168  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
108306503  [KO:K02977]
108306609  [KO:K08341]
108306695  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
108306798  [KO:K10802]
108306856  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108306883  BECN2; beclin-2 [KO:K08334]
108306951  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
108307144  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
108307607  UVRAG; UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
108307653  ATG16L2; protein Atg16l2 isoform X1 [KO:K20868]
108307684  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
108307790  STX7; syntaxin-7 [KO:K08488]
108308095  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
108308213  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
108308820  BIRC6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
108309036  [KO:K04345] [EC:2.7.11.11]
108309088  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
108309569  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108309821  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108310018  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
108310270  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
108310302  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108310354  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
108310419  HMGB1; high mobility group protein B1 [KO:K10802]
108310465  [KO:K08341]
108310631  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
108310829  SUPT20H; transcription factor SPT20 homolog isoform X11 [KO:K21245]
108310961  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
108311469  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108312053  MTMR4; myotubularin-related protein 4 isoform X2 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
108312073  VMP1; vacuole membrane protein 1 isoform X1 [KO:K21248]
108312078  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108312250  [KO:K10802]
108312258  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X2 [KO:K21348]
108312520  CTSB; cathepsin B isoform X2 [KO:K01363] [EC:3.4.22.1]
108312772  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108312849  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
108313251  ATG4C; cysteine protease ATG4C isoform X2 [KO:K08342] [EC:3.4.22.-]
108313818  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
108314512  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
108314621  [KO:K17606]
108314631  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
108314738  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
108314880  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
108315123  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
108315158  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
108315696  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108315748  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
108315802  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
108315963  [KO:K02977]
108316111  ATG101; autophagy-related protein 101 [KO:K19730]
108316554  ATG4A; cysteine protease ATG4A isoform X1 [KO:K08342] [EC:3.4.22.-]
108316556  IRS4; insulin receptor substrate 4 [KO:K17446]
108316991  DAPK1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
108316997  CTSL; procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
108317379  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
108317391  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
108317591  [KO:K21250]
108318076  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
108318322  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
119468660  [KO:K03237]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
cimi04010  MAPK signaling pathway
cimi04141  Protein processing in endoplasmic reticulum
cimi04142  Lysosome biogenesis
cimi04150  mTOR signaling pathway
cimi04152  AMPK signaling pathway
cimi04910  Insulin signaling pathway
KO pathway
ko04140   

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