KEGG   PATHWAY: dle04010
Entry
dle04010                    Pathway                                
Name
MAPK signaling pathway - Delphinapterus leucas (beluga whale)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dle04010  MAPK signaling pathway
dle04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162753  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
111162913  CRKL; crk-like protein [KO:K04438]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111163124  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
111163180  FGF10; fibroblast growth factor 10 [KO:K04358]
111163214  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
111163216  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111163411  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
111163412  STMN1; stathmin [KO:K04381]
111163578  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111163585  KITLG; kit ligand isoform X1 [KO:K05461]
111163761  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111163906  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
111163990  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111164342  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
111164350  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
111164391  MYC; myc proto-oncogene protein [KO:K04377]
111164604  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
111164625  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
111164744  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
111164861  FGFR3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
111165229  RRAS2; ras-related protein R-Ras2 [KO:K07830]
111165554  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111165564  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
111165669  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
111165930  PSPN; persephin isoform X2 [KO:K25416]
111165931  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111166011  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111166030  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
111166036  NRTN; neurturin [KO:K25414]
111166060  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111166150  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111166300  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111166302  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111166330  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
111166426  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
111166610  JUND; transcription factor jun-D [KO:K04449]
111166674  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111166727  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
111166783  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111166804  NTRK2; BDNF/NT-3 growth factors receptor isoform X2 [KO:K04360] [EC:2.7.10.1]
111166813  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111167087  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
111167102  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111167112  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
111167113  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
111167284  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111167407  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
111167550  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
111167562  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
111167640  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111167700  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
111167739  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
111167745  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
111167945  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
111168108  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111168311  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
111168340  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
111168464  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X4 [KO:K04428] [EC:2.7.11.25]
111168922  VEGFD; vascular endothelial growth factor D [KO:K05449]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111169009  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111169035  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111169265  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111169371  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111169388  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X2 [KO:K04346]
111169490  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
111169643  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111169672  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
111169692  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111169850  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
111169895  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111170190  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
111170227  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111170265  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111170311  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111170417  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
111170477  EFNA2; ephrin-A2 [KO:K05462]
111170514  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
111170584  FLNA; filamin-A isoform X1 [KO:K04437]
111170605  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
111170618  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
111170657  TNF; tumor necrosis factor [KO:K03156]
111170662  [KO:K03283]
111170663  [KO:K03283]
111170664  [KO:K03283]
111170902  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111170922  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111170969  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111171309  [KO:K16858]
111171792  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
111172240  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111172258  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
111172314  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111172359  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111172396  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111172519  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111172624  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
111172703  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
111172760  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
111172872  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X3 [KO:K04424] [EC:2.7.11.25]
111172890  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
111173006  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
111173064  MAX; protein max isoform X1 [KO:K04453]
111173071  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
111173096  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111173342  VEGFC; vascular endothelial growth factor C [KO:K05449]
111173359  ANGPT2; angiopoietin-2 [KO:K05466]
111173401  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111173470  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111173523  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111173552  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111173604  FGF20; fibroblast growth factor 20 [KO:K04358]
111173743  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
111173766  RAP1B; ras-related protein Rap-1b [KO:K07836]
111173840  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
111173887  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
111173936  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
111173979  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
111174049  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
111174096  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111174247  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
111174274  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2 [KO:K04860]
111174277  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111174324  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111174347  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
111174353  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
111174812  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
111174847  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111174894  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
111175094  [KO:K04393]
111175159  FGF9; fibroblast growth factor 9 [KO:K04358]
111175185  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
111175188  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
111175710  ARTN; artemin [KO:K25415]
111175769  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
111175871  JUN; transcription factor AP-1 [KO:K04448]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111176157  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
111176232  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
111176238  FOS; proto-oncogene c-Fos [KO:K04379]
111176246  PGF; placenta growth factor isoform X1 [KO:K16859]
111176547  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
111176594  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111176641  FGF6; fibroblast growth factor 6 [KO:K04358]
111176642  FGF23; fibroblast growth factor 23 [KO:K22428]
111176649  NTF3; neurotrophin-3 [KO:K04356]
111176656  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111176775  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111176851  KRAS; GTPase KRas [KO:K07827]
111176963  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
111177009  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111177477  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
111177493  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111177653  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111177754  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
111178115  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
111178133  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
111178181  FGF16; fibroblast growth factor 16 [KO:K04358]
111178262  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111178380  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111178437  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111178438  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111178680  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
111178736  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111178738  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
111178847  SRF; serum response factor isoform X1 [KO:K04378]
111178866  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111179012  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
111179022  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111179104  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
111179107  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111179110  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111179228  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
111179252  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
111179292  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
111179609  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111179654  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111179772  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
111179820  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
111179848  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
111179989  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
111179996  NRAS; GTPase NRas [KO:K07828]
111180034  RAP1A; ras-related protein Rap-1A [KO:K04353]
111180064  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111180340  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
111180390  STK3; serine/threonine-protein kinase 3 [KO:K04412]
111180458  NTF4; neurotrophin-4 [KO:K12457]
111180518  RELB; transcription factor RelB [KO:K09253]
111180612  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
111180622  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
111180649  FGF21; fibroblast growth factor 21 [KO:K22429]
111180712  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
111180824  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111180858  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
111180893  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
111180895  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
111180981  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111180996  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
111181016  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
111181019  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
111181572  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
111181612  FGF7; fibroblast growth factor 7 [KO:K04358]
111181701  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
111181702  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
111181704  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
111181766  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
111181886  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111182019  HSPB1; heat shock protein beta-1 [KO:K04455]
111182167  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111182231  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
111182232  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111182539  CD14; monocyte differentiation antigen CD14 [KO:K04391]
111182584  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
111182605  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
111182681  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111182897  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111182917  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111182918  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
111182919  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
111182970  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111183039  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
111183085  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
111183086  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111183352  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111183521  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111183603  FGF3; fibroblast growth factor 3 [KO:K04358]
111183604  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
111183606  INS; insulin isoform X1 [KO:K04526]
111183745  RELA; transcription factor p65 isoform X1 [KO:K04735]
111183748  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
111183793  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
111183796  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
111183803  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
111183816  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
111183818  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
111183989  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
111184034  FGF19; fibroblast growth factor 19 [KO:K22603]
111184119  FGF4; fibroblast growth factor 4 [KO:K04358]
111184141  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
111184348  ANGPT4; angiopoietin-4 [KO:K05467]
111184400  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
111184512  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111184598  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
111184676  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
111184749  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111184766  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
111184782  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
111184868  ARRB1; beta-arrestin-1 isoform X4 [KO:K04439]
111184900  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111185133  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
111185148  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
111185473  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111185506  FGF18; fibroblast growth factor 18 [KO:K04358]
111185687  CRK; adapter molecule crk isoform X1 [KO:K04438]
111185721  NF1; neurofibromin isoform X1 [KO:K08052]
111185735  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
111185755  TP53; cellular tumor antigen p53 [KO:K04451]
111185955  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
111185994  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
111186018  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
111186075  FGF2; fibroblast growth factor 2 [KO:K18497]
111186135  EGF; pro-epidermal growth factor [KO:K04357]
111186212  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
111186216  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
111186225  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
111186344  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111186361  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186364  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186368  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
111186464  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111186550  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
111186607  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111186935  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
111187153  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
111187347  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111187373  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
111187377  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
111187389  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
111187492  IL1B; interleukin-1 beta [KO:K04519]
111187501  IL1A; interleukin-1 alpha [KO:K04383]
111187508  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111187587  FGF5; fibroblast growth factor 5 [KO:K04358]
111187609  EREG; proepiregulin [KO:K09784]
111187637  AREG; amphiregulin isoform X1 [KO:K09782]
111187803  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
111187819  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
111188083  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
111188120  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
dle04070  Phosphatidylinositol signaling system
dle04110  Cell cycle
dle04115  p53 signaling pathway
dle04210  Apoptosis
dle04310  Wnt signaling pathway
dle04668  TNF signaling pathway
KO pathway
ko04010   

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