KEGG   Homo sapiens (human): 7430
Entry
7430              CDS       T01001                                 
Symbol
EZR, CVIL, CVL, HEL-S-105, VIL2
Name
(RefSeq) ezrin
  KO
K08007  ezrin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa04971  Gastric acid secretion
hsa05130  Pathogenic Escherichia coli infection
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
Network
nt06180  Pathogenic Escherichia coli
nt06546  IgSF CAM signaling
  Element
N01095  Escherichia Map to LPA-GNA12/13-RhoA signaling pathway
N01933  NrCAM interactions
N01934  L1CAM interactions
N01935  NFASC interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    7430 (EZR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    7430 (EZR)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    7430 (EZR)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    7430 (EZR)
  09154 Digestive system
   04971 Gastric acid secretion
    7430 (EZR)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    7430 (EZR)
   05205 Proteoglycans in cancer
    7430 (EZR)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    7430 (EZR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    7430 (EZR)
   04147 Exosome [BR:hsa04147]
    7430 (EZR)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Ezrin/Radixin/Moesin
     7430 (EZR)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   7430 (EZR)
SSDB
Motif
Pfam: ERM_C FERM_M ERM_helical FERM_C FERM_N
Other DBs
NCBI-GeneID: 7430
NCBI-ProteinID: NP_001104547
OMIM: 123900
HGNC: 12691
Ensembl: ENSG00000092820
UniProt: P15311
Structure
LinkDB
Position
6:complement(158765748..158819368)
AA seq 586 aa
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLK
LDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPE
TAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHR
GMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK
AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAE
LAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEP
VSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQ
ARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
NT seq 1761 nt   +upstreamnt  +downstreamnt
atgccgaaaccaatcaatgtccgagttaccaccatggatgcagagctggagtttgcaatc
cagccaaatacaactggaaaacagctttttgatcaggtggtaaagactatcggcctccgg
gaagtgtggtactttggcctccactatgtggataataaaggatttcctacctggctgaag
ctggataagaaggtgtctgcccaggaggtcaggaaggagaatcccctccagttcaagttc
cgggccaagttctaccctgaagatgtggctgaggagctcatccaggacatcacccagaaa
cttttcttcctccaagtgaaggaaggaatccttagcgatgagatctactgcccccctgag
actgccgtgctcttggggtcctacgctgtgcaggccaagtttggggactacaacaaagaa
gtgcacaagtctgggtacctcagctctgagcggctgatccctcaaagagtgatggaccag
cacaaacttaccagggaccagtgggaggaccggatccaggtgtggcatgcggaacaccgt
gggatgctcaaagataatgctatgttggaatacctgaagattgctcaggacctggaaatg
tatggaatcaactatttcgagataaaaaacaagaaaggaacagacctttggcttggagtt
gatgcccttggactgaatatttatgagaaagatgataagttaaccccaaagattggcttt
ccttggagtgaaatcaggaacatctctttcaatgacaaaaagtttgtcattaaacccatc
gacaagaaggcacctgactttgtgttttatgccccacgtctgagaatcaacaagcggatc
ctgcagctctgcatgggcaaccatgagttgtatatgcgccgcaggaagcctgacaccatc
gaggtgcagcagatgaaggcccaggcccgggaggagaagcatcagaagcagctggagcgg
caacagctggaaacagagaagaaaaggagagaaaccgtggagagagagaaagagcagatg
atgcgcgagaaggaggagttgatgctgcggctgcaggactatgaggagaagacaaagaag
gcagagagagagctctcggagcagattcagagggccctgcagctggaggaggagaggaag
cgggcacaggaggaggccgagcgcctagaggctgaccgtatggctgcactgcgggctaag
gaggagctggagagacaggcggtggatcagataaagagccaggagcagctggctgcggag
cttgcagaatacactgccaagattgccctcctggaagaggcgcggaggcgcaaggaggat
gaagttgaagagtggcagcacagggccaaagaagcccaggatgacctggtgaagaccaag
gaggagctgcacctggtgatgacagcacccccgcccccaccaccccccgtgtacgagccg
gtgagctaccatgtccaggagagcttgcaggatgagggcgcagagcccacgggctacagc
gcggagctgtctagtgagggcatccgggatgaccgcaatgaggagaagcgcatcactgag
gcagagaagaacgagcgtgtgcagcggcagctgctgacgctgagcagcgagctgtcccag
gcccgagatgagaataagaggacccacaatgacatcatccacaacgagaacatgaggcaa
ggccgggacaagtacaagacgctgcggcagatccggcagggcaacaccaagcagcgcatc
gacgagttcgaggccctgtaa

KEGG   Homo sapiens (human): 5962
Entry
5962              CDS       T01001                                 
Symbol
RDX, DFNB24
Name
(RefSeq) radixin
  KO
K05762  radixin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
hsa04530  Tight junction
hsa04810  Regulation of actin cytoskeleton
hsa05205  Proteoglycans in cancer
hsa05206  MicroRNAs in cancer
Network
nt06546  IgSF CAM signaling
  Element
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00605  Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    5962 (RDX)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    5962 (RDX)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5962 (RDX)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    5962 (RDX)
   05205 Proteoglycans in cancer
    5962 (RDX)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    5962 (RDX)
   04147 Exosome [BR:hsa04147]
    5962 (RDX)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Ezrin/Radixin/Moesin
     5962 (RDX)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   5962 (RDX)
SSDB
Motif
Pfam: ERM_C FERM_M ERM_helical FERM_C FERM_N
Other DBs
NCBI-GeneID: 5962
NCBI-ProteinID: NP_002897
OMIM: 179410
HGNC: 9944
Ensembl: ENSG00000137710
UniProt: P35241 B0YJ88 Q6PKD3
LinkDB
Position
11:complement(110174922..110296614)
AA seq 583 aa
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLK
LNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPE
TAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHR
GMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIK
AQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAE
LAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIP
PTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARD
ETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
NT seq 1752 nt   +upstreamnt  +downstreamnt
atgccgaaaccaatcaacgtaagagtaactacaatggatgctgagctggaatttgccatt
cagcccaatacaactggcaaacaactttttgaccaggtggtgaaaacagttggtttgcgt
gaggtctggttttttgggctgcagtatgtagacagcaaaggttattctacatggcttaaa
ctaaataaaaaggtaacacagcaggatgttaaaaaagagaatcctttacagttcaagttt
agagctaaattctttcctgaagatgtttctgaggaattaattcaagaaataacccagaga
ctcttcttcttgcaagttaaagaagccatcttaaatgatgagatatattgcccgccagaa
actgcagttcttttggcttcctatgctgtccaagccaagtatggagattacaataaagag
attcataagccaggctacctggctaatgatagactcctaccccagcgtgtattggaacaa
cacaaactaacaaaagaacagtgggaagaaagaatacagaactggcatgaagaacataga
ggaatgttaagggaggattctatgatggaatacctgaagattgcacaagatctagaaatg
tatggagtcaactattttgaaataaaaaataaaaaaggaactgaattgtggctaggtgtt
gatgctttgggtctgaatatttatgagcatgacgacaagttaacacctaaaattggtttt
ccctggagtgaaatcagaaatatttcatttaatgacaaaaaatttgttataaagccaatc
gacaaaaaggcacctgattttgtgttttatgcacctcgtctgagaatcaataagcggatt
ttggccttatgtatgggaaaccatgaactatacatgcgaagaaggaagcctgatactatt
gaagtacaacagatgaaggctcaggctagggaggagaaacatcagaagcagttggaaagg
gcacaattagagaatgaaaagaagaaaagagaaatagcagaaaaggaaaaggaaagaata
gaacgtgaaaaggaagagctaatggaacgtctaaaacaaattgaagagcagacaattaaa
gctcagaaagaactagaagaacagactcgaaaagctctagaactggatcaagaacgaaaa
cgagcaaaagaagaagcagaacgacttgaaaaggagcgtcgagctgctgaagaggcaaag
tctgccatagcaaaacaagctgccgaccagatgaagaatcaggagcagctagcagcagaa
cttgctgaattcactgccaagattgcacttctagaggaagccaagaagaaaaaggaagag
gaagctactgagtggcaacacaaagcttttgcagcccaggaagacttggaaaagaccaaa
gaagagttaaaaactgtgatgtctgccccccctccacctccaccaccaccagtcattcct
ccaacagaaaacgaacatgatgaacacgatgagaataatgctgaagctagtgctgaatta
tcaaatgaaggggtaatgaaccatagaagcgaggaagaacgtgtaaccgaaacacagaaa
aatgagcgtgttaagaagcaacttcaggcattaagttcagaattagcccaagccagagat
gaaaccaagaaaacacaaaatgatgttcttcatgctgagaatgttaaagcaggccgtgat
aagtacaagactctgcgacagattcgacaaggcaatacaaagcagcgtatcgatgagttt
gaagcaatgtga

KEGG   Homo sapiens (human): 4478
Entry
4478              CDS       T01001                                 
Symbol
MSN, HEL70, IMD50
Name
(RefSeq) moesin
  KO
K05763  moesin
Organism
hsa  Homo sapiens (human)
Pathway
hsa04517  IgSF CAM signaling
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05162  Measles
hsa05205  Proteoglycans in cancer
Network
nt06546  IgSF CAM signaling
  Element
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    4478 (MSN)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    4478 (MSN)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    4478 (MSN)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    4478 (MSN)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    4478 (MSN)
  09172 Infectious disease: viral
   05162 Measles
    4478 (MSN)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4478 (MSN)
   04147 Exosome [BR:hsa04147]
    4478 (MSN)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Ezrin/Radixin/Moesin
     4478 (MSN)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   4478 (MSN)
SSDB
Motif
Pfam: ERM_C FERM_M ERM_helical FERM_C FERM_N
Other DBs
NCBI-GeneID: 4478
NCBI-ProteinID: NP_002435
OMIM: 309845
HGNC: 7373
Ensembl: ENSG00000147065
UniProt: P26038 V9HWC0
Structure
LinkDB
Position
X:65588377..65741931
AA seq 577 aa
MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLK
LNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPE
TAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHR
GMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGF
PWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTI
EVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKK
AQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALE
MAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQ
DEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTA
NDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM
NT seq 1734 nt   +upstreamnt  +downstreamnt
atgcccaaaacgatcagtgtgcgtgtgaccaccatggatgcagagctggagtttgccatc
cagcccaacaccaccgggaagcagctatttgaccaggtggtgaaaactattggcttgagg
gaagtttggttctttggtctgcagtaccaggacactaaaggtttctccacctggctgaaa
ctcaataagaaggtgactgcccaggatgtgcggaaggaaagccccctgctctttaagttc
cgtgccaagttctaccctgaggatgtgtccgaggaattgattcaggacatcactcagcgc
ctgttctttctgcaagtgaaagagggcattctcaatgatgatatttactgcccgcctgag
accgctgtgctgctggcctcgtatgctgtccagtctaagtatggcgacttcaataaggaa
gtgcataagtctggctacctggccggagacaagttgctcccgcagagagtcctggaacag
cacaaactcaacaaggaccagtgggaggagcggatccaggtgtggcatgaggaacaccgt
ggcatgctcagggaggatgctgtcctggaatatctgaagattgctcaagatctggagatg
tatggtgtgaactacttcagcatcaagaacaagaaaggctcagagctgtggctgggggtg
gatgccctgggtctcaacatctatgagcagaatgacagactaactcccaagataggcttc
ccctggagtgaaatcaggaacatctctttcaatgataagaaatttgtcatcaagcccatt
gacaaaaaagccccggacttcgtcttctatgctccccggctgcggattaacaagcggatc
ttggccttgtgcatggggaaccatgaactatacatgcgccgtcgcaagcctgataccatt
gaggtgcagcagatgaaggcacaggcccgggaggagaagcaccagaagcagatggagcgt
gctatgctggaaaatgagaagaagaagcgtgaaatggcagagaaggagaaagagaagatt
gaacgggagaaggaggagctgatggagaggctgaagcagatcgaggaacagactaagaag
gctcagcaagaactggaagaacagacccgtagggctctggaacttgagcaggaacggaag
cgtgcccagagcgaggctgaaaagctggccaaggagcgtcaagaagctgaagaggccaag
gaggccttgctgcaggcctcccgggaccagaaaaagactcaggaacagctggccttggaa
atggcagagctgacagctcgaatctcccagctggagatggcccgacagaagaaggagagt
gaggctgtggagtggcagcagaaggcccagatggtacaggaagacttggagaagacccgt
gctgagctgaagactgccatgagtacacctcatgtggcagagcctgctgagaatgagcag
gatgagcaggatgagaatggggcagaggctagtgctgacctacgggctgatgctatggcc
aaggaccgcagtgaggaggaacgtaccactgaggcagagaagaatgagcgtgtgcagaag
cacctgaaggccctcacttcggagctggccaatgccagagatgagtccaagaagactgcc
aatgacatgatccatgctgagaacatgcgactgggccgagacaaatacaagaccctgcgc
cagatccggcagggcaacaccaagcagcgcattgacgaatttgagtctatgtaa

KEGG   Homo sapiens (human): 87
Entry
87                CDS       T01001                                 
Symbol
ACTN1, BDPLT15
Name
(RefSeq) actinin alpha 1
  KO
K05699  actinin alpha 1/4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05131  Shigellosis
hsa05146  Amoebiasis
hsa05203  Viral carcinogenesis
hsa05322  Systemic lupus erythematosus
Network
nt06182  Shigella
nt06546  IgSF CAM signaling
  Element
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01082  Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H01235  Bleeding disorder platelet-type
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    87 (ACTN1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    87 (ACTN1)
   04520 Adherens junction
    87 (ACTN1)
   04530 Tight junction
    87 (ACTN1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    87 (ACTN1)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    87 (ACTN1)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    87 (ACTN1)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    87 (ACTN1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    87 (ACTN1)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    87 (ACTN1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    87 (ACTN1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    87 (ACTN1)
   04147 Exosome [BR:hsa04147]
    87 (ACTN1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    87 (ACTN1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     87 (ACTN1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   87 (ACTN1)
  Exosomal proteins of colorectal cancer cells
   87 (ACTN1)
  Exosomal proteins of bladder cancer cells
   87 (ACTN1)
SSDB
Motif
Pfam: Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 EF-hand_5 XisI Uds1
Other DBs
NCBI-GeneID: 87
NCBI-ProteinID: NP_001093
OMIM: 102575
HGNC: 163
Ensembl: ENSG00000072110
UniProt: P12814 A0A024R694
Structure
LinkDB
Position
14:complement(68874128..68979302)
AA seq 892 aa
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR
DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV
KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC
ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT
YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR
VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM
VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK
DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC
DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT
IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI
NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM
HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL
LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY
DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK
NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL
NT seq 2679 nt   +upstreamnt  +downstreamnt
atggaccattatgattctcagcaaaccaacgattacatgcagccagaagaggactgggac
cgggacctgctcctggacccggcctgggagaagcagcagagaaagacattcacggcatgg
tgtaactcccacctccggaaggcggggacacagatcgagaacatcgaagaggacttccgg
gatggcctgaagctcatgctgctgctggaggtcatctcaggtgaacgcttggccaagcca
gagcgaggcaagatgagagtgcacaagatctccaacgtcaacaaggccctggatttcata
gccagcaaaggcgtcaaactggtgtccatcggagccgaagaaatcgtggatgggaatgtg
aagatgaccctgggcatgatctggaccatcatcctgcgctttgccatccaggacatctcc
gtggaagagacttcagccaaggaagggctgctcctgtggtgtcagagaaagacagcccct
tacaaaaatgtcaacatccagaacttccacataagctggaaggatggcctcggcttctgt
gctttgatccaccgacaccggcccgagctgattgactacgggaagctgcggaaggatgat
ccactcacaaatctgaatacggcttttgacgtggcagagaagtacctggacatccccaag
atgctggatgccgaagacatcgttggaactgcccgaccggatgagaaagccatcatgact
tacgtgtctagcttctaccacgccttctctggagcccagaaggcggagacagcagccaat
cgcatctgcaaggtgttggccgtcaaccaggagaacgagcagcttatggaagactacgag
aagctggccagtgatctgttggagtggatccgccgcacaatcccgtggctggagaaccgg
gtgcccgagaacaccatgcatgccatgcaacagaagctggaggacttccgggactaccgg
cgcctgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacg
ctgcagaccaagctgcggctcagcaaccggcctgccttcatgccctctgagggcaggatg
gtctcggacatcaacaatgcctggggctgcctggagcaggtggagaagggctatgaggag
tggttgctgaatgagatccggaggctggagcgactggaccacctggcagagaagttccgg
cagaaggcctccatccacgaggcctggactgacggcaaagaggccatgctgcgacagaag
gactatgagaccgccaccctctcggagatcaaggccctgctcaagaagcatgaggccttc
gagagtgacctggctgcccaccaggaccgtgtggagcagattgccgccatcgcacaggag
ctcaatgagctggactattatgactcacccagtgtcaacgcccgttgccaaaagatctgt
gaccagtgggacaatctgggggccctaactcagaagcgaagggaagctctggagcggacc
gagaaactgctggagaccattgaccagctgtacttggagtatgccaagcgggctgcaccc
ttcaacaactggatggagggggccatggaggacctgcaggacaccttcattgtgcacacc
attgaggagatccagggactgaccacagcccatgagcagttcaaggccaccctccctgat
gccgacaaggagcgcctggccatcctgggcatccacaatgaggtgtccaagattgtccag
acctaccacgtcaatatggcgggcaccaacccctacacaaccatcacgcctcaggagatc
aatggcaaatgggaccacgtgcggcagctggtgcctcggagggaccaagctctgacggag
gagcatgcccgacagcagcacaatgagaggctacgcaagcagtttggagcccaggccaat
gtcatcgggccctggatccagaccaagatggaggagatcgggaggatctccattgagatg
catgggaccctggaggaccagctcagccacctgcggcagtatgagaagagcatcgtcaac
tacaagccaaagattgatcagctggagggcgaccaccagctcatccaggaggcgctcatc
ttcgacaacaagcacaccaactacaccatggagcacatccgtgtgggctgggagcagctg
ctcaccaccatcgccaggaccatcaatgaggtagagaaccagatcctgacccgggatgcc
aagggcatcagccaggagcagatgaatgagttccgggcctccttcaaccactttgaccgg
gatcactccggcacactgggtcccgaggagttcaaagcctgcctcatcagcttgggttat
gatattggcaacgacccccagggagaagcagaatttgcccgcatcatgagcattgtggac
cccaaccgcctgggggtagtgacattccaggccttcattgacttcatgtcccgcgagaca
gccgacacagatacagcagaccaagtcatggcttccttcaagatcctggctggggacaag
aactacattaccatggacgagctgcgccgcgagctgccacccgaccaggctgagtactgc
atcgcgcggatggccccctacaccggccccgactccgtgccaggtgctctggactacatg
tccttctccacggcgctgtacggcgagagtgacctctaa

KEGG   Homo sapiens (human): 81
Entry
81                CDS       T01001                                 
Symbol
ACTN4, ACTININ-4, FSGS, FSGS1
Name
(RefSeq) actinin alpha 4
  KO
K05699  actinin alpha 1/4
Organism
hsa  Homo sapiens (human)
Pathway
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04670  Leukocyte transendothelial migration
hsa04810  Regulation of actin cytoskeleton
hsa05131  Shigellosis
hsa05146  Amoebiasis
hsa05203  Viral carcinogenesis
hsa05322  Systemic lupus erythematosus
Network
nt06182  Shigella
nt06546  IgSF CAM signaling
  Element
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01082  Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00626  Focal segmental glomerulosclerosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    81 (ACTN4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    81 (ACTN4)
   04520 Adherens junction
    81 (ACTN4)
   04530 Tight junction
    81 (ACTN4)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    81 (ACTN4)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    81 (ACTN4)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    81 (ACTN4)
  09171 Infectious disease: bacterial
   05131 Shigellosis
    81 (ACTN4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    81 (ACTN4)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    81 (ACTN4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    81 (ACTN4)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    81 (ACTN4)
   04147 Exosome [BR:hsa04147]
    81 (ACTN4)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    81 (ACTN4)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     81 (ACTN4)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   81 (ACTN4)
  Exosomal proteins of colorectal cancer cells
   81 (ACTN4)
  Exosomal proteins of bladder cancer cells
   81 (ACTN4)
SSDB
Motif
Pfam: Spectrin CH EFhand_Ca_insen EF-hand_1 EF-hand_6 EF-hand_7 EF-hand_8 XisI
Other DBs
NCBI-GeneID: 81
NCBI-ProteinID: NP_004915
OMIM: 604638
HGNC: 166
Ensembl: ENSG00000130402
UniProt: O43707 A0A0S2Z3G9
Structure
LinkDB
Position
19:38647649..38731589
AA seq 911 aa
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC
NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA
SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM
LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK
LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ
KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL
NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES
NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD
HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT
DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS
FSTALYGESDL
NT seq 2736 nt   +upstreamnt  +downstreamnt
atggtggactaccacgcggcgaaccagtcgtaccagtacggccccagcagcgcgggcaat
ggcgctggcggcgggggcagcatgggcgactacatggcccaggaggacgactgggaccgg
gacctgctgctggacccggcctgggagaagcagcagcgcaagaccttcacggcatggtgc
aactcccacctgcggaaggcaggcacacagatcgagaacattgatgaggacttccgagac
gggctcaagctcatgctgctcctggaggtcatatcaggggagcggttacctaagccggag
cgggggaagatgagagtgcacaaaatcaacaatgtgaacaaagcgctggactttattgcc
agcaaaggcgtcaagctggtctccatcggggcagaagagattgtggacggcaacgcaaag
atgaccctgggaatgatctggaccatcatccttaggttcgccatccaggacatctccgtg
gaagagacctcggccaaggaagggctccttctctggtgccagagaaagacagccccgtat
aagaacgtcaatgtgcagaacttccacatcagctggaaggatggtcttgccttcaatgcc
ctgatccaccggcacagaccagagctgattgagtatgacaagctgaggaaggacgaccct
gtcaccaacctgaacaatgccttcgaagtggctgagaaatacctcgacatccccaagatg
ctggatgcagaggacatcgtgaacacggcccggcccgacgagaaggccataatgacctat
gtgtccagcttctaccatgccttttcaggagcgcagaaggctgaaactgccgccaaccgg
atctgtaaggtgctggctgtcaaccaagagaacgagcacctgatggaggactacgagaag
ctggccagcgacctcctggagtggatccggcgcaccatcccctggctggaggaccgtgtg
ccccaaaagactatccaggagatgcagcagaagctggaggacttccgcgactaccggcgt
gtgcacaagccgcccaaggtgcaggagaagtgccagctggagatcaacttcaacacgctg
cagaccaagctgcgcctcagcaaccggcccgccttcatgccctccgagggcaagatggtc
tcggacatcaacaatggctggcagcacttggagcaggctgagaagggctacgaggagtgg
ctgctgaatgagatccgcaggctggagcggctcgaccacctggcagagaagttccggcag
aaggcctccatccacgaggcctggactgacgggaaggaagccatgctgaagcaccgggac
tacgagacggccacactatcggacatcaaagccctcattcgcaagcacgaggccttcgag
agcgacctggctgcgcaccaggaccgcgtggagcagatcgccgccattgcccaggagctc
aacgagctggattactacgactcccacaatgtcaacacccggtgccagaagatctgtgac
cagtgggacgccctcggctctctgacacatagtcgcagggaagccctggagaaaacagag
aagcagctggaggccatcgaccagctgcacctggaatacgccaagcgcgcggcccccttc
aacaactggatggagagcgccatggaggacctccaggacatgttcatcgtccataccatc
gaggagattgagggcctgatctcagcccatgaccagttcaagtccaccctgccggacgcc
gatagggagcgcgaggccatcctggccatccacaaggaggcccagaggatcgctgagagc
aaccacatcaagctgtcgggcagcaacccctacaccaccgtcaccccgcaaatcatcaac
tccaagtgggagaaggtgcagcagctggtgccaaaacgggaccatgccctcctggaggag
cagagcaagcagcagtccaacgagcacctgcgccgccagttcgccagccaggccaatgtt
gtggggccctggatccagaccaagatggaggagatcgggcgcatctccattgagatgaac
gggaccctggaggaccagctgagccacctgaagcagtatgaacgcagcatcgtggactac
aagcccaacctggacctgctggagcagcagcaccagctcatccaggaggccctcatcttc
gacaacaagcacaccaactataccatggagcacatccgcgtgggctgggagcagctgctc
accaccattgcccgcaccatcaacgaggtggagaaccagatcctcacccgcgacgccaag
ggcatcagccaggagcagatgcaggagttccgggcgtccttcaaccacttcgacaaggat
catggcggggcgctggggcccgaggagttcaaggcctgcctcatcagcctgggctacgac
gtggagaacgaccggcagggtgaggccgagttcaaccgcatcatgagcctggtcgacccc
aaccatagcggccttgtgaccttccaagccttcatcgacttcatgtcgcgggagaccacc
gacacggacacggctgaccaggtcatcgcttccttcaaggtcttagcaggggacaagaac
ttcatcacagctgaggagctgcggagagagctgccccccgaccaggccgagtactgcatc
gcccgcatggcgccataccagggccctgacgccgtgcccggtgccctcgactacaagtcc
ttctccacggccttgtatggcgagagcgacctgtga

KEGG   Homo sapiens (human): 60
Entry
60                CDS       T01001                                 
Symbol
ACTB, BKRNS, BNS, BRWS1, CSMH, DDS1, PS1TP5BP1, THC8
Name
(RefSeq) actin beta
  KO
K05692  actin beta/gamma 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04670  Leukocyte transendothelial migration
hsa04714  Thermogenesis
hsa04810  Regulation of actin cytoskeleton
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04971  Gastric acid secretion
hsa05014  Amyotrophic lateral sclerosis
hsa05100  Bacterial invasion of epithelial cells
hsa05110  Vibrio cholerae infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05164  Influenza A
hsa05205  Proteoglycans in cancer
hsa05225  Hepatocellular carcinoma
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05416  Viral myocarditis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06529  Thermogenesis
nt06539  Cytoskeleton in muscle cells
nt06541  Cytoskeleton in neurons
nt06546  IgSF CAM signaling
  Element
N00465  Deleted DMD to dystrophin-associated protein complex
N01066  ARNO-ARF-ACTB_G signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01078  EGF-EGFR-Actin signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01081  Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01161  Actin polymerization
N01162  Mutation-caused aberrant PFN1 to actin polymerization
N01287  Tight junction-Actin signaling pathway
N01304  ANXA2-S100A10-regulated actin cytoskeleton
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
N01688  ADRB3-UCP1 signaling pathway
N01815  Vinculin-talin-integrin macromolecular complex
N01837  Regulation of neurite extension, NAV1-TRIO
N01838  Regulation of synaptic plasticity, p140Cap
N01848  Membrane-associated periodic skeleton (MPS)
N01849  Axonal actin ring structure
N01850  MYO5B-mediated vesicle transport
N01851  MYO5A-mediated vesicle transport
N01852  MYO6-mediated vesicle transport
N01933  NrCAM interactions
N01934  L1CAM interactions
N01935  NFASC interactions
N01943  SLIT-ROBO signaling in podocyte
N01953  NECL1 interactions
N01954  NECL2 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00978  Thrombocytopenia (THC)
H01255  Juvenile-onset dystonia
H02023  Baraitser-Winter syndrome
H02716  Becker nevus syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    60 (ACTB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    60 (ACTB)
   04390 Hippo signaling pathway
    60 (ACTB)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    60 (ACTB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    60 (ACTB)
  09143 Cell growth and death
   04210 Apoptosis
    60 (ACTB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    60 (ACTB)
   04520 Adherens junction
    60 (ACTB)
   04530 Tight junction
    60 (ACTB)
  09142 Cell motility
   04814 Motor proteins
    60 (ACTB)
   04820 Cytoskeleton in muscle cells
    60 (ACTB)
   04810 Regulation of actin cytoskeleton
    60 (ACTB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    60 (ACTB)
   04613 Neutrophil extracellular trap formation
    60 (ACTB)
   04670 Leukocyte transendothelial migration
    60 (ACTB)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    60 (ACTB)
   04919 Thyroid hormone signaling pathway
    60 (ACTB)
  09154 Digestive system
   04971 Gastric acid secretion
    60 (ACTB)
  09159 Environmental adaptation
   04714 Thermogenesis
    60 (ACTB)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    60 (ACTB)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    60 (ACTB)
  09172 Infectious disease: viral
   05164 Influenza A
    60 (ACTB)
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    60 (ACTB)
   05130 Pathogenic Escherichia coli infection
    60 (ACTB)
   05132 Salmonella infection
    60 (ACTB)
   05131 Shigellosis
    60 (ACTB)
   05135 Yersinia infection
    60 (ACTB)
   05100 Bacterial invasion of epithelial cells
    60 (ACTB)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    60 (ACTB)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    60 (ACTB)
   05410 Hypertrophic cardiomyopathy
    60 (ACTB)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    60 (ACTB)
   05414 Dilated cardiomyopathy
    60 (ACTB)
   05416 Viral myocarditis
    60 (ACTB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    60 (ACTB)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    60 (ACTB)
   03036 Chromosome and associated proteins [BR:hsa03036]
    60 (ACTB)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    60 (ACTB)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    60 (ACTB)
   04147 Exosome [BR:hsa04147]
    60 (ACTB)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Coactivators
    BAF/PBAF complex
     60 (ACTB)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     60 (ACTB)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    TIP60 complex
     60 (ACTB)
    NuA4 complex
     60 (ACTB)
  Chromatin remodeling factors
   BAF complex
    60 (ACTB)
   PBAF complex
    60 (ACTB)
   GBAF(ncBAF) complex
    60 (ACTB)
   SWR1 complex
    60 (ACTB)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Actin cytoskeleton organization
    60 (ACTB)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     60 (ACTB)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   60 (ACTB)
SSDB
Motif
Pfam: Actin
Other DBs
NCBI-GeneID: 60
NCBI-ProteinID: NP_001092
OMIM: 102630
HGNC: 132
Ensembl: ENSG00000075624
UniProt: P60709 Q1KLZ0
Structure
LinkDB
Position
7:complement(5527148..5530601)
AA seq 375 aa
MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
NT seq 1128 nt   +upstreamnt  +downstreamnt
atggatgatgatatcgccgcgctcgtcgtcgacaacggctccggcatgtgcaaggccggc
ttcgcgggcgacgatgccccccgggccgtcttcccctccatcgtggggcgccccaggcac
cagggcgtgatggtgggcatgggtcagaaggattcctatgtgggcgacgaggcccagagc
aagagaggcatcctcaccctgaagtaccccatcgagcacggcatcgtcaccaactgggac
gacatggagaaaatctggcaccacaccttctacaatgagctgcgtgtggctcccgaggag
caccccgtgctgctgaccgaggcccccctgaaccccaaggccaaccgcgagaagatgacc
cagatcatgtttgagaccttcaacaccccagccatgtacgttgctatccaggctgtgcta
tccctgtacgcctctggccgtaccactggcatcgtgatggactccggtgacggggtcacc
cacactgtgcccatctacgaggggtatgccctcccccatgccatcctgcgtctggacctg
gctggccgggacctgactgactacctcatgaagatcctcaccgagcgcggctacagcttc
accaccacggccgagcgggaaatcgtgcgtgacattaaggagaagctgtgctacgtcgcc
ctggacttcgagcaagagatggccacggctgcttccagctcctccctggagaagagctac
gagctgcctgacggccaggtcatcaccattggcaatgagcggttccgctgccctgaggca
ctcttccagccttccttcctgggcatggagtcctgtggcatccacgaaactaccttcaac
tccatcatgaagtgtgacgtggacatccgcaaagacctgtacgccaacacagtgctgtct
ggcggcaccaccatgtaccctggcattgccgacaggatgcagaaggagatcactgccctg
gcacccagcacaatgaagatcaagatcattgctcctcctgagcgcaagtactccgtgtgg
atcggcggctccatcctggcctcgctgtccaccttccagcagatgtggatcagcaagcag
gagtatgacgagtccggcccctccatcgtccaccgcaaatgcttctag

KEGG   Homo sapiens (human): 71
Entry
71                CDS       T01001                                 
Symbol
ACTG1, ACT, ACTG, DFNA20, DFNA26, HEL-176
Name
(RefSeq) actin gamma 1
  KO
K05692  actin beta/gamma 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03082  ATP-dependent chromatin remodeling
hsa04015  Rap1 signaling pathway
hsa04145  Phagosome
hsa04210  Apoptosis
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04520  Adherens junction
hsa04530  Tight junction
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04670  Leukocyte transendothelial migration
hsa04714  Thermogenesis
hsa04810  Regulation of actin cytoskeleton
hsa04814  Motor proteins
hsa04820  Cytoskeleton in muscle cells
hsa04919  Thyroid hormone signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04971  Gastric acid secretion
hsa05014  Amyotrophic lateral sclerosis
hsa05100  Bacterial invasion of epithelial cells
hsa05110  Vibrio cholerae infection
hsa05130  Pathogenic Escherichia coli infection
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05164  Influenza A
hsa05205  Proteoglycans in cancer
hsa05225  Hepatocellular carcinoma
hsa05410  Hypertrophic cardiomyopathy
hsa05412  Arrhythmogenic right ventricular cardiomyopathy
hsa05414  Dilated cardiomyopathy
hsa05416  Viral myocarditis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06180  Pathogenic Escherichia coli
nt06181  Salmonella
nt06182  Shigella
nt06464  Amyotrophic lateral sclerosis
nt06529  Thermogenesis
nt06539  Cytoskeleton in muscle cells
nt06541  Cytoskeleton in neurons
nt06546  IgSF CAM signaling
  Element
N00465  Deleted DMD to dystrophin-associated protein complex
N01066  ARNO-ARF-ACTB_G signaling pathway
N01067  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
N01078  EGF-EGFR-Actin signaling pathway
N01079  Shigella IpaC to Actin signaling pathway
N01080  ITGA/B-TALIN/VINCULIN signaling pathway
N01081  Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway
N01086  Escherichia EspT to RAC signaling pathway
N01092  Escherichia Eae/Tir to Actin signaling pathway
N01094  Escherichia Eae/Tir/TccP to Actin signaling pathway
N01096  Escherichia Map to CDC42 signaling pathway
N01128  Salmonella SopE to RAC signaling pathway
N01129  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway
N01161  Actin polymerization
N01162  Mutation-caused aberrant PFN1 to actin polymerization
N01287  Tight junction-Actin signaling pathway
N01304  ANXA2-S100A10-regulated actin cytoskeleton
N01305  Salmonella SopB to ANXA2-S100A10-regulated actin cytoskeleton
N01688  ADRB3-UCP1 signaling pathway
N01815  Vinculin-talin-integrin macromolecular complex
N01837  Regulation of neurite extension, NAV1-TRIO
N01838  Regulation of synaptic plasticity, p140Cap
N01848  Membrane-associated periodic skeleton (MPS)
N01849  Axonal actin ring structure
N01850  MYO5B-mediated vesicle transport
N01851  MYO5A-mediated vesicle transport
N01852  MYO6-mediated vesicle transport
N01933  NrCAM interactions
N01934  L1CAM interactions
N01935  NFASC interactions
N01943  SLIT-ROBO signaling in podocyte
N01953  NECL1 interactions
N01954  NECL2 interactions
N01962  ICAM1 interactions
N01965  ICAM2 interactions
N01966  ICAM3 interactions
Disease
H00604  Deafness, autosomal dominant
H01705  Bilateral sudden sensorineural hearing loss
H02023  Baraitser-Winter syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09126 Chromosome
   03082 ATP-dependent chromatin remodeling
    71 (ACTG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    71 (ACTG1)
   04390 Hippo signaling pathway
    71 (ACTG1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    71 (ACTG1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    71 (ACTG1)
  09143 Cell growth and death
   04210 Apoptosis
    71 (ACTG1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    71 (ACTG1)
   04520 Adherens junction
    71 (ACTG1)
   04530 Tight junction
    71 (ACTG1)
  09142 Cell motility
   04814 Motor proteins
    71 (ACTG1)
   04820 Cytoskeleton in muscle cells
    71 (ACTG1)
   04810 Regulation of actin cytoskeleton
    71 (ACTG1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    71 (ACTG1)
   04613 Neutrophil extracellular trap formation
    71 (ACTG1)
   04670 Leukocyte transendothelial migration
    71 (ACTG1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    71 (ACTG1)
   04919 Thyroid hormone signaling pathway
    71 (ACTG1)
  09154 Digestive system
   04971 Gastric acid secretion
    71 (ACTG1)
  09159 Environmental adaptation
   04714 Thermogenesis
    71 (ACTG1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    71 (ACTG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    71 (ACTG1)
  09172 Infectious disease: viral
   05164 Influenza A
    71 (ACTG1)
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    71 (ACTG1)
   05130 Pathogenic Escherichia coli infection
    71 (ACTG1)
   05132 Salmonella infection
    71 (ACTG1)
   05131 Shigellosis
    71 (ACTG1)
   05135 Yersinia infection
    71 (ACTG1)
   05100 Bacterial invasion of epithelial cells
    71 (ACTG1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    71 (ACTG1)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    71 (ACTG1)
   05410 Hypertrophic cardiomyopathy
    71 (ACTG1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    71 (ACTG1)
   05414 Dilated cardiomyopathy
    71 (ACTG1)
   05416 Viral myocarditis
    71 (ACTG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    71 (ACTG1)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    71 (ACTG1)
   03036 Chromosome and associated proteins [BR:hsa03036]
    71 (ACTG1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    71 (ACTG1)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    71 (ACTG1)
   04147 Exosome [BR:hsa04147]
    71 (ACTG1)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Coactivators
    BAF/PBAF complex
     71 (ACTG1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Factors involved in mRNA localization
    Factors that have mRNA localization signals
     71 (ACTG1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   HAT complexes
    TIP60 complex
     71 (ACTG1)
    NuA4 complex
     71 (ACTG1)
  Chromatin remodeling factors
   BAF complex
    71 (ACTG1)
   PBAF complex
    71 (ACTG1)
   GBAF(ncBAF) complex
    71 (ACTG1)
   SWR1 complex
    71 (ACTG1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Actin cytoskeleton organization
    71 (ACTG1)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     71 (ACTG1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   71 (ACTG1)
SSDB
Motif
Pfam: Actin
Other DBs
NCBI-GeneID: 71
NCBI-ProteinID: NP_001186883
OMIM: 102560
HGNC: 144
Ensembl: ENSG00000184009
UniProt: P63261
Structure
LinkDB
Position
17:complement(81509971..81512799)
AA seq 375 aa
MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF
NT seq 1128 nt   +upstreamnt  +downstreamnt
atggaagaagagatcgccgcgctggtcattgacaatggctccggcatgtgcaaagctggt
tttgctggggacgacgctccccgagccgtgtttccttccatcgtcgggcgccccagacac
cagggcgtcatggtgggcatgggccagaaggactcctacgtgggcgacgaggcccagagc
aagcgtggcatcctgaccctgaagtaccccattgagcatggcatcgtcaccaactgggac
gacatggagaagatctggcaccacaccttctacaacgagctgcgcgtggccccggaggag
cacccagtgctgctgaccgaggcccccctgaaccccaaggccaacagagagaagatgact
cagattatgtttgagaccttcaacaccccggccatgtacgtggccatccaggccgtgctg
tccctctacgcctctgggcgcaccactggcattgtcatggactctggagacggggtcacc
cacacggtgcccatctacgagggctacgccctcccccacgccatcctgcgtctggacctg
gctggccgggacctgaccgactacctcatgaagatcctcactgagcgaggctacagcttc
accaccacggccgagcgggaaatcgtgcgcgacatcaaggagaagctgtgctacgtcgcc
ctggacttcgagcaggagatggccaccgccgcatcctcctcttctctggagaagagctac
gagctgcccgatggccaggtcatcaccattggcaatgagcggttccggtgtccggaggcg
ctgttccagccttccttcctgggtatggaatcttgcggcatccacgagaccaccttcaac
tccatcatgaagtgtgacgtggacatccgcaaagacctgtacgccaacacggtgctgtcg
ggcggcaccaccatgtacccgggcattgccgacaggatgcagaaggagatcaccgccctg
gcgcccagcaccatgaagatcaagatcatcgcacccccagagcgcaagtactcggtgtgg
atcggtggctccatcctggcctcactgtccaccttccagcagatgtggattagcaagcag
gagtacgacgagtcgggcccctccatcgtccaccgcaaatgcttctaa

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