KEGG ORTHOLOGY: K23611

ORTHOLOGY: K23611

Entry

K23611                      KO

Symbol

SMCR8

Name

guanine nucleotide exchange protein SMCR8

Pathway

map04140

Autophagy - animal

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K23611  SMCR8; guanine nucleotide exchange protein SMCR8
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K23611  SMCR8; guanine nucleotide exchange protein SMCR8
   05022 Pathways of neurodegeneration - multiple diseases
    K23611  SMCR8; guanine nucleotide exchange protein SMCR8
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K23611  SMCR8; guanine nucleotide exchange protein SMCR8
Membrane trafficking [BR:ko04131]
Autophagy
  Other autophagy associated proteins
   Rab associated proteins
    K23611  SMCR8; guanine nucleotide exchange protein SMCR8

Genes

HSA:	140775(SMCR8)

PTR:	743260(SMCR8)

PPS:	100969931(SMCR8)

GGO:	101153485(SMCR8)

PON:	100441513(SMCR8)

PPYG:

129018033(SMCR8)

NLE:	100595941(SMCR8)

HMH:	116484034(SMCR8)

SSYN:

129462224(SMCR8)

MCC:	701074(SMCR8)

MCF:	102121961(SMCR8)

MTHB:

126939025

MNI:	105491047(SMCR8)

CSAB:

103242490(SMCR8)

CATY:

105598217(SMCR8)

PANU:

101021465(SMCR8)

TGE:	112609196(SMCR8)

MLEU:

105536018(SMCR8)

RRO:	104665857(SMCR8)

RBB:	108516620(SMCR8)

TFN:	117074641(SMCR8)

PTEH:

111526162(SMCR8)

CANG:

105525856(SMCR8)

CJC:	100394718(SMCR8)

SBQ:	101048432(SMCR8)

CIMI:

108293472(SMCR8)

ANAN:

105707727(SMCR8)

CSYR:

103264921(SMCR8)

MMUR:

105861975(SMCR8)

LCAT:

123621103(SMCR8)

PCOQ:

105826962(SMCR8)

OGA:	100960281(SMCR8)

MMU:	237782(Smcr8)

MCAL:

110305223(Smcr8)

MPAH:

110331543(Smcr8)

RNO:	497918(Smcr8)

MCOC:

116079133(Smcr8)

ANU:	117710460(Smcr8)

ASYL:

127695180(Smcr8)

MUN:	110561681(Smcr8)

CGE:	100772792(Smcr8)

MAUA:

101839715(Smcr8)

PROB:

127219184(Smcr8)

PLEU:

114683270(Smcr8)

MORG:

121457166(Smcr8)

MFOT:

126514661

AAMP:

119813354(Smcr8)

NGI:	103724827(Smcr8)

HGL:	101696614(Smcr8)

CPOC:

100733304(Smcr8)

CCAN:

109688188(Smcr8)

DORD:

105985826(Smcr8)

DSP:	122103226(Smcr8)

DMER:

138830807(Smcr8)

PLOP:

125366185(Smcr8)

NCAR:

124980778

MMMA:

107157191(Smcr8)

ITI:	101968094(Smcr8)

OPI:	101534190(SMCR8)

OCZ:	121152441(SMCR8)

TUP:	102472641(SMCR8)

GVR:	103585298(SMCR8)

CLUD:

112647262(SMCR8)

VVP:	112924951(SMCR8)

VLG:	121499622(SMCR8)

NPO:	129497260(SMCR8)

AML:	100472274(SMCR8)

UMR:	103658543(SMCR8)

UAH:	113271285(SMCR8)

UAR:	123779771(SMCR8)

ELK:

111139265

LLV:

125087935

MPUF:

101670526(SMCR8)

MNP:	132004146(SMCR8)

MLK:	131816748(SMCR8)

NVS:	122906870(SMCR8)

ORO:	101369745(SMCR8)

EJU:	114198194(SMCR8)

ZCA:	113908023(SMCR8)

MLX:	118000137(SMCR8)

NSU:	110584557(SMCR8)

LWW:	102733633(SMCR8)

FCA:	101099338(SMCR8)

PYU:	121015817(SMCR8)

PCOO:

112857149(SMCR8)

PBG:	122485034(SMCR8)

PVIV:

125151979(SMCR8)

LRUF:

124519586

LGF:	123603108(SMCR8)

AJU:

106981397

PTG:	102956182(SMCR8)

PPAD:

109245784(SMCR8)

PUC:

125926947

PLEZ:

122205841(SMCR8)

HHV:	120228731(SMCR8)

BTA:	781661(SMCR8)

BOM:	102274044(SMCR8)

BIU:	109573266(SMCR8)

BBUB:

102407942(SMCR8)

BBIS:

104990669(SMCR8)

CHX:	102191734(SMCR8)

OAS:	101120176(SMCR8)

BTAX:

128064415(SMCR8)

CSUM:

138084807(SMCR8)

ODA:	120867396(SMCR8)

CCAD:

122444014(SMCR8)

MREE:

136149022(SMCR8)

OVR:	110150968(SMCR8)

MBEZ:

129544213(SMCR8)

SSC:	100620365(SMCR8)

CFR:	102506594(SMCR8)

CBAI:

105083438(SMCR8)

CDK:	105100568(SMCR8)

VPC:	102533376(SMCR8)

BACU:

103007136(SMCR8)

BMUS:

118886574(SMCR8)

LVE:	103076144(SMCR8)

OOR:	101281225(SMCR8)

LALB:

132511762(SMCR8)

GMF:	115855757(SMCR8)

DDP:	132414606(SMCR8)

DLE:	111167764(SMCR8)

PCAD:

102976081(SMCR8)

PSIU:

116745223(SMCR8)

PPHC:

136138907(SMCR8)

NASI:

112405423(SMCR8)

ECB:	100050558(SMCR8)

EPZ:	103559088(SMCR8)

EAI:	106837924(SMCR8)

MYB:	102241859(SMCR8)

MYD:	102770227(SMCR8)

MMYO:

118649395(SMCR8)

MLF:	102441169(SMCR8)

MDT:	132217927(SMCR8)

MYUM:

138994798(SMCR8)

PKL:	118726738(SMCR8)

EFUS:

103299357(SMCR8)

MNA:	107524527(SMCR8)

DRO:	112308427(SMCR8)

SHON:

119002708(SMCR8)

AJM:	119062239(SMCR8)

PDIC:

114515011(SMCR8)

PHAS:

123809199(SMCR8)

MMF:	118641312(SMCR8)

PPAM:

129068762(SMCR8)

HAI:	109390331(SMCR8)

RFQ:	117012830(SMCR8)

PALE:

102879073(SMCR8)

PGIG:

120589855(SMCR8)

PVP:	105291321(SMCR8)

RAY:	107511080(SMCR8)

MJV:	108395478 118972607

TOD:	119230449(SMCR8)

SARA:

101538737(SMCR8)

SFUM:

130044425(SMCR8)

SETR:

126013668(SMCR8)

LAV:	100670084(SMCR8)

TMU:

101349459

ETF:	101645881(SMCR8)

DNM:	101415011(SMCR8)

MDO:	100015486(SMCR8)

GAS:	123231316(SMCR8)

SHR:	100924626(SMCR8)

PCW:	110194807(SMCR8)

TVP:	118832678(SMCR8)

PBRV:

138161080(SMCR8)

MLAO:

141502745(SMCR8)

OAA:	100078736(SMCR8)

TACU:

119942789(SMCR8)

GGA:	416519(SMCR8)

PCOC:

116237555(SMCR8)

MGP:	100545693(SMCR8)

CJO:	107320579(SMCR8)

TPAI:

128079274(SMCR8)

LMUT:

125700616(SMCR8)

NMEL:

110405615(SMCR8)

APLA:

101791532(SMCR8)

ACYG:

106032191(SMCR8)

CATA:

118256363(SMCR8)

AFUL:

116495429(SMCR8)

TGU:	100225140(SMCR8)

LSR:	110481475(SMCR8)

SCAN:

103817833(SMCR8)

PMOA:

120512942(SMCR8)

OTC:	121334488(SMCR8)

PRUF:

121350770(SMCR8)

ATRC:

139597990(SMCR8)

GFR:	102042195(SMCR8)

FAB:	101819500(SMCR8)

OMA:	130259260(SMCR8)

PHI:	102114113(SMCR8)

PMAJ:

107211102(SMCR8)

CCAE:

111936150(SMCR8)

CCW:	104684769(SMCR8)

CBRC:

103615390(SMCR8)

ACOE:

138118771(SMCR8)

ETL:	114065957(SMCR8)

ZAB:	102067216(SMCR8)

ZLE:	135454343(SMCR8)

ACHL:

103803433(SMCR8)

SVG:	106850135(SMCR8)

MMEA:

130582521(SMCR8)

HRT:	120759527(SMCR8)

SATI:

136367970(SMCR8)

CCIC:

134050522(SMCR8)

FPG:	101921772(SMCR8)

FCH:	102055186(SMCR8)

CCRI:

104157493(SMCR8)

NNT:	104401151(SMCR8)

SHAB:

115606760(SMCR8)

ACUN:

113485551(SMCR8)

TALA:

104364387(SMCR8)

ACHC:

115335827(SMCR8)

HALD:

104325365(SMCR8)

HLE:	104833617(SMCR8)

AGEN:

126033916

HHAR:

128134641(SMCR8)

GCL:

127022666

CSTI:

104558379(SMCR8)

LDI:	104339857(SMCR8)

MNB:	103779513(SMCR8)

DPUB:

104297506(SMCR8)

PPUS:

135180793(SMCR8)

AVIT:

104280198(SMCR8)

BRHI:

104501395(SMCR8)

EGZ:	104135757(SMCR8)

NNI:	104015124(SMCR8)

PCRI:

104029493(SMCR8)

PCAO:

104045277(SMCR8)

PADL:

103921425(SMCR8)

AFOR:

103904911(SMCR8)

FGA:	104078824(SMCR8)

CBOR:

142089243(SMCR8)

GSTE:

104263483(SMCR8)

CBOY:

140659259(SMCR8)

MAME:

142416222(SMCR8)

CLV:	102094907(SMCR8)

CNIC:

135994513(SMCR8)

MUI:	104536976(SMCR8)

PGUU:

104462690(SMCR8)

PLET:

104616663(SMCR8)

EHS:	104512384(SMCR8)

CMAC:

104482626(SMCR8)

CUCA:

104060393(SMCR8)

TEO:	104379665(SMCR8)

BREG:

104641210(SMCR8)

OHA:	104327452(SMCR8)

ACAR:

104521284(SMCR8)

CPEA:

104394044(SMCR8)

CVF:	104289594(SMCR8)

RTD:	128913608(SMCR8)

CRID:

134520232(SMCR8)

LMIC:

141748050(SMCR8)

AAM:	106492932(SMCR8)

AROW:

112974298(SMCR8)

NPD:	112959753(SMCR8)

TGT:	104566237(SMCR8)

DNE:	112980374(SMCR8)

SCAM:

104139726(SMCR8)

ASN:	102387260(SMCR8)

AMJ:	102575405(SMCR8)

CPOO:

109314658(SMCR8)

GGN:	109294362(SMCR8)

PSS:	102445329(SMCR8)

CIZ:	142021468(SMCR8)

CMY:	102942739(SMCR8)

CCAY:

125644245(SMCR8)

DCC:	119862369(SMCR8)

CPIC:

101948851(SMCR8)

TST:	117883683(SMCR8)

CABI:

116814783(SMCR8)

MRV:	120373259(SMCR8)

ACS:	100567619(smcr8)

ASAO:

132782107(SMCR8)

PVT:	110090793(SMCR8)

SUND:

121914182(SMCR8)

PBI:	103064583(SMCR8)

PMUR:

107289126(SMCR8)

CTIG:

120319282(SMCR8)

TSR:	106553106(SMCR8)

PGUT:

117679511(SMCR8)

PCAE:

139325340(SMCR8)

APRI:

131185118(SMCR8)

PTEX:

113438847(SMCR8)

NSS:	113422344(SMCR8)

VKO:	123025046(SMCR8)

PMUA:

114584609(SMCR8)

PRAF:

128401318(SMCR8)

ZVI:	118092699(SMCR8)

HCG:	128336489(SMCR8)

GJA:	107108722(SMCR8)

STOW:

125430999(SMCR8)

EMC:	129340659(SMCR8)

XLA:	108701680(smcr8.L) 108703233(smcr8.S)

XTR:	100486182(smcr8)

NPR:	108797675(SMCR8)

RTEM:

120943229(SMCR8)

ACAT:

141148714(SMCR8)

BBUF:

121008352(SMCR8)

BGAR:

122944830(SMCR8)

DTC:	141069133(SMCR8)

PWL:	138261293(SMCR8)

MUO:	115476383(SMCR8)

GSH:	117369187(SMCR8)

DRE:	407723(smcr8b) 558696(smcr8a)

SRX:	107720091 107722967 107725400 107737714

SANH:

107674654 107692669 107702539 107703424

SGH:	107564620 107581729 107590705 107591684

CCAR:

109047705(smcr8a) 109047714 109071813(smcr8b)

CAUA:

113044541 113049280 113078090

CGIB:

127948910 127951914 127952409

PTET:

122336349(smcr8a) 122346807(smcr8b)

LROH:

127162600(smcr8b) 127162982(smcr8a)

GRF:	141333831(smcr8a) 141336563(smcr8b)

OMC:	131536423(smcr8a) 131545616(smcr8b)

PPRM:

120490230(smcr8a)

RKG:	130091054(smcr8b) 130094995(smcr8a)

MAMB:

125269387(smcr8a) 125272695(smcr8b)

CIDE:

127509529 127510394

CERY:

137017768(smcr8a) 137032873(smcr8b)

MASI:

127443838 127450140 127451680

TROS:

130553641(smcr8b) 130562201(smcr8a)

TDW:	130413162(smcr8b) 130426731(smcr8a)

MANU:

129432780(smcr8a) 129444951(smcr8b)

PDAB:

135735762(smcr8b) 135746417(smcr8a)

IPU:	108257061(smcr8a) 108258855(smcr8b)

IFU:	128600222(smcr8a) 128601798(smcr8b)

PHYP:

113535818 113536003(smcr8)

SMEO:

124375982(smcr8a) 124378296(smcr8b)

TFD:	113640544(smcr8b) 113643971(smcr8a)

TVC:	132839703(smcr8b) 132863892(smcr8a)

CGAR:

128506119(smcr8b) 128519609(smcr8a)

NGRA:

132865999(smcr8b) 132900756(smcr8a)

TRN:	134307062(smcr8a) 134329413(smcr8b)

AMEX:

103033618(smcr8a) 103042343(smcr8b)

CMAO:

118798193(smcr8b) 118805703(smcr8a)

EEE:	113580905 113584954(smcr8)

CHAR:

105894504(smcr8b) 122129266(smcr8a)

SPIL:

134059086 134076351(smcr8a)

ASAD:

121704610(smcr8a)

TRU:	101070002 101078682 115248466

TFS:	130514721(smcr8a) 130526811

TNG:	GSTEN00011896G001 GSTEN00015749G001

LCO:	104921180 104932067(smcr8)

NCC:	104951183 104958634(smcr8)

TBEN:

117481610(smcr8b) 117493586(smcr8a)

CGOB:

115009597 115012717(smcr8)

PGEO:

117447667(smcr8b) 117451554(smcr8a)

GACU:

117534884(smcr8a) 117556135(smcr8b)

EMAC:

134864317(smcr8b) 134877635(smcr8a)

ELY:	117255570(smcr8b) 117268640(smcr8a)

EFO:	125879242(smcr8a) 125885806(smcr8b)

PLEP:

121941636(smcr8b) 121956767(smcr8a)

SLUC:

116042736(smcr8b) 116065240(smcr8a)

ECRA:

117952841(smcr8b) 117958047(smcr8a)

ESP:	116695098 116703100(smcr8)

PFLV:

114564789 114570361(smcr8)

GAT:	120825553(smcr8b) 120827415(smcr8a)

PPUG:

119218313(smcr8b) 119221125(smcr8a)

AFB:	129095679(smcr8b) 129099158(smcr8a)

CLUM:

117735224(smcr8b) 117735517(smcr8a)

PSWI:

130189243(smcr8a) 130190675(smcr8b)

CANA:

137786376(smcr8a) 137793359(smcr8b)

CVE:	137878572(smcr8a) 137892371(smcr8b)

MSAM:

119881859 119898725(smcr8b)

SCHU:

122870542(smcr8b)

CUD:	121508970(smcr8b) 121529102(smcr8a)

SPUL:

138595359(smcr8b) 138604148(smcr8a)

LMIX:

132953865(smcr8a) 132988117(smcr8b)

HTC:	141809914(smcr8a) 141811043(smcr8b)

ALAT:

119013284(smcr8a) 119019896(smcr8b)

ASTR:

137600122(smcr8b) 137609802(smcr8a)

MZE:	101466587 101477562(smcr8)

ONL:	100699914 102078765

OAU:	116327845(smcr8a) 116335292(smcr8b)

OLA:	101165127 101168121(smcr8)

OML:	112137200(smcr8b) 112146669(smcr8a)

CSAI:

133422120(smcr8a) 133441988(smcr8b)

XMA:	102220980 102235076(smcr8)

XCO:	114145225 114160226(smcr8)

XHE:	116719755 116735873(smcr8)

PRET:

103462186 103468467(smcr8)

PFOR:

103136363 103153431(smcr8)

PLAI:

106948330 106961609(smcr8)

PMEI:

106908074 106933459(smcr8)

GAF:	122822201(smcr8a) 122828985(smcr8b)

PPRL:

129363859(smcr8a) 129376784(smcr8b)

CVG:	107093106 107094096(smcr8) 107096515

CTUL:

119783717(smcr8b) 119799507(smcr8a)

GMU:	124862260 124864748 124868500(smcr8b)

NFU:	107376335(smcr8) 107388958

KMR:	108236049(smcr8a) 108241918(smcr8b)

ALIM:

106519627 106520674(smcr8)

NWH:	119422117(smcr8a) 119422983

AOCE:

111570335(smcr8a) 111576480(smcr8b)

EJA:	138198265(smcr8a) 138208890(smcr8b)

BFRE:

138615831(smcr8b) 138622507(smcr8a)

MCEP:

124998491(smcr8a) 125004435(smcr8b)

CSEM:

103383491(smcr8) 103393335

POV:	109641511(smcr8) 109642173

SSEN:

122770642 122785658(smcr8a)

SSOE:

131466945 131475949(smcr8a)

HHIP:

117766226(smcr8a) 117768425(smcr8b)

HSP:	118122333(smcr8b) 118123263(smcr8a)

PPLT:

128434584(smcr8b) 128458274(smcr8a)

SMAU:

118288695(smcr8a) 118311865(smcr8b)

LCF:	108877673(smcr8a) 108899377(smcr8b)

SDU:	111216673 111230342(smcr8)

SLAL:

111647577(smcr8) 111672937

XGL:	120788047(smcr8a) 120800264(smcr8b)

HCQ:	109511263 109527042(smcr8)

SSCV:

125968711(smcr8b) 125983122(smcr8a)

SBIA:

133506605(smcr8b) 133515121(smcr8a)

PEE:	133415246(smcr8a)

PTAO:

133465719(smcr8a) 133476657(smcr8b)

BPEC:

110153520 110162351(smcr8)

ENY:	140358725(smcr8a) 140377631

MALB:

109952653 109973292

BSPL:

114853422(smcr8b) 114860150(smcr8a)

SJO:	128377398(smcr8b) 128379036(smcr8a)

SSCO:

133999135(smcr8a) 134000783(smcr8b)

TTY:	137167907(smcr8a) 137180023(smcr8b)

GMH:	115531217 115539856

SASA:

106593225 106594291

STRU:

115184039 115188900 115188901

OTW:	112242362 112242395

OMY:	110512918 110516028 110516784 110519383

OGO:	124019949(smcr8a) 124021631 124022095

OKI:	109886658 109887588(smcr8) 116358882 116371837

OKE:	127919015 127923705(smcr8a) 127928281(smcr8b)

OMM:	135533721 135533776 135538764

OCLA:

139365274 139370005 139421678 139421679 139424246

SALP:

112078826

SFON:

129844785

CCLU:

121561275 121581843

ELS:	105029649 105030480(smcr8)

OEP:	134008946(smcr8b) 134039625(smcr8a)

SFM:	108926127 108941779

PKI:	111845532 111849117

AANG:

118216479 118220539

AROT:

135243359 135248217(smcr8b)

CCOG:

133113991(smcr8a) 133121767

LOC:	102697513(smcr8)

PSPA:

121301494 121331216

ARUT:

117417905 117431616

PSEX:

120542465(smcr8a)

LCM:	102351764(SMCR8)

CMK:	103185159(smcr8a)

RTP:	109928660(smcr8a)

CPLA:

122560790(smcr8a)

HOC:	132825489(smcr8a)

SCAU:

119978518

LERI:

129706637(smcr8a)

HAKA:

140735486(smcr8a)

PMRN:

116951487(SMCR8)

LRJ:	133340562(SMCR8)

BFO:

BBEL:

SPU:

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SKO:

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PVM:

PJA:

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PCLA:

PTRU:

HAZT:

DSV:

RSAN:

RMP:

VDE:

VJA:

SDM:

CEL:	CELE_R144.5(smcr-8)

CBR:

CBG_16529

CRQ:	GCK72_009904

LGI:	LOTGIDRAFT_232675

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

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CRG:

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CVN:

OED:

MYI:

PMAX:

AIRR:

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MMER:

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OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

AQU:

Reference

PMID:11997338

Authors

Bi W, Yan J, Stankiewicz P, Park SS, Walz K, Boerkoel CF, Potocki L, Shaffer LG, Devriendt K, Nowaczyk MJ, Inoue K, Lupski JR

Title

Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse.

Journal

Genome Res 12:713-28 (2002)
DOI:10.1101/gr.73702

Sequence

[hsa:140775]

LinkDB

DBGET integrated database retrieval system