KEGG   PATHWAY: dle04820
Entry
dle04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Delphinapterus leucas (beluga whale)
Class
Cellular Processes; Cell motility
Pathway map
dle04820  Cytoskeleton in muscle cells
dle04820

Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162981  MYOM1; myomesin-1 isoform X1 [KO:K24495]
111163079  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
111163281  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
111163348  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
111163350  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
111163413  MYOM3; myomesin-3 isoform X1 [KO:K24495]
111163556  MYH11; myosin-11 isoform X1 [KO:K10352]
111163621  DCN; decorin [KO:K04660]
111163923  NID1; nidogen-1 isoform X1 [KO:K06826]
111163929  ACTN2; alpha-actinin-2 [KO:K21073]
111163953  ACTA1; actin, alpha skeletal muscle isoform X1 [KO:K10354]
111164302  ITGA9; integrin alpha-9 [KO:K06585]
111164535  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
111164877  MYL5; myosin light chain 5 [KO:K12753]
111165064  [KO:K10388]
111165200  SNTB1; beta-1-syntrophin isoform X1 [KO:K24064]
111165297  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
111165780  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
111165781  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
111166081  COL5A3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
111166126  FBN3; fibrillin-3 isoform X1 [KO:K23342]
111166290  SGCA; alpha-sarcoglycan [KO:K12565]
111166388  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
111166398  JUP; junction plakoglobin [KO:K10056]
111166407  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
111166490  TCAP; telethonin [KO:K19879]
111166617  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
111166713  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
111166972  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
111166986  [KO:K01539] [EC:7.2.2.13]
111166987  [KO:K01539] [EC:7.2.2.13]
111167017  SYNE1; nesprin-1 isoform X1 [KO:K19326]
111167038  LMNA; lamin isoform X1 [KO:K12641]
111167157  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
111167247  CSRP2; cysteine and glycine-rich protein 2 isoform X1 [KO:K09377]
111167389  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
111167626  ANK3; ankyrin-3 isoform X1 [KO:K09259]
111167859  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
111167894  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
111168165  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
111168189  [KO:K06238]
111168235  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
111168261  LAMA2; laminin subunit alpha-2 [KO:K05637]
111168318  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
111168319  TNNI1; troponin I, slow skeletal muscle isoform X1 [KO:K10371]
111168323  CSRP1; cysteine and glycine-rich protein 1 isoform X1 [KO:K09377]
111168334  LMOD1; leiomodin-1 [KO:K22030]
111168402  DMD; dystrophin isoform X1 [KO:K10366]
111168754  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
111168806  FBLN2; fibulin-2 isoform X1 [KO:K17307]
111168853  TMEM43; transmembrane protein 43 [KO:K27488]
111169003  PDLIM2; LOW QUALITY PROTEIN: PDZ and LIM domain protein 2 [KO:K23353]
111169123  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
111169267  OBSCN; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
111169345  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
111169446  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
111169751  TMOD4; tropomodulin-4 [KO:K10370]
111169836  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
111169866  SGCB; beta-sarcoglycan [KO:K12566]
111169901  CUNH10orf71; cardiac-enriched FHL2-interacting protein [KO:K28413]
111170156  TNNC2; troponin C, skeletal muscle [KO:K12042]
111170203  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
111170236  ITGA2B; integrin alpha-IIb [KO:K06476]
111170317  [KO:K12046]
111170330  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
111170332  [KO:K12046]
111170344  ACTB; actin, cytoplasmic 1 [KO:K05692]
111170609  BGN; biglycan [KO:K08118]
111170610  EMD; emerin isoform X1 [KO:K12569]
111170921  LMNB2; lamin-B2 isoform X1 [KO:K07611]
111171621  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
111171639  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111171645  COL3A1; collagen alpha-1(III) chain [KO:K19720]
111171646  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
111171786  ITGB5; integrin beta-5 [KO:K06588]
111171803  FN1; fibronectin isoform X1 [KO:K05717]
111171858  DES; desmin [KO:K07610]
111171889  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
111171891  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
111171971  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111172083  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
111172288  NRAP; nebulin-related-anchoring protein [KO:K24421]
111172431  ANKRD2; ankyrin repeat domain-containing protein 2 isoform X1 [KO:K21434]
111172469  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
111172503  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
111172757  NEB; nebulin [KO:K18267]
111172762  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
111172869  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111172919  TTN; titin [KO:K12567] [EC:2.7.11.1]
111172949  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
111172955  XIRP2; xin actin-binding repeat-containing protein 2 isoform X1 [KO:K27381]
111173075  SYNE2; nesprin-2 isoform X1 [KO:K19346]
111173105  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
111173323  NID2; nidogen-2 [KO:K06826]
111173363  MYOM2; myomesin-2 isoform X1 [KO:K24495]
111173422  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
111173575  SGCZ; zeta-sarcoglycan [KO:K27062]
111173908  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
111173917  ITGA5; integrin alpha-5 [KO:K06484]
111173950  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
111174025  FMNL3; formin-like protein 3 isoform X3 [KO:K23957]
111174141  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
111174199  LMOD3; leiomodin-3 [KO:K22030]
111174393  DAG1; dystroglycan [KO:K06265]
111174466  MYL3; myosin light chain 3 [KO:K12749]
111174776  [KO:K09290]
111174958  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
111175038  SDC1; syndecan-1 [KO:K06257]
111175161  SGCG; gamma-sarcoglycan [KO:K12564]
111175483  SDC3; syndecan-3 isoform X1 [KO:K16337]
111175611  FHL3; four and a half LIM domains protein 3 [KO:K24414]
111175648  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
111176012  INF2; inverted formin-2 isoform X1 [KO:K23958]
111176114  SYNE3; nesprin-3 isoform X1 [KO:K21761]
111176383  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
111176384  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
111176527  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
111176537  PKP2; plakophilin-2 isoform X1 [KO:K12642]
111176699  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
111176859  SSPN; sarcospan isoform X1 [KO:K22194]
111177069  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
111177157  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
111177293  COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721]
111177302  ZYX; zyxin [KO:K06273]
111177515  LBR; delta(14)-sterol reductase LBR [KO:K19532] [EC:1.3.1.70]
111177617  TMOD2; tropomodulin-2 [KO:K10370]
111177620  TMOD3; tropomodulin-3 isoform X1 [KO:K10370]
111177685  TLN2; talin-2 isoform X1 [KO:K06271]
111177687  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
111177762  ITGA11; integrin alpha-11 [KO:K06587]
111178037  ITGB1; integrin beta-1 [KO:K05719]
111178044  NEBL; nebulette isoform X1 [KO:K25865]
111178094  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
111178108  VIM; vimentin [KO:K07606]
111178248  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
111178360  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
111178654  FLNC; filamin-C isoform X1 [KO:K27393]
111178669  COL11A2; LOW QUALITY PROTEIN: collagen alpha-2(XI) chain [KO:K19721]
111178779  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
111179079  PDLIM5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
111179257  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
111179283  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
111179587  SNTB2; beta-2-syntrophin [KO:K24064]
111179851  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
111179908  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
111179935  ITGA10; integrin alpha-10 [KO:K06586]
111179983  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
111180027  CAPZA1; F-actin-capping protein subunit alpha-1 isoform X1 [KO:K10364]
111180068  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
111180081  MYBPHL; LOW QUALITY PROTEIN: myosin-binding protein H-like [KO:K24494]
111180105  COL11A1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
111180402  SDC2; syndecan-2 [KO:K16336]
111180512  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
111180746  CKM; creatine kinase M-type [KO:K27382]
111180802  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
111180846  SPTBN4; spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
111181012  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
111181027  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
111181056  MYH14; myosin-14 isoform X1 [KO:K10352]
111181088  COL1A2; collagen alpha-2(I) chain [KO:K06236]
111181122  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
111181341  DSP; desmoplakin isoform X1 [KO:K10381]
111181497  DSC2; desmocollin-2 isoform X1 [KO:K07601]
111181498  DSG2; desmoglein-2 [KO:K07597]
111181513  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
111181573  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
111181619  FBN1; fibrillin-1 isoform X1 [KO:K06825]
111181696  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
111181763  THBS1; thrombospondin-1 [KO:K16857]
111181781  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
111181867  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
111181944  ITGB8; integrin beta-8 [KO:K06591]
111182048  ELN; elastin [KO:K14211]
111182378  LMNB1; lamin-B1 [KO:K07611]
111182389  FBN2; fibrillin-2 [KO:K23342]
111182409  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
111182486  MYOT; myotilin [KO:K19875]
111182587  MYL4; myosin light chain 4 isoform X1 [KO:K12750]
111182589  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111182710  ACTG1; actin, cytoplasmic 2 [KO:K05692]
111182817  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
111182825  LMOD2; LOW QUALITY PROTEIN: leiomodin-2 [KO:K22030]
111183020  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
111183148  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
111183179  MYOZ3; myozenin-3 isoform X1 [KO:K26050]
111183266  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
111183436  MYPN; myopalladin [KO:K22028]
111183523  MYOZ1; myozenin-1 [KO:K26050]
111183536  VCL; vinculin isoform X1 [KO:K05700]
111183696  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
111183701  ACTN3; alpha-actinin-3 isoform X1 [KO:K21073]
111184024  FMN2; LOW QUALITY PROTEIN: formin-2 [KO:K02184]
111184070  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
111184140  SDC4; syndecan-4 [KO:K16338]
111184217  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
111184242  MYH7B; myosin-7B isoform X1 [KO:K24220]
111184279  SNTA1; alpha-1-syntrophin [KO:K24063]
111184514  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
111184589  MYBPH; myosin-binding protein H [KO:K24494]
111184630  VCAN; versican core protein isoform X1 [KO:K06793]
111184890  THBS4; thrombospondin-4 [KO:K04659]
111185637  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
111185675  [KO:K24220]
111185832  [KO:K24220]
111185833  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
111185951  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
111186001  MYH10; myosin-10 isoform X5 [KO:K10352]
111186011  [KO:K24220]
111186012  [KO:K24220]
111186125  ANK2; ankyrin-2 isoform X1 [KO:K09255]
111186154  SYNPO2; synaptopodin-2 [KO:K24066]
111186155  MYOZ2; myozenin-2 [KO:K26050]
111186354  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111186376  FBLN1; fibulin-1 isoform X1 [KO:K17307]
111186385  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
111186428  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
111186603  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
111186728  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111186789  ITGA2; integrin alpha-2 [KO:K06481]
111186810  ITGA1; integrin alpha-1 [KO:K06480]
111187002  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
111187096  AGRN; agrin isoform X1 [KO:K06254]
111187129  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
111187370  ANKRD23; LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 23 [KO:K21438]
111187415  FHL2; four and a half LIM domains protein 2 [KO:K14380]
111187829  MYH9; myosin-9 [KO:K10352]
111187860  MYBPC1; myosin-binding protein C, slow-type [KO:K12557]
111187945  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
111188003  TLN1; talin-1 [KO:K06271]
111188045  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
dle04512  ECM-receptor interaction
dle04814  Motor proteins
KO pathway
ko04820   

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