KEGG   PATHWAY: ely04150
Entry
ely04150                    Pathway                                
Name
mTOR signaling pathway - Epinephelus lanceolatus (giant grouper)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
ely04150  mTOR signaling pathway
ely04150

Organism
Epinephelus lanceolatus (giant grouper) [GN:ely]
Gene
117245840  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
117246057  [KO:K06519]
117246090  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
117246115  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
117246218  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
117246430  [KO:K06519]
117246801  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
117246806  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
117246906  wnt3; proto-oncogene Wnt-3 [KO:K00312]
117246921  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117247061  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
117247242  [KO:K04467] [EC:2.7.11.10]
117247362  [KO:K02145] [EC:7.1.2.2]
117247415  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117247733  wdr24; GATOR complex protein WDR24 [KO:K20408]
117247843  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
117247863  [KO:K04467] [EC:2.7.11.10]
117247924  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117248395  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117248604  [KO:K08270]
117248654  wnt8b; protein Wnt-8b [KO:K00714]
117248938  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
117248976  atp6v1f; V-type proton ATPase subunit F [KO:K02151]
117248977  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
117249115  wnt5b; protein Wnt-5b [KO:K00444]
117249166  lrp6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
117249226  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
117249252  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117249288  wnt7ba; protein Wnt-7b isoform X1 [KO:K00572]
117249481  wnt16; protein Wnt-16 [KO:K01558]
117249619  [KO:K20411]
117249891  wnt10a; protein Wnt-10a [KO:K01357]
117249964  [KO:K02432]
117250029  cab39l; calcium-binding protein 39-like [KO:K08272]
117250091  stradb; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
117251051  wnt6b; protein Wnt-6 [KO:K00445]
117251073  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117251447  [KO:K02432]
117251517  [KO:K08266]
117251762  fzd5; frizzled-5 [KO:K02375]
117251910  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
117251947  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
117252022  [KO:K07205]
117252529  [KO:K02649]
117252591  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117252779  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
117252789  [KO:K08267]
117252809  wdr59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
117253150  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
117253153  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117253208  fzd10; frizzled-10 [KO:K02842]
117253448  [KO:K00922] [EC:2.7.1.153]
117253608  [KO:K05087] [EC:2.7.10.1]
117253876  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
117254032  tbc1d7; TBC1 domain family member 7 [KO:K20396]
117254143  [KO:K02649]
117254148  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117254181  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117254209  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
117254935  tsc2; tuberin isoform X1 [KO:K07207]
117254945  [KO:K19662] [EC:2.7.11.13]
117255058  [KO:K03099]
117255147  rptor; regulatory-associated protein of mTOR [KO:K07204]
117255414  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117255533  [KO:K04688] [EC:2.7.11.1]
117255629  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117255631  rps6; 40S ribosomal protein S6 [KO:K02991]
117256038  lpin1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
117256353  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
117256372  wnt4; protein Wnt-4a [KO:K00408]
117256388  zgc:123305; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
117256392  nprl2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
117256439  [KO:K02329]
117256458  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
117256688  sec13; protein SEC13 homolog [KO:K14004]
117256806  rhoca; ras homolog family member Ca [KO:K04513]
117257115  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
117257391  [KO:K04513]
117257432  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
117257496  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
117257692  wnt10b; protein Wnt-10b isoform X1 [KO:K01357]
117257693  wnt1; protein Wnt-1 [KO:K03209]
117257706  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117257761  [KO:K00572]
117257802  [KO:K00182]
117257804  tti1; LOW QUALITY PROTEIN: TELO2-interacting protein 1 homolog [KO:K20403]
117257918  [KO:K04513]
117257951  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
117258114  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117258233  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117258243  [KO:K04513]
117258264  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117258277  dvl1a; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
117258283  [KO:K13780]
117258353  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117258556  wnt5a; protein Wnt-5a [KO:K00444]
117258562  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117258667  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
117258873  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
117258881  [KO:K07203] [EC:2.7.11.1]
117258901  igf3; insulin-like growth factor 3 [KO:K05459]
117259067  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
117259070  [KO:K06519]
117259591  [KO:K04688] [EC:2.7.11.1]
117259836  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117259841  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117259845  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
117259954  cab39; calcium-binding protein 39 [KO:K08272]
117260005  [KO:K02353]
117260025  fzd4; frizzled-4 [KO:K02354]
117260314  fzd9b; frizzled-9b [KO:K02842]
117260702  rps6kal; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
117261006  [KO:K03259]
117261192  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
117261385  insb; preproinsulin b [KO:K04526]
117261400  [KO:K00714]
117261450  [KO:K00714]
117261639  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
117261726  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117261871  wnt2; protein Wnt-2 [KO:K00182]
117262168  kras; GTPase KRas isoform X1 [KO:K07827]
117262356  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117262364  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
117262365  [KO:K20411]
117262369  [KO:K02833]
117262427  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
117262830  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
117262862  prr5l; proline-rich protein 5-like [KO:K20411]
117263004  sesn2; sestrin-2 isoform X1 [KO:K20394]
117263236  rragcb; ras-related GTP binding Cb [KO:K16186]
117263376  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
117263481  wnt11; protein Wnt-11 [KO:K01384]
117263599  [KO:K20064]
117263797  rraga; ras-related GTP-binding protein A [KO:K16185]
117263820  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
117263947  [KO:K03156]
117264195  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
117264279  [KO:K15728] [EC:3.1.3.4]
117264338  fzd8a; frizzled-8a [KO:K02375]
117264737  [KO:K04373] [EC:2.7.11.1]
117265017  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117265123  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
117265212  atp6v1c1a; V-type proton ATPase subunit C 1-A [KO:K02148]
117265478  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117265570  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
117265588  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K03156]
117265591  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
117265709  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117265828  deptor; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
117265833  flcn; folliculin isoform X1 [KO:K09594]
117265856  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
117266014  mios; GATOR complex protein MIOS [KO:K20407]
117266180  sgk2b; serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
117266207  fzd1; frizzled-1 [KO:K02432]
117266229  [KO:K02376]
117266230  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
117266301  [KO:K02432]
117266338  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
117266351  rragca; ras-related GTP binding Ca [KO:K16186]
117266754  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
117266858  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
117266867  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
117267058  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117267154  sos2; son of sevenless homolog 2 [KO:K03099]
117267343  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117267509  rragd; ras-related GTP-binding protein D [KO:K16186]
117267659  [KO:K06519]
117267875  fzd2; frizzled-2 [KO:K02235]
117268019  wnt9b; protein Wnt-9b [KO:K01064]
117268077  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117268140  [KO:K19662] [EC:2.7.11.13]
117268156  [KO:K04456] [EC:2.7.11.1]
117268290  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117268340  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
117268354  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117268371  zgc:55558; GTPase HRas [KO:K07827]
117268490  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
117268541  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
117268599  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
117269279  atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
117269393  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
117269441  [KO:K07205]
117269552  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117269635  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
117269687  slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
117269688  ulk1b; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
117269696  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
117269732  atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
117269772  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
117269861  clip1b; CAP-Gly domain-containing linker protein 1 [KO:K10421]
117270288  si:ch73-21k16.1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
117270452  ins; insulin [KO:K04526]
117270637  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
117270714  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
117271012  fzd3a; frizzled-3a [KO:K02329]
117271475  [KO:K02375]
117271479  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b isoform X1 [KO:K04369] [EC:2.7.12.2]
117271502  [KO:K02649]
117271508  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117271532  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
117271746  wnt3a; protein Wnt-3a [KO:K00312]
117271781  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
117271837  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
117271943  [KO:K00922] [EC:2.7.1.153]
117272002  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
117272006  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117272303  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
117272325  [KO:K02353]
117272364  rheb; GTP-binding protein Rheb [KO:K07208]
117272466  wnt9a; protein Wnt-9a [KO:K01064]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
ely00561  Glycerolipid metabolism
ely04010  MAPK signaling pathway
ely04140  Autophagy - animal
ely04810  Regulation of actin cytoskeleton
ely04910  Insulin signaling pathway
KO pathway
ko04150   

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