KEGG   PATHWAY: efo04010
Entry
efo04010                    Pathway                                
Name
MAPK signaling pathway - Epinephelus fuscoguttatus (brown-marbled grouper)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
efo04010  MAPK signaling pathway
efo04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Epinephelus fuscoguttatus (brown-marbled grouper) [GN:efo]
Gene
125878590  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125878776  [KO:K19662] [EC:2.7.11.13]
125878781  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125878874  si:ch211-195b15.8; uncharacterized protein si:ch211-195b15.8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125878881  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
125878923  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
125878978  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
125878991  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125879032  [KO:K04347]
125879037  [KO:K04392]
125879042  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
125879105  atf4b; activating transcription factor 4b [KO:K04374]
125879149  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
125879172  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
125879253  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
125879324  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125879348  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
125879506  [KO:K04433] [EC:2.7.12.2]
125879584  taok2a; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
125879595  [KO:K03283]
125879596  [KO:K03283]
125879604  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
125879641  mapk8ip1b; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
125879663  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
125879703  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
125879708  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
125879778  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
125879954  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125879979  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
125880010  zgc:55558; GTPase KRas [KO:K07827]
125880085  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
125880092  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
125880136  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125880157  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
125880334  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
125880365  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
125880367  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
125880373  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
125880384  fgf7; fibroblast growth factor 7 [KO:K04358]
125880386  [KO:K04467] [EC:2.7.11.10]
125880390  mapta; microtubule-associated protein tau isoform X1 [KO:K04380]
125880486  mapk8b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
125880551  [KO:K04392]
125880629  [KO:K04466] [EC:2.7.11.25]
125880680  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
125880839  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
125880891  ngfrb; nerve growth factor receptor b [KO:K02583]
125881024  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
125881116  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
125881262  [KO:K22429]
125881323  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125881350  dusp3a; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125881579  map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
125881613  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
125881649  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
125881832  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
125881839  flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125881987  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
125882091  myca; transcriptional regulator Myc-A [KO:K04377]
125882095  [KO:K04361] [EC:2.7.10.1]
125882159  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125882230  [KO:K04373] [EC:2.7.11.1]
125882507  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
125882572  [KO:K04441] [EC:2.7.11.24]
125882589  ptprr; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
125882680  fgf23; fibroblast growth factor 23 [KO:K22428]
125882684  [KO:K04358]
125882719  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125882725  [KO:K05461]
125882761  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
125882814  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
125882826  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
125882923  igf1; insulin-like growth factor I [KO:K05459]
125883075  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
125883098  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125883245  [KO:K07836]
125883250  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125883501  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
125883509  [KO:K04419] [EC:2.7.11.25]
125883512  rela; transcription factor p65 [KO:K04735]
125883513  [KO:K12361]
125883672  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
125883763  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125883865  tp53; cellular tumor antigen p53 [KO:K04451]
125884025  [KO:K04348] [EC:3.1.3.16]
125884091  arrb2b; arrestin, beta 2b [KO:K04439]
125884667  [KO:K04407] [EC:2.7.11.1]
125884821  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
125884958  [KO:K05085] [EC:2.7.10.1]
125885207  [KO:K04865]
125885230  [KO:K05449]
125885353  [KO:K16342] [EC:3.1.1.4]
125885389  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125885427  fgf8b; fibroblast growth factor 8b [KO:K04358]
125885436  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
125885446  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
125885448  [KO:K04867]
125885455  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125885505  [KO:K04359]
125885541  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125885556  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
125885562  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125885635  elk4; ETS domain-containing protein Elk-4 [KO:K04376]
125885663  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
125885669  [KO:K25416]
125885732  [KO:K19662] [EC:2.7.11.13]
125885735  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125885753  [KO:K04358]
125885789  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b [KO:K04344]
125885879  [KO:K03099]
125885880  [KO:K04378]
125885939  [KO:K04856]
125886015  si:ch211-79m20.1; transcription factor SPT20 homolog [KO:K17386]
125886058  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
125886092  [KO:K04857]
125886108  vegfc; vascular endothelial growth factor C [KO:K05449]
125886123  [KO:K04866]
125886186  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125886243  kitb; KIT proto-oncogene, receptor tyrosine kinase b [KO:K05091] [EC:2.7.10.1]
125886278  [KO:K04869]
125886389  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
125886476  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
125886520  [KO:K04870]
125886723  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
125886736  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
125886753  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125886763  kitlga; kit ligand a [KO:K05461]
125886790  [KO:K22428]
125886792  [KO:K04358]
125886906  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125886996  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
125887085  kras; GTPase KRas isoform X1 [KO:K07827]
125887130  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
125887180  erbb3a; receptor tyrosine-protein kinase erbB-3a isoform X1 [KO:K05084] [EC:2.7.10.1]
125887195  [KO:K04411]
125887218  [KO:K05460]
125887227  [KO:K04858]
125887272  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125887452  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
125887517  [KO:K02833]
125887738  [KO:K17333]
125887861  [KO:K04861]
125887866  mapk8ip1a; C-Jun-amino-terminal kinase-interacting protein 1a [KO:K04434]
125888027  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
125888078  ptpn5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
125888117  igf2b; insulin-like growth factor 2b [KO:K13769]
125888135  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
125888327  rasgrp4; RAS guanyl-releasing protein 4 [KO:K04350]
125888349  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
125888540  rasa2; ras GTPase-activating protein 2 [KO:K08053]
125888636  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125888762  mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
125888855  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125888901  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
125888922  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
125889069  nf1a; neurofibromin isoform X1 [KO:K08052]
125889086  nlk2; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
125889182  crk; adapter molecule crk [KO:K04438]
125889246  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
125889264  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
125889325  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
125889408  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
125889430  relb; transcription factor RelB homolog isoform X1 [KO:K09253]
125889528  [KO:K04723]
125889535  arrb1; beta-arrestin-1 [KO:K04439]
125889741  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
125889747  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
125889847  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
125889905  efna5b; ephrin-A5b isoform X1 [KO:K05462]
125889921  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125889945  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
125889970  [KO:K04352]
125889997  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
125890002  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
125890071  taok3a; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
125890125  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125890145  [KO:K04519]
125890147  fgf5; fibroblast growth factor 5 [KO:K04358]
125890185  gdnfb; glial cell line-derived neurotrophic factor [KO:K05452]
125890225  [KO:K04849]
125890244  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125890245  traf2a; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
125890277  fgf17; fibroblast growth factor 17 [KO:K04358]
125890362  fgf10b; fibroblast growth factor 10b [KO:K04358]
125890421  [KO:K09784]
125890463  ngfb; nerve growth factor [KO:K02582]
125890593  [KO:K12326]
125890600  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125891024  [KO:K04393]
125891090  [KO:K04857]
125891151  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125891248  angpt4; angiopoietin-1 [KO:K05465]
125891276  epha2a; ephrin type-A receptor 2a [KO:K05103] [EC:2.7.10.1]
125891314  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
125891334  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
125891335  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
125891336  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
125891347  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
125891405  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
125891457  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
125891517  [KO:K04353]
125891519  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a isoform X1 [KO:K04864]
125891603  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125891630  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
125891648  epha2b; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
125891672  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
125891793  [KO:K04465]
125891925  irak1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
125891928  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125891929  erbb3b; receptor tyrosine-protein kinase erbB-3b isoform X1 [KO:K05084] [EC:2.7.10.1]
125891941  nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125891952  [KO:K04393]
125891977  flna; filamin-A [KO:K04437]
125892050  igf3; insulin-like growth factor 3 isoform X1 [KO:K05459]
125892100  [KO:K04443] [EC:2.7.11.1]
125892197  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
125892319  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
125892335  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125892401  [KO:K02582]
125892420  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125892435  [KO:K18019] [EC:3.1.3.48]
125892733  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125892777  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125892854  [KO:K04388] [EC:2.7.11.30]
125892868  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
125892885  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
125892983  efna1b; ephrin-A1b [KO:K05462]
125892984  efna3b; ephrin-A3b [KO:K05462]
125893072  stmn1b; stathmin 1b [KO:K04381]
125893142  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125893170  cdc42l; cell division cycle 42, like [KO:K04393]
125893311  [KO:K04444] [EC:2.7.11.1]
125893444  [KO:K04446]
125893607  si:dkey-246i14.3; ephrin-A4 [KO:K05462]
125893640  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125893652  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125893695  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
125893733  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
125893821  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
125893882  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
125894017  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
125894019  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
125894020  egf; pro-epidermal growth factor [KO:K04357]
125894041  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
125894067  fgf20b; fibroblast growth factor 20b [KO:K04358]
125894074  si:zfos-2326c3.2; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
125894114  [KO:K04859]
125894197  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
125894199  fgf2; fibroblast growth factor 2 [KO:K18497]
125894243  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
125894263  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
125894271  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125894296  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
125894303  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
125894304  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
125894358  fgf16; fibroblast growth factor 16 [KO:K04358]
125894361  cd40lg; CD40 ligand [KO:K04389]
125894430  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
125894470  insb; preproinsulin b [KO:K04526]
125894522  casp3b; caspase-3b [KO:K02187] [EC:3.4.22.56]
125894559  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
125894577  vegfba; vascular endothelial growth factor A [KO:K05448]
125894589  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125894739  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
125894799  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
125894963  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125895051  [KO:K04358]
125895265  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
125895404  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125895405  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
125895445  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125895468  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
125895577  [KO:K05462]
125895583  [KO:K04402]
125895649  [KO:K04852]
125895742  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
125895747  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125895827  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
125895897  [KO:K25415]
125895951  jun; transcription factor AP-1 [KO:K04448]
125895955  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125895963  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
125896016  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
125896143  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
125896285  [KO:K04449]
125896336  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
125896412  fgf22; fibroblast growth factor 22 [KO:K04358]
125896466  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
125896682  [KO:K13377]
125896731  max; protein max isoform X1 [KO:K04453]
125896733  [KO:K04379]
125896734  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
125896855  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
125896939  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
125896957  [KO:K04353]
125896958  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125897007  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
125897250  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125897313  [KO:K16859]
125897587  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
125897632  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
125897887  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
125898032  [KO:K03283]
125898033  [KO:K03283]
125898151  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
125898179  [KO:K04456] [EC:2.7.11.1]
125898196  [KO:K05089] [EC:2.7.10.1]
125898197  csf1rb; macrophage colony-stimulating factor 1 receptor 2 isoform X1 [KO:K05090] [EC:2.7.10.1]
125898218  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125898274  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
125898309  taok1b; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125898362  hspb1; heat shock protein beta-1 [KO:K04455]
125898461  [KO:K18496]
125898763  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
125898795  ins; insulin [KO:K04526]
125898846  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
125898975  [KO:K04438]
125899176  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
125899499  mrasa; ras-related protein M-Ras [KO:K07831]
125899694  [KO:K04407] [EC:2.7.11.1]
125899698  [KO:K04386]
125899788  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
125899825  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125899842  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
125899935  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
125900030  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125900135  [KO:K04423] [EC:2.7.11.25]
125900168  [KO:K05085] [EC:2.7.10.1]
125900429  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125900475  sos2; son of sevenless homolog 2 [KO:K03099]
125900476  map3k9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
125900555  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
125900645  [KO:K04350]
125900668  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125900692  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
125900720  [KO:K04410] [EC:2.7.11.1]
125900843  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125900854  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
125900956  [KO:K04427] [EC:2.7.11.25]
125900998  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
125901043  [KO:K04453]
125901055  pgfb; placenta growth factor isoform X1 [KO:K16859]
125901069  [KO:K04402]
125901110  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
125901306  [KO:K05087] [EC:2.7.10.1]
125901405  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125901467  efna2a; ephrin-A2 [KO:K05462]
125901481  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
125901820  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
125901912  [KO:K25414]
125901916  [KO:K04852]
125902093  [KO:K04424] [EC:2.7.11.25]
125902200  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
125902260  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125902294  [KO:K04377]
125902348  [KO:K04448]
125902384  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
125902597  [KO:K25415]
125902599  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
125902606  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
125902633  [KO:K04449]
125902781  fgf3; fibroblast growth factor 3 [KO:K04358]
125902786  fgf4; fibroblast growth factor 4 [KO:K04358]
125902792  fgf19; fibroblast growth factor 19 [KO:K22603]
125902964  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
125903016  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125903023  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125903024  rras2; ras-related protein R-Ras2 [KO:K07830]
125903102  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125903134  [KO:K06268]
125903140  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
125903160  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
125903226  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
125903278  fas; tumor necrosis factor receptor superfamily member 26 isoform X1 [KO:K04390]
125903284  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125903455  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
125903596  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
125903667  angpt2a; angiopoietin-2a [KO:K05466]
125903733  [KO:K04467] [EC:2.7.11.10]
125903824  [KO:K04406] [EC:2.7.11.1]
125903889  srfb; serum response factor b isoform X1 [KO:K04378]
125903962  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
125904019  fgf8a; fibroblast growth factor 8 [KO:K04358]
125904247  [KO:K04388] [EC:2.7.11.30]
125904465  [KO:K04393]
125904615  [KO:K03156]
125904657  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125904740  stk3; serine/threonine-protein kinase 3 [KO:K04412]
125904794  angpt1; angiopoietin-1 [KO:K05465]
125904827  efna1a; ephrin-A1a isoform X1 [KO:K05462]
125904963  angpt2b; angiopoietin-2b [KO:K05466]
125904984  daxx; death domain-associated protein 6 [KO:K02308]
125905010  [KO:K04381]
125905060  [KO:K04873]
125905062  [KO:K04872]
125905064  [KO:K04871]
125905323  efna3a; ephrin-A3 [KO:K05462]
125905635  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
125905692  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
125905730  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
125905740  [KO:K04455]
125905897  [KO:K03173] [EC:2.3.2.27]
125905904  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
125905924  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
125905933  [KO:K04402]
125905962  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125906000  [KO:K05462]
125906048  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
125906055  [KO:K04362] [EC:2.7.10.1]
125906105  [KO:K04349]
125906119  crkl; crk-like protein [KO:K04438]
125906192  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
125906209  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
125906213  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125906290  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
efo04070  Phosphatidylinositol signaling system
efo04110  Cell cycle
efo04115  p53 signaling pathway
efo04210  Apoptosis
efo04310  Wnt signaling pathway
KO pathway
ko04010   

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