KEGG   PATHWAY: efo04110
Entry
efo04110                    Pathway                                
Name
Cell cycle - Epinephelus fuscoguttatus (brown-marbled grouper)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
efo04110  Cell cycle
efo04110

Other DBs
GO: 0000278
Organism
Epinephelus fuscoguttatus (brown-marbled grouper) [GN:efo]
Gene
125878597  [KO:K04681]
125878921  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125878941  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
125879074  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
125879216  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125879233  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
125879375  cdk21; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125879559  ccndx; cyclin Dx [KO:K10151]
125880049  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
125880083  [KO:K04682]
125880439  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125880459  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
125880482  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125880626  waplb; wings apart-like protein homolog [KO:K25163]
125880698  [KO:K23605]
125880836  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
125880864  dbf4b; uncharacterized protein dbf4b [KO:K06629]
125881056  [KO:K21770]
125881064  [KO:K21770]
125881143  bub3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
125881497  [KO:K03347]
125881735  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
125882091  myca; transcriptional regulator Myc-A [KO:K04377]
125882633  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125882672  orc5; origin recognition complex subunit 5 [KO:K02607]
125882679  [KO:K10151]
125882802  cdkn1d; cyclin-dependent kinase inhibitor 1D isoform X1 [KO:K06625]
125882862  cdkn1ba; cyclin-dependent kinase inhibitor 1Ba [KO:K06624]
125883405  anapc10; LOW QUALITY PROTEIN: anaphase-promoting complex subunit 10 [KO:K03357]
125883731  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125883865  tp53; cellular tumor antigen p53 [KO:K04451]
125884113  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
125884138  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
125884393  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
125884395  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
125884888  orc4; origin recognition complex subunit 4 [KO:K02606]
125885468  cdc6; cell division control protein 6 homolog [KO:K02213]
125885522  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
125885678  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
125885752  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
125885949  cdkn2a/b; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
125886232  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
125886396  plk1; serine/threonine-protein kinase PLK1 isoform X1 [KO:K06631] [EC:2.7.11.21]
125886442  pds5a; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
125886785  e2f4; transcription factor E2F4 [KO:K04682]
125886786  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
125886968  wee2; wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
125887114  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125887373  smc1b; structural maintenance of chromosomes protein 1B [KO:K06636]
125887499  cdkn1bb; cyclin-dependent kinase inhibitor 1Bb [KO:K06624]
125887563  [KO:K04503]
125887687  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
125887698  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
125887886  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
125888014  ticrr; treslin isoform X1 [KO:K26117]
125888048  [KO:K09993]
125888052  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
125888389  ywhag2; 14-3-3 protein gamma-B [KO:K16198]
125888531  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
125888765  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
125888922  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
125889188  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
125889334  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
125889518  [KO:K21770]
125889774  [KO:K04501]
125889829  cdc14b; dual specificity protein phosphatase CDC14B isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
125889971  ccnh; cyclin-H isoform X1 [KO:K06634]
125889973  [KO:K04500]
125889997  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
125890175  nipbla; nipped-B-like protein A isoform X1 [KO:K06672]
125890180  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
125890215  cdc45; cell division control protein 45 homolog [KO:K06628]
125890350  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
125890409  [KO:K03363]
125890647  [KO:K04382] [EC:3.1.3.16]
125890677  pcna; proliferating cell nuclear antigen [KO:K04802]
125890839  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
125890878  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
125891007  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
125891091  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
125891195  [KO:K16197]
125891650  zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
125891736  rad21l1; double-strand-break repair protein rad21-like protein 1 isoform X1 [KO:K06670]
125892153  e2f1; transcription factor E2F1 [KO:K17454]
125892228  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
125892530  [KO:K16197]
125892868  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
125893365  dbf4; protein DBF4 homolog A [KO:K06629]
125893387  ywhaba; 14-3-3 protein beta/alpha-A [KO:K16197]
125893430  [KO:K06670]
125893517  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
125893559  [KO:K06620]
125893564  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
125893598  ttk; LOW QUALITY PROTEIN: dual specificity protein kinase Ttk [KO:K08866] [EC:2.7.12.1]
125893655  rbl1; retinoblastoma-like protein 1 [KO:K04681]
125893850  [KO:K26116]
125893906  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
125893992  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
125894017  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
125894305  stag2b; cohesin subunit SA-2 [KO:K06671]
125894308  [KO:K06671]
125894433  aurkb; aurora kinase B [KO:K11479] [EC:2.7.11.1]
125894602  pttg1; securin [KO:K06635]
125894777  mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
125894904  ccna2; cyclin-A2 [KO:K06627]
125895058  [KO:K04382] [EC:3.1.3.16]
125895279  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
125895583  [KO:K04402]
125895585  cdc14ab; dual specificity protein phosphatase CDC14AB isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
125896012  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
125896120  espl1; separin [KO:K02365] [EC:3.4.22.49]
125896232  [KO:K03364]
125896258  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
125896336  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
125896347  [KO:K11266]
125896447  cdkn2c; cyclin-dependent kinase 4 inhibitor C isoform X1 [KO:K06622]
125896480  orc1; origin recognition complex subunit 1 [KO:K02603]
125896521  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125896640  knl1; uncharacterized protein knl1 [KO:K11542]
125896682  [KO:K13377]
125897243  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
125897281  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
125897326  [KO:K06067] [EC:3.5.1.98]
125897362  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
125897472  esco2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
125897764  stag2a; cohesin subunit SA-2a isoform X1 [KO:K06671]
125897793  ccna1; cyclin-A1 [KO:K06627]
125897929  [KO:K10779]
125898125  rb1; retinoblastoma-associated protein [KO:K06618]
125898268  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
125898363  ywhag1; 14-3-3 protein gamma-1 [KO:K16198]
125898389  pds5b; sister chromatid cohesion protein PDS5 homolog B isoform X1 [KO:K11267]
125898579  cdc23; cell division cycle protein 23 homolog [KO:K03355]
125898727  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125898884  skp1; S-phase kinase-associated protein 1 [KO:K03094]
125898982  [KO:K06630]
125899355  cdc16; cell division cycle protein 16 homolog [KO:K03353]
125899493  si:ch211-269e2.1; cohesin subunit SA-2 [KO:K06671]
125899883  [KO:K04683]
125900028  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125900432  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125900567  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
125900660  [KO:K16197]
125900707  bub1bb; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
125900716  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
125900813  stag1a; cohesin subunit SA-1a [KO:K06671]
125900854  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
125901035  [KO:K06067] [EC:3.5.1.98]
125901069  [KO:K04402]
125901193  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
125901270  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
125901481  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
125901680  e2f5; transcription factor E2F5 isoform X1 [KO:K04682]
125901955  cdc20; cell division cycle protein 20 homolog isoform X1 [KO:K03363]
125901987  [KO:K06639] [EC:3.1.3.16 3.1.3.48]
125902294  [KO:K04377]
125902343  fzr1b; fizzy-related protein homolog [KO:K03364]
125902374  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
125902382  [KO:K03364]
125902448  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
125902511  orc2; origin recognition complex subunit 2 [KO:K02604]
125902516  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
125902576  cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
125902599  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
125902657  mcm6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
125902738  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125903286  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
125903293  fbxo5; F-box only protein 5 [KO:K10292]
125903514  cdkn1ca; cyclin-dependent kinase inhibitor 1Ca [KO:K09993]
125903595  wapla; wings apart-like protein homolog [KO:K25163]
125903796  [KO:K26093]
125903921  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125903963  cdt1; DNA replication factor Cdt1 [KO:K10727]
125904001  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
125904392  e2f3; transcription factor E2F3 [KO:K06620]
125904494  [KO:K16197]
125904573  [KO:K06067] [EC:3.5.1.98]
125904684  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125904703  sgo1; shugoshin 1 [KO:K11580]
125904836  smad10a; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
125905033  [KO:K06626]
125905071  [KO:K06670]
125905138  cdca5; sororin [KO:K17390]
125905496  [KO:K06672]
125905581  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
125905617  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
125905662  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125905887  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
125905906  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
125905915  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
125905924  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
125905933  [KO:K04402]
125906320  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
efo03030  DNA replication
efo04010  MAPK signaling pathway
efo04120  Ubiquitin mediated proteolysis
efo04210  Apoptosis
KO pathway
ko04110   

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