KEGG   PATHWAY: dle04540
Entry
dle04540                    Pathway                                
Name
Gap junction - Delphinapterus leucas (beluga whale)
Description
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
dle04540  Gap junction
dle04540

Other DBs
GO: 0005921
Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162959  [KO:K07374]
111163019  TUBB6; tubulin beta-6 chain [KO:K07375]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111163074  [KO:K07374]
111164225  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
111164400  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
111164599  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111164686  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
111164991  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111165190  GJA1; gap junction alpha-1 protein [KO:K07372]
111165617  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111165653  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111165771  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111166066  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
111166070  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
111166674  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111166689  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
111166890  DRD2; D(2) dopamine receptor [KO:K04145]
111167557  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
111167562  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
111167618  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111167739  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111169371  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111169692  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111170121  [KO:K07374]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111170669  TUBB; tubulin beta chain [KO:K07375]
111171650  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111171848  [KO:K07374]
111171851  [KO:K07374]
111171924  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
111172295  ADRB1; beta-1 adrenergic receptor [KO:K04141]
111172539  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111174035  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
111174050  [KO:K07374]
111174051  [KO:K07374]
111174052  [KO:K07374]
111174169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111174368  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111174571  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111175000  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
111175327  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
111176582  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
111176583  [KO:K07374]
111176851  KRAS; GTPase KRas [KO:K07827]
111176861  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111176980  TUBB4B; tubulin beta-4B chain [KO:K07375]
111177336  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111177754  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
111178380  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111178556  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
111178692  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111179006  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
111179007  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
111179012  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
111179686  [KO:K07375]
111179996  NRAS; GTPase NRas [KO:K07828]
111180070  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
111180981  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111181308  TUBB2A; tubulin beta-2A chain [KO:K07375]
111181312  [KO:K07375]
111181588  GJD2; gap junction delta-2 protein [KO:K07373]
111181753  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111182232  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111182667  CSNK1D; casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111182917  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111183086  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111183352  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111183812  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111184199  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111184534  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111184956  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
111185250  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111185456  DRD1; D(1A) dopamine receptor [KO:K04144]
111186135  EGF; pro-epidermal growth factor [KO:K04357]
111186344  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111186724  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
111186741  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
111186746  [KO:K04632]
111187663  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00681  1-Acyl-sn-glycerol 3-phosphate
C00780  Serotonin
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
Reference
PMID:14506308
  Authors
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
  Title
Plasma membrane channels formed by connexins: their regulation and functions.
  Journal
Physiol Rev 83:1359-400 (2003)
DOI:10.1152/physrev.00007.2003
Reference
PMID:15033580
  Authors
Warn-Cramer BJ, Lau AF.
  Title
Regulation of gap junctions by tyrosine protein kinases.
  Journal
Biochim Biophys Acta 1662:81-95 (2004)
DOI:10.1016/j.bbamem.2003.10.018
Reference
PMID:9535909
  Authors
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
  Title
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
  Journal
J Biol Chem 273:9188-96 (1998)
DOI:10.1074/jbc.273.15.9188
Reference
PMID:10751659
  Authors
Roerig B, Feller MB.
  Title
Neurotransmitters and gap junctions in developing neural circuits.
  Journal
Brain Res Brain Res Rev 32:86-114 (2000)
DOI:10.1016/S0165-0173(99)00069-7
Reference
PMID:10873290
  Authors
Hatton GI.
  Title
Synaptic modulation of neuronal coupling.
  Journal
Cell Biol Int 22:765-80 (1998)
DOI:10.1006/cbir.1998.0386
Reference
PMID:12566218
  Authors
Cruciani V, Mikalsen SO.
  Title
Connexins, gap junctional intercellular communication and kinases.
  Journal
Biol Cell 94:433-43 (2002)
DOI:10.1016/S0248-4900(02)00014-X
Reference
PMID:15094344
  Authors
Giepmans BN.
  Title
Gap junctions and connexin-interacting proteins.
  Journal
Cardiovasc Res 62:233-45 (2004)
DOI:10.1016/j.cardiores.2003.12.009
Reference
PMID:15955302
  Authors
Laird DW.
  Title
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
  Journal
Biochim Biophys Acta 1711:172-82 (2005)
DOI:10.1016/j.bbamem.2004.09.009
Reference
PMID:15033579
  Authors
Peracchia C.
  Title
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
  Journal
Biochim Biophys Acta 1662:61-80 (2004)
DOI:10.1016/j.bbamem.2003.10.020
Reference
PMID:15033578
  Authors
Bukauskas FF, Verselis VK.
  Title
Gap junction channel gating.
  Journal
Biochim Biophys Acta 1662:42-60 (2004)
DOI:10.1016/j.bbamem.2004.01.008
Related
pathway
dle04010  MAPK signaling pathway
dle04020  Calcium signaling pathway
dle04060  Cytokine-cytokine receptor interaction
dle04070  Phosphatidylinositol signaling system
dle04080  Neuroactive ligand-receptor interaction
KO pathway
ko04540   

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